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Advanced strategies for production of natural products in yeast

Ruibing Chen, Shan Yang, Lei Zhang, Yongjin J. Zhou
2020 iScience  
In this review, we have summarized current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids.  ...  Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use.  ...  Rewriting the central carbon metabolism, combined with the microbial tyrosine ammonia lyase and plant cinnamic acid hydroxylase branches, enabled high-level production of p-CA (12.5 g/L) in S. cerevisiae  ... 
doi:10.1016/j.isci.2020.100879 pmid:32087574 pmcid:PMC7033514 fatcat:aq7vevol6fhinh6rji325pq4vy

High-throughput screening for improved microbial cell factories, perspective and promise

Michael D Leavell, Amoolya H Singh, Benjamin B Kaufmann-Malaga
2020 Current Opinion in Biotechnology  
High-throughput screening is a critical part of any industrial strain engineering effort, helping ensure the lowest cost product is produced in the shortest amount of time.  ...  In this review, the current state of high-throughput screening, the technological advances for the next generation strain screening pipeline, and options for implementation are reviewed.  ...  Acknowledgement The authors would like to thank Adam Navidi for many helpful comments on this manuscript. References and recommended reading  ... 
doi:10.1016/j.copbio.2019.07.002 pmid:31513989 fatcat:wj3ma2xhdre25j5osd2z6fppje

Chasing bacterial chassis for metabolic engineering: a perspective review from classical to non-traditional microorganisms

Patricia Calero, Pablo I. Nikel
2018 Microbial Biotechnology  
The last few years have witnessed an unprecedented increase in the number of novel bacterial species that hold potential to be used for metabolic engineering.  ...  Historically, however, only a handful of bacteria have attained the acceptance and widespread use that are needed to fulfil the needs of industrial bioproductionand only for the synthesis of very few,  ...  Further research on the central carbon metabolism of V. natriegens has been performed in glucose-grown cells using 13 C-based metabolic flux analysis, showing a flux distribution in central carbon metabolism  ... 
doi:10.1111/1751-7915.13292 pmid:29926529 fatcat:kicdodkeojdjrjpf2p7mwnwiie

LIFE SCIENCE TECHNOLOGIES MEETING CHAIRS Unparalleled product quality, validation, and technical support

Michael Hayden, Canada, Adrian Bird, Howard Cedar, Aharon Razin, Synthetic Genomics, Cammy Abernathy, Paul Braun, Masashi Kawasaki, Kathryn Wahl
2010 unpublished
. ™ MPI Research is the CRO that defines responsiveness, moving your drug development program forward with customized solutions for all your preclinical research and early clinical support needs.  ...  From discovery services to safety evaluation, including analytical and bioanalytical support, you can count on MPI Research for quick quotes, frequent updates, rapid turnaround, and scientific rigor.  ...  Keasling's team started by transplanting a yeast mevalonate isoprenoid pathway and a synthetic (codon-optimized) amorphadiene synthase gene into E. coli, creating a strain capable of turning sugar into  ... 

New and improved methods for integrated models of metabolism and gene expression

Pierre Guy Rémy Salvy
In particular, models of metabolism and gene expression (ME-models) were the first formulation to account simultaneously for cell metabolism, and the expression mechanisms translating genetic information  ...  Margaux, tu asété un monument central de ces années en Suisse. C'est vrai que c'était un peu différent de la Californie.  ...  Examples include the industrial bio-production of artemisinic acid, an anti-malarial drug precursor (6) , and the production of isoprenoids -chemical compounds of interest for biofuels, bioplastics, and  ... 
doi:10.5075/epfl-thesis-8489 fatcat:oxc4bv7g3ja2heayetctcxjq2y

Phylogenetic Analysis [chapter]

An Introduction to Computational Biochemistry  
Some of its products (secondary products) may be eliminated from primary metabolism and are of no importance to the living organisms producing them. 5.  ...  The transcription rewrites parts of the genetic messages in DNA into the form of RNA (mRNA).  ...  Retrieve nucleotide sequence (fasta file) and atomic coordinates (pdb file) of yeast Asp-tRNA.  ... 
doi:10.1002/0471223840.ch13 fatcat:nipg4bxrevau3efb6bagqscufy

Journal of undergraduate research, vol. 8, no. 1, Fall 2017 [article]

(:Unkn) Unknown, Colorado State University. Libraries
I look forward to what the future has to offer for those graduating, and what the year holds for new and returning members.  ...  We are a journal for undergraduates and by undergraduates.  ...  I am grateful for the generous funding for fieldwork provided by the International Political Economy Department at the University of Puget Sound.  ... 
doi:10.25675/10217/233606 fatcat:3gup3tpxhfapnj6xyzjcl2odkq