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Reward circuitry is perturbed in the absence of the serotonin transporter

Elaine L. Bearer, Xiaowei Zhang, Davit Janvelyan, Benoit Boulat, Russell E. Jacobs
2009 NeuroImage  
Thus, molecular disruptions of SERT that produce behavioral changes also alter the functional anatomy of the reward circuitry in which all the monoamine systems are involved.  ...  Here we use high-resolution magnetic resonance imaging (MRI) and spectroscopy to elucidate the effects of disruption of the serotonin transporter in an animal model system: the SERT knock-out mouse.  ...  Acknowledgements We thank Mike Tyszka at Caltech for creation and implementation of the DTI routines; and  ... 
doi:10.1016/j.neuroimage.2009.03.026 pmid:19306930 pmcid:PMC2693299 fatcat:r56rxqtds5attnetlwknmyqlde

Addiction science: Uncovering neurobiological complexity

N.D. Volkow, R.D. Baler
2014 Neuropharmacology  
we investigate the neurobiology of substance use disorders (SUD) and the factors that modulate risk and resilience.  ...  Until very recently addiction-research was limited by existing tools and strategies that were inadequate for studying the inherent complexity at each of the different phenomenological levels.  ...  On the other hand, carriers of the MAOA-H allele (in combination with the s/s version of the serotonin transporter (5HTT)) display more efficient executive control of working memoryrelated performance  ... 
doi:10.1016/j.neuropharm.2013.05.007 pmid:23688927 pmcid:PMC3818510 fatcat:opq3a4qwbbgdvmubfwy52vk53u

Insights into the Role of the Habenular Circadian Clock in Addiction

Nora L. Salaberry, Jorge Mendoza
2016 Frontiers in Psychiatry  
This brain structure modulates the activity of dopaminergic neurons from the ventral tegmental area, a central part of the reward system.  ...  Evidence concerning the role of clock genes in drug intake has been previously reported. However, the implication of a timekeeping brain locus is much less known.  ...  The LHb in the Dopamine Circuitry: implications in Addiction The reward system is an intricate network involving diverse structures.  ... 
doi:10.3389/fpsyt.2015.00179 pmid:26779042 pmcid:PMC4700272 fatcat:rkhlkug7yfgvtb5okbakmyojte

Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors

Kenneth Blum, Marjorie C. Gondré-Lewis, David Baron, Panayotis K. Thanos, Eric R. Braverman, Jennifer Neary, Igor Elman, Rajendra D. Badgaiyan
2018 Frontiers in Psychiatry  
reward circuitry that has a key role in addiction symptomatology.  ...  The Serotonin Transporter Gene The serotonin transporter gene encoded by (SLC6A4) located with the 5-HTTLPR polymorphism on chromosome 17, occurs in the promoter region of the gene.  ...  The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.  ... 
doi:10.3389/fpsyt.2018.00548 pmid:30542299 pmcid:PMC6277779 fatcat:meazvzftovcnzl2f6et2k3bqoy

Neural and neurochemical basis of reinforcement-guided decision making

Abbas Khani, Gregor Rainer
2016 Journal of Neurophysiology  
Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive-compulsive disorder. Behav Brain Res 195: 159 -163, 2008.  ...  Serotonin and tolerance to delay of reward in rats. Psychopharmacology 146: 400 -412, 1999. Bloomfield MA, Morgan CJ, Kapur S, Curran HV, Howes OD.  ...  The value of delayed and uncertain rewards is also dependent on these circuitries and is modulated by several neuromodulators, particularly the serotonin system.  ... 
doi:10.1152/jn.01113.2015 pmid:27226454 fatcat:wpqjzj2sxnh2dh5lfqw5pszuhq

Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: What depression has in common with impulsive aggression

Charles S. Carver, Sheri L. Johnson, Jutta Joormann
2008 Psychological bulletin  
that responds more reflectively and planfully; that low serotonergic function is linked to relative dominance of the lower-order system; that how dominance of the lower-order system is manifested depends  ...  Literatures reviewed include work on two-mode models; studies of brain function supporting the biological plausibility of the two-mode view and the involvement of serotonergic pathways in functions pertaining  ...  A: A reactive system for approaching rewards and a reactive system for avoiding threats or punishment compete for ascendance; in the absence of effortful control, the resultant of that competition is expressed  ... 
doi:10.1037/a0013740 pmid:18954161 pmcid:PMC2847478 fatcat:hyy63trqfnf5jjjbnm4ctyjycu

Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment

Naomi A Fineberg, Annemieke M Apergis-Schoute, Matilde M Vaghi, Paula Banca, Claire M Gillan, Valerie Voon, Samuel R Chamberlain, Eduardo Cinosi, Jemma Reid, Sonia Shahper, Edward T Bullmore, Barbara J Sahakian (+1 others)
2017 International Journal of Neuropsychopharmacology  
In obsessive compulsive disorder, distributed network perturbation appears focused around the prefrontal cortex, caudate, putamen, and associated neuro-circuitry.  ...  there is an absence of ventromedial prefrontal cortex safety signaling in obsessive compulsive disorder, which potentially undermines explicit Fineberg et al. | 43 contingency knowledge and may help to  ...  Statement of Interest She has in the recent past consulted for Lundbeck, Servier, and Otsuka and received grants from Peak and Janssen/JandJ.  ... 
doi:10.1093/ijnp/pyx088 pmid:29036632 pmcid:PMC5795357 fatcat:5mtwrbt4krdxtghkebaps7l7la

RNA-binding proteins, neural development and the addictions

C. D. Bryant, N. Yazdani
2016 Genes, Brain and Behavior  
More than 50% of these RBPs are expressed in the brain where they regulate alternative splicing, transport, localization, stability and translation of RNAs during development and adulthood.  ...  More than 1000 genes in the eukaryotic genome code for multifunctional RNA-binding proteins (RBPs) that can regulate all levels of RNA biogenesis.  ...  Appico for assistance in neuronal cell culture and imaging as well as Drs  ... 
doi:10.1111/gbb.12273 pmid:26643147 pmcid:PMC4944654 fatcat:7vf5pvzdgfalla6plsmdncp2nm

Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35

Justin M. Drerup, Kanehiro Hayashi, Huxing Cui, Gabriel L. Mettlach, Michael A. Long, Marian Marvin, Xiankai Sun, Matthew S. Goldberg, Michael Lutter, James A. Bibb
2010 Biological Psychiatry  
Mice lacking the Cdk5-activating cofactor p35 are deficient in cortical lamination, suggesting altered motor/ reward circuitry.  ...  Methods-We employed mice lacking p35 to study the effect of altered circuitry in vivo.  ...  J.M.D. was the recipient of a Green Fellowship from UT Dallas and a Summer Undergraduate Research Fellowship from UT Southwestern. Support was also provided by a NARSAD Young Investigator Award  ... 
doi:10.1016/j.biopsych.2010.07.016 pmid:20832057 pmcid:PMC2997929 fatcat:uehu6r56afb4lbka3mk5i6lg4m

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

Cheryl A. Frye, Jason J. Paris, Danielle M. Osborne, Joannalee C. Campbell, Tod E. Kippin
2011 Frontiers in Psychiatry  
Thus, there is evidence for PNS-induced changes in the structural and functional integrity of the dopamine reward circuitry among rodents.  ...  Involvement of the HPA axis is further implied in studies of perinatal perturbation.  ...  Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest  ... 
doi:10.3389/fpsyt.2011.00052 pmid:22022315 pmcid:PMC3195272 fatcat:tb63uk6bovffjc643gy43suuse

The good, the bad and the brain: neural correlates of appetitive and aversive values underlying decision making

Mathias Pessiglione, Mauricio R Delgado
2015 Current Opinion in Behavioral Sciences  
Here we contrast this hypothesis with recent neuroscience studies exploring the human brain from brainstem nuclei to cortical areas.  ...  Approaching rewards and avoiding punishments could be considered as core principles governing behavior.  ...  It suggests that context in which an appetitive reinforcer is viewed (i.e., in the presence or absence of a potential aversive stimulus) can influence value related neural signals.  ... 
doi:10.1016/j.cobeha.2015.08.006 pmid:31179377 pmcid:PMC6553864 fatcat:x5g4zb33gvbglb4ckjunjrmbiq

Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction

Kathryn A. Cunningham, Noelle C. Anastasio
2014 Neuropharmacology  
This review emphasizes the role of 5-HT and its receptor proteins in key addiction phenotypes and the implications of current findings to the future of therapeutics in addiction.  ...  As such, 5-HT is an important target in the quest to understand the neurobiology of relapse-predictive phenotypes, to successfully treat this complex disorder and improve diagnostic and prognostic capabilities  ...  Essie Anastasio who passed away during the writing of this review.  ... 
doi:10.1016/j.neuropharm.2013.06.030 pmid:23850573 pmcid:PMC4090081 fatcat:eoinsxnc75ej3lzftaacsa4u4u

Gonadal steroid regulation of mood: The lessons of premenstrual syndrome☆

2006 Frontiers in neuroendocrinology (Print)  
This question is the easiest to answer, for the neuroregulatory eVects of gonadal steroids are myriad, well known, and widely appreciated.  ...  Indeed, wherever one Wnds a system believed to play a role in the etiology or treatment of ଝ  ...  replacement and altered activation of reward circuitry as a function of menstrual cycle phase; speciWcally, activation is greater in the follicular phase than in the luteal phase in the orbitofrontal  ... 
doi:10.1016/j.yfrne.2006.02.003 pmid:16650465 fatcat:mgfbsh4o5rfnvma6wym763jyd4

Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry

Trevor Archer, Kenneth Blum
2012 Journal of genetic syndrome & gene therapy  
While many reward gene polymorphisms are involved in impulsive behaviors, a polymorphism by itself may not translate to the development of a particular behavioral disorder unless it is impacted by epigenetic  ...  of the neurotrophin are associated with both cognitive and aggressive impulsiveness.  ...  Acknowledgements The writing of this paper was supported in part by the US Department of Health and Human Services, NIAAA (R01 AA 07112, K05 AA 00219), and by the Medical Research Service of the US Department  ... 
doi:10.4172/2157-7412.1000115 pmid:23264884 pmcid:PMC3526005 fatcat:pzcajhcpizgeth3u6u53ik5mqa

Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, pathophysiology, and treatment

Christopher Pittenger, Michael H. Bloch, Kyle Williams
2011 Pharmacology and Therapeutics  
Nevertheless, the evidence supporting some important perturbation of glutamate in the disorder is increasingly strong.  ...  Recent evidence suggests that the ubiquitous excitatory neurotransmitter glutamate is dysregulated in OCD, and that this dysregulation may contribute to the pathophysiology of the disorder.  ...  Conflict of interest statement The authors are aware of no real or apparent conflict of interest that might influence the content of this review. C. Pittenger is a consultant to F.  ... 
doi:10.1016/j.pharmthera.2011.09.006 pmid:21963369 pmcid:PMC3205262 fatcat:nlemju7ndvcgbo3j22mx5pq6cy
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