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Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships

Xiaoyan A Qu, Ranga C Gudivada, Anil G Jegga, Eric K Neumann, Bruce J Aronow
2009 BMC Bioinformatics  
Using the complex disease Systemic Lupus Erythematosus (SLE) as an example, a high-dimensional pharmacome-diseasome graph network was generated as RDF XML, and subjected to graph-theoretic proximity and  ...  Ontology (DDCO), formalized in OWL, that integrates multiple ontologies, controlled vocabularies, and data schemas and interlinks these with diverse datasets extracted from pharmacological and biological  ...  Figure 4 illustrates the relations using a schematic view of the RDF data model referenced via links to the DDCO OWL ontology.  ... 
doi:10.1186/1471-2105-10-s5-s4 pmid:19426461 pmcid:PMC2679404 fatcat:y5a36ldx4zdrtlgzmwz7l2vj7u