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Numerical workflow of irreversible electroporation for deep-seated tumor

Olivier Gallinato, Baudouin Denis de Senneville, Olivier Seror, Clair Poignard
2019 Physics in Medicine and Biology  
The paper provides a numerical workflow, based on the 'real-life' clinical workflow of irreversible electroporation (IRE) performed for the treatment of deep-seated liver tumors.  ...  As a proof of concept, we show on a specific clinical case of IRE ablation of liver tumor that clinical data could be advantageously combined to numerical simulations in a near future, in order to give  ...  Acknowledgement The authors thank very warmly the referees for their helpful comments and suggestions, that help to improve the manusript.  ... 
doi:10.1088/1361-6560/ab00c4 pmid:30669121 fatcat:3ybhhnxzgfaahgdmuixndgqs6m

An evaluation of irreversible electroporation thresholds in human prostate cancer and potential correlations to physiological measurements

Sabrina Campelo, Massimo Valerio, Hashim U. Ahmed, Yipeng Hu, Sara L. Arena, Robert E. Neal, Mark Emberton, Christopher B. Arena
2017 APL Bioengineering  
Irreversible electroporation (IRE) is an emerging cancer treatment that utilizes non-thermal electric pulses for tumor ablation.  ...  Accurate treatment planning and prediction of the ablation volume require a priori knowledge of the tissue-specific electric field threshold for cell death.  ...  Irreversible electroporation (IRE) is an emerging cancer treatment that utilizes non-thermal electric pulses for tumor ablation.  ... 
doi:10.1063/1.5005828 pmid:31069281 pmcid:PMC6481690 fatcat:vnqg7t7wqjczpdqdexfsliymry

Irreversible electroporation: state of the art

Peter Wagstaff, Mara Buijs, Willemien van den Bos, Daniel de Bruin, Patricia Zondervan, Jean de la Rosette, Pilar Laguna
2016 OncoTargets and Therapy  
The field of focal ablative therapy for the treatment of cancer is characterized by abundance of thermal ablative techniques that provide a minimally invasive treatment option in selected tumors.  ...  Irreversible electroporation (IRE) is a novel ablation modality based on the principle of electroporation or electropermeabilization, in which electric pulses are used to create nanoscale defects in the  ...  11 Kingham et al, 38 2012 Liver 65 CT/MRi Directly, 1/3/6 mo iRe is safe for the treatment of liver tumors; one persistence and one recurrence observed Retrospective cohort 4 Cannon  ... 
doi:10.2147/ott.s88086 pmid:27217767 pmcid:PMC4853139 fatcat:rjuvjyqsvbcj7aeip2e4itphle

Numerical modelling challenges for clinical electroporation ablation technique of liver tumors

Olivier Gallinato, Baudouin Denis de Senneville, Olivier Seror, Clair Poignard, Florence Hubert
2020 Mathematical Modelling of Natural Phenomena  
In this paper, we present the recent advances and challenges on the numerical modeling of clinical electroporation ablation of liver tumors.  ...  Electroporation ablation is a promising non surgical and minimally invasive technique of tumor ablation, for which no monitoring is currently available.  ...  This study has been carried out within the frame of the LABEX TRAIL, ANR-10-LABX-0057 with financial support from the French State, managed by the French National Research Agency (ANR) in the frame of  ... 
doi:10.1051/mmnp/2019037 fatcat:d2ru73tbu5apjh7xgnf4nzjdei

Stereotactic Image-Guidance for Ablation of Malignant Liver Tumors [chapter]

Iwan Paolucci, Raluca-Maria Sandu, Pascale Tinguely, Corina Kim-Fuchs, Martin Maurer, Daniel Candinas, Stefan Weber, Anja Lachenmayer
2019 Liver Cancer [Working Title]  
Stereotactic percutaneous ablation is a rapidly advancing modality for treatment of tumors in soft solid organs such as the liver.  ...  Stereotactic image-guidance leads to a simple, fast, and accurate placement of the ablation probe into the liver tumor, which is a prerequisite for a complete destruction of the tumor by ablation.  ...  Irreversible electroporation Irreversible electroporation (IRE) is non-thermal ablation technique that delivers short pulses of high-voltage electrical energy directly to a tumor.  ... 
doi:10.5772/intechopen.89722 fatcat:ykahhxpsabhhdldoxscpcqthdi

Minimally invasive local therapies for liver cancer

David Li, Josephine Kang, Benjamin J Golas, Vincent W Yeung, David C Madoff
2014 Cancer Biology and Medicine  
Surgical resection and/or transplantation, locally ablative therapies and regional or locoregional therapies have filled the gap in liver tumor treatments, providing improved survival outcomes for both  ...  Minimally invasive local therapies have an increasing role in the treatment of both primary and metastatic liver tumors.  ...  Numerous locoregional treatment options have been explored for the treatment of large or multinodular tumors.  ... 
doi:10.7497/j.issn.2095-3941.2014.04.001 pmid:25610708 pmcid:PMC4296086 fatcat:uzfxakb7cjgzjol2v6pjnzzi5m

Percutaneous Therapies for Hepatocellular Carcinoma: Evolution of Liver Directed Therapies

Timothy C Huber, Teodora Bochnakova, Yilun Koethe, Brian Park, Khashayar Farsad
2021 Journal of Hepatocellular Carcinoma  
Percutaneous ablation is a mainstay of treatment for early stage, unresectable hepatocellular carcinoma (HCC).  ...  The purpose of this review is to familiarize readers with the technical and clinical aspects of both existing and emerging percutaneous treatment options for HCC.  ...  Safe use of IRE for hepatic tumors encasing, abutting or within 1.0 cm of a vessel has been validated in numerous pre-clinical and clinical trials.  ... 
doi:10.2147/jhc.s268300 pmid:34589446 pmcid:PMC8476177 fatcat:ngwqo4mvvbewpeiwxvhyg3irmi

Locally Advanced Pancreatic Cancer: Work-Up, Staging, and Local Intervention Strategies

Eran van Veldhuisen, Claudia van den Oord, Lilly J. Brada, Marieke S. Walma, Jantien A. Vogel, Johanna W. Wilmink, Marco del Chiaro, Krijn P. van Lienden, Martijn R. Meijerink, Geertjan van Tienhoven, Thilo Hackert, Christopher L. Wolfgang (+7 others)
2019 Cancers  
In case a resection is not considered possible but stable disease is observed, local ablative techniques are being studied, such as irreversible electroporation, radiofrequency ablation, and stereotactic  ...  Pragmatic, multicenter, randomized studies will ultimately have to confirm the exact role of both surgical exploration and ablation in these patients.  ...  A proposed work-up and treatment plan of LAPC is depicted in Figure 2 .  ... 
doi:10.3390/cancers11070976 pmid:31336859 pmcid:PMC6679311 fatcat:c4hmxlscajeqlao6g24vhknixm

A Surgical Perspective on Targeted Therapy of Hepatocellular Carcinoma

Claire Faltermeier, Ronald Busuttil, Ali Zarrinpar
2015 Diseases  
Since HCC is predominantly diagnosed in patients with cirrhosis, treatment planning must consider both the severity of liver disease and tumor burden.  ...  Patients with decompensated cirrhosis and small tumors are optimal candidates for liver transplantation, which offers the best chance of long-term survival.  ...  Similar to RFA/MWA for tumors <2 cm, superior efficacy for tumors >2 cm [141, 142] Irreversible electroporation (IRE) Suitable for tumors adjacent to blood vessels [143, 144] Prospective studies only  ... 
doi:10.3390/diseases3040221 pmid:28943622 pmcid:PMC5548262 fatcat:i2iekenkwjhddde62hqrrtaioq

Ablation therapy for hepatocellular carcinoma: past, present and future perspectives

David J Niemeyer, Kerri A Simo, David A Iannitti, Iain H McKillop
2014 Hepatic Oncology  
Treatment of HCC must consider both the tumors present, as well as the remaining dysfunctional liver that both hinders treatment and can produce additional HCC over time.  ...  Irreversible electroporation is an emerging nonthermal ablation technology that preserves tissue architecture.  ...  No writing assistance was utilized in the production of this manuscript.  ... 
doi:10.2217/hep.13.8 pmid:30190942 pmcid:PMC6114009 fatcat:se232o7pvjafvdaiivpr7cmt3q

Validation of a Web-Based Planning Tool for Percutaneous Cryoablation of Renal Tumors

Tim J van Oostenbrugge, Jan Heidkamp, Michael Moche, Phil Weir, Panchatcharam Mariappan, Ronan Flanigan, Mika Pollari, Stephen Payne, Marina Kolesnik, Sjoerd F M Jenniskens, Jurgen J Fütterer
2020 Cardiovascular and Interventional Radiology  
To validate a simulation environment for virtual planning of percutaneous cryoablation of renal tumors.  ...  Prospectively collected data from 19 MR-guided procedures were used for validation of the simulation model.  ...  Within the Go-Smart project, of which the development of the cryoablation planning tool was a part, also simulation tools for microwave (MWA)-and radiofrequency ablation (RFA) and irreversible electroporation  ... 
doi:10.1007/s00270-020-02634-y pmid:32935141 pmcid:PMC7591419 fatcat:eeimyej5tncgzpugfavagpu4g4

Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

Bela Kis, Ghassan El-Haddad, Rahul A. Sheth, Nainesh S. Parikh, Suvranu Ganguli, Paul B. Shyn, Junsung Choi, Karen T. Brown
2017 Cancer Control: Journal of the Moffitt Cancer Cente  
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC) are primary liver cancers where all or most of the tumor burden is usually confined to the liver.  ...  Locoregional liver-directed therapies provide survival benefit for patients with HCC and IHC compared to best medical treatment and have lower comorbid risks compared to surgical resection.  ...  years, there has been significant advancement and development of energy-based ablative technologies, including radiofrequency ablation (RFA), microwave ablation (MWA), cryoablation, irreversible electroporation  ... 
doi:10.1177/1073274817729244 pmid:28975829 pmcid:PMC5937250 fatcat:ouxzxidhxjd7rju5e7vad2qhla

Locoregional treatments for hepatocellular carcinoma: Current evidence and future directions

Riccardo Inchingolo, Alessandro Posa, Martin Mariappan, Stavros Spiliopoulos
2019 World Journal of Gastroenterology  
therapy many of which are often the first-line treatment for select stages of HCC or serve as a conduit to liver transplant.  ...  This has led to the advent of numerous minimally invasive options including but not limited to trans-arterial chemoembolization, radiofrequency/microwave ablation and more recently selective internal radiation  ...  Newer technologies such as laser ablation (LA) and irreversible electroporation (IRE) remain under investigation for their efficacy [44] [45] [46] .  ... 
doi:10.3748/wjg.v25.i32.4614 pmid:31528090 pmcid:PMC6718039 fatcat:l2naftvbfrdlddtk6m3b7bkcni

RFA Guardian: Comprehensive Simulation of Radiofrequency Ablation Treatment of Liver Tumors

Philip Voglreiter, Panchatcharam Mariappan, Mika Pollari, Ronan Flanagan, Roberto Blanco Sequeiros, Rupert Horst Portugaller, Jurgen Fütterer, Dieter Schmalstieg, Marina Kolesnik, Michael Moche
2018 Scientific Reports  
Cryo Ablation 3 , Irreversible Electroporation 4 or hyperthermia in conjunction with other treatment methods 5,6 ), the clincial routine prefers RFA (or, occasionally, microwave ablation) treatment for  ...  Radiofrequency ablation (RFA) of liver malignancies has become an important alternative therapy for patients who disqualify for standard surgical treatment or are in an early tumor stage 1,2 .  ...  Acknowledgements This work was co-funded by the European Union in the projects ClinicIMPPACT (grant no. 610886) and GoSmart (grant no. 600641).  ... 
doi:10.1038/s41598-017-18899-2 pmid:29335429 pmcid:PMC5768804 fatcat:heftmcc42jhgbprnstzwvbb4ae

Current State of Liver-Directed Therapies and Combinatory Approaches with Systemic Therapy in Hepatocellular Carcinoma (HCC)

Pedro Viveiros, Ahsun Riaz, Robert J. Lewandowski, Devalingam Mahalingam
2019 Cancers  
The increasing set of liver-directed therapies (LDT) have become an integral part of hepatocellular carcinoma (HCC) treatment.  ...  In real practice, many patients may take benefit from LDT used as a bridge to curative treatment such as resection and liver transplantation.  ...  Conflicts of Interest  ... 
doi:10.3390/cancers11081085 pmid:31370248 pmcid:PMC6721343 fatcat:dnuojrjrunb5hjy7cgfmacfrdy
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