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Numerical workflow of irreversible electroporation for deep-seated tumor
2019
Physics in Medicine and Biology
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The paper provides a numerical workflow, based on the 'real-life' clinical workflow of irreversible electroporation (IRE) performed for the treatment of deep-seated liver tumors. ...
As a proof of concept, we show on a specific clinical case of IRE ablation of liver tumor that clinical data could be advantageously combined to numerical simulations in a near future, in order to give ...
Acknowledgement The authors thank very warmly the referees for their helpful comments and suggestions, that help to improve the manusript. ...
doi:10.1088/1361-6560/ab00c4
pmid:30669121
fatcat:3ybhhnxzgfaahgdmuixndgqs6m
An evaluation of irreversible electroporation thresholds in human prostate cancer and potential correlations to physiological measurements
2017
APL Bioengineering
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Irreversible electroporation (IRE) is an emerging cancer treatment that utilizes non-thermal electric pulses for tumor ablation. ...
Accurate treatment planning and prediction of the ablation volume require a priori knowledge of the tissue-specific electric field threshold for cell death. ...
Irreversible electroporation (IRE) is an emerging cancer treatment that utilizes non-thermal electric pulses for tumor ablation. ...
doi:10.1063/1.5005828
pmid:31069281
pmcid:PMC6481690
fatcat:vnqg7t7wqjczpdqdexfsliymry
Irreversible electroporation: state of the art
2016
OncoTargets and Therapy
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The field of focal ablative therapy for the treatment of cancer is characterized by abundance of thermal ablative techniques that provide a minimally invasive treatment option in selected tumors. ...
Irreversible electroporation (IRE) is a novel ablation modality based on the principle of electroporation or electropermeabilization, in which electric pulses are used to create nanoscale defects in the ...
11
Kingham
et al, 38 2012
Liver
65
CT/MRi
Directly,
1/3/6 mo
iRe is safe for the treatment of
liver tumors; one persistence and
one recurrence observed
Retrospective
cohort
4
Cannon ...
doi:10.2147/ott.s88086
pmid:27217767
pmcid:PMC4853139
fatcat:rjuvjyqsvbcj7aeip2e4itphle
Numerical modelling challenges for clinical electroporation ablation technique of liver tumors
2020
Mathematical Modelling of Natural Phenomena
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In this paper, we present the recent advances and challenges on the numerical modeling of clinical electroporation ablation of liver tumors. ...
Electroporation ablation is a promising non surgical and minimally invasive technique of tumor ablation, for which no monitoring is currently available. ...
This study has been carried out within the frame of the LABEX TRAIL, ANR-10-LABX-0057 with financial support from the French State, managed by the French National Research Agency (ANR) in the frame of ...
doi:10.1051/mmnp/2019037
fatcat:d2ru73tbu5apjh7xgnf4nzjdei
Stereotactic Image-Guidance for Ablation of Malignant Liver Tumors
[chapter]
2019
Liver Cancer [Working Title]
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Stereotactic percutaneous ablation is a rapidly advancing modality for treatment of tumors in soft solid organs such as the liver. ...
Stereotactic image-guidance leads to a simple, fast, and accurate placement of the ablation probe into the liver tumor, which is a prerequisite for a complete destruction of the tumor by ablation. ...
Irreversible electroporation Irreversible electroporation (IRE) is non-thermal ablation technique that delivers short pulses of high-voltage electrical energy directly to a tumor. ...
doi:10.5772/intechopen.89722
fatcat:ykahhxpsabhhdldoxscpcqthdi
Minimally invasive local therapies for liver cancer
2014
Cancer Biology and Medicine
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Surgical resection and/or transplantation, locally ablative therapies and regional or locoregional therapies have filled the gap in liver tumor treatments, providing improved survival outcomes for both ...
Minimally invasive local therapies have an increasing role in the treatment of both primary and metastatic liver tumors. ...
Numerous locoregional treatment options have been explored for the treatment of large or multinodular tumors. ...
doi:10.7497/j.issn.2095-3941.2014.04.001
pmid:25610708
pmcid:PMC4296086
fatcat:uzfxakb7cjgzjol2v6pjnzzi5m
Percutaneous Therapies for Hepatocellular Carcinoma: Evolution of Liver Directed Therapies
2021
Journal of Hepatocellular Carcinoma
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Percutaneous ablation is a mainstay of treatment for early stage, unresectable hepatocellular carcinoma (HCC). ...
The purpose of this review is to familiarize readers with the technical and clinical aspects of both existing and emerging percutaneous treatment options for HCC. ...
Safe use of IRE for hepatic tumors encasing, abutting or within 1.0 cm of a vessel has been validated in numerous pre-clinical and clinical trials. ...
doi:10.2147/jhc.s268300
pmid:34589446
pmcid:PMC8476177
fatcat:ngwqo4mvvbewpeiwxvhyg3irmi
Locally Advanced Pancreatic Cancer: Work-Up, Staging, and Local Intervention Strategies
2019
Cancers
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In case a resection is not considered possible but stable disease is observed, local ablative techniques are being studied, such as irreversible electroporation, radiofrequency ablation, and stereotactic ...
Pragmatic, multicenter, randomized studies will ultimately have to confirm the exact role of both surgical exploration and ablation in these patients. ...
A proposed work-up and treatment plan of LAPC is depicted in Figure 2 . ...
doi:10.3390/cancers11070976
pmid:31336859
pmcid:PMC6679311
fatcat:c4hmxlscajeqlao6g24vhknixm
A Surgical Perspective on Targeted Therapy of Hepatocellular Carcinoma
2015
Diseases
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Since HCC is predominantly diagnosed in patients with cirrhosis, treatment planning must consider both the severity of liver disease and tumor burden. ...
Patients with decompensated cirrhosis and small tumors are optimal candidates for liver transplantation, which offers the best chance of long-term survival. ...
Similar to RFA/MWA for tumors <2 cm, superior efficacy for tumors >2 cm [141, 142] Irreversible electroporation (IRE) Suitable for tumors adjacent to blood vessels [143, 144] Prospective studies only ...
doi:10.3390/diseases3040221
pmid:28943622
pmcid:PMC5548262
fatcat:i2iekenkwjhddde62hqrrtaioq
Ablation therapy for hepatocellular carcinoma: past, present and future perspectives
2014
Hepatic Oncology
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Treatment of HCC must consider both the tumors present, as well as the remaining dysfunctional liver that both hinders treatment and can produce additional HCC over time. ...
Irreversible electroporation is an emerging nonthermal ablation technology that preserves tissue architecture. ...
No writing assistance was utilized in the production of this manuscript. ...
doi:10.2217/hep.13.8
pmid:30190942
pmcid:PMC6114009
fatcat:se232o7pvjafvdaiivpr7cmt3q
Validation of a Web-Based Planning Tool for Percutaneous Cryoablation of Renal Tumors
2020
Cardiovascular and Interventional Radiology
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To validate a simulation environment for virtual planning of percutaneous cryoablation of renal tumors. ...
Prospectively collected data from 19 MR-guided procedures were used for validation of the simulation model. ...
Within the Go-Smart project, of which the development of the cryoablation planning tool was a part, also simulation tools for microwave (MWA)-and radiofrequency ablation (RFA) and irreversible electroporation ...
doi:10.1007/s00270-020-02634-y
pmid:32935141
pmcid:PMC7591419
fatcat:eeimyej5tncgzpugfavagpu4g4
Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
2017
Cancer Control: Journal of the Moffitt Cancer Cente
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Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC) are primary liver cancers where all or most of the tumor burden is usually confined to the liver. ...
Locoregional liver-directed therapies provide survival benefit for patients with HCC and IHC compared to best medical treatment and have lower comorbid risks compared to surgical resection. ...
years, there has been significant advancement and development of energy-based ablative technologies, including radiofrequency ablation (RFA), microwave ablation (MWA), cryoablation, irreversible electroporation ...
doi:10.1177/1073274817729244
pmid:28975829
pmcid:PMC5937250
fatcat:ouxzxidhxjd7rju5e7vad2qhla
Locoregional treatments for hepatocellular carcinoma: Current evidence and future directions
2019
World Journal of Gastroenterology
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therapy many of which are often the first-line treatment for select stages of HCC or serve as a conduit to liver transplant. ...
This has led to the advent of numerous minimally invasive options including but not limited to trans-arterial chemoembolization, radiofrequency/microwave ablation and more recently selective internal radiation ...
Newer technologies such as laser ablation (LA) and irreversible electroporation (IRE) remain under investigation for their efficacy [44] [45] [46] . ...
doi:10.3748/wjg.v25.i32.4614
pmid:31528090
pmcid:PMC6718039
fatcat:l2naftvbfrdlddtk6m3b7bkcni
RFA Guardian: Comprehensive Simulation of Radiofrequency Ablation Treatment of Liver Tumors
2018
Scientific Reports
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Cryo Ablation 3 , Irreversible Electroporation 4 or hyperthermia in conjunction with other treatment methods 5,6 ), the clincial routine prefers RFA (or, occasionally, microwave ablation) treatment for ...
Radiofrequency ablation (RFA) of liver malignancies has become an important alternative therapy for patients who disqualify for standard surgical treatment or are in an early tumor stage 1,2 . ...
Acknowledgements This work was co-funded by the European Union in the projects ClinicIMPPACT (grant no. 610886) and GoSmart (grant no. 600641). ...
doi:10.1038/s41598-017-18899-2
pmid:29335429
pmcid:PMC5768804
fatcat:heftmcc42jhgbprnstzwvbb4ae
Current State of Liver-Directed Therapies and Combinatory Approaches with Systemic Therapy in Hepatocellular Carcinoma (HCC)
2019
Cancers
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The increasing set of liver-directed therapies (LDT) have become an integral part of hepatocellular carcinoma (HCC) treatment. ...
In real practice, many patients may take benefit from LDT used as a bridge to curative treatment such as resection and liver transplantation. ...
Conflicts of Interest ...
doi:10.3390/cancers11081085
pmid:31370248
pmcid:PMC6721343
fatcat:dnuojrjrunb5hjy7cgfmacfrdy
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