Filters








966 Hits in 4.8 sec

A Data Science Framework for Data Quality Assessment and Inconsistency Detection

Anusuya Ramasamy, Berhanu Sisay, Amanuel Bahiru
2021 International Journal of Advanced Computer Science and Applications  
In this research, we examine the problem of the detection of incoherence and the repair of the OMD data model (OMD). We propose a framework for data quality evaluation and an OMD repair framework.  ...  The accurate analysis of data requires high-quality data. However, inconsistencies occur frequently in the actual data and lead to untrustworthy decisions in the downstream data analysis pipeline.  ...  with those weights from the subset, will restore consistency in the OMD model.  ... 
doi:10.14569/ijacsa.2021.0120476 fatcat:sch7qfzyejhy7ebyoxvyatxcqq

Linked Data in Government

Nigel Shadbolt, Kieron O'Hara
2013 IEEE Internet Computing  
Those using data in the DCLG find it easier to consume their own linked data via the Local Authority Dashboard than integrate the data manually as they used to.  ...  Other works in progress from the W3C include a vocabulary for describing data catalogues, and ontologies for organizations and people.  ... 
doi:10.1109/mic.2013.72 fatcat:vwirluui5vh2ngnq35hudlyzoe

Transcriptomic Approaches to Neural Repair

J. N. Dulin, A. Antunes-Martins, V. Chandran, M. Costigan, J. K. Lerch, D. E. Willis, M. H. Tuszynski
2015 Journal of Neuroscience  
Though the studies featured here specifically focus on neural repair, the approaches highlighted in this mini-symposium will be of broad interest and utility to neuroscientists working in diverse areas  ...  As we progress into an era in which the high-throughput interrogation of gene expression is commonplace and our knowledge base of interactome data is rapidly expanding, we can now begin to assemble a more  ...  In ongoing work in our laboratory, the analysis of this CREB-activated, AP-1dependent gene module by nonbiased weighted gene coexpression network analysis (WGCNA) of RNA-Seq data shows that Ͼ1600 genes  ... 
doi:10.1523/jneurosci.2599-15.2015 pmid:26468186 pmcid:PMC4604224 fatcat:4cqj22vvprhg3j7sp2amfvrbfy

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

Julie A. Mattison, Mingyi Wang, Michel Bernier, Jing Zhang, Sung-Soo Park, Stuart Maudsley, Steven S. An, Lakshmi Santhanam, Bronwen Martin, Shakeela Faulkner, Christopher Morrell, Joseph A. Baur (+9 others)
2014 Cell Metabolism  
In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation  ...  An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events.  ...  The resveratrol used in this study was a generous gift from DSM Nutritional Products (resVida).  ... 
doi:10.1016/j.cmet.2014.04.018 pmid:24882067 pmcid:PMC4254394 fatcat:sluuz43hnvbo7bqotbpus4z5jq

Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice

Koustav Ganguly, Swapna Upadhyay, Martin Irmler, Shinji Takenaka, Katrin Pukelsheim, Johannes Beckers, Eckard Hamelmann, Holger Schulz, Tobias Stoeger
2009 Particle and Fibre Toxicology  
Epidemiological studies suggest that individuals with favourable lung physiology are at lower risk for particulate matter associated respiratory diseases probably due to efficient control of inflammation and repair  ...  Histological analysis and BAL-protein concentration did not reveal any evidence of tissue injury in 20 μg CNP instilled animals.  ...  The tissue response/repair and remodeling mechanism involves the interaction of various growth factors and fibroblasts to restore homeostasis [24] .  ... 
doi:10.1186/1743-8977-6-31 pmid:19954533 pmcid:PMC2809500 fatcat:ver4yuo6ovgndlbl4xm4toxdaa

Genomics of Acute Lung Injury and Vascular Barrier Dysfunction [chapter]

Roberto F. Machado, Joe G. N. Garcia
2010 Textbook of Pulmonary Vascular Disease  
Moreover, marked differences in strain-specific ALI responses to inflammatory and injurious agents are observed in preclinical animal models.  ...  Genome-wide searches in animal models have identified a number of quantitative trait loci that associate with ALI susceptibility.  ...  in African-Americans [75] consistent with data linking this chromosomal locus (MYLK, 3q21.1) to asthma and asthmarelated phenotypes [75] .  ... 
doi:10.1007/978-0-387-87429-6_63 fatcat:vrzxnuqdlzc7xajhnkrvhydxd4

Transcriptional responses to thermal acclimation in the eurythermal fish Gillichthys mirabilis (Cooper 1864)

Cheryl A. Logan, George N. Somero
2010 American Journal of Physiology. Regulatory Integrative and Comparative Physiology  
Gene ontology analysis of these genes identified protein biosynthesis, transport, and several metabolic categories as processes showing the greatest change in expression.  ...  The upregulation of several classes of stress-related proteins, e.g., heat shock proteins, seen in the species' response to acute thermal stress was not observed in the long-term 28°C-acclimated fish.  ...  Denny for helpful discussions regarding data analysis and interpretation. Finally, we thank three anonymous reviewers for their comments and suggestions.  ... 
doi:10.1152/ajpregu.00306.2010 pmid:20610827 fatcat:ih2xeqeo4rc2jbi5t6eu3gg64a

Proteomic Analysis of Estrogen-Mediated Enhancement of Mesenchymal Stem Cell-Induced Angiogenesis In Vivo

Maria Cristina Mihai, Mirel Adrian Popa, Viorel Iulian Șuică, Felicia Antohe, Edwin K. Jackson, Brigitte Leeners, Maya Simionescu, Raghvendra K. Dubey
2021 Cells  
Together, these data provide evidence for increased angiogenesis by MSCs treated with the sex hormone E2.  ...  Here, using a proteomics approach, we investigated the angiogenic potential of MSCs in vivo and the modulatory actions of E2 on mechanisms involved in tissue repair.  ...  In this regard, angiogenesis plays a critical role in restoring perfusion and mitigating hypoxia, processes that promote the repair of infarcted myocardium [37, 38] .  ... 
doi:10.3390/cells10092181 pmid:34571830 pmcid:PMC8468955 fatcat:tzjukf7ukfgavjjqnunwtegtl4

Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models

Fang Liu, Allen D. Smith, Gloria Solano-Aguilar, Thomas T. Y. Wang, Quynhchi Pham, Ethiopia Beshah, Qingjuan Tang, Joseph F. Urban, Changhu Xue, Robert W. Li
2020 Microbiome  
Parasite-dependent intestinal mucosal damage and microbial dysbiosis induced by Trichuris suis infection in pigs were partially restored by feeding KO.  ...  In this study, we attempted to understand the mechanisms through which KO modulates the gut microbiome and metabolome using in vitro and in vivo colitis models and a multi-omics based approach.  ...  Acknowledgements Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the US  ... 
doi:10.1186/s40168-020-00843-8 pmid:32498703 fatcat:lvgnis4pzjfsdl6soetcyzsxcq

An approach for pipelining nested collections in scientific workflows

Timothy M. McPhillips, Shawn Bowers
2005 SIGMOD record  
Moreover, he thanks Gianluigi Greco for his recent contribution to the weighted extension, and Alfredo Mazzitelli for his valuable work in designing and implementing the tools for experiments.  ...  When you see these people, please thank them personally for their role in achieving quick reviews of submitted papers.  ...  Virtual repairing [1] does not change the database but rather returns query answers true in all repairs (consistent query answers).  ... 
doi:10.1145/1084805.1084809 fatcat:sgtpcat7vzc3veb4dx2jgskpte

Crawler [chapter]

Kenneth A. Ross, Christian S. Jensen, Richard Snodgrass, Curtis E. Dyreson, Christian S. Jensen, Richard Snodgrass, Spiros Skiadopoulos, Cristina Sirangelo, Mary Lynette Larsgaard, Gösta Grahne, Daniel Kifer, Hans-Arno Jacobsen (+106 others)
2009 Encyclopedia of Database Systems  
Synonyms Cache-aware query processing; Cache-sensitive query processing Definition Query processing algorithms are designed to efficiently exploit the available cache units in the memory hierarchy.  ...  As a result, it is common (at the time of writing) for data accesses to RAM to require several hundred CPU cycles to resolve.  ...  the purpose of restoring consistency.  ... 
doi:10.1007/978-0-387-39940-9_2315 fatcat:x4qspjdytvhvroc7h753dihp7u

Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage

Yiqing Shen, Wensong Yang, Xin Xiong, Xinhui Li, Zhongsong Xiao, Jialun Yu, Fangyu Liu, Siwen Gui, Xiongfei Xie, Fajin Lv, Libo Zhao, Liangbo Hu (+4 others)
2021 Oxidative Medicine and Cellular Longevity  
model, as well as pointed out that Serpina3n/SERPINA3 was a potential biomarker associated with poor functional outcome in ICH patients.  ...  Taken together, the results of our study exhibited molecular changes related to ICH-induced brain injury by multidimensional analysis and effectively identified three biomarker candidates in a mouse ICH  ...  In this context, integrated analysis of multiomics (intergromics) has emerged as a novel approach to facilitate interpretation of the multidimensional data and provide a global-wide insight into the pathological  ... 
doi:10.1155/2021/2510847 fatcat:2brmchr5dnbzhbezxllm4crhn4

Enhanced Antioxidant Capacity of Dental Pulp-Derived iPSC-Differentiated Hepatocytes and Liver Regeneration by Injectable HGF-Releasing Hydrogel in Fulminant Hepatic Failure

Chih-Hung Chiang, Wai-Wah Wu, Hsin-Yang Li, Yueh Chien, Cho-Chin Sun, Chi-Hsien Peng, Alex Tong-Long Lin, Chi-Shuan Huang, Ying-Hsiu Lai, Shih-Hwa Chiou, Shuen-Iu Hung, Yuh-Lih Chang (+6 others)
2015 Cell Transplantation  
vitro and in an immunocompromised AHF mouse model induced by thioacetamide (TAA).  ...  engraftment in iPSC-based therapy against AHF.  ...  ACKNOWLEDGMENTS: This study was assisted in part by the Division of Experimental  ... 
doi:10.3727/096368915x686986 pmid:25668102 fatcat:haspu2dgfve33ldm264eovyhom

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

Chloé Amouyal, Julien Castel, Claudiane Guay, Amélie Lacombe, Jessica Denom, Stéphanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides, Serge Luquet, Hervé Le Stunff (+7 others)
2020 EBioMedicine  
Our aim was to identify pathways, evident in the islet transcriptome, that characterize the adaptive response to bariatric surgery independently of body weight changes.  ...  Taken together, our data highlight novel miRNA-gene interactions in the pancreatic islet during the resolution of diabetes after bariatric surgery that form part of a blood signature of diabetes reversal  ...  Acknowledgements Authors thank physicians (Prof Christine Poitou and Dr Judith Aron-Wisnewsky) and clinical research staff (Dr Florence Marchelli) for patient recruitment, phenotyping and data management  ... 
doi:10.1016/j.ebiom.2020.102895 pmid:32739864 pmcid:PMC7393530 fatcat:ft23zmu3yzgdhpu5xkdz5s4wfu

Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology

Jose A. Santiago, Virginie Bottero, Judith A. Potashkin
2017 Frontiers in Aging Neuroscience  
of data remains a challenge.  ...  Network biology has become a powerful platform to integrate multiple omics data to comprehensively explore the molecular networks in the context of health and disease.  ...  Furthermore, treatment with an enzymatic product of NAMPT elicited neuroprotective effects via activation of SIRT1 in an in vitro model of PD (Zou et al., 2016) .  ... 
doi:10.3389/fnagi.2017.00166 pmid:28611656 pmcid:PMC5446999 fatcat:izyqm5j33rep3dihl4jqu77va4
« Previous Showing results 1 — 15 out of 966 results