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Baseline Brain Perfusion and the Serotonin Transporter Promoter Polymorphism

Roberto Viviani, Eun-Jin Sim, Hanna Lo, Petra Beschoner, Nadine Osterfeld, Christiane Maier, Angela Seeringer, Ana Leonor Godoy, Araceli Rosa, David Comas, Julia Kirchheiner
2010 Biological Psychiatry  
In the amygdala, variability in baseline perfusion was explained in large part by global cerebral flow levels (between 50% and 55%), in minor part by sex (between 4% and 5%), but not by genotype (less  ...  The serotonin transporter length repeat polymorphism (5-HTTLPR) in the promoter region of the serotonin transporter gene (SLC6A4) has been associated in healthy subjects with changes in basal perfusion  ...  Explanation of symbols: 44 bp: 44 base pair promoter genotype; gCBF: global cerebral blood flow; all: full model. 5-HTTLPR, serotonin transporter length repeat polymorphism; CBF, cerebral blood flow.  ... 
doi:10.1016/j.biopsych.2009.08.035 pmid:19878929 fatcat:7kbtmv7ez5g7ddco6hxsy54fme

Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders:

LeeAnn M. Perry, Andrea N. Goldstein-Piekarski, Leanne M. Williams
2016 Journal of Neuroscience Research  
First, we consider sex differences in response to early life stress and the effects of stress on gene-sex interactions involving the serotonin-transporter-linked polymorphic region (5-HTTLPR) in the serotonin  ...  We propose three potential pathways through which polymorphisms in genes involved in serotonin synthesis, transport, and breakdown may differentially impact behavior as a function of sex.  ...  Resting-state cerebral blood flow in amygdala is modulated by sex and serotonin transporter geno-polymorphisms in the serotonin system and traumatic life events modulate the neural basis of fear acquisition  ... 
doi:10.1002/jnr.23877 pmid:27870440 pmcid:PMC5119468 fatcat:jhh2jzugivevtiokv5g2ebrlfu

Serotonin transporter genotype modulates resting state and predator stress-induced amygdala perfusion in mice in a sex-dependent manner

Jann F Kolter, Markus F Hildenbrand, Sandy Popp, Stephan Nauroth, Julian Bankmann, Lisa Rother, Jonas Waider, Jürgen Deckert, Esther Asan, Peter M Jakob, Klaus-Peter Lesch, Angelika Schmitt-Böhrer
2021 PLoS ONE  
In female mice the perfusion was not modulated by the 5-Htt-genotype, but by estrous cycle stages. We conclude that amygdala reactivity is modulated by the 5-Htt genotype in males.  ...  Furthermore, functional magnetic resonance imaging (fMRI) studies reported increased cerebral blood flow (CBF) during resting state (RS) and amygdala hyperreactivity. 5-HTT deficient mice as an established  ...  Acknowledgments Special thanks go to Sabine Voll, Marion Winnig, and Eva-Kristin Broschk for excellent technical assistance.  ... 
doi:10.1371/journal.pone.0247311 pmid:33606835 pmcid:PMC7895400 fatcat:du32whv74ff4xc3wlwanz67qdu

Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age

Inger Sundström Poromaa, Erika Comasco, Torbjörn Bäckström, Marie Bixo, Peter Jensen, Vibe G. Frokjaer
2019 Frontiers in Psychology  
Availability of serotonin in the synaptic cleft is regulated by the serotonin transporter (SERT), which can be imaged in the living human brain by use of positron emission tomography (PET) and the radiotracer  ...  Age, BMI, and daylight minutes were included as covariates in the analyses and SERT genotype (5-HTTLPR) was considered a potential confounder.  ...  The funding body had no role in the design of the study, collection and analysis of data and decision to publish. IS  ... 
doi:10.3389/fpsyg.2018.02767 pmid:30687199 pmcid:PMC6336902 fatcat:uwmwgm4jlbaajju3pbbunimrmi

Neural correlates of epigenesis

T. Canli, M. Qiu, K. Omura, E. Congdon, B. W. Haas, Z. Amin, M. J. Herrmann, R. T. Constable, K. P. Lesch
2006 Proceedings of the National Academy of Sciences of the United States of America  
Based on functional MRI and perfusion data, we found support for a model by which life stress interacts with the effect of serotonin transporter genotype on amygdala and hippocampal resting activation,  ...  The effect of life stress on depression is moderated by a repeat length variation in the transcriptional control region of the serotonin transporter gene, which renders carriers of the short variant vulnerable  ...  Steigerwald for assistance with genotyping, H. Lin for assistance with the psychophysiological interaction analyses, and A. Aron for advice on statistical analyses.  ... 
doi:10.1073/pnas.0601674103 pmid:17032778 pmcid:PMC1592642 fatcat:2fytju6bqvei5hsrwum5ffuo6m

Serotonin Transporter Gene Polymorphism Modulates Activity and Connectivity within an Emotional Arousal Network of Healthy Men during an Aversive Visceral Stimulus

Lisa A. Kilpatrick, Emeran A. Mayer, Jennifer S. Labus, Arpana Gupta, Toyohiro Hamaguchi, Tomoko Mizuno, Hazuki Komuro, Michiko Kano, Motoyori Kanazawa, Masashi Aoki, Shin Fukudo, Antonella Gasbarri
2015 PLoS ONE  
Changes in regional cerebral blood flow (rCBF) were analyzed using partial least squares (PLS) and structural equation modeling (SEM).  ...  and Aims The 5-hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) has been linked to increased stress responsiveness and negative emotional states.  ...  This research was supported by grants of SF: Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan, Grant-in-Aid for Scientific Research from the Ministry of  ... 
doi:10.1371/journal.pone.0123183 pmid:25893242 pmcid:PMC4404144 fatcat:zukmagfdivgnbav6rg3yfzksey

Serotonin transporter genotype modulates amygdala activity during mood regulation

Seth J. Gillihan, Hengyi Rao, Jiongjiong Wang, John A. Detre, Jessica Breland, Geena Mary V. Sankoorikal, Edward S. Brodkin, Martha J. Farah
2009 Social Cognitive and Affective Neuroscience  
Regional cerebral blood flow was measured with perfusion functional magnetic resonance imaging during four scanning blocks: baseline, sad mood, mood recovery and following return to baseline.  ...  Recent studies have implicated the short allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) in depression vulnerability, particularly in the context of stress.  ...  Perfusion weighted image series were then generated by pair-wise subtraction of the label and control images, followed by conversion to absolute cerebral blood flow [CBF] image series based on a single  ... 
doi:10.1093/scan/nsp035 pmid:19858108 pmcid:PMC2840838 fatcat:4vihdks7hjaihj2rb3ok2oiwza

5-HTTLPR, anxiety and gender interaction moderates right amygdala volume in healthy subjects

Antonio Cerasa, Aldo Quattrone, Fabrizio Piras, Graziella Mangone, Angela Magariello, Sabrina Fagioli, Paolo Girardi, Maria Muglia, Carlo Caltagirone, Gianfranco Spalletta
2013 Social Cognitive and Affective Neuroscience  
Although numerous studies have investigated the influence of 5-HTTLPR genotype on the neural systems involved in emotional regulation, none have investigated how these effects are modulated by gender and  ...  Genetic variants within the serotonin transporter gene (5-HTTLPR) impact the neurobiology and risk for anxiety-related behaviours.  ...  From a functional point of view, a novel study investigated the modulation of sex and serotonin transporter genotype on resting-state cerebral blood flow (rCBF) in amygdala and blood-oxygen-level-dependent  ... 
doi:10.1093/scan/nst144 pmid:23986266 pmcid:PMC4187269 fatcat:3o36pojmffcg7ix4m72uhhlioq

Brain-Derived Neurotrophic Factor Val66Met Polymorphism Affects Resting Regional Cerebral Blood Flow and Functional Connectivity Differentially in Women Versus Men

S.-M. Wei, D. P. Eisenberg, P. D. Kohn, J. S. Kippenhan, B. S. Kolachana, D. R. Weinberger, K. F. Berman
2012 Journal of Neuroscience  
individuals with H 2 15 O PET to assess regional cerebral blood flow (rCBF) during rest and tested for between-genotype differences.  ...  regions showing between-genotype group differences covaries with rCBF in other nodes throughout the brain in a genotype-or sex-dependent manner.  ...  regional cerebral blood flow (rCBF), an indicator of local cerebral metabolism and a parameter that is as yet unstudied in this context.  ... 
doi:10.1523/jneurosci.5375-11.2012 pmid:22593075 pmcid:PMC3362630 fatcat:zu7xo4phtveuzlr5aykqd7xhfm

Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity

Reut Avinun, Adam Nevo, Annchen R. Knodt, Maxwell L. Elliott, Ahmad R. Hariri
2018 Biological Psychiatry  
3) conditions affecting AC cerebral blood flow and metabolism (e.g., hypertension).  ...  Oathes DJ, Hilt LM, Nitschke JB (2015): Affective Neural Responses Modulated by Serotonin Transporter Genotype in Clinical Anxiety and Depression. PLoS ONE. 10:e0115820. 15.  ... 
doi:10.1016/j.biopsych.2017.11.010 pmid:29279201 pmcid:PMC5955809 fatcat:tlim2abocfh2hlybwsiu7cki2u

Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders

Michiko Kano, Patrick Dupont, Qasim Aziz, Shin Fukudo
2018 Journal of Neurogastroenterology and Motility  
Studies using resting-state functional magnetic resonance imaging reported abnormal local and global connectivity in the areas related to pain processing and the default mode network (a physiological baseline  ...  of brain activity at rest associated with self-awareness and memory) in FGIDs.  ...  More available and better temporal resolution than PET ASL Measures cerebral blood flow directly, by using arterial blood as an endogenous tracer.  ... 
doi:10.5056/jnm18072 pmid:30041284 pmcid:PMC6175554 fatcat:j6ewl6vz5bemfj7bplpmlfzbqi

Tryptophan supplementation and serotonin function: genetic variations in behavioural effects

E. L. Gibson
2018 Proceedings of the Nutrition Society  
Yet, another key genetic variable is sex: in women, the S/S′ genotype predicts sensitivity to improved mood and reduced cortisol by TRP supplementation, during stressful challenges, whereas the L/L′ genotype  ...  However, 95 % of serotonin is synthesised and used in the periphery, and TRP is also metabolised via non-5-HT routes such as the kynurenine pathway.  ...  local blood flow.  ... 
doi:10.1017/s0029665117004451 pmid:29368666 fatcat:lkekhlhut5bkrlll55g6e4yh6q

Increased neurokinin-1 receptor availability in the amygdala in social anxiety disorder: a positron emission tomography study with [11C]GR205171

A Frick, F Ahs, C Linnman, M Jonasson, L Appel, M Lubberink, B Långström, M Fredrikson, T Furmark
2015 Translational Psychiatry  
The neurokinin-1 (NK1) receptor is abundantly expressed in the fear circuitry of the brain, including the amygdala, where it modulates stress and anxiety.  ...  Thus, we demonstrate that exaggerated social anxiety is related to enhanced NK1 receptor availability in the amygdala.  ...  ACKNOWLEDGMENTS Financial support was provided by the Swedish Research Council, the Swedish Research Council for Health, Working Life and Welfare, the Swedish Brain Foundation, and Riksbankens Jubileumsfond-the  ... 
doi:10.1038/tp.2015.92 pmid:26151925 pmcid:PMC5068728 fatcat:scpkdbz46rfwtedvd6na3ujpfe

The influence of serotonin transporter polymorphisms on cortical activity: A resting EEG study

Tien-Wen Lee, Younger WY Yu, Chen-Jee Hong, Shih-Jen Tsai, Hung-Chi Wu, Tai-Jui Chen
2011 BMC Neuroscience  
The serotonin transporter gene (5-HTT) is a key regulator of serotonergic neurotransmission and has been linked to various psychiatric disorders.  ...  Methods: Blood samples and resting state eyes-closed electroencephalography (EEG) signals were collected from 195 healthy women and stratified into 2 sets of comparisons of 2 groups each: L-allele carriers  ...  Acknowledgements This work was supported by a grant (DOH94-NNB-1035) from the Department of Health, Taiwan, ROC, and a grant (KS92-015) from the Kai-Suan Psychiatric Hospital-Kaohsiung, ROC.  ... 
doi:10.1186/1471-2202-12-33 pmid:21507249 pmcid:PMC3110125 fatcat:qtdkmtojkjg33hlc6my5aeufh4

Imaging phenotypes of major depressive disorder: genetic correlates

J.B. Savitz, W.C. Drevets
2009 Neuroscience  
In MDD, increased activity of the amygdala in response to negative stimuli appears to be a mood-congruent phenomenon, and is likely moderated by the serotonin transporter gene (SLC6A4) promoter polymorphism  ...  Potentially indicative of inter-study variation in MDD etiology or mood state, both increased and decreased binding potential of the serotonin transporter has been reported.  ...  In line with these data, sgACC metabolism and cerebral blood flow (CBF) are higher in the depressed, unmedicated phase versus the remitted phase within MDD subjects (Mayberg et al., 1999) (Drevets  ... 
doi:10.1016/j.neuroscience.2009.03.082 pmid:19358877 pmcid:PMC2760612 fatcat:tq7cpwflwbgqdll7t5cfsk2xae
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