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EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: RESULTS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK

Brian A. Gordon, Tyler Blazey, Yi Su, Amrita Hari-Raj, Aylin Dincer, Shaney Flores, Jon Christensen, Eric McDade, Guoqiao Wang, Chengjie Xiong, Nigel J. Cairns, Jason Hassenstab (+12 others)
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/skzqffpatvawfgf7uspguqs4yu" style="color: black;">Alzheimer&#39;s &amp; Dementia</a> </i> &nbsp;
Disruption of resting state functional connectivity (FC) might represent early functional consequences associated with amyloid pathology.  ...  This study examines the association of FC for 10 resting state networks (RSNs) with amyloid pathology in a sample of cognitively healthy elderly monozygotic twins.  ...  IC-P-054 EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: RESULTS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK Background:Models of Alzheimer pathology propose that  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2017.06.2327">doi:10.1016/j.jalz.2017.06.2327</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/q6adm43iireerc7cp4rsyouf7y">fatcat:q6adm43iireerc7cp4rsyouf7y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200505103244/https://deepblue.lib.umich.edu/bitstream/handle/2027.42/152668/alzjjalz2017062327.pdf;jsessionid=D4DC1C1384543424C1C383A2103828D8?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/12/5e/125efb8f3d7b868b06729669f149d6e23eb7524d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2017.06.2327"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Impaired default network functional connectivity in autosomal dominant Alzheimer disease

J. P. Chhatwal, A. P. Schultz, K. Johnson, T. L. S. Benzinger, C. Jack, B. M. Ances, C. A. Sullivan, S. P. Salloway, J. M. Ringman, R. A. Koeppe, D. S. Marcus, P. Thompson (+15 others)
<span title="2013-07-24">2013</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dogs2nidlzdtxigbzvv6d2bbc4" style="color: black;">Neurology</a> </i> &nbsp;
Conclusion: Functional disruption of the DMN occurs early in the course of autosomal dominant Alzheimer disease, beginning before clinically evident symptoms, and worsening with increased impairment.  ...  These findings suggest that DMN fcMRI may prove useful as a biomarker across a wide spectrum of disease, and support the feasibility of DMN fcMRI as a secondary endpoint in upcoming multicenter clinical  ...  [5] [6] [7] Of particular relevance to AD is a set of cortical regions collectively known as the default mode network (DMN). 4, [8] [9] [10] [11] Intact functional connectivity within the DMN at rest  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1212/wnl.0b013e3182a1aafe">doi:10.1212/wnl.0b013e3182a1aafe</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23884042">pmid:23884042</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3776464/">pmcid:PMC3776464</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/noyn3alh4zhlzhtvkj7t26lt4a">fatcat:noyn3alh4zhlzhtvkj7t26lt4a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170829212331/https://ncrad.iu.edu/docs/Publications/147_Chhatwal_2013.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/62/8e/628ef389dae05c1777d9ed06de05109655d91464.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1212/wnl.0b013e3182a1aafe"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776464" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Revolution of Resting-State Functional Neuroimaging Genetics in Alzheimer's Disease

Patrizia A. Chiesa, Enrica Cavedo, Simone Lista, Paul M. Thompson, Harald Hampel
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/53wtswjt2balnct24ywxu4bzzu" style="color: black;">Trends in Neurosciences</a> </i> &nbsp;
Potential influence on functional connectivity: 1) impaired neurite outgrowth; 2) cytoskeletal disruption and hyperphosphorylation of tau; 3) mitochondrial dysfunction in neurons; 4) impaired synaptogenesis  ...  To this end, we emphasize the need for a paradigm shift towards integrative disease modeling and neuroimaging biomarker-guided precision medicine for AD and other neurodegenerative diseases. 22 Box 2:  ...  Ce travail a bénéficié d'une aide de l'Etat « Investissements d'avenir » ANR-10-IAIHU-06 (HH).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.tins.2017.06.002">doi:10.1016/j.tins.2017.06.002</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28684173">pmid:28684173</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5798613/">pmcid:PMC5798613</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/aw2urgtht5hkhcznbbhlut6ruy">fatcat:aw2urgtht5hkhcznbbhlut6ruy</a> </span>
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Dissection of prodromal Alzheimer rsquo s disease

Ying Han
<span title="">2018</span> <i title="Frontiers in Bioscience"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mfwufqll45bepinkdxuteuecia" style="color: black;">Frontiers in Bioscience</a> </i> &nbsp;
The application of different biomarkers including neuroimaging, biochemical substances and genes makes AD-related pathology detectable in vivo and exploring novel biomarkers with relatively non-invasive  ...  Prodromal stage of AD, a great opportunity for effective treatment and postponing the disease onset, has drawn extensive attention.  ...  Therefore, we propose that in individuals with autosomal dominant Alzheimer disease, characteristically structural, functional and pathological changes would be present at the stage of preclinical and  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2741/4643">doi:10.2741/4643</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28930599">pmid:28930599</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5yzeruxgl5evpi2buq4qxmezru">fatcat:5yzeruxgl5evpi2buq4qxmezru</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190303192826/http://pdfs.semanticscholar.org/ba97/e49258bb56064f56adf396684da57844511f.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ba/97/ba97e49258bb56064f56adf396684da57844511f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2741/4643"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Alzheimer Disease: New Concepts on Its Neurobiology and the Clinical Role Imaging Will Play

Clifford R. Jack
<span title="">2012</span> <i title="Radiological Society of North America (RSNA)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6go2jt6u45cpxdr3wujqofftpu" style="color: black;">Radiology</a> </i> &nbsp;
Figure 8 8 Figure 8 Figure 9 : 9 Resting-state functional connectivity in AD.  ...  The available genetic evidence in both autosomal dominant and sporadic late onset AD points to the Ab pathway.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1148/radiol.12110433">doi:10.1148/radiol.12110433</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22517954">pmid:22517954</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3329271/">pmcid:PMC3329271</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kxtmmttn5bfzhlwd4gyklsvkxy">fatcat:kxtmmttn5bfzhlwd4gyklsvkxy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191202154839/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3329271&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ce/93/ce934c78baeb9a54a03abf5cf695b701015bf11f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1148/radiol.12110433"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329271" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Is amyloid-β harmful to the brain? Insights from human imaging studies

William Jagust
<span title="2015-11-27">2015</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
The frequent presence of amyloid-b in the brains of cognitively healthy older people has been interpreted as evidence against a causative role.  ...  Although the amyloid-b protein associated with the Alzheimer's disease plaque has been detectable in living people for over a decade, its importance in the pathogenesis of Alzheimer's disease is still  ...  Funding This work was supported in part by NIH grant AG034570.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awv326">doi:10.1093/brain/awv326</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26614753">pmid:26614753</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4990654/">pmcid:PMC4990654</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gks652s4szbipco5x2yh56c75i">fatcat:gks652s4szbipco5x2yh56c75i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190308090003/http://pdfs.semanticscholar.org/eff5/8b7a4a96a42ad17488c15210df09be7f5b12.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ef/f5/eff58b7a4a96a42ad17488c15210df09be7f5b12.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awv326"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990654" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Fact, Fiction, or Evolution: Mechanism Hypothesis of Alzheimer's Disease [chapter]

José V. Pardo
<span title="2019-03-27">2019</span> <i title="IntechOpen"> Alzheimer&#39;s Dementia and Korsakoff&#39;s Disease - Linking Memory Pathology to the Autobiographical Self [Working Title] </i> &nbsp;
A more recent model highlights the interrelationships between the default mode network (DMN) and biomarkers such as CMRglu, amyloid, and tau.  ...  The metabolism hypothesis of Alzheimer's disease (AD) was first proposed in 1975.  ...  Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/intechopen.83824">doi:10.5772/intechopen.83824</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j5yjihob4fgwdk4br3jx6m45rq">fatcat:j5yjihob4fgwdk4br3jx6m45rq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501190639/https://cdn.intechopen.com/pdfs/66404.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1d/22/1d22c3353230f39a2182d970e6ddab40903ec2b7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/intechopen.83824"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Trajectory of Unawareness of Memory Decline in Individuals With Autosomal Dominant Alzheimer Disease

Patrizia Vannini, Bernard J. Hanseeuw, Jennifer R. Gatchel, Sietske A. M. Sikkes, Diana Alzate, Yesica Zuluaga, Sonia Moreno, Luis Mendez, Ana Baena, Paula Ospina-Lopera, Victoria Tirado, Eliana Henao (+4 others)
<span title="2020-12-02">2020</span> <i title="American Medical Association (AMA)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/aj4ubaiwqfeknejtsyuk2st4su" style="color: black;">JAMA Network Open</a> </i> &nbsp;
Recent studies have suggested that unawareness, or anosognosia, of memory decline is present in predementia stages of Alzheimer disease (AD) and may serve as an early symptomatic indicator of AD.  ...  This cohort study investigated a total of 2379 members of a Colombian kindred with autosomal dominant AD who were part of the Alzheimer's Prevention Initiative Registry.  ...  with resting state functional connectivity) between different brain regions (ie, network breakdown)  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1001/jamanetworkopen.2020.27472">doi:10.1001/jamanetworkopen.2020.27472</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33263761">pmid:33263761</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7711319/">pmcid:PMC7711319</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lcklzavx7bf3jb7q55kjjexty4">fatcat:lcklzavx7bf3jb7q55kjjexty4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201212123159/https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2773465/vannini_2020_oi_200882_1605815023.49472.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/cd/7f/cd7f5925683274fe45e23bb7cb44a42bf8ff8898.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1001/jamanetworkopen.2020.27472"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711319" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Evolution of Preclinical Alzheimer's Disease: Implications for Prevention Trials

Reisa Sperling, Elizabeth Mormino, Keith Johnson
<span title="">2014</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5lze265mrrcddlccx7zpfjyjwi" style="color: black;">Neuron</a> </i> &nbsp;
As the field begins to test the concept of preclinical neurodegenerative disease, the hypothetical stage of disease when the pathophysiological process has begun in the brain but clinical symptoms are  ...  not yet manifest, a number of intriguing questions have already arisen.  ...  Similarly, there have been multiple reports of Aβ-related disruptions in resting state or taskfree functional connectivity MRI, and the default network appears to be particularly vulnerable to amyloid-related  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuron.2014.10.038">doi:10.1016/j.neuron.2014.10.038</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25442939">pmid:25442939</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4285623/">pmcid:PMC4285623</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qyzgd7sbirfl7ml7hokqs33h5a">fatcat:qyzgd7sbirfl7ml7hokqs33h5a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191107211115/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4285623&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b3/47/b34770e25cd508b71e475fd60efd575a6b574fa3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuron.2014.10.038"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285623" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Imaging Brain Metabolism and Pathology in Alzheimer 's Disease with Positron Emission Tomography

Riddle WR Claassen D
<span title="">2014</span> <i title="OMICS Publishing Group"> Journal of Alzheimer&#39;s Disease &amp; Parkinsonism </i> &nbsp;
Current Positron Emission Tomography (PET) biomarkers for Alzheimer's disease (AD) assess either neuronal function, or associated pathological features of this common neurodegenerative disease.  ...  We place special emphasis on PET data analysis and interpretation techniques, as well as radiochemistry for imaging metabolism and assessing Aβ and tau pathology.  ...  [24] showed the implementation of a voxel-wise interregional correlation analysis on FDG-PET as a robust tool for highlighting resting state metabolic connectivity.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4172/2161-0460.1000143">doi:10.4172/2161-0460.1000143</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25343059">pmid:25343059</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4204649/">pmcid:PMC4204649</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3v6l6lhojbbwbkfw6yrkgt7zia">fatcat:3v6l6lhojbbwbkfw6yrkgt7zia</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191023143032/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4204649&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/dc/a4/dca4d5645feec9e0a67da663d1693bbb2a4450b6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4172/2161-0460.1000143"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204649" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing

Jasmeer P Chhatwal, Aaron P Schultz, Keith A Johnson, Trey Hedden, Sehily Jaimes, Tammie L S Benzinger, Clifford Jack, Beau M Ances, John M Ringman, Daniel S Marcus, Bernardino Ghetti, Martin R Farlow (+18 others)
<span title="2018-03-07">2018</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
Importantly, a nascent form of the pattern observed across the autosomal-dominant Alzheimer's disease spectrum was also detectable in clinically normal elderly with clear biomarker evidence of Alzheimer's  ...  In contrast, ageing in the absence of Alzheimer's disease biomarkers was characterized by a far less network-specific degradation across cognitive and sensory networks, of between-and within-network connections  ...  Support was provided by the German Center for Neurodegenerative Disease (DZNE) for DIAN performance sites in Tuebingen and Munich, by the NIHR Queen Square Dementia Biomedical Research Unit and the MRC  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awy053">doi:10.1093/brain/awy053</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29522171">pmid:29522171</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/v2iinxh23zgcrhgkjl62k5rfgu">fatcat:v2iinxh23zgcrhgkjl62k5rfgu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190302162739/http://pdfs.semanticscholar.org/a620/597695ef5f406d19c61377931fd8c027a433.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a6/20/a620597695ef5f406d19c61377931fd8c027a433.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awy053"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a>

Cognitive Impairment in Genetic Parkinson's Disease

A. Planas-Ballvé, D. Vilas, Antonio Pisani
<span title="2021-12-30">2021</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ho44hu6idnfvhmsg63sv7jwk2i" style="color: black;">Parkinson&#39;s Disease</a> </i> &nbsp;
In this review, we summarize data regarding cognitive function on clinical studies, neuroimaging, and biological markers of cognitive decline in autosomal dominant PD linked to mutations in LRRK2 and SNCA  ...  Cognitive impairment is common in idiopathic Parkinson's disease (PD). Knowledge of the contribution of genetics to cognition in PD is increasing in the last decades.  ...  Other functional imaging approaches such as resting-state functional MRI showed that cognitive decline in PD seems to be associated with disruption of corticostriatal and frontal cortex functional connectivity  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/8610285">doi:10.1155/2021/8610285</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35003622">pmid:35003622</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8739522/">pmcid:PMC8739522</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/g6iar24vuneatmds7kurtjt3ta">fatcat:g6iar24vuneatmds7kurtjt3ta</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220203151754/https://downloads.hindawi.com/journals/pd/2021/8610285.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4f/df/4fdfae465afca39e94c48c457dc6b9e8b40f5330.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/8610285"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739522" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Resting-state network dysfunction in Alzheimer′s disease: a systematic review and meta-analysis [article]

AmanPreet Badhwar, Angela Tam, Christian Dansereau, Pierre Orban, Felix Hoffstaedter, Pierre Bellec
<span title="2017-02-14">2017</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
DISCUSSION Convergent evidence across the literature supports the use of resting-state connectivity as a biomarker of AD.  ...  impairment (MCI), using resting-state functional magnetic resonance imaging (rsfMRI).  ...  ACKNOWLEDGEMENTS The computational resources used to perform the data analysis were provided by ComputeCanada (www.computecanada.org) and CLUMEQ (www.clumeq.mcgill.ca), which is funded in part by NSERC  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/108282">doi:10.1101/108282</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ql6h46iyzzbxheyg3i5l4actje">fatcat:ql6h46iyzzbxheyg3i5l4actje</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190503120251/https://www.biorxiv.org/content/biorxiv/early/2017/02/14/108282.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d1/25/d125264d17ee8c78b8acd76aaab4ee2e714fef55.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/108282"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

Nicolai Franzmeier, Emrah Düzel, Frank Jessen, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Christian Haass, Marc Suárez-Calvet, Anne M Fagan, Katrina Paumier, Tammie Benzinger (+44 others)
<span title="2018-02-15">2018</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
Acknowledgements We would like to thank all the researchers in the DIAN (www.dian-info.org/personnel.htm) and DELCODE study.  ...  Cognitive and biomarker changes as a function of Alzheimer's disease severity.  ...  This has been consistently shown in sporadic and autosomal dominantly inherited Alzheimer's disease, where key hubs such as the posterior cingulate, precuneus or hippocampus show disruptions early in the  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awy008">doi:10.1093/brain/awy008</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29462334">pmid:29462334</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5888938/">pmcid:PMC5888938</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tmxzhydqz5h47aglry4swucjke">fatcat:tmxzhydqz5h47aglry4swucjke</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190304101752/http://pdfs.semanticscholar.org/da2f/9af4f891d64a7886bf23abe127f4d4e0f717.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/da/2f/da2f9af4f891d64a7886bf23abe127f4d4e0f717.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awy008"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888938" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Sensitivity, Specificity and Potential for Clinical Use

Cristina d'Abramo, Luciano D'Adamio, Luca Giliberto
<span title="2020-09-08">2020</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xuwogpw7hnaoljkcejqtymrqsa" style="color: black;">Journal of Personalized Medicine</a> </i> &nbsp;
Furthermore, other pathological elements of AD, such as the loss of neurons, inflammation and metabolic derangement, have translated to the definition of other CSF and blood biomarkers, which are not specific  ...  In this review, we discuss the role of current and hypothetical biomarkers of Alzheimer's disease, their specificity, and the caveats of current high-sensitivity platforms for their peripheral detection  ...  In a small percentage of the cases, the disease is inherited as autosomal dominant (FAD: familial AD), with an early age of onset, as early as the 40s, and a faster progression [57] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/jpm10030116">doi:10.3390/jpm10030116</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32911755">pmid:32911755</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3p4uqti3ibhrxgaaf6isjsvdmi">fatcat:3p4uqti3ibhrxgaaf6isjsvdmi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201107072934/https://res.mdpi.com/d_attachment/jpm/jpm-10-00116/article_deploy/jpm-10-00116.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ef/e4/efe46cc852e589d4d74d0c3285f80c2cb6d313e1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/jpm10030116"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>
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