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Focused Ultrasound for Noninvasive, Focal Pharmacologic Neurointervention

Jeffrey B. Wang, Tommaso Di Ianni, Daivik B. Vyas, Zhenbo Huang, Sunmee Park, Niloufar Hosseini-Nassab, Muna Aryal, Raag D. Airan
2020 Frontiers in Neuroscience  
within the brain without the need for blood-brain barrier opening.  ...  First, we discuss blood-brain barrier opening to deliver therapeutic agents of a variety of sizes to the central nervous system.  ...  in Patients With Parkinson's Disease Dementia Parkinson's disease dementia Spain Recruiting NCT03321487 April 2018 Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients  ... 
doi:10.3389/fnins.2020.00675 pmid:32760238 pmcid:PMC7372945 fatcat:ove42vwm5bgwxkz7guef5j772a

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

Raluca Ioana Teleanu, Manuela Daniela Preda, Adelina-Gabriela Niculescu, Oana Vladâcenco, Crina Ioana Radu, Alexandru Mihai Grumezescu, Daniel Mihai Teleanu
2022 Pharmaceutics  
The bloodbrain barrier (BBB) has shown to be a significant obstacle to brain medication delivery.  ...  The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB.  ...  harvested omental free flap Recruiting NCT04222309 Glioblastoma Multiforme (rGBM) Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients with Amyotrophic Lateral Sclerosis Device:  ... 
doi:10.3390/pharmaceutics14050987 fatcat:tssrroy4m5cwxfqcrc3wl5l3f4

Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future

Na Young Jung, Jin Woo Chang
2018 Journal of Korean medical science  
Other potential treatment candidates being examined in ongoing clinical trials include brain tumors, Alzheimer's disease, and epilepsy, based on MRgFUS abilities of thermal ablation and opening the blood-brain  ...  Magnetic resonance-guided focused ultrasound (MRgFUS) is a new emerging neurosurgical procedure applied in a wide range of clinical fields.  ...  Jin Woo Chang as the laureate of the 14th Bayer Prize in Clinical Medicine, 2018.  ... 
doi:10.3346/jkms.2018.33.e279 fatcat:cddupmrjebfbjplzl2a4k44ctm

Magnetic Resonance Methods for Focused Ultrasound-Induced Blood-Brain Barrier Opening

Allegra Conti, Hermes A. S. Kamimura, Anthony Novell, Andrea Duggento, Nicola Toschi
2020 Frontiers in Physics  
In 2019, the same group investigated resting-state (i.e., task-free) functional connectivity changes in the bilateral frontoparietal network induced in Alzheimer's Disease patients by FUS-induced BBB opening  ...  In future studies, this technique may also be used to e.g., evaluate improvements of cognitive function induced by ultrasound-mediated blood-brain barrier opening in Alzheimer's Disease with and without  ...  accordance with accepted academic practice.  ... 
doi:10.3389/fphy.2020.547674 fatcat:xrm3zuapvbb5jiyvp77nb4527u

Clinical Intervention Using Focused Ultrasound (FUS) Stimulation of the Brain in Diverse Neurological Disorders

Hongchae Baek, Daniel Lockwood, Emily Jo Mason, Emmanuel Obusez, Matthew Poturalski, Richard Rammo, Sean J. Nagel, Stephen E. Jones
2022 Frontiers in Neurology  
It can deliver acoustic energy through the physical barrier of the brain and eliminate abnormal brain cells to treat patients with Parkinson's disease and essential tremor.  ...  Focused ultrasound (FUS) is a new brain stimulation modality that can exert a therapeutic effect on diseased brain cells, with this effect ranging from permanent ablation of the pathological neural circuit  ...  AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; BBB, blood-brain barrier; GBM, glioblastoma multiforme; OCD, obsessive-compulsive disorder.  ... 
doi:10.3389/fneur.2022.880814 pmid:35614924 pmcid:PMC9124976 fatcat:h5g4ro2fbfdwhc63hpcvtr6soa

Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications

Ko-Ting Chen, Kuo-Chen Wei, Hao-Li Liu
2021 Pharmaceutics  
The bloodbrain barrier (BBB) protects the central nervous system (CNS) from invasive pathogens and maintains the homeostasis of the brain.  ...  Through a physical acoustic cavitation effect, focused ultrasound (FUS) combined with microbubbles achieves the local detachment of tight junctions of capillary endothelial cells without inducing neuronal  ...  Todd et al. further analyzed changes in functional connectivity between the sensory cortex hindlimb region and other cortices after FUS-BBBO using resting-state fMRI [106] .  ... 
doi:10.3390/pharmaceutics13071084 fatcat:53pmn4v535hlrczz45pmolxjme

5th International Symposium on Focused Ultrasound

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna (+1008 others)
2016 Journal of Therapeutic Ultrasound  
A5 Focused ultrasound facilitated gene delivery for neuro-restoration in Parkinson's disease mice  ...  Recent data from a multi-institution, randomized controlled clinical trial demonstrated that Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy improves upper limb tremor in medically refractory  ...  A28 Initial experience in a pilot study of Blood-Brain Barrier opening for chemo-drug delivery to brain tumors by MR-guided Focused [1] .  ... 
doi:10.1186/s40349-016-0076-5 fatcat:4vm7i5mt6vheni3hflxd3pwl2i

Abstract Book of the 5th Annual Meeting of the International Society for Neurovascular Disease

Marcello Mancini
2015 Veins and Lymphatics  
Breakdown of the blood-brain barrier, as in diabetes, leads to marked vascular changes, which can be signaled early. This is e.g. exploited in large screening programs for diabetes worldwide.  ...  Objectives: To assess the current state-of-the-art MR imaging methods with and without contrast agents to study the microvasculature of the brain.  ...  Correlation of ET-1 levels with SP subtype of disease opens new insights in MS pathogenesis. Key words: Multiple sclerosis; endothelial factors; ET-1.  ... 
doaj:471b7b244b3b426f928138517111dfdb fatcat:q5kenxy6pfc45nitkah4os7ojy

Inorganic Nanomaterial for Biomedical Imaging of Brain Diseases

Wenxian Du, Lingling Zhou, Qiang Zhang, Xin Liu, Xiaoer Wei, Yuehua Li
2021 Molecules  
Moreover, these nanomaterials with special physicochemical characteristics can be modified by surface modification or combined with functional materials to improve targeting in different diseases of the  ...  In the past few decades, brain diseases have taken a heavy toll on human health and social systems.  ...  Acknowledgments: The authors express their sincere thanks to those involed in helpful discussions. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/molecules26237340 pmid:34885919 pmcid:PMC8658999 fatcat:3ma7de7jovgp7ey4hdfpchol4m

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

Zsofia I. Kovacs, Saejeong Kim, Neekita Jikaria, Farhan Qureshi, Blerta Milo, Bobbi K. Lewis, Michele Bresler, Scott R. Burks, Joseph A. Frank
2016 Proceedings of the National Academy of Sciences of the United States of America  
MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of ultrasound contrast agent microbubbles (MB) causes localized blood-brain barrier (BBB) disruption that is currently being  ...  Further investigation will be required before this approach can be widely implemented in clinical trials. pulsed focused ultrasound | microbubbles | blood-brain barrier | sterile inflammation | magnetic  ...  MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of ultrasound contrast agent microbubbles (MB) causes localized blood-brain barrier (BBB) disruption that is currently being  ... 
doi:10.1073/pnas.1614777114 pmid:27994152 pmcid:PMC5224365 fatcat:nf27c3h6mbcorlzro2ftqx7raq

Novel targeted therapies for Parkinson's disease

Theodora Ntetsika, Paraskevi-Evita Papathoma, Ioanna Markaki
2021 Molecular Medicine  
Large biomarker development programs are undertaken to identify disease signatures that will improve patient selection and outcome measures in clinical trials.  ...  AbstractParkinson's disease (PD) is the second more common neurodegenerative disease with increasing incidence worldwide associated to the population ageing.  ...  Ioannis Mantas for his help with the illustration included in this Review.  ... 
doi:10.1186/s10020-021-00279-2 pmid:33632120 fatcat:6h3kdfq73befzeilcibg5y5j3y

Neurocognitive Function after Cardiac Surgery

Miles Berger, Niccolò Terrando, S. Kendall Smith, Jeffrey N. Browndyke, Mark F. Newman, Joseph P. Mathew
2018 Anesthesiology  
For half a century, we have known that some patients experience neurocognitive dysfunction after cardiac surgery, yet defining its incidence, course, and causes remains challenging and controversial.  ...  Delirium is a clinical diagnosis included in the diagnostic and statistical manual of mental disorders (fifth edition, DSM-V).  ...  EEG monitors) for a postoperative recovery study in older adults from Masimo. MB has also received legal consulting fees related to postoperative cognition in an older adult.  ... 
doi:10.1097/aln.0000000000002194 pmid:29621031 pmcid:PMC6148379 fatcat:6t5ob6pksfbo3daabr3mckeqye

Abstracts from the International Society for Therapeutic Ultrasound Conference 2017

2018 Journal of Therapeutic Ultrasound  
Kovacs Journal of Therapeutic Ultrasound 2018, 6(Suppl 1):O1 OBJECTIVES Blood brain barrier (BBB) disruption with MR-guided pulsed focused ultrasound (pFUS) and microbubbles (MB) has been advocated as  ...  Acoustic energy was delivered to the brain using "BBB configuration function" based on algorithm reported (O'Reilly et al. 2012) to determine optimal acoustic pressure for BBB opening via 1.5f 0 and 2.5f  ...  Acknowledgements This work was supported by the Bettencourt Schueller Foundation and the "Agence Nationale de la Recherche" under the program "Future Investments" with the reference ANR-10-EQPX-15.  ... 
doi:10.1186/s40349-018-0110-x fatcat:4nn4nwntgbfl5cdwvqc3wfxszu

Multi-scale optoacoustic molecular imaging of brain diseases

Daniel Razansky, Jan Klohs, Ruiqing Ni
2021 European Journal of Nuclear Medicine and Molecular Imaging  
imaging modalities with unprecedented capacities for interrogating the brain under physiological and diseased conditions.  ...  In addition, advanced molecular probe designs allow for efficient visualization of pathophysiological processes playing a central role in a variety of neurodegenerative diseases, brain tumors, and stroke  ...  Focused ultrasound subthalamotomy in patients with asymmetric Parkinso's disease: a pilot study. Lancet Neurol. 2018;17:54-63. https://doi.org/10.1016/s1474-4422(17)30403-9. 21.  ... 
doi:10.1007/s00259-021-05207-4 pmid:33594473 pmcid:PMC8566397 fatcat:djy2fspznnaylpqe4wrjd2jvlu

Poster Viewing Session VI

2017 Journal of Cerebral Blood Flow and Metabolism  
Abstract Arterial networks coordinates blood flow delivery to the brain in accordance with metabolic demand.  ...  To change blood flow magnitude, vasoactive stimuli generated in the grey matter must dilate cortical surface vessels Abstract Objectives: The "obesity paradox" describes improved outcome in obese patients  ...  Specifically, metabolites produced by the gut microbiome can impact brain vascular function, such as by decreasing blood brain barrier permeability.  ... 
doi:10.1177/0271678x17695990 pmid:28366132 pmcid:PMC5441167 fatcat:6z42kszazjdxfgbi5avzlmphdu
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