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Resting state activity and connectivity of the nucleus basalis of Meynert and globus pallidus in Lewy body dementia and Parkinson's disease dementia

James Gratwicke, Ashwini Oswal, Harith Akram, Marjan Jahanshahi, Marwan Hariz, Ludvic Zrinzo, Tom Foltynie, Vladimir Litvak
2020 NeuroImage  
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are two related diseases which can be difficult to distinguish.  ...  We recorded bilateral local field potentials (LFPs) from the nucleus basalis of Meynert (NBM) and the internal globus pallidus (GPi) with simultaneous cortical magnetoencephalography (MEG) in six PDD and  ...  Introduction Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are two of the most common neurodegenerative dementias ( Aarsland and Kurz, 2010 ; Jellinger, 2018 ) .  ... 
doi:10.1016/j.neuroimage.2020.117184 pmid:32711059 pmcid:PMC7762815 fatcat:x5inkoob2rfifmkjevpn3fmy3a

Deep brain stimulation for dementias

David S. Xu, Francisco A. Ponce
2018 Neurosurgical Focus  
METHODS Two targets are current topics of investigation in the treatment of AD and PDD, the fornix and the nucleus basalis of Meynert.  ...  Clinical Dementia Rating Sum of Boxes; Ch4i = intermediate portion of the NBM; DBS = deep brain stimulation; MCI = mild cognitive impairment; NBM = nucleus basalis of Meynert; NINDS-ADRDA = National Institute  ...  Acknowledgments We thank the staff of Neuroscience Publications at Barrow Neurological Institute for assistance with image and manuscript preparation.  ... 
doi:10.3171/2018.5.focus18172 pmid:30064323 fatcat:n5glud7fgjeubgzbegmjnal6su

Bilateral Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson Disease Dementia

James Gratwicke, Ludvic Zrinzo, Joshua Kahan, Amy Peters, Mazda Beigi, Harith Akram, Jonathan Hyam, Ashwini Oswal, Brian Day, Laura Mancini, John Thornton, Tarek Yousry (+4 others)
2018 JAMA Neurology  
IMPORTANCE Deep brain stimulation of the nucleus basalis of Meynert (NBM DBS) has been proposed as a treatment option for Parkinson disease dementia.  ...  OBJECTIVE To evaluate the safety and potential symptomatic effects of NBM DBS in patients with Parkinson disease dementia.  ...  Author Contributions: Drs Gratwicke and Foltynie had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.  ... 
doi:10.1001/jamaneurol.2017.3762 pmid:29255885 pmcid:PMC5838617 fatcat:bnnnlqroafbehdiib4opcio6m4

Current Research on Deep Brain Stimulation and Cognitive Impairment in Parkinson's Disease [chapter]

Kiarash Shahlaie, Laura Sperry, Luhua Wei, Lin Zhang
2021 Dementia in Parkinson's Disease [Working Title]  
The nucleus basalis of Meynert, a hub in the cognitive network, is chosen by most studies as the stimulation target.  ...  Recent advances in neuroscience have developed new models for the pathophysiology of Parkinson's disease dementia, based on which clinical research have showed promising results.  ...  An EEGbased study showed a significantly greater reduction in alpha reactivity in Lewy body dementia than Alzheimer's disease and healthy controls.  ... 
doi:10.5772/intechopen.101603 fatcat:rhpi3ivs6rarvhlziu6sobv3yi

Multimodal magnetic resonance imaging investigation of basal forebrain damage and cognitive deficits in Parkinson's disease

Fatma Gargouri, Cécile Gallea, Marie Mongin, Nadya Pyatigorskaya, Romain Valabregue, Claire Ewenczyk, Marie Sarazin, Lydia Yahia‐Cherif, Marie Vidailhet, Stéphane Lehéricy
2018 Movement Disorders  
Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex.  ...  Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and  ...  The network of referring neurologists and collaborators is listed in the appendix. Acknowledgments: We thank E.C. Hirsch, C. Duyckaerts, and Y. Agid for providing the histological material.  ... 
doi:10.1002/mds.27561 pmid:30536444 pmcid:PMC6590238 fatcat:h3yfzjasejdmxjpdqftfohzjgm

Intersection of structural and functional connectivity of the nucleus basalis of Meynert in Parkinson's disease dementia and Lewy body dementia [article]

Ashwini Oswal, james gratwicke, Harith Akram, Marjan Jahanshahi, Laszlo Zaborszky, Peter Brown, Marwan Hariz, Ludvic Zrinzo, Tom Foltynie, Vladimir Litvak
2020 bioRxiv   pre-print
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction.  ...  Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides the dominant source of cortical cholinergic innervation, has been implicated in the pathogenesis of both PDD  ...  Introduction Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are two of the commonest neurodegenerative dementias (Aarsland and Kurz, 2010; Jellinger, 2018) .  ... 
doi:10.1101/2020.07.27.221853 fatcat:dr4exlz27zex3nopkriteq4cue

Cortical connectivity of the nucleus basalis of Meynert in Parkinson's disease and Lewy body dementias

Ashwini Oswal, James Gratwicke, Harith Akram, Marjan Jahanshahi, Laszlo Zaborszky, Peter Brown, Marwan Hariz, Ludvic Zrinzo, Tom Foltynie, Vladimir Litvak
2020 Brain  
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction.  ...  Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides the dominant source of cortical cholinergic innervation, has been implicated in the pathogenesis of both PDD  ...  Introduction Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are two of the commonest neurodegenerative dementias (Aarsland and Kurz, 2010; Jellinger, 2018) .  ... 
doi:10.1093/brain/awaa411 pmid:33521808 pmcid:PMC8041337 fatcat:sdil6vkyyfekpinqnlkybmwss4

Neuroimaging of Parkinson's disease: Expanding views

Carol P. Weingarten, Mark H. Sundman, Patrick Hickey, Nan-kuei Chen
2015 Neuroscience and Biobehavioral Reviews  
Advances in molecular and structural and functional neuroimaging are rapidly expanding the complexity of neurobiological understanding of Parkinson's disease (PD).  ...  We begin with description of motor features of Parkinsonism, other diagnoses that may be considered in the differential diagnosis of PD, and the importance of nonmotor co-morbid syndromes (section 2.1)  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of  ... 
doi:10.1016/j.neubiorev.2015.09.007 pmid:26409344 pmcid:PMC4763948 fatcat:66ruxnmpyjdoplebvahzyibydq

Parkinson's disease dementia: a neural networks perspective

James Gratwicke, Marjan Jahanshahi, Thomas Foltynie
2015 Brain  
Abbreviations: AChEI = acetylcholinesterase inhibitor; MTL = medial temporal lobe; NBM = nucleus basalis of Meynert; PDD = Parkinson's disease dementia; PD-MCI = Parkinson's disease with mild cognitive  ...  In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease.  ...  For example, the nucleus basalis of Meynert (NBM) cholinergic network is strongly implicated in maintenance of an attentive state (discussed below), and degenerates significantly in PDD leading to widespread  ... 
doi:10.1093/brain/awv104 pmid:25888551 pmcid:PMC4614131 fatcat:qftf2vrq5fffpjra3yxev3t724

Serendipitous Stimulation of Nucleus Basalis of Meynert—The Effect of Unintentional, Long-Term High-Frequency Stimulation on Cognition in Parkinson's Disease

I. Daria Bogdan, D. L. Marinus Oterdoom, Teus van Laar, Rients B. Huitema, Vincent J. Odekerken, Judith A. Boel, Rob M. A. de Bie, J. Marc C. van Dijk, on behalf of the NSTAPS Study Group
2022 Journal of Clinical Medicine  
There is a growing interest in deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) as a potential therapeutic modality for Parkinson's disease dementia (PDD).  ...  With the aim to expand the understanding of NBM-DBS, we share our experience with serendipitous NBM-DBS in patients treated with DBS of the internal Globus pallidus (GPi) for Parkinson's disease.  ...  Abbreviations: AD = Alzheimer's disease; DLB = Dementia with Lewy bodies; GPi = internal globus pallidus; LFS = low-frequency stimulation; MCI = mild cognitive impairment; NBM = nucleus basalis of Meynert  ... 
doi:10.3390/jcm11020337 pmid:35054031 pmcid:PMC8779041 fatcat:xhc2ab2i6vbv5cm6vu6edh5zge

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

Usman Saeed, Anthony E. Lang, Mario Masellis
2020 Frontiers in Neurology  
and diffusion tensor MRI, (3) resting-state and task-based functional MRI, (4) proton magnetic resonance spectroscopy, (5) transcranial B-mode sonography for measuring substantia nigra and lentiform nucleus  ...  Based on the predominant protein aggregates observed within the brain, these disorders are categorized as, (1) α-synucleinopathies, which include PD and other Lewy body spectrum disorders as well as multiple  ...  The opinions, results and conclusions are those of the authors and no endorsement by the Ontario Brain Institute is intended or should be inferred.  ... 
doi:10.3389/fneur.2020.572976 pmid:33178113 pmcid:PMC7593544 fatcat:hwzze5o27zh4jg63xp6bx7quxa

Parkinson Disease

2016 Home Healthcare Now  
A Lewy body-related degeneration in the nucleus basalis of Meynert is always present and, consequently, loss of cholinergic innervation of the hippocampus and frontal cortex.  ...  In the cholinergic nucleus basalis, neuronal loss and occurrence of Lewy bodies is frequently observed in Parkinson disease.  ... 
doi:10.1097/nhh.0000000000000429 pmid:27243440 fatcat:qfd6qxhxlfhz5f3kigub3gtr2y

Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism

David J. Brooks
2021 Neurotherapeutics  
The similarities and differences in imaging findings in Lewy body dementia, Parkinson's disease dementia, and Alzheimer's disease are discussed.  ...  The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated  ...  The cholinergic system originates in the pedunculopontine nucleus (PPN), which sends projections to the thalamus, and in the nucleus basalis of Meynert (NBM), which sends projections to cortical and limbic  ... 
doi:10.1007/s13311-020-00994-4 pmid:33432494 pmcid:PMC8423977 fatcat:xve2cmyvr5bvpcercif3k2tv5i

Sleep in Neurodegenerative Disorders

Roneil Malkani, Hrayr Attarian
2015 Current Sleep Medicine Reports  
RBD can precede PD motor symptoms by several years, and it represents a window of opportunity to treat the disease process when a disease-modifying therapy for PD becomes available in the future.  ...  In Parkinson's disease (PD), various sleep disorders, such as insomnia, hypersomnia, and REM sleep behavior disorder (RBD) are often seen.  ...  In addition, the degeneration of the nucleus basalis of Meynert, a major source of cholinergic input, can further affect sleep-wake rhythms [9] .  ... 
doi:10.1007/s40675-015-0016-x fatcat:y3ys6buhc5atjlsqrqx7aj2wjq

Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders

Shichun Peng, Vijay Dhawan, David Eidelberg, Yilong Ma
2021 Bioelectronic Medicine  
In this article, we review some applications of deep brain stimulation for the treatment of several diseases in the field of neurology and psychiatry.  ...  It is aimed to restore brain dysfunction by the targeted delivery of specific electronic signal within or outside the brain to modulate neural activity on local and circuit levels.  ...  The authors read and approved the final manuscript.  ... 
doi:10.1186/s42234-021-00065-9 pmid:33781350 fatcat:h4qjs6t2qvea5awq42ymxecmha
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