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Neuroimaging in aphasia treatment research: Quantifying brain lesions after stroke

Jenny Crinion, Audrey L. Holland, David A. Copland, Cynthia K. Thompson, Argye E. Hillis
2013 NeuroImage  
This paper presents recommendations for quantification of brain lesions derived from discussions among international researchers at the Neuroimaging in Aphasia Treatment Research Workshop held at Northwestern  ...  Moreover, we aimed to provide the reader with a set of general practical guidelines and references to facilitate choosing adequate structural imaging strategies that facilitate fMRI studies in aphasia  ...  Acknowledgments The authors wish to thank the School of Communication  ... 
doi:10.1016/j.neuroimage.2012.07.044 pmid:22846659 pmcid:PMC3534842 fatcat:a5wcleiigncxnisxzvrnhdlvqa


D M Feeney, J C Baron
1986 Stroke  
Acknowledgments We wish to express our gratitude to Elise Scott and Dr. Irene Meissner for assistance in the preparation of this manuscript.  ...  Most early studies of diaschisis were restricted to stroke patients, were limited in their interpretation of the location and extent of the lesion.  ...  hemisphere, which will impair a number of more complicated nervous processes (apraxia, aphasia, agnosia)." 1 3) Diaschisis "undergoes gradual regression in well defined phases" such that resolution  ... 
doi:10.1161/01.str.17.5.817 pmid:3532434 fatcat:4ggnpbn5zzhgzg6t2jxm5tosji

Contributions of Neuroimaging to Understanding Language Deficits in Acute Stroke

Bonnie Breining, Rajani Sebastian
2018 Seminars in Speech and Language  
In this article, we review the various structural and functional imaging methods currently used to study language deficits in acute stroke.  ...  We also discuss the advantages and the limitations of each imaging modality and the applications of each modality in the clinical and research settings in the study of language deficits.  ...  The content is solely the responsibility of the authors and does not necessarily represent the views of the National Institutes of Health. The authors declare no competing financial interests.  ... 
doi:10.1055/s-0037-1608854 pmid:29359306 pmcid:PMC5840876 fatcat:hulhp3palnb7lbe4mq3il7vfi4

Restorative neurology. Drugs and recovery following stroke

L B Goldstein, J N Davis
1990 Stroke  
in laboratory animals and may be relevant to recovery in stroke patients. 6 For example, Knopman and coworkers 7 found that lesion volume was correlated with recovery from aphasia after stroke.  ...  Diaschisis is a term originated by Von Monakow to indicate remote, functional depression of brain distant from the site of the primary injury.  ... 
doi:10.1161/01.str.21.11.1636 pmid:2237961 fatcat:ne57a3ifsjcxhpcjpi7a7xteca

Nuclear Medicine in Cerebrovascular Disease

David H. Lewis, Lauren K. Toney, Jean-Claude Baron
2012 Seminars in nuclear medicine  
Finally, Nuclear Medicine investigations of stroke recovery and cerebral plasticity appear to indicate that enhanced activity of preexisting networks, rather than substitution of function, represents the  ...  Nuclear Medicine, primarily via tomographic methods, has made significant contributions to the understanding of the hemodynamic and metabolic consequences of cerebrovascular diseases.  ...  Before the early 1980's, functional recovery after stroke had been largely explained by resolution of a widespread "neural shock"-in analogy to the "spinal shock" that accompanies acute cord lesions.  ... 
doi:10.1053/j.semnuclmed.2012.06.002 pmid:23026361 fatcat:nopdgqbvnvejlac5c4xw376vfa

Neuroplasticity Associated with Treated Aphasia Recovery [chapter]

Julius Fridriksson, Kimberly Smith
2016 Neurobiology of Language  
These improvements may be accounted for by diaschisis resolution and strong bilateral activation (Saur & Hartwigsen, 2012) .  ...  That is, very early recovery from aphasia may be driven in part by neurovascular changes, whereas later recovery appears to rely more on actual neuroplasticity and, possibly, angiogenesis (the formation  ... 
doi:10.1016/b978-0-12-407794-2.00080-8 fatcat:dkccrd2mtrbfrpkp5oprh3dlqu

Enhancing Recovery after Stroke with Noradrenergic Pharmacotherapy: A New Frontier?

David J. Gladstone, Sandra E. Black
2000 Canadian Journal of Neurological Sciences  
There is now increasing interest in the development of stroke recovery drugs and innovative rehabilitation techniques to promote functional recovery after completed stroke.  ...  Amphetamine, a monoamine agonist that increases brain norepinephrine levels, is the most extensively studied drug shown to promote recovery of function in animal models of focal brain injury.  ...  ACKNOWLEDGEMENTS The authors gratefully acknowledge the support of the Royal College of Physicians and Surgeons of Canada/University of Toronto Department of Medicine Clinician-Scientist Program.  ... 
doi:10.1017/s0317167100052173 fatcat:n3q2ozbvwrdfphsahyi6lpihmu

Brain-Mapping Techniques for Evaluating Poststroke Recovery and Rehabilitation: A Review

James C. Eliassen, Erin L. Boespflug, Martine Lamy, Jane Allendorfer, Wen-Jang Chu, Jerzy P. Szaflarski
2008 Topics in Stroke Rehabilitation  
Brain-mapping techniques have proven to be vital in understanding the molecular, cellular, and functional mechanisms of recovery after stroke.  ...  This article briefly summarizes the current molecular and functional concepts of stroke recovery and addresses how various neuroimaging techniques can be used to observe these changes.  ...  Eliassen and Szaflarski are currently supported by National Institutes of Health grants K01-DA020485 and K23 NS052468, respectively.  ... 
doi:10.1310/tsr1505-427 pmid:19008203 pmcid:PMC2663338 fatcat:6yy5loaienfwpj4dc73paqmokq

The Impact of Recovery of Visuo-Spatial Neglect on Motor Recovery of the Upper Paretic Limb after Stroke

Tanja C. W. Nijboer, Boudewijn J. Kollen, Gert Kwakkel, Francesco Di Russo
2014 PLoS ONE  
The seemingly suppressive effect of neglect on upper-limb motor recovery appears to take place mainly during spontaneous neurological recovery of first 10 weeks post-stroke.  ...  All time-dependent measures were taken weekly, starting within 14 days post-stroke. From week 10 to 20 biweekly measurements are obtained.  ...  Author Contributions  ... 
doi:10.1371/journal.pone.0100584 pmid:24950224 pmcid:PMC4065089 fatcat:6chgipa64fhm3a3qxqedefcqj4

The management of subacute and chronic vascular aphasia: an updated review

Samwel Sylvester Msigwa, Xianglin Cheng
2020 The Egyptian Journal of Neurology Psychiatry and Neurosurgery  
Post-stroke aphasia (PSA) is an impairment of the generation or comprehension of language due to acute cerebrovascular lesions.  ...  Subacute phase span the 7th day to 24 weeks post-onset while > 6 months is termed chronic phase. Language recovery does not arise immediately in chronic PSA, unlike the acute phase.  ...  Authors' contributions Authors contributed to this paper, with the design (SSM), literature search (SSM), drafting (SSM), revision (SSM and XC), and editing (SSM and XC).  ... 
doi:10.1186/s41983-020-00224-w fatcat:vn3i2ovr7jfmjogpkolkvpoc3i

Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges

Swathi Kiran, Cynthia K. Thompson
2019 Frontiers in Neurology  
In this review, we first discuss mechanisms of damage and plasticity in the post-stroke brain, both in the acute and the chronic phase of recovery.  ...  Ultimately, we encourage researchers to propose sophisticated intervention studies that bring us closer to the goal of providing precision treatment for patients with aphasia and a better understanding  ...  post-stroke aphasia.  ... 
doi:10.3389/fneur.2019.00295 pmid:31001187 pmcid:PMC6454116 fatcat:n4ttx3pesrhzdghsjl3ddhc2ha

Contribution of Neuro-Imaging for Prediction of Functional Recovery after Ischemic Stroke

Wolf-Dieter Heiss
2017 Cerebrovascular Diseases  
Despite a statistically significant reduction in the rates of incidence, mortality, and disability-adjusted life years from 1990 to 2013, the absolute number of people affected by stroke has increased  ...  In addition to the primary lesion, the involvement of fiber tracts contributes to prognosis, and consequently the use of diffusion tensor imaging (DTI) to assess primary and secondary pathways improves  ...  Chances for improvement of post-stroke aphasia can be estimated from the performance in word repetition from a language screening task, supporting the importance of perception and motor production for  ... 
doi:10.1159/000479594 pmid:28869961 fatcat:2tc5s3i4z5cnleazqopmynuyta

Language processing in aphasia: changes in lateralization patterns during recovery reflect cerebral plasticity in adults

Christine Thomas, Eckart Altenmüller, Georg Marckmann, Jürgen Kahrs, Johannes Dichgans
1997 Electroencephalography and Clinical Neurophysiology  
basis of recovery from aphasia. 0 1997 Elsevier Science Ireland Ltd.  ...  In 11 stroke patients with permanent aphasia this physiological pattern changed to bilateral activation reflecting an additional right-hemispheric involvement in compensatory mechanisms in aphasia.  ...  This may indicate a relationship of the type of aphasia or the state of recovery from aphasia to the pattern of lateralization rather than a pure correlation with time elapsed after stroke.  ... 
doi:10.1016/s0921-884x(96)95653-2 pmid:9060859 fatcat:uwm7qapqubhqtiu2vf6byb4c5i

Language Reorganization After Stroke: Insights from fMRI [chapter]

Vanja Kljajevic
2012 Functional Magnetic Resonance Imaging - Advanced Neuroimaging Applications  
fMRI of post-stroke aphasia Establishing potential for long-term recovery of language in post-stroke patients requires information on which neuroanatomical areas are damaged by a stroke, what the extent  ...  Imaging the impact of language training on post-stroke brain After a stroke, spontaneous language recovery takes places during the first 6 to 12 months.  ... 
doi:10.5772/28654 fatcat:u7apgzycdfh3ho4gf4wxxljchu

Dynamics of language reorganization after stroke

D. Saur
2006 Brain  
In the acute phase [mean: 1.8 days post-stroke (dps)], patients' group analysis showed little early activation of non-infarcted lefthemispheric language structures, while in the subacute phase (mean: 12.1  ...  Previous functional imaging studies of chronic stroke patients with aphasia suggest that recovery of language occurs in a pre-existing, bilateral network with an upregulation of undamaged areas and a recruitment  ...  The work was supported by the Deutsche Forschungsgemeinschaft (DFG, WE 1352/13-1), Bundesministerium für Bildung und Forschung (BMBF, 01GO0205-7) and the Medizinische Fakultät of the Albert-Ludwigs-Universität  ... 
doi:10.1093/brain/awl090 pmid:16638796 fatcat:4s6iokpn7rfnrjhhdbmjgpsp2y
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