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The left temporal pole is important for retrieving words for unique concrete entities

Daniel Tranel
2009 Aphasiology  
In lesion-deficit studies, we found that damage to the left temporal polar (TP) region leads to reliable and specific impairments in naming famous persons (e.g., "George Clooney") and famous landmarks  ...  In functional imaging studies, we found that when participants name famous persons and landmarks, they produce specific activation (increases in regional cerebral blood flow) in the left TP region.  ...  The search volume for the PET activations comprised the left and right temporal poles (the latter because we expected the recognition part of the process to activate the right TP region, as before).  ... 
doi:10.1080/02687030802586498 pmid:20161625 pmcid:PMC2813036 fatcat:gnuhkgarsfbohhfe45me4vsw6q

Surgically disconnected temporal pole exhibits resting functional connectivity with remote brain regions [article]

David E Warren, Matthew J Sutterer, Joel Bruss, Taylor J Abel, Andrew Jones, Hiroto Kawasaki, Michelle Voss, Martin Cassell, Matthew A Howard, Daniel Tranel
2017 bioRxiv   pre-print
In sharp contrast to our prediction, we observed significant functional connectivity between the disconnected temporal pole and remote brain regions in each disconnection case.  ...  Functional connectivity, as measured by resting-state fMRI, has proven a powerful method for studying brain systems in the context of behavior, development, and disease states.  ...  Funding Sources We would like to acknowledge our funding sources: Author Contributions All authors designed the research; DEW, MJS, JB, TJA, & AJ performed the research and conducted the analyses; all  ... 
doi:10.1101/127571 fatcat:kdvqs6sg55ekncm4y54bbir4aq

Neural systems behind word and concept retrieval

H Damasio, D Tranel, T Grabowski, R Adolphs, A Damasio
2004 Cognition  
from name retrieval in the lesion study.  ...  the retrieval of words which denote concrete entities belonging to distinct conceptual categories depends upon partially segregated regions in higher-order cortices of the left temporal lobe; and (B)  ...  Acknowledgements This study was supported in part by NINDS grant PO1 NS19632 and NIDCD P50 DC03189.  ... 
doi:10.1016/j.cognition.2002.07.001 pmid:15037130 fatcat:uytralcoxrhgdelistqkko32dm

The Neural Substrate of Picture Naming

Susan Murtha, Howard Chertkow, Mario Beauregard, Alan Evans
1999 Journal of Cognitive Neuroscience  
Abnormal retrieval of names of people was related to damage at the left temporal pole, abnormal retrieval of words for animals was correlated with damage to the left anterior inferior temporal lobe, and  ...  We therefore note (see Table 1) that no other PET study of picture naming has produced activation in this anterior inferior left temporal region, particularly the temporal pole, including the overlap region  ... 
doi:10.1162/089892999563508 pmid:10471848 fatcat:kfkiwadkozdr5gvk3rariaw7li

Listening to Narrative Speech after Aphasic Stroke: the Role of the Left Anterior Temporal Lobe

Jennifer T. Crinion, Elizabeth A. Warburton, Matthew A. Lambon-Ralph, David Howard, Richard J.S. Wise
2005 Cerebral Cortex  
Listening to narratives in normal subjects activated the posterior-anterior extent of the left STS, as far forward as the temporal pole.  ...  to aphasic patients without temporal lobe damage and normal controls.  ...  activated voxels in intact cortex in yellow. 1, activation in the anterior left STS, spreading into the temporal pole; 2, activation in the posterior left STS; 3, activation in the anterior left fusiform  ... 
doi:10.1093/cercor/bhj053 pmid:16251507 fatcat:cwedqxtno5cffna3oc5tpgqo5u

Left-hemisphere processing of emotional connotation during word generation

Bruce Crosson, Krestin Radonovich, Joseph R. Sadek, Didem Gökçay, Russell M. Bauer, Ira S. Fischler, Margaret A. Cato, Leeza Maron, Edward J. Auerbach, Samuel R. Browd, Richard W. Briggs
1999 NeuroReport  
Lane and colleagues [12] did not ®nd activity near the temporal pole in their PET study where subjects viewed pictures from the same corpus as Canli and colleagues' study.  ...  When compared to a tone monitoring control task, monitoring of emotional words yielded extensive left frontal activity, including the same region near the frontal pole as the current study and left temporal  ... 
doi:10.1097/00001756-199908200-00003 pmid:10574350 fatcat:jmtroptc4banjflwfoo2o3ccvi

The Cortical Representation of Speech

B. M. Mazoyer, N. Tzourio, V. Frak, A. Syrota, N. Murayama, O. Levrier, G. Salamon, S. Dehaene, L. Cohen, J. Mehler
1993 Journal of Cognitive Neuroscience  
Absttact I In this study, we compare regional cerebral blood flow temporal gyrus, the left and right temporal poles, and a supe-(rCBF) while French monolingual subjects listen to continuous rior prefrontal  ...  Among these respeech in an unknown language, to lists of French words, or gions, only the temporal poles remain activated whenever to meaningful and distorted stories in French.  ...  Funding for this work was provided by the Minisdre de la Recherche et de la Technologie (Action Sciences de la Cognition) and by the Human Frontier Science Program.  ... 
doi:10.1162/jocn.1993.5.4.467 pmid:23964919 fatcat:sv6ywq6f2jg3jh55dhmle7cza4

Conscious visual perception without VI

J. L. Barbur, J. D. G. Watson, R. S. J. Frackowiak, S. Zeki
1993 Brain  
We used the technique of PET to determine whether visual signals reach visual area V5, specialized for visual motion, when a human patient, blinded by a lesion in area VI, discriminates the direction of  ...  The results showed that area V5 was active without a parallel activation of area VI, implying that the visual input can reach V5 without passing first through VI and that such an input is sufficient for  ...  Lewington, Ms A Williams and Mr A. Blyth for their help in carrying out the PET scans, and Mr A. Harlow for his help with the psychophysical investigations.  ... 
doi:10.1093/brain/116.6.1293 pmid:8293272 fatcat:3zxhwsi4vjfireshfnzxemvp5a

An area essential for linking word meanings to word forms: Evidence from primary progressive aphasia

D.S. Race, K. Tsapkini, J. Crinion, M. Newhart, C. Davis, Y. Gomez, A.E. Hillis, A.V. Faria
2013 Brain and Language  
Across most tasks, error rates were correlated with atrophy in the left middle and posterior inferior temporal gyrus.  ...  We tested patients, across multiple input modalities, on traditional naming tasks (picture naming) and more complex tasks (sentence completion with a name, naming in response to a question) and obtained  ...  Its contents are solely the responsibility of the authors and do not necessarily represent the official view of any of these Institutes.  ... 
doi:10.1016/j.bandl.2013.09.004 pmid:24183469 pmcid:PMC3906671 fatcat:becitllnl5e3hbhpjpze7bg7ou

Extensive metabolic and neuropsychological abnormalities associated with discrete infarction of the genu of the internal capsule

F E Chukwudelunzu
2001 Journal of Neurology, Neurosurgery and Psychiatry  
The aim was to characterise the radiographic, electroencephalographic, and neuropsychometric abnormalities in a woman who had a history of recurrent transient memory loss. Method-Case report.  ...  Follow up evaluation 7 months after the stroke showed improvement in some areas of the cognitive domain, but residual neuropsychometric and neurophysiological abnormalities persisted.  ...  In a case report by Moreaud et al, 42 PET demonstrated hypometabolism in the left frontotemporoparietal, left caudate, left thalamus, and right cerebellar cortices 2 months after a left capsular genu  ... 
doi:10.1136/jnnp.71.5.658 pmid:11606679 pmcid:PMC1737596 fatcat:gvkhltbdafeexfcwgnhzkzkmbq

The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval

E. A. Maguire
2001 Brain  
Jon activated the same brain regions during memory retrieval as control subjects, both medial and lateral on the left.  ...  In contrast to controls, Jon also activated many homologous regions on the right.  ...  Acknowledgements We are indebted to Jon and his parents for their cooperation in this study. We wish to thank C. J. Mummery for assistance with control data collection, and C.  ... 
doi:10.1093/brain/124.6.1156 pmid:11353732 fatcat:7ljlupeourdwdlq2eudqzsuk7u

Cognitive and Anatomical Underpinnings of the Conceptual Knowledge for Common Objects and Familiar People: A Repetitive Transcranial Magnetic Stimulation Study

Fabio Campanella, Franco Fabbro, Cosimo Urgesi, Alessio Avenanti
2013 PLoS ONE  
Here we applied repetitive transcranial magnetic stimulation (rTMS) over the left and right temporal poles before asking healthy individuals to perform a speeded word-to-picture matching task using familiar  ...  The application of rTMS to the left temporal pole modulated, for both categories, semantic distance, but not familiarity effects, revealing that accessing object and face concepts might rely on overlapping  ...  In a PET study, the authors showed a left anterior temporal activation during identification of faces, but a right hemisphere lateralization for the perceptual analysis of faces.  ... 
doi:10.1371/journal.pone.0064596 pmid:23704999 pmcid:PMC3660352 fatcat:47b5wwbqk5gzfmscnvifs53nta

A Functional Neuroimaging Description of Two Deep Dyslexic Patients

C. J. Price, D. Howard, K. Patterson, E. A. Warburton, K. J. Friston, R. S. J. Frackowiak
1998 Journal of Cognitive Neuroscience  
One is that deep dyslexia results from a residual left-hemisphere reading system that has lost the ability to pro- nounce a printed word without reference to meaning.  ...  Concurrent activation of the left anterior temporal pole and the left posterior temporo-parietal cortex has also been reported during sentence comprehension tasks (Bottini et al., 1994; Mazoyer et al.,  ... 
doi:10.1162/089892998562753 pmid:9869706 fatcat:hf7ulrdrqfadba7zb5y2rzhbi4

Segregation of anterior temporal regions critical for retrieving names of unique and non-unique entities reflects underlying long-range connectivity

Sonya Mehta, Kayo Inoue, David Rudrauf, Hanna Damasio, Daniel Tranel, Thomas Grabowski
2016 Cortex  
Lesion-deficit studies support the hypothesis that the left anterior temporal lobe (ATL) plays a critical role in retrieving names of concrete entities.  ...  Damage to the basolateral ATL was associated with naming deficits for both unique (famous faces) and non-unique entities, whereas the damage to the temporal pole was associated with naming deficits for  ...  Acknowledgements Research support was provided by NINDS R01 NS058658, by NINDS P50 NS019632, and by an NRSA to S.M (F31 NS090855).  ... 
doi:10.1016/j.cortex.2015.10.020 pmid:26707082 pmcid:PMC4754140 fatcat:hrxzbkv42nbdjouceghqzbhwc4

Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia

C. J. Mahoney, J. D. Rohrer, J. C. Goll, N. C. Fox, M. N. Rossor, J. D. Warren
2011 Journal of Neurology, Neurosurgery and Psychiatry  
Methods 43 patients with a diagnosis of SemD attending a specialist cognitive disorders clinic were retrospectively studied. 14 patients (32% of the cohort) reported at least moderately severe chronic  ...  Results Compared with SemD patients with no history of auditory symptoms, patients with tinnitus or hyperacusis had relative preservation of grey matter in the posterior superior temporal lobe and reduced  ...  Acknowledgements We are grateful to all of our subjects for their participation.  ... 
doi:10.1136/jnnp.2010.235473 pmid:21531705 pmcid:PMC3188784 fatcat:i2dgw2rv6bblznh4ifskve2rem
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