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Exploring the Power and Promise of In Silico Clinical Trials with Application in COVID-19 Infection

Abdelrahman H. Abdelmoneim, Safinaz I. Khalil, Hiba Awadelkareem Osman Fadl, Ayesan Rewane, Sahar G. Elbager
<span title="2021-09-30">2021</span> <i title="Knowledge E"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dqwgsijflvfmnhe6ork5gro7wi" style="color: black;">Sudan Journal of Medical Sciences</a> </i> &nbsp;
Results: Successful use of in silico trials was observed in many of the reviewed evidence. Conclusion: In silico clinical trials can be used in refining clinical trials for COVID-19 infection.  ...  for clinical trials on COVID-19 and other diseases.  ...  Acknowledgements The authors would like to thank Israa Isam for helping in designing Figure 1 . Ethical Considerations Not required.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18502/sjms.v16i3.9697">doi:10.18502/sjms.v16i3.9697</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qmaw3blnqrfcti2o3mwmbmujru">fatcat:qmaw3blnqrfcti2o3mwmbmujru</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20211012140648/https://knepublishing.com/index.php/SJMS/article/download/9697/16106" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/dd/00/dd00f12d7bb1ddfb64cb742eea64c30b62529236.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18502/sjms.v16i3.9697"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Drug Repurposing for Cancer: An NLP Approach to Identify Low-Cost Therapies [article]

Shivashankar Subramanian, Ioana Baldini, Sushma Ravichandran, Dmitriy A. Katz-Rogozhnikov, Karthikeyan Natesan Ramamurthy, Prasanna Sattigeri, Kush R. Varshney, Annmarie Wang, Pradeep Mangalath, Laura B. Kleiman
<span title="2019-12-05">2019</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Due to their long history of safe patient use, low cost, and widespread availability, repurposing of generic drugs represents a major opportunity to rapidly improve outcomes for cancer patients and reduce  ...  Using the subject matter expertise on our team, we create our own datasets for these specialized domain-specific tasks.  ...  Scientific publications such as preclinical laboratory studies and small clinical trials contain evidence on generic drugs being tested for cancer use.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1911.07819v2">arXiv:1911.07819v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uvs6mcztsff35fnljztbfbbebm">fatcat:uvs6mcztsff35fnljztbfbbebm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200822160847/https://arxiv.org/pdf/1911.07819v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/af/f1/aff18321e1cce79f1636d5c77899cb5c40894ea5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1911.07819v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Changing Trends in Computational Drug Repositioning

Jaswanth Yella, Suryanarayana Yaddanapudi, Yunguan Wang, Anil Jegga
<span title="2018-06-05">2018</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lecpmp3vs5hulh3xiqgqnyhrge" style="color: black;">Pharmaceuticals</a> </i> &nbsp;
basis for the discovery of a new drug is to start with an old drug".  ...  , complex, or dispersed and buried in silos of information.  ...  Projects using most of these assets can go directly into Phase II clinical trials, while some may require additional pre-clinical investigations or a Phase I clinical trial (e.g., testing in target populations  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ph11020057">doi:10.3390/ph11020057</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29874824">pmid:29874824</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6027196/">pmcid:PMC6027196</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kd5w6uulcjgvnd6m66hwy3hmje">fatcat:kd5w6uulcjgvnd6m66hwy3hmje</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180728100530/https://res.mdpi.com/def502008fdb5080dd142f4ef389e8ab657b360b24f4d403e1179c2baa1ddf0be64007a5e758d15e3e96fe5f90c614f974cd098b67beca424b3b95c8e7510447317b8de9f8b87f80a092b05a08a2ab1f827c3b2869f4aa826125ff1f296795eb474c3d731530917fe93800a983ee3a45778998608dfab07b88903dd32b58535e716e8fc604c4727b2267d33267aedbd43e937266ca1a509555041f54cc5a42b4d4f70fafbf86f924?filename=&amp;attachment=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ab/53/ab53ea3635c756802de5d72c05de004d80fc3064.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ph11020057"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027196" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Computational and Experimental Advances in Drug Repositioning for Accelerated Therapeutic Stratification

Khader Shameer, Ben Readhead, Joel T. Dudley
<span title="2015-01-14">2015</span> <i title="Bentham Science Publishers Ltd."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/k222f4mitzcuhmu2nnbcda5dqa" style="color: black;">Current Topics in Medicinal Chemistry</a> </i> &nbsp;
Efficient tools are now available for systematic drug-repositioning methods using large repositories of compounds with biological activities.  ...  We also discuss recent approaches in utilizing electronic health record for outcome assessment of drug repositioning and future avenues of drug repositioning in the light of targeting disease comorbidities  ...  Focused clinical trials may be required to re-validate the use of repurposed indications.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2174/1568026615666150112103510">doi:10.2174/1568026615666150112103510</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25579574">pmid:25579574</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uryq36httvcwrfub36lstr6tw4">fatcat:uryq36httvcwrfub36lstr6tw4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190220211106/http://pdfs.semanticscholar.org/2e94/716fb7f78bb69fa36f6aad8f0e9e6005f75b.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2e/94/2e94716fb7f78bb69fa36f6aad8f0e9e6005f75b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2174/1568026615666150112103510"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases – recommendations of the IRDiRC Data Mining and Repurposing Task Force

Noel T Southall, on behalf of the IRDiRC Data Mining and Repurposing Task Force, Madhusudan Natarajan, Lilian Pek Lian Lau, Anneliene Hechtelt Jonker, Benoît Deprez, Tim Guilliams, Lawrence Hunter, Carin MA Rademaker, Virginie Hivert, Diego Ardigò
<span title="2019-10-15">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jqqqzntbsfb7xhmhuedzk4sxzi" style="color: black;">Orphanet Journal of Rare Diseases</a> </i> &nbsp;
to identify new opportunities to use existing pharmaceutical compounds in new ways and to accelerate the pace of drug development for rare disease patients.  ...  In reviewing past successes of data mining for drug repurposing, and planning for future biomedical research capacity, the DMR Task Force identified four strategic infrastructure investment areas to focus  ...  Disclaimer The findings and recommendations in this article are those of the contributors, who participated based on their individual expertise and are responsible for the contents, and do not necessarily  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13023-019-1193-3">doi:10.1186/s13023-019-1193-3</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31615551">pmid:31615551</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6794821/">pmcid:PMC6794821</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z2c2ruabnndu7fs7hmfkqozewi">fatcat:z2c2ruabnndu7fs7hmfkqozewi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201103181742/https://openaccess.leidenuniv.nl/bitstream/handle/1887/106083/Southall_et_al_2019.pdf?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b8/fa/b8fa0991429978ed5a61242d258185625e005d16.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13023-019-1193-3"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794821" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Role of Molecular Modeling and Bioinformatics in Treating a Pandemic Disease: The Case of COVID-19

Abdallah S. Abdelsattar, Zahraa M. El-Awadly, Mai Abdelgawad, Fayrouz Mahmoud, Sahar A. Allam, Mohamed A. Helal
<span title="2021-12-23">2021</span> <i title="Bentham Science Publishers Ltd."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z5v43fqqmfhutes6kb64jxo66y" style="color: black;">The Open COVID Journal</a> </i> &nbsp;
The genotyping analysis for SARS-CoV-2 is also useful in identifying different mutations, SNPs, and conservative domains along the viral genome.  ...  Among different study types, in silico drug prediction and repurposing have the lowest risk with less off-target results.  ...  ACKNOWLEDGEMENTS The authors thank Fareed Aboul-ela for the critical evaluation of the manuscript's English language.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2174/2666958702101010216">doi:10.2174/2666958702101010216</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5f3j73jx7ffyjcwgmi2xxvvk7e">fatcat:5f3j73jx7ffyjcwgmi2xxvvk7e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220117221810/https://opencovidjournal.com/contents/volumes/V1/TOCOVIDJ-1-216/TOCOVIDJ-1-216.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f6/8e/f68e42c7613ed376a081d2161be853ab911692f1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2174/2666958702101010216"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19 [article]

Luca Menestrina, Chiara Cabrelle, Maurizio Recanatini
<span title="2021-03-09">2021</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
In this context, we observed an unmet need of depicting the continuously evolving scenario of the ongoing drug clinical trials through an easy-to-use, freely accessible online tool.  ...  Here, we describe the web app and show through some examples how one can explore the whole landscape of medicines in clinical trial for the treatment of COVID-19 and try to probe the consistency of the  ...  The authors wish to thank Fabrizio De Ponti for the helpful discussions and Riccardo Ocello for the support in the server management.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.03.05.433897">doi:10.1101/2021.03.05.433897</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pqoiv2q6z5bytkwgm43oae7gza">fatcat:pqoiv2q6z5bytkwgm43oae7gza</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210717112355/https://www.biorxiv.org/content/biorxiv/early/2021/03/09/2021.03.05.433897.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9e/f4/9ef40075bb161a18528c694a744e7f28e6187a60.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.03.05.433897"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Deep Learning in Drug Discovery and Medicine; Scratching the Surface

Dibyendu Dana, Satishkumar Gadhiya, Luce St. Surin, David Li, Farha Naaz, Quaisar Ali, Latha Paka, Michael Yamin, Mahesh Narayan, Itzhak Goldberg, Prakash Narayan
<span title="2018-09-18">2018</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dstyyzbt45gknhqqjsh45p55h4" style="color: black;">Molecules</a> </i> &nbsp;
and the mining of large databases in health-privacy-protected vaults.  ...  Indeed, precision medicine-based therapies that first found their place in oncology are rapidly finding uses in autoimmune, renal and other diseases.  ...  In summary, the use of precision medicine can reduce noise in clinical trials, can reduce cost and The signalosome of ANG3070, an orally bioavailable small molecule fibrokinase inhibitor is depicted within  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/molecules23092384">doi:10.3390/molecules23092384</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30231499">pmid:30231499</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6225282/">pmcid:PMC6225282</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3ckeayuv4jfdlfffd7dz53wc4y">fatcat:3ckeayuv4jfdlfffd7dz53wc4y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190228032910/http://pdfs.semanticscholar.org/8b6b/d9628d1bc7febafff59015798eedfcb62d45.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8b/6b/8b6bd9628d1bc7febafff59015798eedfcb62d45.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/molecules23092384"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225282" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Orphan/rare drug discovery through drug repositioning

Ramaiah Muthyala
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6ybz2i5vd5dkjdh7zof5f7k6eu" style="color: black;">Drug Discovery Today : Therapeutic Strategies</a> </i> &nbsp;
Scientific discoveries and new technologies are creating many opportunities for drug repositioning.  ...  There are many, often life-threatening, rare/orphan diseases for which there are few or no therapeutic options.  ...  Profit margins for orphan drugs are higher than blockbuster drugs due to a small patient pool resulting in smaller clinical trials and a higher price point support for orphan drugs.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ddstr.2011.10.003">doi:10.1016/j.ddstr.2011.10.003</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pslebyurxvbargznyc66d3y4qm">fatcat:pslebyurxvbargznyc66d3y4qm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170809105911/http://csmres.co.uk/cs.public.upd/article-downloads/Muthyala_2011-2012_Drug-Discovery-Today-Therapeutic-Strategies.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/28/9a/289ae1d6d377b7a52f3c2685e2b13b1dd2ceef23.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ddstr.2011.10.003"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Applications of Machine Learning in Drug Discovery I: Target Discovery and Small Molecule Drug Design [chapter]

John W. Cassidy
<span title="2020-09-09">2020</span> <i title="IntechOpen"> Artificial Intelligence in Oncology Drug Discovery and Development </i> &nbsp;
Machine learning (ML) has re-emerged in the last several years as a powerful set of tools for unlocking value from large datasets.  ...  In this chapter, we will provide a basic primer to ML before discussing methods for, and examples of, the use of ML-based techniques in target identification and structure-based drug design.  ...  of uses of ML in the drug discovery process to the clinical arena.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/intechopen.93159">doi:10.5772/intechopen.93159</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z5xuzsnga5ggfnp5sofk6hyodi">fatcat:z5xuzsnga5ggfnp5sofk6hyodi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201004220216/https://api.intechopen.com/chapter/pdf-download/72799.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c2/59/c2591aa4ae31fe3c6df9668cb38652614dc64ad1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/intechopen.93159"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Development of an electronic health record-based Clinical Trial Alert system to enhance recruitment at the point of care

Peter J Embi, Anil Jain, Jeffrey Clark, C Martin Harris
<span title="">2005</span> <i title="American Medical Informatics Association"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/g6q27b56yzeupjryv6lby2r2pa" style="color: black;">AMIA Annual Symposium Proceedings</a> </i> &nbsp;
We describe the design, operation and initial testing of a new Clinical Trial Alert (CTA) system built upon the existing capabilities of a commercial EHR in use across a large academic healthcare system  ...  Previously described approaches have largely relied on locally developed technology or been designed for use in specialized settings, thereby limiting their generalizability.  ...  Embi's contributions were supported in part by a career award from the National Library of Medicine (LM008534). This report was sponsored by the AMIA Clinical Trials Working Group.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/16779036">pmid:16779036</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1560758/">pmcid:PMC1560758</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xdynofqx4fh5rkewskugoudszi">fatcat:xdynofqx4fh5rkewskugoudszi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210043012/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1560758&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1e/ca/1ecaac20b46bc5d313d66bd9e4091de64f7b3118.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560758" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Network Medicine: A Clinical Approach for Precision Medicine and Personalized Therapy in Coronary Heart Disease

Teresa Infante, Luca Del Viscovo, Maria Luisa De Rimini, Sergio Padula, Pio Caso, Claudio Napoli
<span title="2019-11-12">2019</span> <i title="Japan Atherosclerosis Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nk2uk3vgpzfxhkoglsy4wgmw2m" style="color: black;">Journal of atherosclerosis and thrombosis</a> </i> &nbsp;
Several clinical trials have exploited epigenetic tags and epigenetic sensitive drugs both in primary and secondary prevention.  ...  Due to their stability in plasma and easiness of detection, many ongoing clinical trials are focused on the evaluation of circulating miRNAs (e.g. miR-8059 and miR-320a) in blood, in association with imaging  ...  The next step is validation of network findings in cell-based models, small and large animal models and in clinical trials.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5551/jat.52407">doi:10.5551/jat.52407</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31723086">pmid:31723086</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7192819/">pmcid:PMC7192819</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/i5qi7y24jfdufic6gxgztiaslq">fatcat:i5qi7y24jfdufic6gxgztiaslq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200509104000/https://www.jstage.jst.go.jp/article/jat/27/4/27_52407/_pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c3/1b/c31b4b0df62550e27b7acbe2641bd012564e1139.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5551/jat.52407"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192819" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Evaluating Performance of Drug Repurposing Technologies [article]

Jim Schuler, Zackary Falls, William Mangione, Matthew L Hudson, Liana Bruggemann, Ram Samudrala
<span title="2020-12-03">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Here, we review and compare performance evaluation measures for these technologies using version 2 of our shotgun repurposing Computational Analysis of Novel Drug Opportunities (CANDO) platform to illustrate  ...  Drug repurposing technologies are growing in number and maturing. However, comparison to each other and to reality is hindered due to lack of consensus with respect to performance evaluation.  ...  A small number of mistakes or inconsistencies in a large drug repurposing technology do not necessarily invalidate it, but necessitate the need for manual expert inspection and curation.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.12.03.410274">doi:10.1101/2020.12.03.410274</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tw4pv3slv5cs3jl36bdoccj6su">fatcat:tw4pv3slv5cs3jl36bdoccj6su</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427082235/https://www.biorxiv.org/content/biorxiv/early/2020/12/03/2020.12.03.410274.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7e/03/7e03265db09e6a9d1340342b7eaeb96237db7cd8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.12.03.410274"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach

Sinead M. O'Donovan, Ali Imami, Hunter Eby, Nicholas D. Henkel, Justin Fortune Creeden, Sophie Asah, Xiaolu Zhang, Xiaojun Wu, Rawan Alnafisah, R. Travis Taylor, James Reigle, Alexander Thorman (+3 others)
<span title="2021-02-24">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tnqhc2x2aneavcd3gx5h7mswhm" style="color: black;">Scientific Reports</a> </i> &nbsp;
We identified a shortlist of 20 candidate drugs: 8 are already under trial for the treatment of COVID-19, the remaining 12 have antiviral properties and 6 have antiviral efficacy against coronaviruses  ...  specifically, in vitro.  ...  Several of the candidate drugs identified for repurposing are already undergoing clinical trial for COVID-19.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41598-021-84044-9">doi:10.1038/s41598-021-84044-9</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33627767">pmid:33627767</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7904823/">pmcid:PMC7904823</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/u3u4hupllrallae4xm4w7twhiu">fatcat:u3u4hupllrallae4xm4w7twhiu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718101618/https://www.nature.com/articles/s41598-021-84044-9.pdf?error=cookies_not_supported&amp;code=161611e7-cb0f-4f89-a11a-f61c869b3a4e" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9b/a8/9ba88b24ca3d238c5174df54b06ab73dd6cb996c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41598-021-84044-9"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904823" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Artificial intelligence-driven drug repurposing and structural biology for SARS-CoV-2

Kartikay Prasad, Vijay Kumar
<span title="2021-07-28">2021</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/noiwokwjinbfjhnlpxh7zxtpom" style="color: black;">Current Research in Pharmacology and Drug Discovery</a> </i> &nbsp;
AI and machine learning (ML) allow for rapid drug development including repurposing existing drugs.  ...  Algorithms were used to search for novel or approved antiviral drugs capable of inhibiting SARS-CoV-2.  ...  Acknowledgments The authors sincerely thank Amity University, Noida for providing facilities.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.crphar.2021.100042">doi:10.1016/j.crphar.2021.100042</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34870150">pmid:34870150</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8317454/">pmcid:PMC8317454</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ayz42cti5nagvd2cejy4menxli">fatcat:ayz42cti5nagvd2cejy4menxli</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210802060257/https://pdf.sciencedirectassets.com/321103/1-s2.0-S2590257120X00034/1-s2.0-S2590257121000298/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEN7%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJIMEYCIQCI9L1wVSnA8W9M%2B7QMVykLVmtmYPNToma4GiyviXLs%2BAIhAL7tQ0%2FTWQHJgrOJ04OWr%2BhBY5WpPAwXYOCbX80ldHbqKoMECOf%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEQBBoMMDU5MDAzNTQ2ODY1IgzA%2B2%2FUL%2B9j8ZiKtkEq1wN3PLtxIvxUkqAkBniSd4cY1I2b4i7j%2BqHvJbSZHlTGNLy6wyljLb4fGeJraYHO9CnpNVuRrYO4PG9Pi0nCybOVgwq2M6b4ccTr65K2Ftebb4nQtbVS0T50jVSdk%2B8OqqjDtOB6P88ALEK13n%2FffStfV6uuZ1njMCKp4fj6TxSR4dnjCZ6rxaeCCetBC4bvO%2FMBFkSSQr7FHQzTu1FO0kg1VS2%2FDEojH9LOPBTBe7JnpMrHjGP7AYaUyv7blF49LekOgPYHnFUY%2BhhHAkWjxobO3a7kRZxer0%2BxhHWQ6EtLF0zzbsGpST9mixe35paDEM3nXZbBZr%2Fwbl3xq4ndykTglD3o7r4T2jc3XrDfs4WJn3ZI7KQlwtjaQvhuxfH%2Bjx6IU8RyUlLLnVMSRGBJz%2BF3H3EdemKVWqDdwdsgy9Wz2to2Nu8SlaQJxrOl%2ByD2NJBZEC%2FqYzhdJEOCsKCA4dDpPsNU8VAQzHIwHel4VoVNK4lWS6lk6DrkTm8fv4UYt4TjrAqgJiNiLxDR0%2B8otnJc0A8gL%2ByNf6VUa7GxW%2BXOShDp0p2XBnx13RjYXP0oOcJd8lRkZ%2BAX44ahNpV%2FeuHYBDe91gMhV5zipHdhw7VdonSsdjgjHIswr4OeiAY6pAELm3ZWDDnqwDL2cuFvz%2F0%2FoQMA5sZp76kE8owHY3PPbANtsj1fl7s%2FDaTOgSTYzQnYGKKh7yWbm0pQwgmZqNyz0SmiwqP0PYkC%2B%2FzU8ROP2cIv5Rn%2FEd%2Bn3DB9o8G8LwhvXpyggi8pMLp7eNTlZeAo%2FusT3pIBo7UaLj6tKO38aZYZJqPx9Nm4IPytGuQfEgW2bFLAQMJQQ5%2BBLP0nc1cqXKBgOg%3D%3D&amp;X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20210802T060252Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=300&amp;X-Amz-Credential=ASIAQ3PHCVTY5VEF565P%2F20210802%2Fus-east-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=37792d75027413379adb5f6fb8f93607ce76090b85f6434ac3b774109bf247a5&amp;hash=3e3acfde94f96cb6322a611f7e05fc66d48040fadba260fd28cea3d8fe896353&amp;host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&amp;pii=S2590257121000298&amp;tid=spdf-19153c2b-54bb-46b3-ac7b-2522fa24f66b&amp;sid=eec9e9806713e240db593a7-6664ec6a46adgxrqa&amp;type=client" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d2/f4/d2f4751201e63182290a47bef6247f2f825b4b18.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.crphar.2021.100042"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317454" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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