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fMRI study of the role of glutamate NMDA receptor in the olfactory processing in monkeys

Fuqiang Zhao, Marie A. Holahan, Xiaohai Wang, Jason M. Uslaner, Andrea K. Houghton, Jeffrey L. Evelhoch, Christopher T. Winkelmann, Catherine D. G. Hines, Nadine Ravel
2018 PLoS ONE  
In this study, the effect of the glutamate NMDA receptor antagonist MK801 on odorant-induced olfactory responses in the OB and PC of anesthetized NHPs (rhesus monkeys) was investigated by cerebral blood  ...  Studies in rodents show that olfactory processing in the principal neurons of olfactory bulb (OB) and piriform cortex (PC) is controlled by local inhibitory interneurons, and glutamate NMDA receptor plays  ...  The reproducibility of activations was tested by evaluating the correspondence of the fMRI activations between odd and even fMRI measurements.  ... 
doi:10.1371/journal.pone.0198395 pmid:29870538 pmcid:PMC5988321 fatcat:habrc6gltvcbrfrfhrxqn6ixnm

Tactile and Non-tactile Sensory Paradigms for fMRI and Neurophysiologic Studies in Rodents [chapter]

Basavaraju G. Sanganahalli, Christopher J. Bailey, Peter Herman, Fahmeed Hyder
2009 Msphere  
In the last decade, we have directed our efforts towards the development of stimulation protocols for a variety of modalities in rodents with fMRI.  ...  The discovery of functional MRI (fMRI) by Seiji Ogawa in 1990 [5] further reinforced the role of functional imaging studies in neuroscience.  ...  We are also extremely appreciative of other MRRC/QNMR engineers and staff (i.e., Terry Nixon, Peter Brown, Mark Abildgaard, Bei Wang) for assistance in other parts of our experimental setup.  ... 
doi:10.1007/978-1-59745-543-5_10 pmid:18839094 pmcid:PMC3703391 fatcat:nxforwdxpffmhoyhpxt4j2jtem

Perceptual and Neural Pliability of Odor Objects

Jay A. Gottfried, Keng Nei Wu
2009 Annals of the New York Academy of Sciences  
The findings presented here highlight the important role of experience in shaping odor object perception and in ensuring the human sense of smell achieves its full perceptual potential.  ...  However, because relatively few volatile chemicals in the environment carry intrinsic biological value, the meaning of an odor often needs to be acquired through learning and experience.  ...  Wen Li, James Howard, and Nicholas Bowman for their tireless work and enthusiasm, Nathan Sandalow for his contributions to odor deprivation, staff of the Northwestern Memorial Hospital General Clinical  ... 
doi:10.1111/j.1749-6632.2009.03917.x pmid:19686155 pmcid:PMC2830742 fatcat:kjfeos3mynhvjcsoailv6nk6va

Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

Tomokazu Tsurugizawa, Kota Tamada, Nobukazu Ono, Sachise Karakawa, Yuko Kodama, Clement Debacker, Junichi Hata, Hideyuki Okano, Akihiko Kitamura, Andrew Zalesky, Toru Takumi
2020 Science Advances  
Our results demonstrate the utility of awake rodent fMRI and provide a rationale for further investigation of DCS therapy.  ...  Compared to wild-type mice, we find that 15q dup is associated with whole-brain functional hypoconnectivity and diminished fMRI responses to odors of stranger mice.  ...  Kato (The Jikei University School of Medicine), E. Kuwazawa, and T. Tokita (Animal Support Kobe, Kobe, Japan) for technical assistance with the MRI measurements, and we thank K.  ... 
doi:10.1126/sciadv.aav4520 pmid:32076634 pmcid:PMC7002125 fatcat:k3in3un7arbivf2tafvpw4ggcu

Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI [article]

Jaakko Paasonen, Petteri Stenroos, Hanne Laakso, Tiina Pirttimaki, Ekaterina Paasonen, Raimo A Salo, Heikki Tanila, Djaudat Idiyatullin, Michael Garwood, Shalom Michaeli, Silvia Mangia, Olli Grohn
2021 bioRxiv   pre-print
Third, we show odor-induced activation of olfactory system with high correlation between the fMRI and behavioral responses.  ...  We conclude that the applied methodology enables novel behavioral study designs in rodents focusing on tasks, cognition, emotions, physical exercise, and social interaction.  ...  Acknowledgements This work was supported by the National Institutes of Health grants U01-NS103569-01 and P41-EB027061, and Jane & Aatos Erkko Foundation.  ... 
doi:10.1101/2021.06.15.448321 fatcat:gfwx5vstybbnjeygcbfy6hszh4

CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity

Kelly Kent, Kenneth Hess, Susumu Tonegawa, Scott A. Small
2007 Hippocampus  
This goal was achieved in part by using a dedicated mouse scanner to image odor-evoked activity, and by using non-EPI (echo planer imaging) pulse sequences.  ...  As in humans, odors were found to evoke a ventralpredominant activation pattern in the mouse hippocampus. More importantly, odor-evoked activity shifted in an experience-dependent manner.  ...  Acknowledgment Mark Albers is thanked for his aid in developing the olfactory stimulation task.  ... 
doi:10.1002/hipo.20332 pmid:17607765 fatcat:5o625azebjfjvn27hlhmzwdso4

Page 907 of Psychological Abstracts Vol. 89, Issue 3 [page]

2002 Psychological Abstracts  
Our fMRI maps of ocular dominance columns are strikingly similar in appearance, size, and orienta- tion to those reported in the literature using optical imaging of intrinsic sig- nals (OIS) in animal  ...  Robarts Re- search Inst, Lab for Funtional Magnetic Resonance Research, London, ON, Canada) Brief visual stimulation allows mapping of ocular domi- nance in visual cortex using fMRI.  ... 

Mapping stress networks using functional magnetic resonance imaging in awake animals

David Dopfel, Nanyin Zhang
2018 Neurobiology of Stress  
This review discussed the use of fMRI in animal studies of stress.  ...  Functional magnetic resonance imaging (fMRI), with the advantages of noninvasiveness and a large field of view, can be used for functionally mapping brain-wide regions and circuits critical to the stress  ...  Acknowledgement The present study was partially supported by National Institute of Neurological Disorders and Stroke Grant R01NS085200 (PI: Nanyin Zhang, PhD) and National Institute of Mental Health Grant  ... 
doi:10.1016/j.ynstr.2018.06.002 pmid:30450389 pmcid:PMC6234259 fatcat:4fgcpah53fdi5h23bbjmft6tbq

Functional Activities Detected in the Olfactory Bulb and Associated Olfactory Regions in the Human Brain Using T2-Prepared BOLD Functional MRI at 7T

Xinyuan Miao, Adrian G. Paez, Suraj Rajan, Di Cao, Dapeng Liu, Alex Y. Pantelyat, Liana I. Rosenthal, Peter C. M. van Zijl, Susan S. Bassett, David M. Yousem, Vidyulata Kamath, Jun Hua
2021 Frontiers in Neuroscience  
T2-prepared (T2prep) BOLD fMRI is an alternative approach developed especially for performing fMRI in regions affected by large susceptibility artifacts.  ...  The purpose of this technical study is to evaluate T2prep BOLD fMRI for olfactory functional experiments in humans. Olfactory fMRI scans were performed on 7T in 14 healthy participants.  ...  ACKNOWLEDGMENTS The authors thank the staff in the F.M.  ... 
doi:10.3389/fnins.2021.723441 pmid:34588949 pmcid:PMC8476065 fatcat:t7urfz45rbbyhdlr74cd4vehwy

On the scent of human olfactory orbitofrontal cortex: Meta-analysis and comparison to non-human primates

Jay A. Gottfried, David H. Zald
2005 Brain Research Reviews  
This review questions this assumption by providing a critical survey of the localization of primate and human olfactory neocortex.  ...  Given this cross-species conservation of structure, it has generally been presumed that the olfactory projection area in human OFC occupies the same posterior portions of OFC as seen in non-human primates  ...  (D) A detailed cytoarchitectural map of the macaque ventral frontal lobe. [Reproduced from Fig. 2 of: D. Ongur, A.T. Ferry, J.L.  ... 
doi:10.1016/j.brainresrev.2005.08.004 pmid:16213593 fatcat:t7u4pfpbhbd2hhstelpxfntgaq

Visualizing odor representation in the brain: a review of imaging techniques for the mapping of sensory activity in the olfactory glomeruli

F. Pain, B. L'Heureux, H. Gurden
2011 Cellular and Molecular Life Sciences (CMLS)  
Work in our laboratory is supported by Agence Nationale de la Recherche ANR-09-JCJC-0117-01.  ...  of the entire MOB by fMRI.  ...  by rodents in olfactory tasks.  ... 
doi:10.1007/s00018-011-0708-4 pmid:21584811 fatcat:xhrndc4sbnbajbswv5fj3s7lba

Considerations for resting state functional MRI and functional connectivity studies in rodents

Wen-Ju Pan, Jacob C. W. Billings, Joshua K. Grooms, Sadia Shakil, Shella D. Keilholz
2015 Frontiers in Neuroscience  
of rs-fMRI in rodents.  ...  Resting state functional MRI (rs-fMRI) and functional connectivity mapping have become widely used tools in the human neuroimaging community and their use is rapidly spreading into the realm of rodent  ...  The first observation of non-stationarity in rodents was reported by Majeed et al., who found reproducible, quasiperiodic spatiotemporal patterns of BOLD fluctuations in the anesthetized rat (Majeed et  ... 
doi:10.3389/fnins.2015.00269 pmid:26300718 pmcid:PMC4525377 fatcat:izgtvld2k5fwdh4jdsqy63vlsm

Functional MRI of the Olfactory System in Conscious Dogs

Hao Jia, Oleg M. Pustovyy, Paul Waggoner, Ronald J. Beyers, John Schumacher, Chester Wildey, Jay Barrett, Edward Morrison, Nouha Salibi, Thomas S. Denney, Vitaly J. Vodyanoy, Gopikrishna Deshpande (+1 others)
2014 PLoS ONE  
This is critical given the fact that behavior is driven by filtered sensory representations in higher order cognitive areas rather than the raw odor maps of the olfactory bulb.  ...  We built a custom computer-controlled odorant delivery system which was synchronized with image acquisition, allowing the investigation of brain regions activated by odors.  ...  FMRI provides for the apparatus to investigate the dog olfactory system in vivo and noninvasively, and has been used to study the neural basis of olfaction in humans [24, 25] , monkeys [26] and rodents  ... 
doi:10.1371/journal.pone.0086362 pmid:24466054 pmcid:PMC3900535 fatcat:yhqoridnabdidefcwzhfjutioq

Attention to Odor Modulates Thalamocortical Connectivity in the Human Brain

J. Plailly, J. D. Howard, D. R. Gitelman, J. A. Gottfried
2008 Journal of Neuroscience  
It is widely assumed that the thalamus is functionally irrelevant for the sense of smell.  ...  The main prediction was that neural connectivity in the indirect pathway linking PC, MD thalamus, and OFC would be selectively enhanced when subjects attend to odors (vs tones), over and above attention-induced  ...  After model estimation in SPM5, we contrasted odor versus no-odor conditions, to generate statistical parametric maps of odor-responsive cortex, on a subject-by-subject basis, liberally thresholded at  ... 
doi:10.1523/jneurosci.5607-07.2008 pmid:18480282 pmcid:PMC2706104 fatcat:utfnratw5vddnanetule3eyxfm

Cross-species studies of orbitofrontal cortex and value-based decision-making

Jonathan D Wallis
2011 Nature Neuroscience  
Recent work has emphasized the role that orbitofrontal cortex (OFC) plays in value-based decision-making.  ...  This will enable us to fully realize the benefits of using multiple approaches to understand OFC function.  ...  Acknowledgments The preparation of this manuscript was supported by NIDA grant R01DA19028 and NINDS grant P01NS04081.  ... 
doi:10.1038/nn.2956 pmid:22101646 pmcid:PMC3549638 fatcat:pabpyuum5fhhxhk42iiow3nyci
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