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Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: Implications for clinical trial design

Teddy Tjandra, Jonathan C.W. Brooks, Patricia Figueiredo, Richard Wise, Paul M. Matthews, Irene Tracey
2005 NeuroImage  
BOLD contrast is the most commonly used functional MRI method for studies of brain activity.  ...  To determine whether direct CBF measurement is a more reliable technique, we compared the localisation of activation and reproducibility of relative signal change measured by optimised BOLD versus CBF  ...  Acknowledgments The authors are grateful to Peter Hobden, Stuart Clare and Peter Jezzard for their help with the experiments.  ... 
doi:10.1016/j.neuroimage.2005.04.021 pmid:15921936 fatcat:hwsylm7hejcb7mjkdin6i5i3hm

Temporal and Spatial Independent Component Analysis for fMRI data sets embedded in a R package [article]

Cécile Bordier and Michel Dojat and Pierre Lafaye de Micheaux
2010 arXiv   pre-print
For statistical analysis of functional Magnetic Resonance Imaging (fMRI) data sets, we propose a data-driven approach based on Independent Component Analysis (ICA) implemented in a new version of the AnalyzeFMRI  ...  For fMRI data sets, spatial dimension being much greater than temporal dimension, spatial ICA is the tractable approach generally proposed.  ...  The authors would also like to thank Professor Christian Jutten for many helpful comments.  ... 
arXiv:1012.0269v1 fatcat:mt334iqrhbbwhipy4koqr5exzq

Neuroprediction, Violence, and the Law: Setting the Stage

Thomas Nadelhoffer, Stephanos Bibas, Scott Grafton, Kent A. Kiehl, Andrew Mansfield, Walter Sinnott-Armstrong, Michael Gazzaniga
2010 Neuroethics  
In "Violence Risk Assessment and the Law", we briefly examine the role currently played by predictions of violence in three high stakes legal contexts: capital Neuroethics (2012) 5:67-99  ...  In this paper, our goal is to (a) survey some of the legal contexts within which violence risk assessment already plays a prominent role, (b) explore whether developments in neuroscience could potentially  ...  Moreover, his clinical predictions of future dangerousness were used in the trials of nearly one-third of all Texas death row inmates. For more on Dr.  ... 
doi:10.1007/s12152-010-9095-z pmid:25083168 pmcid:PMC4114735 fatcat:gmguctr43fcajkg6w3xyj6ymeu

Methodological Considerations for Setting Up Deep Brain Stimulation Studies for New Indications

Jana V. P. Devos, Yasin Temel, Linda Ackermans, Veerle Visser-Vandewalle, Oezguer A. Onur, Koen Schruers, Jasper Smit, Marcus L. F. Janssen
2022 Journal of Clinical Medicine  
This paper provides an overview of the key aspects that are essential for setting up a DBS study.  ...  The number of clinical studies is expanding because of DBS for new indications and efforts to improve DBS for existing indications. To date, various methods have been used to perform DBS studies.  ...  Acknowledgments: We would like to thank Jackson Boonstra for proofreading the manuscript. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/jcm11030696 pmid:35160153 pmcid:PMC8836606 fatcat:exfi3lqau5e6joyyg53ma7px6m

Temporal and Spatial Independent Component Analysis for fMRI Data Sets Embedded in theAnalyzeFMRIRPackage

Cécile Bordier, Michel Dojat, Pierre Lafaye de Micheaux
2011 Journal of Statistical Software  
For statistical analysis of functional magnetic resonance imaging (fMRI) data sets, we propose a data-driven approach based on independent component analysis (ICA) implemented in a new version of the AnalyzeFMRI  ...  For fMRI data sets, spatial dimension being much greater than temporal dimension, spatial ICA is the computationally tractable approach generally proposed.  ...  The authors would also like to thank Professor Christian Jutten for many helpful comments, as well as the referees and associate editors.  ... 
doi:10.18637/jss.v044.i09 fatcat:cejmlly4evhyxn4mo35ns4dt5y

The role of fMRI in drug development

Owen Carmichael, Adam J. Schwarz, Christopher H. Chatham, David Scott, Jessica A. Turner, Jaymin Upadhyay, Alexandre Coimbra, James A. Goodman, Richard Baumgartner, Brett A. English, John W. Apolzan, Preetham Shankapal (+1 others)
2018 Drug Discovery Today  
Here, we briefly review the roles that fMRI can have in the drug development process and the requirements it must meet to be useful in this setting.  ...  Functional magnetic resonance imaging (fMRI) has been known for over a decade to have the potential to greatly enhance the process of developing novel therapeutic drugs for prevalent health conditions.  ...  It grew out of discussions that took place at the 'Functional MRI in Clinical Trials: State of the Science and Future Directions' symposium that was held December 1-3, 2015, at Pennington Biomedical Research  ... 
doi:10.1016/j.drudis.2017.11.012 pmid:29154758 pmcid:PMC5931333 fatcat:cpfshk7mnvhlpoh5sxamuuvnxu

A new empirical angle on the variability debate: Quantitative neurosyntactic analyses of a large data set from Broca's Aphasia

Dan Drai, Yosef Grodzinsky
2006 Brain and Language  
We discuss the clinical and theoretical implications of our results.  ...  While a certain amount of variability is indeed evident in the data, our quantitative analyses reveal a highly robust selective impairment pattern for the group: the patientsÕ ability to analyze syntactic  ...  This is necessary in view of the fact that the number of trials for the two branches of a contrast are not always equal in a given experiment (if it was not specifically designed to test the contrast under  ... 
doi:10.1016/j.bandl.2004.10.016 pmid:16115671 fatcat:zys2quy3hvddzfvdnkxt4qrr6i

Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults

Deepti Putcha, Kelly O'Keefe, Pete LaViolette, Jackie O'Brien, Doug Greve, Dorene M. Rentz, Joseph Locascio, Alireza Atri, Reisa Sperling
2011 Human Brain Mapping  
Overall, these results are encouraging for the utility of fMRI in "Proof of Concept" clinical trials investigating the efficacy of potentially therapeutic agents for treatment of age-related memory changes  ...  be advantageous for use in clinical trials.  ...  We are also grateful for the participation of our research subjects. This work was supported by the National Institute on Aging R01 AG-027435; P01 AG036694; K23 AG027171 and P50 AG005134.  ... 
doi:10.1002/hbm.21166 pmid:21259385 pmcid:PMC3551453 fatcat:vpougjc5mzag7ap45mszzlofdy

Conditioned task-set competition: Neural mechanisms of emotional interference in depression

Aleks Stolicyn, J. Douglas Steele, Peggy Seriès
2016 Cognitive, Affective, & Behavioral Neuroscience  
Depression has been associated with increased response times at the incongruent-, neutral-, and negative-word trials of the classical and emotional Stroop tasks (Epp et al., Clinical Psychology Review,  ...  at the classical Stroop task (Cohen, Dunbar, & McClelland, in addition suggesting that negative emotional words represent conditioned stimuli for future negative outcomes.  ...  Appendix 2 outlines the set of parameters investigated to reproduce the depressively abnormal Stroop performance.  ... 
doi:10.3758/s13415-016-0478-4 pmid:27943159 fatcat:2iv4wqbszjhsdirj7wt4fympie

Attentional Set-Shifting Deficit in Parkinson's Disease Is Associated with Prefrontal Dysfunction: An FDG-PET Study

Yoichi Sawada, Yoshiyuki Nishio, Kyoko Suzuki, Kazumi Hirayama, Atsushi Takeda, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yasuto Itoyama, Shoki Takahashi, Hiroshi Fukuda, Etsuro Mori, Antonio Verdejo García
2012 PLoS ONE  
The attentional set-shifting deficit that has been observed in Parkinson's disease (PD) has long been considered neuropsychological evidence of the involvement of meso-prefrontal and prefrontal-striatal  ...  Although several neuroimaging studies have addressed this issue, the results of these studies were confounded by the use of tasks that required other cognitive processes in addition to set-shifting, such  ...  Acknowledgments We are grateful to Takafumi Hasegawa, Akio Kikuchi, and Shigenori Kanno for referring patients to us and to Kazue Okada, Mayumi Shinohara, and Nobuhito Abe for their assistance and helpful  ... 
doi:10.1371/journal.pone.0038498 pmid:22685575 pmcid:PMC3369918 fatcat:yuv6463yhrdnxh7omrvsl2sow4

Using Virtual Reality to Provide a Naturalistic Setting for the Treatment of Pathological Gambling [chapter]

Stéphane Bouchard, Claudie Loranger, Isabelle Giroux, Christian Jacques, Geneviève Robillard
2014 The Thousand Faces of Virtual Reality  
VR as a naturalistic setting http://dx.doi.org/10.5772/59240 VR as a naturalistic setting http://dx.  ...  in the current randomized clinical trial.  ...  Multiple advantages of using immersion in VR have been identified by the therapists after the pilot clinical trial [20] .  ... 
doi:10.5772/59240 fatcat:vv6sgbbqh5a3hlqua2tizyh4lq

How socioemotional setting modulates late-stage conflict resolution processes in the lateral prefrontal cortex

Marie Luise Schreiter, Witold X. Chmielewski, Christian Beste
2018 Cognitive, Affective, & Behavioral Neuroscience  
The data show that conflicts are stronger and more difficult to resolve in a negative emotional task-relevant setting than in a positive emotional task-relevant setting, where incongruent information barely  ...  The degree of emotional conflict critically depends on the contextual emotional valence (positive or negative) in which this conflict occurs.  ...  Acknowledgements This work was partly supported by a grant from the Deutsche Forschungsgemeinschaft (DFG) SFB 940 project B8.  ... 
doi:10.3758/s13415-018-0585-5 pmid:29693215 fatcat:zgrdidlgsnd2rfbzdgu2f3rqfq

Navigated TMS in the ICU: Introducing Motor Mapping to the Critical Care Setting

Severin Schramm, Alexander F. Haddad, Lawrence Chyall, Sandro M. Krieg, Nico Sollmann, Phiroz E. Tarapore
2020 Brain Sciences  
Our findings support further studies regarding the clinical value of nTMS in critical care settings.  ...  In conclusion, we present an approach for the safe and reliable use of nTMS motor mapping in the ICU setting and outline possible benefits.  ...  Acknowledgments: We would like to thank the UCSF Biomagnetic Imaging Laboratory for their support of this study. Conflicts of  ... 
doi:10.3390/brainsci10121005 pmid:33352857 fatcat:peiqqihqqjbjnl5zwvtt3yrxka

Five Best Practices for fMRI research

Colleen Mills-Finnerty
2021 Journal for Reproducibility in Neuroscience  
Acknowledgements: I would like to thank Gary Glover, PhD for his input on fMRI best practices, and Halee Staggs, BS for assistance editing the commentary.  ...  For example, splitting data into a "testing set" and a "hold out set" allows the researcher to demonstrate that patterns found in the test set are robust enough to apply to an unseen sample.  ...  The FSL design efficiency tool can be used to evaluate whether the trials in a task are spaced appropriately as well as if it is statistically distinguishable from one another, or if there is too much  ... 
doi:10.31885/jrn.2.2021.1517 fatcat:3w4zsy4mgfcxxbcyyqurwbhcla

The Promise of Neurotechnology in Clinical Translational Science

Susan W. White, J. Anthony Richey, Denis Gracanin, Martha Ann Bell, Stephen LaConte, Marika Coffman, Andrea Trubanova, Inyoung Kim
2014 Clinical Psychological Science  
We also offer a framework for developing and evaluating neurotechnologies that is intended to expedite progress at the nexus of clinical science and neural interface designs by providing a comprehensive  ...  vocabulary to describe the necessary features of neurotechnology in the clinic.  ...  In keeping with this truism, we challenge the assumption that reproducibility is the sole domain of the engineering design and argue that in fact, the burden for ensuring reproducibility lies at the opposite  ... 
doi:10.1177/2167702614549801 pmid:26504676 pmcid:PMC4615684 fatcat:sjlkusi3mvgmxmhqtdnkmxzulm
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