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Computing and Experiments

Viola Schiaffonati, Mario Verdicchio
2013 Philosophy & Technology  
systems work (science) Robotics between science and engineering Philosophical Issues of CS 18 In the traditional experimental protocol in the natural sciences the researcher should be an outsider  ...  Comparison of results of different instances of the same experiments Adoption of a precise language to give rigor and precision to experimental data Principles deeply rooted in the history of science  ... 
doi:10.1007/s13347-013-0126-7 fatcat:6s5tkiqr3jc63aghsvwsgahq5u

Replication in computing education research

Alireza Ahadi, Arto Hellas, Petri Ihantola, Ari Korhonen, Andrew Petersen
2016 Proceedings of the 16th Koli Calling International Conference on Computing Education Research - Koli Calling '16  
This work reports on the value the computing education research community associates with studies that aim to replicate, reproduce or repeat earlier research.  ...  In particular, researchers agree that original works -novel works that report new phenomena -have more impact and are more prestigious.  ...  In this paper as well as in the survey, we have argued that as a community, we use the terms replicate, reproduce and repeat interchangeably.  ... 
doi:10.1145/2999541.2999554 fatcat:vwjaputhvbalhmm6mn3imugxqq

RF in the Jungle: Effect of Environment Assumptions on Wireless Experiment Repeatability

R. Burchfield, E. Nourbakhsh, J. Dix, K. Sahu, S. Venkatesan, R. Prakash
2009 2009 IEEE International Conference on Communications  
In this paper we examine and test several common explicit and implicit assumptions that researchers tend to make about the wireless environment.  ...  We find that because the environment is always in flux, it is almost impossible to reproduce the results of an experiment.  ...  Hence, there is a critical need to develop rigorous experimental methodology so that different wireless networking research groups can independently reproduce results of experiments and validate various  ... 
doi:10.1109/icc.2009.5199421 dblp:conf/icc/BurchfieldNDSVP09 fatcat:3rapn5agzbhzbgavw2a4qvxc6i

Upper Limb Kinematics Using Inertial and Magnetic Sensors: Comparison of Sensor-to-Segment Calibrations

Brice Bouvier, Sonia Duprey, Laurent Claudon, Raphaël Dumas, Adriana Savescu
2015 Sensors  
(reproducibility) validity criteria.  ...  The OPEN ACCESS Sensors 2015, 15 18814 very good overall accuracy (trueness and precision) of MIMU-based joint angle data seems to be more dependent on the level of rigor of the experimental procedure  ...  Author Contributions All authors participated in the study design, and the analysis and interpretation of data. Data acquisition was carried out by Brice Bouvier and Adriana Savescu.  ... 
doi:10.3390/s150818813 pmid:26263993 pmcid:PMC4570347 fatcat:mxj36vnfbbdcnni6jmsydodmbu

The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation

Isaac K. Sundar, Kahkashan Rashid, Michael T. Sellix, Irfan Rahman
2017 Biochemical and Biophysical Research Communications - BBRC  
Graphical abstract Cigarette smoke (CS) causes reduction in nuclear receptor REV-ERBα and its knockout mice exposed to acute CS showed increased lung inflammatory and pro-senescence responses in vivo.  ...  To determine the impact of REV-ERBα activation in the CS-induced inflammatory response we treated primary human small airway epithelial cells (SAECs) with CS extract (CSE) or lipopolysaccharide (LPS) in  ...  Our results adhere to NIH standards of reproducibility and scientific rigor.  ... 
doi:10.1016/j.bbrc.2017.09.157 pmid:28974420 pmcid:PMC5756581 fatcat:54l6s3byzvcdpiubihszwb47ny

Citizen Science Practices for Computational Social Science Research: The Conceptualization of Pop-Up Experiments

Oleguer Sagarra, Mario Gutiérrez-Roig, Isabelle Bonhoure, Josep Perelló
2016 Frontiers in Physics  
Our aim here is that this work will serve as a guideline for groups willing to adopt and expand such in vivo practices and we hope it opens up the debate regarding the possibilities (and also the limitations  ...  However, this framework is still far from being well established as a standard tool for computational social science research.  ...  John Palmer in the research papers following the experiments reported here.  ... 
doi:10.3389/fphy.2015.00093 fatcat:2dpkg23a4jcrxkfgwgnprhz2qe

Citizen Science practices for Computational Social Sciences research: The conceptualization of Pop-Up Experiments [article]

Oleguer Sagarra, Mario Gutiérrez-Roig, Isabelle Bonhoure, Josep Perelló
2015 arXiv   pre-print
However, this framework is still far from being well stablished to become a standard tool for Computational Social Sciences research.  ...  The main issues to take into account whenever planning experiments of this type are classified and discused grouped in three categories: public engagement, light infrastructure and knowledge return to  ...  John Palmer in the subsequent research articles from the experiments herein reported.  ... 
arXiv:1509.06575v1 fatcat:xvx6hfg3v5dllg5n4xiyft3el4

Conditioning of Pleurobranchaea

R. Lee
1976 Science  
It was, in fact, for the purpose of objectivity that we specifically selected strong, identifiable, and reproducible behaviors, measured them quantitatively under blind conditions, and repeated the measurements  ...  In our more recent experiments we employed the alternating CS/US control group, and, therefore, Lee's questioning as to whether we have "rigorously demonstrated a behavioral change classifiable as 'conditioning  ... 
doi:10.1126/science.935860 pmid:935860 fatcat:la5wqquvuzaf5j6q2dgjnatgiy

Full Computational Reproducibility in Biological Science: Methods, Software and a Case Study in Protein Biology [article]

Les Hatton, Gregory Warr
2016 arXiv   pre-print
Independent computational reproducibility of scientific results is rapidly becoming of pivotal importance in scientific progress as computation itself plays a more and more central role in so many branches  ...  The burgeoning presence of software in most scientific work adds a new and particularly opaque layer of complexity [29].  ...  the biological data itself in a compliant form, have allowed computationally intensive biological research to be taken out of the lab and straight onto any reasonable desktop where it can be independently  ... 
arXiv:1608.06897v1 fatcat:oopnqg2qqjaippr5wdb4dpi3ie

Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array

Rick J. Koch, Anne Marie Barrette, Alan D. Stern, Bin Hu, Mehdi Bouhaddou, Evren U. Azeloglu, Ravi Iyengar, Marc R. Birtwistle
2018 Scientific Reports  
Scientific research, and in particular that in the biomedical field, has come under harsh scrutiny and debate of late due to questions of reproducibility 1-9 .  ...  While there are many potential reasons for lack of reproducibility, one major reason relates to research reagents, including antibodies 10-12 .  ...  AMB and ADS acknowledge an NIGMS-funded Integrated Pharmacological Sciences Training Program grant (T32GM062754) for support.  ... 
doi:10.1038/s41598-018-29436-0 pmid:30054510 pmcid:PMC6063895 fatcat:ys2ipp6ctresbkgu4ikmbuxlnm

Computer Science: The Third Pillar of Medical Education

Frank Lau, Lindsay Katona, Joseph M. Rosen, Charles Everett Koop
2012 Creative Education  
In 2001, the Institute of Medicine (IOM) and the National Academy of Sciences (NAS) attributed substantial problems in the quality of American medicine to four domains: growing complexity of science and  ...  technology; the increase in chronic conditions; a poorly organized delivery system; and constraints on exploiting the revolution in information technology (IT).  ...  We are unqualified to participate in designing and developing transformative applications. We are poorly equipped to apply the intellectual rigor of CS in research and clinical problem solving.  ... 
doi:10.4236/ce.2012.326120 fatcat:kfpfdwjdfbawrmigmqg6vgylpq

Case Studies and Challenges in Reproducibility in the Computational Sciences [article]

Sylwester Arabas, Michael R. Bareford, Lakshitha R. de Silva, Ian P. Gent, Benjamin M. Gorman, Masih Hajiarabderkani, Tristan Henderson, Luke Hutton, Alexander Konovalov, Lars Kotthoff, Ciaran McCreesh, Miguel A. Nacenta (+4 others)
2014 arXiv   pre-print
This paper investigates the reproducibility of computational science research and identifies key challenges facing the community today.  ...  This paper is open, executable and reproducible: the whole process of writing this paper is captured in the source control repository hosting both the source of the paper, supplementary codes and data;  ...  Acknowledgements The authors of this paper include organisers and participants in the summer school.  ... 
arXiv:1408.2123v2 fatcat:uwvrv673tfhubpc3lgi3xivcly

The Importance of Method Selection in Determining Product Integrity for Nutrition Research

Elizabeth M Mudge, Joseph M Betz, Paula N Brown
2016 Advances in Nutrition  
Only after rigorous validation procedures to ensure that methods are fit for purpose should they be used in a routine setting to verify product authenticity and quality.  ...  This review summarizes advances in method selection, development, and validation regarding herbal supplement analysis and provides several documented examples of inappropriate method selection and application  ...  Acknowledgments We thank the ASN and Barbara Sorkin (NIH Office of Dietary Supplements) for organizing and supporting the symposium at the ASN Scientific Sessions and Annual Meeting at Experimental Biology  ... 
doi:10.3945/an.115.010611 pmid:26980823 pmcid:PMC4785475 fatcat:g42gq7ebk5dbxmliiz5g6f3jkq

Protein-mediated gelation and nano-scale assembly of unfunctionalized hyaluronic acid and chondroitin sulfate

Anthony Tabet, June Y. Park, Jarrod Shilts, Kamil Sokolowski, Vijay K. Rana, Marlous Kamp, Nina Warner, Dominique Hoogland, Oren A. Scherman
2019 F1000Research  
We also summarize the concentrations of HA and CS found in various mammalian brains, which could potentially be useful for biomimetic scaffold development.  ...  Results: We examine the intermolecular interactions of two major glycosaminoglycans found in the human brain, HA and the lower molecular weight CS, with the model protein albumin.  ...  This is repetitive with a sentence later in the intro: 'HA is often chemically modified…….' Methods: The GAG binding pocket of BSA is not shown in Figure 1B .  ... 
doi:10.12688/f1000research.16929.3 fatcat:3mgxbtjo2fd4fgnvnqbx4smq4i

Page 4618 of Mathematical Reviews Vol. , Issue 92h [page]

1992 Mathematical Reviews  
(CS-CSAV-N); Exner, P. (CS-CSAV-N); Seba, H. (CS-CSAV-N) * Dirac Hamiltonian with Coulomb potential and spherically symmetric shell contact interaction. With a Russian summary.  ...  The calculations of complicated multishell multispin cases are simply reduced to the repeated use of single-shell and single-spin matrix elements. A.  ... 
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