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Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy

Xin Lian, Kailin Yang, Renliang Li, Maomao Li, Jing Zuo, Bohao Zheng, Wei Wang, Ping Wang, Shengtao Zhou
2022 Molecular Cancer  
Zheng et al. found that tumor-infiltrated NK cells up-regulated many genes related to mitochondrial fission, such as MIEF2, INF2, and FIS1 [75] .  ... 
doi:10.1186/s12943-021-01486-5 pmid:35062950 pmcid:PMC8780708 fatcat:guocyjnme5h3jdydb3whmth57m

Analysis and Study of FBG Sensor in Crack Monitoring of Aircraft Structure

Lei Liang, Renliang Wang, Gang Xu, Zheng Yi, Bin Tu
2019 IOP Conference Series: Earth and Environment  
Based on the FBG sensing principle, the stress of each test point was measured by fatigue test with the change of tensile time using the strain sensitivity characteristics of FBG (fiber Bragg grating) sensor, and the experimental results were compared with the fatigue theory , FBG sensor can not only monitor the various stages of the crack growth, but also can effectively determine the time of occurrence of fatigue cracks and the top of the general location. This will provide a strong basis for
more » ... the further application of FBG sensors in aircraft structural health monitoring.
doi:10.1088/1755-1315/300/2/022111 fatcat:5w443n6ignemxlxmgzwhq3xpjm

Design of a multifunction novel flexible fault current limiter for AC distribution network

Yao Liu, Lin Guan, Zhe Tan, Kun Yang, Fang Guo, Yong Chen, Renliang Liu, Feng Zheng, Long Wang
2021 PLoS ONE  
Acknowledgments The authors would like to thank Zhe Tan for excellent technical support and doctor Feng Zheng for critically reviewing the manuscript.  ... 
doi:10.1371/journal.pone.0245956 pmid:33830996 fatcat:anqwyf73ebgjjjmhkqxzhvdwz4

Acute intermittent porphyria presenting with seizures and posterior reversible encephalopathy syndrome

Xueping Zheng, Xuejun Liu, Yan Wang, Renliang Zhao, Lintao Qu, Haitao Pei, Miao Tuo, Yong Zhang, Yuqiang Song, Xiaojun Ji, Hongyun Li, Liou Tang (+1 others)
2018 Medicine  
Acute intermittent porphyria (AIP) is a rare and challenging hereditary neurovisceral disease with no specific symptoms. Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome with bilateral reversible posterior gyriform lesions that can be associated with many different conditions, including AIP. Usually, peripheral neuropathy is considered the most common neurological manifestation of AIP. However, AIP should also be considered when seizures and PRES are
more » ... ed with unexplained abdominal pain. Case presentation: Both the patients were presented with seizures and PRES on brain magnetic resonance imaging (MRI). Unexplained abdominal pain occurred before the onset of seizures. The AIP diagnosis was made after repeated Watson-Schwartz tests. Hematin was not available for these 2 patients. However, supportive treatment including adequate nutrition and fluid therapy as well as specific antiepileptic drugs aided the patient's recovery and no acute attacks had occurred by the 3-year follow-up. Conclusion: In contrast to other causes of PRES patients, seizure is the most common symptom in AIP patients with PRES. This is a strong diagnostic clue for AIP when ambiguous abdominal pain patients presented with seizures and PRES on brain MRI. A positive prognosis can be achieved with the combination of early recognition, supportive and intravenous hematin therapy, and withdrawal of precipitating factors, including some antiepileptic drugs. Abbreviations: ADC = apparent diffusion coefficient, AIP = acute intermittent porphyria, ALA = aminolevulinic acid, CSF = cerebral spinal fluid, CT = computed tomography, DWI = diffusion-weighted images, MRI = magnetic resonance imaging, PBG = porphobilinogen, PRES = posterior reversible encephalopathy syndrome, SIADH = inappropriate secretion of antidiuretic hormone.
doi:10.1097/md.0000000000011665 pmid:30200061 pmcid:PMC6133578 fatcat:cm4af4iq3zgpdiwejttzz4f7ty

The GTF2I rs117026326 polymorphism is associated with anti-SSA-positive primary Sjögren's syndrome

Junfeng Zheng, Renliang Huang, Qiaoniang Huang, Fengyuan Deng, Yan Chen, Junping Yin, Juan Chen, Ying Wang, Guixiu Shi, Xing Gao, Zuguo Liu, Frank Petersen (+1 others)
2014 Rheumatology  
N Engl J Med 2011; 365:161223. 4 Han JW, Zheng HF, Cui Y et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.  ... 
doi:10.1093/rheumatology/keu466 pmid:25480810 fatcat:tcgbopbxkjcnlm4jd6mgt5rluu

Sipuleucel-T and Androgen Receptor-Directed Therapy for Castration-Resistant Prostate Cancer: A Meta-Analysis

Renliang Yi, Baoxin Chen, Peng Duan, Chanjiao Zheng, Huanyu Shen, Qun Liu, Chen Yuan, Weilin Ou, Zhiheng Zhou
2016 Journal of Immunology Research  
Two authors (Renliang Yi and Baoxin Chen) conducted literature search and study selection independently.  ...  Two authors (Chanjiao Zheng and Huanyu Shen) conducted data extraction independently. Results were compared and discrepancies were resolved by a discussion with corresponding author (Zhiheng Zhou).  ...  Chanjiao Zheng, Huanyu Shen, and Zhiheng Zhou carried out manuscript revision. Renliang Yi and Baoxin Chen contributed equally to this work.  ... 
doi:10.1155/2016/4543861 pmid:28058266 pmcid:PMC5183769 fatcat:f5ck5nk3kncbxadxczf4qfb7oy

B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren's Syndrome

Junfeng Zheng, Qiaoniang Huang, Renliang Huang, Fengyuan Deng, Xiaoyang Yue, Junping Yin, Wenjie Zhao, Yan Chen, Lifang Wen, Jun Zhou, Renda Huang, Gabriela Riemekasten (+3 others)
2017 Frontiers in Immunology  
No infiltration anti-Ro60_316-335 Yes Yes Yes Yes IgG anti-exocrine gland Yes Yes No No lysate IgG IFN-γ Increased - Not affected Increased IL-17A Increased - Increased Not affected -, not evaluated.6 Zheng  ... 
doi:10.3389/fimmu.2017.01384 pmid:29118759 pmcid:PMC5661054 fatcat:fphbkqlhsrar7oxgxoexcypggi

Autoantibodies against the Second Extracellular Loop of M3R Do neither Induce nor Indicate Primary Sjögren's Syndrome

Yan Chen, Junfeng Zheng, Qiaoniang Huang, Fengyuan Deng, Renliang Huang, Wenjie Zhao, Junping Yin, Lina Song, Juan Chen, Xing Gao, Zuguo Liu, Frank Petersen (+2 others)
2016 PLoS ONE  
Objectives Anti-muscarinic acetylcholine type-3 receptor (anti-M3R) autoantibodies have been suggested to be pathogenic for primary Sjögren's syndrome (pSS), and the second extracellular loop of M3R is suspected to carry a disease-promoting epitope. In this study, we aimed to evaluate the pathogenicity of autoantibodies against peptides derived from the second extracellular loop of M3R in mice and to determine whether those autoantibodies could be used as biomarker for pSS. W, et al. (2016)
more » ... antibodies against the Second Extracellular Loop of M3R Do neither Induce nor Indicate Primary Sjögren's Syndrome. PLoS ONE 11(2): e0149485. Conclusions Our results suggest that the autoantibodies against peptides of the second extracellular loop of M3R are not pathogenic in vivo and they are not suitable as biomarkers for pSS diagnosis.
doi:10.1371/journal.pone.0149485 pmid:26901532 pmcid:PMC4765836 fatcat:bulj7n2gr5ehtdr46gb6hx5dxa

The amino acid variation within the binding pocket 7 and 9 of HLA-DRB1 molecules are associated with primary Sjögren's syndrome

Renliang Huang, Junping Yin, Yan Chen, Fengyuan Deng, Juan Chen, Xing Gao, Zuguo Liu, Xinhua Yu, Junfeng Zheng
2015 Journal of Autoimmunity  
Primary Sj€ ogren's syndrome (pSS) is associated with HLA-DRB1 loci, but the association of amino acid variations in the hypervariable region of the HLA-DR b1 chain with pSS is largely unknown. In this study, we aimed to identify the amino acid variations within the hypervariable region of HLA-DRB1 molecule which are associated with the susceptibility to pSS. We sequenced the 2nd exon of the HLA-DRB1 locus in 52 pSS patients and 179 controls. The HLA-DRB1*0803 is the allele that shows the
more » ... est association with pSS in Chinese population (OR ¼ 3.0, P ¼ 2.4 Â 10 À4 ). Furthermore, amino acid variations within the binding pocket P7 and P9 are associated with the susceptibility to pSS. An interaction between two residues within P7, b47 and b67, is associated with pSS. Structural modeling studies demonstrated that the electrostatics of peptide binding pocket 9 are opposite in pSSsusceptible and -protective HLA-DRB1 alleles. In conclusion, our results suggest that structural heterogeneity of the HLA-DRB1 peptide binding pocket P7 and P9 might play a role in the pathogenesis of pSS.
doi:10.1016/j.jaut.2014.11.006 pmid:25582848 fatcat:lojpzesz6jg47hsvw5egqxb4ci

Diffusion‐weighted imaging‐documented bilateral small embolic stroke involving multiple vascular territories may indicate occult cancer: A retrospective case series and a brief review of the literature

Xiaosa Chi, Renliang Zhao, Haitao Pei, Ang Xing, Song Hu, Jingjiao Chen, Yongjun Mao, Xueping Zheng
2020 Aging Medicine  
Yongjun Mao and Xueping Zheng: Design, literature review, coordination. Xiaosa Chi, Renliang Zhao and Haitao Pei: Literature review, data collection.  ...  Xueping Zheng R E FE R E N C E S 1. Yonemura K, Kimura K, Minematsu K, Uchino M, Yamaguchi T.  ... 
doi:10.1002/agm2.12105 pmid:32232193 pmcid:PMC7099753 fatcat:h3opm4ju2ffdpn4au3sk57jyem

Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome

Junping Yin, Junfeng Zheng, Fengyuan Deng, Wenjie Zhao, Yan Chen, Qiaoniang Huang, Renliang Huang, Lifang Wen, Xiaoyang Yue, Frank Petersen, Xinhua Yu
2018 Frontiers in Immunology  
Ectopic expression of MHC II molecules on glandular cells is a feature of primary Sjögren's syndrome (pSS). However, the cause of this ectopic expression and its potential role in the pathogenesis of the disease remains elusive. Here, we report that ectopic expression of MHC II molecules on glandular cells represents an early presymptomatic event in a mouse model of pSS induced by immunization of Ro60_316-335 peptide emulsified in TiterMax ® as an adjuvant. Ectopic expression of MHC II was
more » ... ed by TiterMax ® but not by complete freund's adjuvant (CFA). Furthermore, immunization with Ro60_316-335 peptide emulsified in TiterMax ® , but not in CFA, induced a pSS-like disease in mice. Our results suggests that ectopic expression of MHC II molecules on glandular cells represents a presymptomatic feature of pSS and that such ectopic expression can be induced by exogenous factors. In addition, this study also provides a novel mechanism how adjuvants can amplify immune responses.
doi:10.3389/fimmu.2018.02362 fatcat:gsdycqrrojfpvjhntut4aqo36q

Helicopter Landing Trajectory Optimization after Tail Rotor Control Failure in Different Collective Pitch

Xufei Yan, Renliang Chen, Ji Xin
2019 Xibei Gongye Daxue Xuebao/Journal of Northwestern Polytechnical University  
北京:科学出版社, 2003:168•184 GAO Zheng, CHEN Renliang. Helicopter Dynamics[ M] . Beijing, Science Press, 2003:168•184 ( in Chinese) [20] 严旭飞,陈仁良. 直升机尾桨完全失效后自转着陆轨迹优化[ J] .  ...  气动实验与测量控制,1996, 10(1) :14•19 XIN Hong, GAO Zheng. A Prediction of the Helicopter Vortex•Ring State Boundary[ J] .  ... 
doi:10.1051/jnwpu/20193761138 fatcat:4itbvmksarbkvis7opns7bljde

Research on Cooperative Optimization Control Strategy of Multitype Energy Sources

Renliang Liu, Yong Chen, Zhe Tan, Chao Liu, Kun Yang, Liang Pei, Raffaele Carli
2021 Mathematical Problems in Engineering  
Zheng, “Hierarchical two-stage robust power supply system, the following conclusions are drawn: in optimisation dispatch based on co-evolutionary theory for the process of energy cooperative  ...  Engineering Volume 2021, Article ID 1207430, 13 pages Research Article Research on Cooperative Optimization Control Strategy of Multitype Energy Sources Renliang  ... 
doi:10.1155/2021/1207430 fatcat:rac33mvxufectbabg5pv3x667i

Timing of the Wudangshan, Yaolinghe volcanic sequences and mafic sills in South Qinling: U-Pb zircon geochronology and tectonic implication

WenLi Ling, BangFang Ren, RuiChun Duan, XiaoMing Liu, XinWu Mao, LianHong Peng, ZaoXue Liu, JianPing Cheng, HongMei Yang
2008 Science Bulletin  
By a combination with zircon Hf and O isotope stusies, Zheng et al.  ...  Precambr Res 2007, 152: 27-47[doi] 28 Zheng YF, Zhao Z F, Wu Y B, et al.  ... 
doi:10.1007/s11434-008-0269-6 fatcat:7wo2jgsppjf75pqdah425i3cxa

Hurdle-Hop Simulation of Tilt-Rotor Aircraft Based on Optimal Control Theory

Jinhe Chen, Zhengzhong Wang, Hongyuan Tian
2020 Xibei Gongye Daxue Xuebao/Journal of Northwestern Polytechnical University  
Analytical Simulation of ADS•33 Mission Task Elements [ C ] ∥ American Helicopter Society 63rd Annual LI Jianbo, GAO Zheng.  ...  航空学报,2010, 31(12) : 2315•2323 LI Pan, CHEN Renliang. Formulation and Validation of a Helicopter Model for Pull•up Maneuver Simulation[ J] .  ... 
doi:10.1051/jnwpu/20203861266 fatcat:rakhnslf6vfydc54vyvzhsnk5u
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