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Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks

Sami Ben Hamida, Sueli Mendonça-Netto, Tanzil Mahmud Arefin, Md. Taufiq Nasseef, Laura-Joy Boulos, Michael McNicholas, Aliza Toby Ehrlich, Eleanor Clarke, Luc Moquin, Alain Gratton, Emmanuel Darcq, Laura Adela Harsan (+2 others)
2018 Biological Psychiatry  
To gain system-level understanding of their alcohol endophenotype, we also analyzed whole-brain functional connectivity (FC) in naïve mice using resting-state functional magnetic resonance imaging.  ...  The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential role for this receptor in drug  ...  Remodeling of Sensorimotor Brain Connectivity in Gpr88 deficient mice. In revision. 2017 37Friston KJ, Kahan J, Biswal B, Razi A. A DCM for resting state fMRI. Neuroimage. 2014; 94:396- 407.  ... 
doi:10.1016/j.biopsych.2018.01.026 pmid:29580570 pmcid:PMC6054571 fatcat:feiiaiqd2vho5op57dw4cao4gi

Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan

Tuan Leng Tay, Catherine Béchade, Ivana D'Andrea, Marie-Kim St-Pierre, Mathilde S. Henry, Anne Roumier, Marie-Eve Tremblay
2018 Frontiers in Molecular Neuroscience  
Mice deficient for C3 were additionally found to be protected from synaptic loss and neuronal death during aging, in the hippocampus CA3, suggesting that microglia are implicated in synaptic loss or remodeling  ...  However, analysis of DAP12-deficient mice revealed several neuronal alterations at adulthood, notably enhanced hippocampal LTP (Roumier et al., 2004) and impaired sensorimotor gating (Kaifu et al.,  ...  We dedicate this work to all women in Science, and to one of our strongest advocates and pioneer of glial research, Prof. Ben A. Barres.  ... 
doi:10.3389/fnmol.2017.00421 pmid:29354029 pmcid:PMC5758507 fatcat:hxuwrzaoxzhhtgo7j3db2hbhwy

Alcoholism and Stress: A Framework for Future Treatment Strategies: Meeting Abstracts

2014 Alcohol  
Translational Neuroimaging in Alcoholism: Identification of Altered Brain Connectivity in postdependent rats Wolfgang H.  ...  Behaviorally, GPR88 knockout mice showed an augmented level of voluntary ethanol consumption and preference compared to wild-type mice.  ...  The functional consequences of these interactions on alcoholrelated behavior became evident in knockout mice lacking CRHR1 expression in D1 neurons.  ... 
doi:10.1016/j.alcohol.2014.01.002 fatcat:lf72g5a76bbgherbr2pusluixm

Electrical stimulation and activity for axonal regeneration

Ioana Goganau
Sensory impairments and delayed regeneration of sensory axons in interleukin-6-deficient mice. J Neurosci, 19, 4305-13. 248. Zhou, F. Q. & Snider, W. D. 2006.  ...  , as well as in the brain.  ...  Genes marked with "*" are also upregulated at the same time point in CL vs naïve. Annotated using DAVID Bioinformatics Resources 6.7.  ... 
doi:10.11588/heidok.00022144 fatcat:k43pla5erfdbpoivfnj4ubs3q4