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Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity

Gaël Chételat, Brigitte Landeau, Eric Salmon, Igor Yakushev, Mohamed Ali Bahri, Florence Mézenge, Audrey Perrotin, Christine Bastin, Alain Manrique, Armin Scheurich, Mathias Scheckenberger, Béatrice Desgranges (+2 others)
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
Normal aging is characterized by brain glucose metabolism decline predominantly in the prefrontal cortex.  ...  The findings offer new perspectives to understand normal aging processes and open avenues for future studies to explore causality between agerelated metabolism and connectivity changes.  ...  allow to infer causality between these processes, assessing the relationships between brain metabolism in regions typically affected by normal aging on the one hand, and structural and functional connectivity  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2013.03.009">doi:10.1016/j.neuroimage.2013.03.009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23518010">pmid:23518010</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z2igqagsezbulffvzj2xph5gdy">fatcat:z2igqagsezbulffvzj2xph5gdy</a> </span>
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Age-Related Changes in Topological Properties of Individual Brain Metabolic Networks in Rats

Xin Xue, Jia-Jia Wu, Bei-Bei Huo, Xiang-Xin Xing, Jie Ma, Yu-Lin Li, Dong Wei, Yu-Jie Duan, Chun-Lei Shan, Mou-Xiong Zheng, Xu-Yun Hua, Jian-Guang Xu
<span title="2022-05-13">2022</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xyafp6gbr5et3ghi4kqddnyolm" style="color: black;">Frontiers in Aging Neuroscience</a> </i> &nbsp;
Normal aging causes profound changes of structural degeneration and glucose hypometabolism in the human brain, even in the absence of disease.  ...  Compared with the young rats, the aged rats showed significantly decreased clustering coefficient (Cp) and local efficiency (Eloc) across the whole-brain metabolic network.  ...  DISCUSSION Interest in characterizing functional, structural, and metabolic brain alterations during normal aging is growing.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnagi.2022.895934">doi:10.3389/fnagi.2022.895934</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35645769">pmid:35645769</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC9136077/">pmcid:PMC9136077</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rfdx6uqhqjd4te4sqcpap46rva">fatcat:rfdx6uqhqjd4te4sqcpap46rva</a> </span>
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Connectivity within the default mode network is related to working memory performance in young but not elderly healthy adults

Igor Yakushev, Gaël Chetelat, Florian Fischer, Brigitte Landeau, Christine Bastin, Armin Scheurich, Mathias Schreckenberger, Eric Salmon, Andreas Fellgiebel
<span title="">2012</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/skzqffpatvawfgf7uspguqs4yu" style="color: black;">Alzheimer&#39;s &amp; Dementia</a> </i> &nbsp;
The relationship between arterial stiffness and deep-brain WMH volume in MCI merits further investigation.  ...  Results: MCI patients showed higher b-stiffness index (7.361.8 vs. 6.361.5, p<0.05) and decreased distensibility (0.3160.07 vs. 0.3760.09%mmHg, P ¼ 0.01) in the CCA when compared to the cognitively normal  ...  P4-187 HETEROGENEITY OF FUNCTIONAL CONNECTIVITY REDUCTIONS IN NORMAL COGNITIVE AGING  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2012.05.196">doi:10.1016/j.jalz.2012.05.196</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mznpoam7hbfqzoumbxtpv4lowy">fatcat:mznpoam7hbfqzoumbxtpv4lowy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170922050051/http://orbi.ulg.ac.be/bitstream/2268/138695/1/Yakushev%20et%20al_2012.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ae/f5/aef579ccdbb066631d056be6b59caa1cda1e8197.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2012.05.196"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Connectivity within the default mode network is related to working memory performance in young but not elderly healthy adults

Igor Yakushev, Gaël Chetelat, Brigitte Landeau, Florian Fischer, Christine Bastin, Armin Scheurich, Mathias Schreckenberger, Eric Salmon, Andreas Fellgiebel
<span title="">2012</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/skzqffpatvawfgf7uspguqs4yu" style="color: black;">Alzheimer&#39;s &amp; Dementia</a> </i> &nbsp;
The relationship between arterial stiffness and deep-brain WMH volume in MCI merits further investigation.  ...  Results: MCI patients showed higher b-stiffness index (7.361.8 vs. 6.361.5, p<0.05) and decreased distensibility (0.3160.07 vs. 0.3760.09%mmHg, P ¼ 0.01) in the CCA when compared to the cognitively normal  ...  P4-187 HETEROGENEITY OF FUNCTIONAL CONNECTIVITY REDUCTIONS IN NORMAL COGNITIVE AGING  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2012.05.1889">doi:10.1016/j.jalz.2012.05.1889</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zenchebflnbehfrzjjmjwayqou">fatcat:zenchebflnbehfrzjjmjwayqou</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170922050051/http://orbi.ulg.ac.be/bitstream/2268/138695/1/Yakushev%20et%20al_2012.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ae/f5/aef579ccdbb066631d056be6b59caa1cda1e8197.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2012.05.1889"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Loss of Olfactory Tract Integrity Affects Cortical Metabolism in the Brain and Olfactory Regions in Aging and Mild Cognitive Impairment

D. J. Cross, Y. Anzai, E. C. Petrie, N. Martin, T. L. Richards, K. R. Maravilla, E. R. Peskind, S. Minoshima
<span title="2013-06-26">2013</span> <i title="Society of Nuclear Medicine"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/es34xtfdxrgybg2kmdq2n5xqry" style="color: black;">Journal of Nuclear Medicine</a> </i> &nbsp;
Conclusion: These findings indicate that impairment of axonal integrity or neuronal loss may be linked to functional metabolic changes and that disease-specific neurodegeneration may affect this relationship  ...  Results: Integrated analysis over all subjects indicated a positive correlation between white matter integrity in the olfactory tract and metabolic activity in olfactory processing structures, including  ...  In normal controls, changes in FA values in the OT correlated with glucose metabolism in connected anterior cerebral structures.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.112.116558">doi:10.2967/jnumed.112.116558</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23804325">pmid:23804325</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3999919/">pmcid:PMC3999919</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/seyrn27svnhnjpfchcos4lvwnu">fatcat:seyrn27svnhnjpfchcos4lvwnu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190228095217/http://pdfs.semanticscholar.org/9010/9b33d841b57ecb5438e23c8371e436f7de41.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/90/10/90109b33d841b57ecb5438e23c8371e436f7de41.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.112.116558"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999919" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Metabolic brain networks in aging and preclinical Alzheimer's disease

Katelyn L. Arnemann, Franziska Stöber, Sharada Narayan, Gil D. Rabinovici, William J. Jagust
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/47gmsc3hojdm5kdlgbg4peyvyi" style="color: black;">NeuroImage: Clinical</a> </i> &nbsp;
We found widespread elevated metabolic correlations and desegregation of metabolic brain networks in normal aging compared to youth and Alzheimer's disease, suggesting that normal aging leads to widespread  ...  loss of independent metabolic function across the brain.  ...  As white matter integrity typically decreases in old age, the pervasive metabolic "hyper-connectivity" observed in the present study does not reflect increased structural connectivity between brain regions  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2017.12.037">doi:10.1016/j.nicl.2017.12.037</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29527500">pmid:29527500</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5842784/">pmcid:PMC5842784</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qghqolzzozdxfj557o7wku5mfu">fatcat:qghqolzzozdxfj557o7wku5mfu</a> </span>
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Structural and Functional Imaging Correlates for Age-Related Changes in the Brain

Paul C. Tumeh, Abass Alavi, Mohamed Houseni, Antje Greenfield, Timothy Chryssikos, Andrew Newberg, Drew A. Torigian, Gul Moonis
<span title="">2007</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4za5crsvcjfnhnj6sx6lnvbfe4" style="color: black;">Seminars in nuclear medicine</a> </i> &nbsp;
Defining normal alterations in brain function and structure allows early detection of disorders such as Alzheimer's and Parkinson's diseases, which are commonly associated with normal aging.  ...  Whole brain metabolism and frontal lobe metabolism both decrease significantly with age (38% and 42%, respectively), whereas cerebellar metabolism does not show a significant decline with age.  ...  relate to aging, confounding the exact relationship between brain function and memory.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1053/j.semnuclmed.2006.10.002">doi:10.1053/j.semnuclmed.2006.10.002</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17289456">pmid:17289456</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/daa3f6qekrezphowqxxp3mwuvu">fatcat:daa3f6qekrezphowqxxp3mwuvu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170809071912/http://medlib.yu.ac.kr/eur_j_oph/se_n_u/s_n_u/37_2_69.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a2/f1/a2f1c1198d1233f7122f7cfe4a777960bee727e4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1053/j.semnuclmed.2006.10.002"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders

Eider M. Arenaza-Urquijo, Brigitte Landeau, Renaud La Joie, Katell Mevel, Florence Mézenge, Audrey Perrotin, Béatrice Desgranges, David Bartrés-Faz, Francis Eustache, Gaël Chételat
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
We assessed the relationships between years of education and i) gray matter volume, ii) gray matter metabolism and iii) functional connectivity in the brain areas showing associations with both volume  ...  All subjects underwent structural MRI, FDG-PET and resting-state functional MRI scans.  ...  It highlights a significant positive relationship between education and gray matter volume and metabolism in similar brain areas, as well as between education and functional connectivity in turns related  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2013.06.053">doi:10.1016/j.neuroimage.2013.06.053</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23796547">pmid:23796547</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/e2exts74jrchxjtyv64fqjeqzq">fatcat:e2exts74jrchxjtyv64fqjeqzq</a> </span>
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Resting State Functional Connectivity in Preclinical Alzheimer's Disease

Yvette I. Sheline, Marcus E. Raichle
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z5ukx73avrb57kufzzr36timya" style="color: black;">Biological Psychiatry</a> </i> &nbsp;
In addition, we discuss evidence for underlying preclinical AD mechanisms, including an important relationship between resting state functional connectivity and brain metabolism, and how this results in  ...  Multiple brain networks are present simultaneously and the relationships within and between networks are in constant dynamic flux.  ...  Moulder and J.C. Morris for contributing an unpublished figure that was adapted as Figure 2 .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.biopsych.2012.11.028">doi:10.1016/j.biopsych.2012.11.028</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23290495">pmid:23290495</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3537262/">pmcid:PMC3537262</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/msh6yrrburcjbiuosuzungl7bi">fatcat:msh6yrrburcjbiuosuzungl7bi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211023743/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3537262&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/10/0f/100f96f6a6f586a3f142fd0dc3b97cd1edda7ef7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.biopsych.2012.11.028"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537262" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Maturation of metabolic connectivity of the adolescent rat brain

Hongyoon Choi, Yoori Choi, Kyu Wan Kim, Hyejin Kang, Do Won Hwang, E Edmund Kim, June-Key Chung, Dong Soo Lee
<span title="2015-11-27">2015</span> <i title="eLife Sciences Publications, Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/en4qj5ijrbf5djxx7p5zzpjyoq" style="color: black;">eLife</a> </i> &nbsp;
Metabolism increased in anterior cerebrum and decreased in thalamus and cerebellum during maturation.  ...  While PET studies revealed maturation-related changes, maturation of metabolic connectivity of the brain is not yet understood.  ...  We identified the specific pattern of changes in regional metabolism and metabolic 144 connectivity during brain development.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7554/elife.11571">doi:10.7554/elife.11571</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26613413">pmid:26613413</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4718811/">pmcid:PMC4718811</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hujkk6o2tvcw7polodlvgycsse">fatcat:hujkk6o2tvcw7polodlvgycsse</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170921202116/https://cdn.elifesciences.org/articles/11571/elife-11571-v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/43/ee/43ee204d2f17e5d5947d51a136fc1bf6ac0b8329.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7554/elife.11571"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elifesciences.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718811" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Imaging Studies of Aging, Neurodegenerative Disease, and Alcoholism

Jamie L Eberling, William J Jagust
<span title="">1995</span> <i title="National Institutes of Health"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/o2n74ogrnrezbf4lozutk7u3eq" style="color: black;">Alcohol health and research world</a> </i> &nbsp;
Similarly, studies analyzing the metabolism in various brain structures have found that, depending on whether dementia was induced by neurodegenerative diseases, alcoholism, or aging, the affected brain  ...  Neurodegenerative diseases such as Alzheimer's disease, disorders such as alcoholism, and the aging process can lead to impaired cognitive function and dementia.  ...  The study found de creased temporal lobe metabolism, with the greatest metabolic deficits in brain regions that mediate widespread recipro cal connections between the temporal and frontal lobes and structures  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31798061">pmid:31798061</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6875739/">pmcid:PMC6875739</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wle56yy7angppch4j4n4555gr4">fatcat:wle56yy7angppch4j4n4555gr4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200428125116/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6875739&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/90/c4/90c4760c77d83c7e0c98aa24dc6965fe1460bffc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875739" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Age-related changes in 'hub' neurons

Abbi R. Hernandez, Sara N. Burke
<span title="2018-10-22">2018</span> <i title="Impact Journals, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vjgpqrqckbe5xfxuw2ce3r5nfa" style="color: black;">Aging</a> </i> &nbsp;
First, humans [3] and animals [4] have disruptions in large-scale functional connectivity across the brain that correspond with cognitive decline in old age.  ...  Second, behaviors that require connectivity between PFC and MTL [5] are more sensitive at detecting age differences than behaviors that do not require communication between these structures [6] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/aging.101606">doi:10.18632/aging.101606</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30348907">pmid:30348907</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6224237/">pmcid:PMC6224237</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tproa4vkavharcqpksktlosedi">fatcat:tproa4vkavharcqpksktlosedi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200507105501/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6224237&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b8/20/b8209ffab2c76d64b691ca51f1c33c352911b059.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/aging.101606"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224237" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Fact, Fiction, or Evolution: Mechanism Hypothesis of Alzheimer's Disease [chapter]

José V. Pardo
<span title="2019-03-27">2019</span> <i title="IntechOpen"> Alzheimer&#39;s Dementia and Korsakoff&#39;s Disease - Linking Memory Pathology to the Autobiographical Self [Working Title] </i> &nbsp;
In normal aging and very mild AD, the cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF) remained approximately constant, but the metabolism of glucose (CMRglu) declined markedly.  ...  These ideas and findings motivate aging and AD-research focus on the biochemistry and cell biology of cerebral metabolism.  ...  Acknowledgements This work was supported by the Minneapolis Veterans Health Care System; the University of Minnesota Libraries Open Access Fund; and Merit Award I01CX000501 (VA CSR&D).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/intechopen.83824">doi:10.5772/intechopen.83824</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j5yjihob4fgwdk4br3jx6m45rq">fatcat:j5yjihob4fgwdk4br3jx6m45rq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501190639/https://cdn.intechopen.com/pdfs/66404.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1d/22/1d22c3353230f39a2182d970e6ddab40903ec2b7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/intechopen.83824"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment

F.H.G. Porto, Artur Martins Coutinho, Fabio Luís de Souza Duran, Ana Lucia de Sá Pinto, Bruno Gualano, Carlos Alberto Buchpiguel, Geraldo Busatto, Ricardo Nitrini, Sonia Maria Dozzi Brucki
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/47gmsc3hojdm5kdlgbg4peyvyi" style="color: black;">NeuroImage: Clinical</a> </i> &nbsp;
Structural equation modeling was used to create latent variables based on regions with significant rBGM changes and to test a hypothetical model about the inter-relationships between these changes.  ...  Such changes were in the direction of the normally expected resting-state metabolic patterns of these networks.  ...  The first author (FHGP) was also sponsored by the Coordination for the Improvement of Higher Education Personnel (CAPES)/Brazil as part of his PhD research in the program Science without Borders (number  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2018.05.002">doi:10.1016/j.nicl.2018.05.002</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29984169">pmid:29984169</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6031093/">pmcid:PMC6031093</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rn3ijezkz5ey7hphh3c6ntauxu">fatcat:rn3ijezkz5ey7hphh3c6ntauxu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209210918/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6031093&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/47/f8/47f85daed81f15d1c496ca618f05d5f249a6aaa9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2018.05.002"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031093" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging

Freddy J. Alfaro, Anna Gavrieli, Patricia Saade-Lemus, Vasileios-Arsenios Lioutas, Jagriti Upadhyay, Vera Novak
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bftdqrp4bbclpnwlxeeolzbtqq" style="color: black;">Metabolism: Clinical and Experimental</a> </i> &nbsp;
Diffusion tensor imaging has offered new opportunities to detect microstructural white matter changes in metabolic syndrome, and a possibility to detect associations between functional and structural abnormalities  ...  This review analyzes the impact of metabolic syndrome on white matter microstructural integrity, brain structure abnormalities and their relationship to cognitive function.  ...  Aging affects all body organs and systems and brain aging is related to consistent differences in brain structure, decreased regenerative capacity for repair, impaired maintenance of synaptic and cognitive  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.metabol.2017.08.009">doi:10.1016/j.metabol.2017.08.009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28920863">pmid:28920863</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5732847/">pmcid:PMC5732847</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/edd5ea66wbf2va7piin2h3hb5u">fatcat:edd5ea66wbf2va7piin2h3hb5u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200207004620/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5732847&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d8/b7/d8b7ef483fd9cb765defce90603a600c79259b64.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.metabol.2017.08.009"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732847" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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