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Hybrid PET/MR Imaging and Brain Connectivity

Marco Aiello, Carlo Cavaliere, Marco Salvatore
2016 Frontiers in Neuroscience  
The study of brain connectivity is characterized by a multifaceted approach providing both structural and functional evidence of the relationship between cerebral regions at different scales.  ...  Moreover, it will discuss practical aspects and state-of-the-art techniques for exploiting hybrid PET/MR imaging to investigate the relationship of physiological processes and brain connectivity.  ...  The following sections will provide a taxonomy of BC methods involved in PET/MR studies: structural connectivity via diffusion tractography (DT), FC via resting state functional MRI (rs-fMRI), and metabolic  ... 
doi:10.3389/fnins.2016.00064 pmid:26973446 pmcid:PMC4771762 fatcat:4lozyt6omzdeveoygnz3vt55um

Editorial: Utilization of Hybrid PET/MR in Neuroimaging

Masoud Tahmasian, Carsten Eggers, Valentin Riedl, Christian Sorg, Alexander Drzezga
2015 Basic and Clinical Neuroscience  
In summary, simultaneous PET and MRI measurement using a hybrid PET/MR scanner is a promising approach that offers unique opportunities to study the relationship between different parameters of neuronal  ...  In the early 2000s, hybrid PET/CT scanners have been introduced to allow regional co-registration between structural and functional imaging in a single scanning procedure.  ... 
pmid:26904170 pmcid:PMC4656986 fatcat:kstbbnvjane6xotnjudla7ynh4

PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias

Xin Y. Zhang, Zhen L. Yang, Guang M. Lu, Gui F. Yang, Long J. Zhang
2017 Frontiers in Molecular Neuroscience  
This review introduces the development of PET/MR imaging systems, technical considerations of PET/MR imaging, special considerations of PET/MR in AD, and the system's potential clinical applications and  ...  The newly emerging PET/MR imaging strategies integrate the advantages of PET and MR to diagnose and monitor AD.  ...  Joseph Schoepf, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA, for helping us polish this manuscript.  ... 
doi:10.3389/fnmol.2017.00343 pmid:29163024 pmcid:PMC5672108 fatcat:qcbronzqqbgw7p4nhias3gsfoa

Alterations in resting-state network dynamics along the Alzheimer's disease continuum: a combined MEG-PET/MR approach [article]

Delphine Puttaert, Nicolas Coquelet, Vincent Wens, Philippe Peigneux, Patrick Fery, Antonin Rovai, Nicola Trotta, Jean-Christophe Bier, Serge Goldman, Xavier De Tiege
2020 bioRxiv   pre-print
We aimed at closing this gap by investigating both brain structure and function using magnetoencephalography (MEG) and hybrid positron emission tomography-magnetic resonance (PET/MR) in 10 healthy elders  ...  HMM patterns were related to participants' cognitive test scores, whole hippocampal grey matter volume and regional brain glucose metabolism.  ...  Furthermore, a hybrid PET-MR combining structural cerebral MRI and FDG-PET imaging was administered just after the MEG session.  ... 
doi:10.1101/2020.05.18.101683 fatcat:5ns6ifchhvatpj6h6335hfgqse

A literature review of MRI techniques used to detect amyloid-beta plaques in Alzheimer's disease patients

Baoting Yu, Yaming Shan, Jun Ding
2021 Annals of Palliative Medicine  
be obtained by the new PET/MR instrument at the same time.  ...  We discuss various magnetic resonance imaging (MRI) based techniques, including direct imaging, indirect imaging, amyloid-beta (Aβ) plaque and radiomics, Hybrid PET/MRI and MRI imaging technology in the  ...  MRI scanner registered, standard MRI and PET images can be acquired simultaneously in one system, which can increase a lot of diagnostic information.  ... 
doi:10.21037/apm-21-825 pmid:34551578 fatcat:uksfnszrtjfghjehcarsr4a4da

Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer's disease

Hidehiko Okazawa, Masamichi Ikawa, Minyoung Jung, Rikiya Maruyama, Tetsuya Tsujikawa, Tetsuya Mori, Mahmudur G. M. Rahman, Akira Makino, Yasushi Kiyono, Hirotaka Kosaka
2020 EJNMMI Research  
MR images such as 3D-T1WI, resting-state functional MRI (RS-fMRI), diffusion tensor image (DTI), and perfusion MRI acquired during the dynamic PET scan were also analyzed to evaluate various brain functions  ...  Multimodal PET/MRI image data simultaneously obtained from patients with early-stage of Alzheimer's disease (eAD) were assessed in order to observe pathophysiologic and functional changes, as well as alterations  ...  and clinical support.  ... 
doi:10.1186/s13550-020-00619-z pmid:32232573 pmcid:PMC7105527 fatcat:2szom7ycrnduhdpsrapksolzam

Elucidating the complementarity of resting-state networks derived from dynamic [18F]FDG and hemodynamic fluctuations using simultaneous small-animal PET/MRI

Tudor M. Ionescu, Mario Amend, Rakibul Hafiz, Bharat B. Biswal, Hans F. Wehrl, Kristina Herfert, Bernd J. Pichler
2021 NeuroImage  
We performed an RSN analysis from simultaneously acquired PET/fMRI data on a single-subject level to directly compare fMRI and [18F]FDG-PET-derived networks during the resting state.  ...  Our findings support previous studies, which show a close link between local synaptic glucose consumption and BOLD-fMRI-derived FC.  ...  This study is also part of the PhD thesis of Tudor Ionescu.  ... 
doi:10.1016/j.neuroimage.2021.118045 pmid:33848625 fatcat:4c42dwfikrfopgjcms5r5i7vse

Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain

Otto M. Henriksen, Mark Bitsch Vestergaard, Ulrich Lindberg, Niels Jacob Aachmann-Andersen, Kristian Lisbjerg, Søren Just Christensen, Peter Rasmussen, Niels Vidiendal Olsen, Julie L. Forman, Henrik Bo Wiberg Larsson, Ian Law
2018 Journal of applied physiology  
Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain.  ...  The aim of the present study was to reassess regional and interindividual relationships between cerebral perfusion and glucose metabolism in the resting brain.  ...  By performing the experiment using a hybrid PET/MR system, simultaneous measurements can be obtained (3, 54) .  ... 
doi:10.1152/japplphysiol.00276.2018 pmid:29975605 fatcat:jjw227fytnasjfwabtzlzlnswy

Positron emission tomography/magnetic resonance imaging (PET/MRI): An update and initial experience at HC-FMUSP

Marcelo A. Queiroz, Felipe de Galiza Barbosa, Carlos Alberto Buchpiguel, Giovanni Guido Cerri
2018 Revista da Associação Médica Brasileira  
The new technology of PET/MRI is a prototype of hybrid imaging, allowing for the combination of molecular data from PET scanning and morphofunctional information derived from MRI scanning.  ...  Our review aimed to highlight the current indications of PET/MRI and discuss the challenges and perspectives of PET/MRI at HC-FMUSP.  ...  anatomy (angioresonance), tissue kinetics (diffusion), cerebral perfusion patterns (perfusion), tissue metabolite concentration (spectroscopy), regional cerebral functional activation (functional MRI)  ... 
doi:10.1590/1806-9282.64.01.71 pmid:29561945 fatcat:lbhvo52n5vcbdgbv2abmlp3mlu

Alterations in resting-state network dynamics along the Alzheimer's disease continuum

D Puttaert, N Coquelet, V Wens, P Peigneux, P Fery, A Rovai, N Trotta, N Sadeghi, T Coolen, J-C Bier, S Goldman, X De Tiège
2020 Scientific Reports  
Correlations were sought between temporal properties of HMM states and participants' cognitive test scores, whole hippocampal grey matter volume and regional brain glucose metabolism.  ...  We aimed at closing this gap by investigating both brain structure and function using magnetoencephalography (MEG) and hybrid positron emission tomography-magnetic resonance (PET/MR) in 10 healthy elders  ...  The PET-MR project at the CUB Hôpital Erasme and Université libre de Bruxelles is financially supported by the Association Vinçotte Nuclear (AVN, Brussels, Belgium).  ... 
doi:10.1038/s41598-020-76201-3 pmid:33319785 fatcat:xiu44ub26renvdjcrc3uaywyba

Constant Infusion Radiotracer Administration for High Temporal Resolution Positron Emission Tomography (PET) of the Human Brain: Application to [18F]-Fluorodexoyglucose PET (FDG-PET) [article]

Sharna D Jamadar, Phillip GD Ward, Alexandra Carey, Richard McIntyre, Linden Parkes, Disha Sasan, John Fallon, Shenpeng Li, Zhaolin Chen, Gary Egan
2019 bioRxiv   pre-print
We detail a method for acquiring blood samples, time-locking PET, MRI and experimental stimulus, and administrating the non-traditional tracer delivery.  ...  Further, new advances in hybrid MR-PET hardware makes it possible to capture fluctuations in glucose and blood oxygenation simultaneously using fMRI and FDG-fPET.  ...  . 16 The majority of existing FDG-PET studies in the human brain have acquired 'static' images of cerebral glucose 17 metabolism.  ... 
doi:10.1101/667352 fatcat:6reulif7l5hihkkpiweoz4gslu

Dissociations between glucose metabolism and blood oxygenation in the human default mode network revealed by simultaneous PET-fMRI

Lars Jonasson Stiernman, Filip Grill, Andreas Hahn, Lucas Rischka, Rupert Lanzenberger, Vania Panes Lundmark, Katrine Riklund, Jan Axelsson, Anna Rieckmann
2021 Proceedings of the National Academy of Sciences of the United States of America  
Using hybrid functional positron emission tomography (PET)-MRI, this study shows that task-positive and -negative BOLD responses do not reflect antagonistic patterns of synaptic metabolism.  ...  Dissociations between glucose metabolism and the BOLD response specific to the DMN reveal functional heterogeneity in this network and demonstrate that negative BOLD responses during cognitive control  ...  We thank the staff and leadership of Umeå Center for Functional Brain Imaging at Umeå University and Cancer Centrum and Nuclear Medicine at Umeå University Hospital for facilitating the data acquisition  ... 
doi:10.1073/pnas.2021913118 pmid:34193521 pmcid:PMC8271663 fatcat:6z5qkch3y5acnmr3lurhpekm2m

Advanced kinetic modelling strategies: towards adoption in clinical PET imaging

Fotis A. Kotasidis, Charalampos Tsoumpas, Arman Rahmim
2014 Clinical and translational imaging  
enhancing the role and clinical importance of PET/MR imaging.  ...  Positron emission tomography (PET) is a highly quantitative imaging modality that can probe a number of functional and biological processes, depending on the radiolabelled tracer used.  ...  Tsoumpas and Dr A. Rahmim declare no conflict of interest. Human and Animal Studies This article does not contain any studies with human or animal subjects performed by any of the authors.  ... 
doi:10.1007/s40336-014-0069-8 fatcat:ped2rw5vlvbzjdsu3v2r43dz6m

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  This study was funded by MINECO SAF2014-54070-JIN. Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

Alpha peak frequency is linked to episodic memory impairment in pathological aging [article]

Delphine Puttaert, Vincent Wens, Patrick Fery, Antonin Rovai, Nicola Trotta, Nicolas Coquelet, Sandra De Breucker, Niloufar Sadeghi, Tim Coolen, Serge Goldman, Philippe Peigneux, Jean-Christophe Bier (+1 others)
2021 bioRxiv   pre-print
resonance imaging (18FDG-PET/MR), and 10 minutes of resting-state magnetoencephalography (MEG).  ...  The APF also correlated positively with patients hippocampal volume and their regional glucose consumption in the posterior cingulate cortex.  ...  acquired simultaneously on a hybrid 3 T SIGNA PET-MR scanner (GE Healthcare, Milwaukee, Wisconsin, USA) at the CUB Hôpital Erasme (Brussels, Belgium).  ... 
doi:10.1101/2021.06.18.448931 fatcat:olfog5ndmvet7f6cukopl4xuam
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