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Relation between branching patterns and perfusion in stochastic generated coronary arterial trees

J. Dankelman, A. J. M. Cornelissen, J. Lagro, E. VanBavel, J. A. E. Spaan
2007 Medical and Biological Engineering and Computing  
To assess the fundamental consequences of branching characteristics, 50 stochastic asymmetrical coronary trees and one nonstochastic symmetrical branching tree were generated.  ...  Biological variation in branching patterns is likely to affect perfusion of tissue.  ...  [6] and VanBavel and Spaan [15] quantified coronary arterial branching patterns.  ... 
doi:10.1007/s11517-006-0139-9 pmid:17203320 fatcat:eytp6hybrfdkffehshvpuskyim

Topologic and Hemodynamic Characteristics of the Human Coronary Arterial Circulation

Janina C. V. Schwarz, Monique G. J. T. B. van Lier, Jeroen P. H. M. van den Wijngaard, Maria Siebes, Ed VanBavel
2020 Frontiers in Physiology  
Most of the pressure drop occurred in vessels between 200 μm and 1 mm in diameter.  ...  This study provides the branching characteristics and hemodynamic analysis of the left coronary arterial circulation of a human heart.  ...  For all trees, there was a linear relation between the log-transformed segment diameter and distal arterial conductance.  ... 
doi:10.3389/fphys.2019.01611 pmid:32038291 pmcid:PMC6989553 fatcat:dhrmusthazfdfmidto35vljm5y

A full 3-D reconstruction of the entire porcine coronary vasculature

Benjamin Kaimovitz, Yoram Lanir, Ghassan S. Kassab
2010 American Journal of Physiology. Heart and Circulatory Physiology  
The epicardial subnetwork and coronary arterial capillary network served as boundary conditions for the reconstruction of the in-between transmural and perfusion networks, which were generated to optimize  ...  The epicardial portion was generated by a simulated annealing search for the optimal coverage of the area perfused by the arterial epicardial vessels.  ...  cylindrical heart model and by Smith et al. (54) in a finite-element model of the heart for the largest six generations of the coronary arterial tree.  ... 
doi:10.1152/ajpheart.00151.2010 pmid:20622105 pmcid:PMC2957345 fatcat:7olag7amovcpfdx2fetyopjhk4

Branching patterns in the porcine coronary arterial tree. Estimation of flow heterogeneity

E VanBavel, J A Spaan
1992 Circulation Research  
From these measurements, "branching rules" were derived that describe the stochastic relation between diameters of parent and daughter segments at arterial nodes, as well as the relation between the unbranched  ...  These relations were used to construct computer models of the coronary arterial tree, covering diameters between 10 and 500 ,um.  ...  Acknowledgments The authors would like to thank Jaap Van Pelt (Netherlands Institute for Brain Research), Wim Hacking, and Paul Boon for their valuable comments on this study.  ... 
doi:10.1161/01.res.71.5.1200 pmid:1394880 fatcat:c3um6ojj45fshaoh2kp3ate2ki

Anatomical Variability and Functional Ability of Vascular Trees Modeled by Constrained Constructive Optimization

Wolfgang Schreiner, Friederike Neumann, Martin Neumann, Adelheid End, Susanne M. Roedler
1997 Journal of Theoretical Biology  
To these ends we used the method of Constrained Constructive Optimization (CCO) to generate optimized computer models of coronary arterial trees.  ...  However, by stochastically casting the locations of the terminal segments, different tree structures were generated, each of which conformed to the same boundary conditions.  ...  This work was sponsored by the Austrian Ministry of Science and Research, grant nr. 49/820/4-24/92 and the Ludwig Boltzmann Institut fu¨r Herzchirurgische Forschung. The authors thank Mrs.  ... 
doi:10.1006/jtbi.1997.0413 pmid:9237885 fatcat:dby3tdjuujerdmaiujzcyzlihi

Staged Growth of Optimized Arterial Model Trees

Rudolf Karch, Friederike Neumann, Martin Neumann, Wolfgang Schreiner
2000 Annals of Biomedical Engineering  
There is a marked difference in the structure of the arterial tree between epi-and endocardial layers of the human heart.  ...  From this study we conclude that the method of CCO combined with staged growth reproduces many characteristics of the different arterial branching patterns in the subendocardium and the subepicardium,  ...  ACKNOWLEDGMENTS The authors gratefully acknowledge the critical comments and valuable suggestions of the unknown reviewers of this study.  ... 
doi:10.1114/1.290 pmid:10925948 fatcat:zyeyziz3pnembigsrfgmkxox6y

Diameter asymmetry of porcine coronary arterial trees: structural and functional implications

Benjamin Kaimovitz, Yunlong Huo, Yoram Lanir, Ghassan S. Kassab
2008 American Journal of Physiology. Heart and Circulatory Physiology  
coronary arterial and venous trees.  ...  The relations between AER and flow velocity, and asymmetry ratio matrix and flow distribution, were considered.  ...  GRANTS This research is supported in part by the US-Israel Binational Science Foundation Grant 2003-095 and National Heart, Lung, and Blood Institute Grant 2 R01 HL055554-11.  ... 
doi:10.1152/ajpheart.00818.2007 pmid:18055515 fatcat:3uoyadx3nncyzg6w6xzufmp4se

Development of a model of the coronary arterial tree for the 4D XCAT phantom

George S K Fung, W Paul Segars, Grant T Gullberg, Benjamin M W Tsui
2011 Physics in Medicine and Biology  
In this work, we first developed a computer generated 3-D model of the coronary arterial tree for the heart in the extended cardiac-torso (XCAT) phantom, thereby creating a realistic computer model of  ...  An iterative rule-based generation method was developed and applied to extend the coronary arterial tree beyond the initial proximal segments.  ...  Acknowledgments The authors thank Takahiro Higuchi, MD, PhD and Kenji Fukushima, MD of Johns Hopkins University for his contributions to the evaluation of the coronary arterial tree model.  ... 
doi:10.1088/0031-9155/56/17/012 pmid:21828911 pmcid:PMC3169781 fatcat:6ocwrlhspbanzijdhvc7i53suq

Analysis of blood flow in the entire coronary arterial tree

N. Mittal, Y. Zhou, C. Linares, S. Ung, B. Kaimovitz, S. Molloi, G. S. Kassab
2005 American Journal of Physiology. Heart and Circulatory Physiology  
Pathological states can then be studied in relation to changes in model parameters that alter coronary perfusion. vascular reconstruction; coronary morphometry; flow simulation; flow resistance; transit  ...  A hemodynamic analysis of coronary blood flow must be based on the measured branching pattern and vascular geometry of the coronary vasculature.  ...  Pathological states can then be studied in relation to changes in model parameters that alter coronary perfusion.  ... 
doi:10.1152/ajpheart.00730.2004 pmid:15792992 fatcat:7kjd4o6rmnbfdoieisb6z6hkwi

Morphometry of human coronary arterial trees

S. Aharinejad, W. Schreiner, F. Neumann
1998 The Anatomical Record  
Conclusions: This article provides new experimental data on branching geometry of coronary arteries (i.e., the trees evaluated in this study are purely delivering rather than conveying).  ...  Some groups, including ours, have been generating arterial tree models using constrained constructive optimization (CCO).  ...  Knowledge of coronary branching pattern is essential for the understanding of myocardial perfusion.  ... 
doi:10.1002/(sici)1097-0185(199805)251:1<50::aid-ar9>3.3.co;2-8 pmid:9605220 fatcat:7q4bnrtcmzcgzea64katlyihdu

Morphometry of human coronary arterial trees

S. Aharinejad, W. Schreiner, F. Neumann
1998 The Anatomical Record  
Conclusions: This article provides new experimental data on branching geometry of coronary arteries (i.e., the trees evaluated in this study are purely delivering rather than conveying).  ...  Some groups, including ours, have been generating arterial tree models using constrained constructive optimization (CCO).  ...  Knowledge of coronary branching pattern is essential for the understanding of myocardial perfusion.  ... 
doi:10.1002/(sici)1097-0185(199805)251:1<50::aid-ar9>3.0.co;2-i pmid:9605220 fatcat:7nmo7ngvtzfb3mpwfp4uuivm3y

A review of multiscale 0D–1D computational modeling of coronary circulation with applications to cardiac arrhythmias

Stefania Scarsoglio, Luca Ridolfi
2021 Reviews in cardiovascular medicine  
Aim of this review is to provide a compact summary of state of the art 0D-1D multiscale models of the arterial coronary system, with particular attention to applications related to cardiac arrhythmias,  ...  The present review can stimulate future investigation, both in computational and clinical research, devoted to the hemodynamic effects induced by cardiac arrhythmias on the coronary circulation.  ...  Acknowledgment We would like to express our gratitude to all the peer reviewers for their opinions and suggestions.  ... 
doi:10.31083/j.rcm2204150 pmid:34957785 fatcat:dtvm6g2hknegbgzusymwhkbxnu

Computational Assessment of Blood Flow Heterogeneity in Peritoneal Dialysis Patients' Cardiac Ventricles

Sanjay R. Kharche, Aaron So, Fabio Salerno, Ting-Yim Lee, Chris Ellis, Daniel Goldman, Christopher W. McIntyre
2018 Frontiers in Physiology  
Blocking of arteries at various orders showed that blocking larger arteries results in multi-modal BF histograms and large patches of low BF, whereas smaller artery blocking results in augmented relative  ...  Using the model, it was found that total coronary BF increased as coronary perfusion pressure was increased. BF heterogeneity was differentially affected by large or small vessel blocking.  ...  ACKNOWLEDGMENTS We thank LHSC IT, Compute Canada, SHARCNet for IT and HPC resources. This study was supported by Heart and Stroke grant (G-17-0018311, PI: CM).  ... 
doi:10.3389/fphys.2018.00511 pmid:29867555 pmcid:PMC5968396 fatcat:ldorv2iifzarrklcwgckt3jgiu

Computational assessment of blood flow heterogeneity in dialysis patients' cardiac ventricles [article]

Sanjay R Kharche, Aaron So, F Salerno, Ting-Yim Lee, Chris Ellis, Daniel Goldman, C W McIntyre
2018 bioRxiv   pre-print
Blocking of arteries at various orders showed that blocking larger arteries results in multi-modal BF histograms and large patches of low BF, whereas smaller artery blocking results in augmented relative  ...  Using the model, it was found that total coronary BF increased as coronary perfusion pressure (CPP) was increased. BF heterogeneity was differentially affected by large or small vessel blocking.  ...  heart's coronary arterial binary tree topologies.  ... 
doi:10.1101/301572 fatcat:v5kla3qk4rbk5i3rfytyi4yauu

Biophysical Model of the Spatial Heterogeneity of Myocardial Flow

Yunlong Huo, Benjamin Kaimovitz, Yoram Lanir, Thomas Wischgoll, Julien I.E. Hoffman, Ghassan S. Kassab
2009 Biophysical Journal  
the interplay between cardiac mechanics and coronary hemodynamics.  ...  This validated threedimensional model of normal diastolic heart will play an important role in elucidating the spatial heterogeneity of coronary blood flow, and serve as a foundation for understanding  ...  This research was supported in part by the U.S.  ... 
doi:10.1016/j.bpj.2009.02.047 pmid:19450475 pmcid:PMC2712153 fatcat:vq2d3oftxzditbspp3gqo3vsvu
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