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Automatic prediction of cognitive and functional decline can significantly decrease the number of subjects required for clinical trials in early Alzheimer's disease [article]

Neda Shafiee, Mahsa Dadar, Simon Ducharme, D. Louis Collins
2021 arXiv   pre-print
METHOD: We built a prognostic model using baseline cognitive scores and MRI-based features to determine which subjects with mild cognitive impairment remained stable and which functionally declined (measured  ...  RESULTS: Combining both sets of features yields 77% accuracy (81% sensitivity and 75% specificity) to predict cognitive decline at 2 years (74% accuracy at 3 years with 75% sensitivity and 73% specificity  ...  In our previous work, we showed that when predicting onset of dementia in subjects with mild cognitive impairment, MRI-based features (SNIPE) are more sensitive compared to cognitive features, and even  ... 
arXiv:2101.08346v1 fatcat:hkgltqqrnrghthuephsqwxmojy

Medial temporal atrophy but not memory deficit predicts progression to dementia in patients with mild cognitive impairment

C Geroldi, R Rossi, C Calvagna, C Testa, L Bresciani, G Binetti, O Zanetti, G B Frisoni
2006 Journal of Neurology, Neurosurgery and Psychiatry  
The diagnosis of mild cognitive impairment (MCI) is clinically unhelpful, as many patients with MCI develop dementia but many do not.  ...  95% CI 2.0 to 171.3) and normal MRI scan (OR 10.0, 95% CI 1.7 to 60.2).  ...  Age-related White Matter Changes; CES-D, Center for Epidemiologic Studies Depression Scale ; CDR, Clinical Dementia Rating; MCI, mild cognitive impairment; MRI, magnetic resonance imaging; MTA, medial  ... 
doi:10.1136/jnnp.2005.082651 pmid:16891386 pmcid:PMC2077364 fatcat:ibgvzeplpzfybksb5fzooprrd4

Cognitive Impairment in Ischaemic Lacunar Stroke

Adrià Arboix, Lorena Blanco-Rojas
2013 European Neurological Review  
In patients with first-ever lacunar infarction, more than half of cases show impairment of the executive functions and meet criteria of mild vascular cognitive impairment.  ...  In the wellcharacterised cohort of 1,636 lacunar stroke patients of the Secondary Prevention of Small Subcortical Strokes (SPS3) trial, mild cognitive impairment was present in nearly half of participants  ...  On the other hand, cerebral microbleeds have been related to executive dysfunction and cognitive impairment.  ... 
doi:10.17925/enr.2013.08.02.144 fatcat:ycjckkemejhgfhfirrp7azne3y

Longitudinal Change of Biomarkers in Cognitive Decline

Raymond Y. Lo
2011 Archives of Neurology  
Participants: A total of 819 participants 55 to 90 years of age with normal cognition, mild cognitive impairment, and AD who were followed up during the period from 2005 to 2007.  ...  Results: Reductions in the level of A␤42 in CSF were numerically greater in participants with normal cognition than in participants with mild cognitive impair-  ...  conversion to dementia in mild cognitive impairment (MCI) in previous studies  ... 
doi:10.1001/archneurol.2011.123 pmid:21670386 pmcid:PMC5604752 fatcat:x4tqesjn3zcktoafme3wvw2x2e

2001–2011: A Decade of the LADIS (Leukoaraiosis And DISability) Study: What Have We Learned about White Matter Changes and Small-Vessel Disease?

2011 Cerebrovascular Diseases  
Abstract Over the last 20 years, evidence about the clinical correlates of cerebral white matter changes (WMC; also called leukoaraiosis) has been accumulating.  ...  The main results of the LADIS study have been released in 2009 with the demonstration that severe WMC more than double the risk of transition from an autonomous to a dependent status after 3 years of follow-up  ...  One major determinant of impaired functionality in relation to WMC, in addition to cognitive, motor and depressive disturbances, is represented by continence problems.  ... 
doi:10.1159/000334498 pmid:22279631 fatcat:vaexuswmx5dvdle3i4hxuqy4wi

Automatic Prediction of Cognitive and Functional Decline Can Significantly Decrease the Number of Subjects Required for Clinical Trials in Early Alzheimer's Disease

Neda Shafiee, Mahsa Dadar, Simon Ducharme, D. Louis Collins, the Alzheimer's Disease Neuroimaging Initiative for
2021 Journal of Alzheimer's Disease  
Methods: Data used in this study included 312 patients with mild cognitive impairment from the ADNI dataset with baseline MRI, cerebrospinal fluid amyloid-β, cognitive test scores, and a minimum of two-year  ...  We built a prognostic model using baseline cognitive scores and MRI-based features to determine which subjects remain stable and which functionally decline over 2 and 3-year follow-up periods.  ...  dementia in 656 persons with mild cognitive impairment.  ... 
doi:10.3233/jad-210664 pmid:34602478 pmcid:PMC8673508 fatcat:i6qswst6azftvj3jcibrnl7r4q

MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers

N. Schuff, N. Woerner, L. Boreta, T. Kornfield, L. M. Shaw, J. Q. Trojanowski, P. M. Thompson, C. R. Jack, M. W. Weiner
2008 Brain  
The mild cognitive impairment and Alzheimer's disease groups showed hippocampal volume loss over 6 months and accelerated loss over 1 year.  ...  The demonstration of considerable hippocampal loss in mild cognitive impairment and Alzheimer's disease patients over only 6 months and accelerated loss over 12 months illustrates the power of MRI to track  ...  Funding to pay the Open Access publication charges for this article was provided by the Alzheimer's Disease Neuroimaging Initiative National Institutes of Health (U01 AG024904 to M.W.).  ... 
doi:10.1093/brain/awp007 pmid:19251758 pmcid:PMC2668943 fatcat:krcpfr6cdvd3rajlu2frh5beey

White Matter Microstructural Damage in Small Vessel Disease Is Associated With Montreal Cognitive Assessment But Not With Mini Mental State Examination Performances: Vascular Mild Cognitive Impairment Tuscany Study

M. Pasi, E. Salvadori, A. Poggesi, L. Ciolli, A. Del Bene, S. Marini, S. Nannucci, F. Pescini, R. Valenti, A. Ginestroni, N. Toschi, S. Diciotti (+3 others)
2014 Stroke  
Methods-Mild cognitive impairment patients with moderate/severe degrees of white matter hyperintensities on MRI were enrolled.  ...  , psychomotor speed, and executive tasks. [3] [4] [5] [6] Diffusion tensor imaging (DTI) is an MRI technique able to detect changes in white matter microstructure that are not evidenced on conventional  ...  White Matter Microstructural Damage in Small Vessel  ... 
doi:10.1161/strokeaha.114.007553 pmid:25395414 fatcat:3rei5vdqing6heet3hdtux6eve

Prediction of Cognitive Decline in Temporal Lobe Epilepsy and Mild Cognitive Impairment by EEG, MRI, and Neuropsychology

Yvonne Höller, Kevin H. G. Butz, Aljoscha C. Thomschewski, Elisabeth V. Schmid, Christoph D. Hofer, Andreas Uhl, Arne C. Bathke, Wolfgang Staffen, Raffaele Nardone, Fabian Schwimmbeck, Markus Leitinger, Giorgi Kuchukhidze (+3 others)
2020 Computational Intelligence and Neuroscience  
Cognitive decline is a severe concern of patients with mild cognitive impairment.  ...  Combining information from EEG, MRI, and neuropsychology in order to predict neuropsychological changes in a heterogeneous population could create a more general model of cognitive performance decline.  ...  Alterations in medication from baseline could contribute to cognitive changes.  ... 
doi:10.1155/2020/8915961 pmid:32549888 pmcid:PMC7256687 fatcat:lmdh4ptwefg35lw7dkvyvwaada

Investigating the temporal pattern of neuroimaging-based brain age estimation as a biomarker for Alzheimer's Disease related neurodegeneration [article]

Alexei Taylor, Fengqing Zhang, Xin Niu, Ashley Heywood, Jane Stocks, Gangyi Feng, Karteek Popuri, Mirza Faisal Beg, Lei Wang
2022 bioRxiv   pre-print
Additionally, the BAG of individuals with progressive mild cognitive impairment increased at a significantly faster rate across time compared to stable groups, where this effect was stronger in female  ...  The BAG was observed to have a linear increasing trajectory across the 8-year period.  ...  Groups are given as stable cognitively normal (sCN), stable mild cognitive impairment (sMCI), and progressive mild cognitive impairment (pMCI).  ... 
doi:10.1101/2022.03.18.484935 fatcat:knkw7plmjzcrhltpoyqdty7zau

Prediction of 7-year's Conversion from Subjective Cognitive Decline to Mild Cognitive Impairment [article]

Ling Yue, Dan Hu, Han Zhang, Junhao Wen, Ye Wu, Wei Li, Lin Sun, Xia Li, Jinghua Wang, Guanjun Li, Tao Wang, Dinggang Shen (+1 others)
2020 biorxiv/medrxiv   pre-print
This work included 76 SCD individuals with two (baseline and seven years later) neuropsychological evaluations and a baseline T1-MRI.  ...  A machine learning-based model was trained based on 198 baseline neuroimage features and a battery of 25 clinical measurements to discriminate 24 progressive SCDs from 52 stable SCDs.  ...  For the partial cor- relation, MoCA scores at the baseline and follow-up, as well as 7 years' MoCA changes were separately used to investigate how the identified MRI features were associated with  ... 
doi:10.1101/2020.05.04.20091256 fatcat:fjbd3zssbvewbfpellelt5jbry

Temporal changes in total and hippocampal brain volume and cognitive function in patients with chronic heart failure—the COGNITION.MATTERS-HF cohort study

Anna Frey, György A Homola, Carsten Henneges, Larissa Mühlbauer, Roxane Sell, Peter Kraft, Maximilian Franke, Caroline Morbach, Marius Vogt, Wolfgang Müllges, Georg Ertl, László Solymosi (+5 others)
2021 European Heart Journal  
Conclusion In patients with predominantly mild HF, the markedly reduced hippocampal volume observed at baseline was associated with impaired cognitive function, but no accelerated deterioration in cognition  ...  This corresponded to a relative change of −1.8% (95% CI −2.3 to −1.2), which was similar in magnitude as observed with physiological aging.  ...  Data availability Data will be made available upon request in adherence with transparency conventions in medical research and through requests to the corresponding authors.  ... 
doi:10.1093/eurheartj/ehab003 pmid:33496311 fatcat:fde4vz2ly5g55aj4dcveo4g6oq

Cognitive reserve moderates long-term cognitive and functional outcome in cerebral small vessel disease

Hanna Jokinen, Susanna Melkas, Sofia Madureira, Ana Verdelho, José M Ferro, Franz Fazekas, Reinhold Schmidt, Philip Scheltens, Frederik Barkhof, Joanna M Wardlaw, Domenico Inzitari, Leonardo Pantoni (+1 others)
2016 Journal of Neurology, Neurosurgery and Psychiatry  
Results: Higher levels of educational and occupational attainment were strongly related to baseline cognitive scores and predicted slower rate of decline in 3-year follow-up in measures of processing speed  ...  The deleterious effect of WMH on processing speed and memory was moderated by education and occupation. Education mitigated the relation of WMH volume on 7-year cognitive status.  ...  At baseline, all subjects had mild to severe WMH on brain MRI according to the modified scale of Fazekas, [13] but they had no or mild disability as assessed by the Instrumental Activities of Daily Living  ... 
doi:10.1136/jnnp-2016-313914 pmid:27951523 fatcat:cfywphu23rcybeq4n7yturfo4i

Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings

M R Piras
2003 Journal of Neurology, Neurosurgery and Psychiatry  
and cerebral lesion burden over time (mean 8.5 year follow up period); (3) to study the relation between clinical, neuropsychological, and MRI data.  ...  Conclusions: These findings revealed mild cognitive impairment in MS patients particularly consistent with slowing information processing over time.  ...  Kujala et al found that only mild impaired patients worsened in a three year controlled follow up in contrast with cognitively preserved MS patients. 8 Combined neuropsychological and MRI follow up investigations  ... 
doi:10.1136/jnnp.74.7.878 pmid:12810771 pmcid:PMC1738564 fatcat:jg3sgjjobzcphgygqp7qovvesq

Cloud-Based Brain Magnetic Resonance Image Segmentation and Parcellation System for Individualized Prediction of Cognitive Worsening

Ryo Sakamoto, Christopher Marano, Michael I. Miller, Constantine G. Lyketsos, Yue Li, Susumu Mori, Kenichi Oishi, Alzheimer's Disease Neuroimaging Initiative ADNI
2019 Journal of Healthcare Engineering  
Despite multiple efforts to apply computational brain magnetic resonance image (MRI) analysis in predicting cognitive worsening, with several successes, brain MRI is not routinely quantified in clinical  ...  in the subsequent two years as the target for prediction.  ...  Acknowledgments We would like to acknowledge support for the statistical analysis from Dr. Martin A. Lindquist and thank Ms. Mary McAllister for help with manuscript editing.  ... 
doi:10.1155/2019/9507193 pmid:30838124 pmcid:PMC6374863 fatcat:jdjoc2mq4bgnvnahvdthbwro7i
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