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Regulation of cytochrome P450 expression in Drosophila: Genomic insights
2010
Pesticide Biochemistry and Physiology
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Our results are compared to the increasingly diverse reports on P450 induction that can be gleaned from whole genome or from "detox" microarray experiments in Drosophila. ...
Genomic tools such as the availability of the Drosophila genome sequence, the relative ease of stable transformation, and DNA microarrays have made the fruit fly a powerful model in insecticide toxicology ...
Dunkov for help with the GFP transgenic lines and the Synthetic Core Facility, Southwest Environmental Health Sciences Center, University of Arizona, for the hexachlorobiphenyls. ...
doi:10.1016/j.pestbp.2009.06.009
pmid:20582327
pmcid:PMC2890303
fatcat:vfrn6feqt5agjfq74t7sq7v5nm
Understanding the Mechanisms Involved in the Regulation of Cytochrome P450 Gene Expression in Drosophila melanogaster (Diptera: Drosophilidae)
2016
Entomology, Ornithology & Herpetology: Current Research
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Acknowledgements This research was supported by Tertiary Education Trust Fund (TETFUND) and the University of Abuja-Nigeria. ...
Molecular Mechanisms of AhR Functions in the Regulation of Cytochrome P450S in Drosophila
Spineless (Ss) Tango (Tgo) signalling pathway The spineless (Ss) protein remains predominantly cytoplasmic as ...
Conclusions Here we have reviewed the role of the spineless/tango and CnCC/ dKeap 1 signalling pathways for their mechanistic role in the regulation of Cytochrome P450s in the activation of xenobiotics ...
doi:10.4172/2161-0983.1000189
fatcat:io7fspafnzbe3kxnt4wjobta44
Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue
1993
Journal of Biological Chemistry
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Estrogen biosynthesis is catalyzed by a microsomal enzyme, aromatase cytochrome P450 (P450arom; the product of the CYP19 gene). The human CYP19 gene comprises nine coding exons, II-X. ...
We conclude that CYP19 gene expression in human adipose tissue likely utilizes two novel promoters and, furthermore, that alternative promoter usage in cultured ASC is a function of the hormonal environment ...
Acknowledgments-We gratefully acknowledge the skilled editorial assistance of Melissa Meister. We thank Gary D. Means for helpful discussions. ...
pmid:7690033
fatcat:puhkvm5ferhhnkfqbiypqnp2va
Insights into the Malpighian tubule from functional genomics
2009
Journal of Experimental Biology
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While it is vital to continue to set insights obtained in Drosophila into the context of work in other species, the combination of post-genomic technologies and physiological validation can provide insights ...
With the sequencing of the Drosophila genome, and the concurrent development of post-genomic technologies such as microarrays, proteomics, metabolomics and systems biology, completely unexpected roles ...
Even more remarkable, the tubule was also highly enriched for mRNAs for detoxification genes, notably cytochrome P450s and glutathione S-transferases. ...
doi:10.1242/jeb.024224
pmid:19151219
fatcat:rp2ywtoao5baxc7f6yhhuxd3yy
Population transcriptomics: insights from Drosophila simulans, Drosophila sechellia and their hybrids
2011
Genetica
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Comparing D. simulans and D. sechellia, we revealed 304 consistently differentially expressed genes, with striking overrepresentation of genes of the cytochrome P450 family, which could be related to their ...
role in detoxification as well as in hormone regulation. ...
Conflict of interest The authors declare no conflict of interest. ...
doi:10.1007/s10709-011-9566-0
pmid:21424276
fatcat:nlrjh5m275fn5o7gb3lr7svicu
Gypsy moth genome provides insights into flight capability and virus–host interactions
2019
Proceedings of the National Academy of Sciences of the United States of America
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Finally, we use our new genomic and transcriptomic tools to provide insights into genome-wide gene-expression changes of the gypsy moth after viral infection. ...
To explore the genetic determinants of these phenotypic differences, we sequenced and annotated a draft genome of L. dispar and used it to identify genetic variation between EGM and AGM populations. ...
Finally, we use our new genomic and transcriptomic tools to provide insights into genome-wide gene-expression changes of the gypsy moth after viral infection. ...
doi:10.1073/pnas.1818283116
fatcat:ec2u5iafqzb2zmvrv7fg5bx7zi
Genomic insights into mite phylogeny, fitness, development, and reproduction
2019
BMC Genomics
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Our transcriptomic analyses of different life stages of N. cucumeris provide new insights into genes involved in its development. ...
Putative genes involved in vitellogenesis, regulation of oviposition, sex determination, development of legs, signal perception, detoxification and stress-resistance, and innate immune systems are identified ...
N. cucumeris, showing phylogenetic relationships (in protein sequences). a of cytochrome P450 (CYP450), b of glutathione-S-transferase (GST) and C of carboxyl/ cholinesterase (CCE). ...
doi:10.1186/s12864-019-6281-1
pmid:31818245
pmcid:PMC6902594
fatcat:nxdbwfwe3vhdjcg74hjhb3pigy
Interaction of plant defense compounds with the insect gut: new insights from genomic and molecular analyses
2015
Current Opinion in Insect Science
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Expanding genome sequence information and genetic approaches to manipulate gene function in both interacting partners are providing new insights into the genetic underpinnings of host preference and plasticity ...
in gut physiology. ...
Well studied examples of gut plasticity include induced expression of insect digestive proteases in response to plant proteinase inhibitors [28] and xenobiotic-induced expression of cytochromes P450 (CYPs ...
doi:10.1016/j.cois.2015.03.004
pmid:32846710
fatcat:kaqqzjvsmngmbgx3lvsxs3erzm
Genome-enabled insights into the biology of thrips as crop pests
2020
BMC Biology
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Conclusions Analysis of the F. occidentalis genome offers insights into the polyphagous behavior of this insect pest that finds, colonizes, and survives on a widely diverse array of plants. ...
encountered in agricultural environments; (2) a comprehensive set of salivary gland genes supported by enriched expression; (3) apparent absence of members of the IMD innate immune defense pathway; and ...
Acknowledgements We thank the staff at the Baylor College of Medicine Human Genome Sequencing Center for their contributions. ...
doi:10.1186/s12915-020-00862-9
pmid:33070780
fatcat:zqqwcbvquffu3jelq6rzxhtkne
De novo gonad transcriptome analysis of the common littoral shrimp Palaemon serratus: novel insights into sex-related genes
2019
BMC Genomics
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These sex-related genes were discussed taking into account whether they were up-regulated in ovary, up-regulated in testis or not differentially expressed between gonads and in the framework of previous ...
Six thousand two hundred seven genes were up-regulated in ovaries meanwhile 4880 genes were up-regulated in testes. ...
We also thank the anonymous reviewers for their improvements in the manuscript. Ethics and consent to participate Not applicable. ...
doi:10.1186/s12864-019-6157-4
pmid:31640556
pmcid:PMC6805652
fatcat:g6j4s45ymzbwhnkomw7tiz4k64
A heterozygous moth genome provides insights into herbivory and detoxification
2013
Nature Genetics
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A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide ...
We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated ...
To estimate the expansion time of LTRs in the P. xylostella and B. mori genomes, we investigated the LTRs using LTR_STRUC 57 . ...
doi:10.1038/ng.2524
pmid:23313953
fatcat:vdwymd4vgvcrfnlo4gnnclerxm
Comparative transcriptome analysis of Glyphodes pyloalis Walker (Lepidoptera: Pyralidae) reveals novel insights into heat stress tolerance in insects
2017
BMC Genomics
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In addition, the expression patterns of ten randomly selected genes, such as HSP and cytochrome P450, were consistent with the transcriptome results obtained through quantitative real-time PCR. ...
In addition, vitamin digestion and absorption pathways and detoxification pathways identified here provided new insights for the investigation of the molecular mechanisms of heat stress tolerance. ...
homeobox protein HHEX homolog; Unigene6953_All, cytochrome P450 B5. ...
doi:10.1186/s12864-017-4355-5
pmid:29258441
pmcid:PMC5735938
fatcat:54pjrujjyzduxeihw42eaq3vri
Genome-enabled insights into the biology of thrips as crop pests
[article]
2020
bioRxiv
pre-print
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Conclusions: Analysis of the F.occidentalis genome offers insights into the polyphagous behavior of this insect pest to find, colonize and survive on a widely diverse array of plants. ...
in agricultural environments; 2) a comprehensive set of salivary gland-associated genes supported by enriched expression; 3) apparent absence of members of the IMD innate immune defense pathway; and 4 ...
642 P450s in other insect genomes. 643 JH and ecdysone titers are tightly regulated via the action of biosynthetic and metabolic 644 genes. ...
doi:10.1101/2020.02.12.941716
fatcat:fnucjymicndd7au5h2vin7o55u
Characterization of Drosophila melanogaster cytochrome P450 genes
2009
Proceedings of the National Academy of Sciences of the United States of America
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In general, functions of insect P450s are less well understood. We characterized Drosophila melanogaster P450 expression patterns in embryos and 2 stages of third instar larvae. ...
Cytochrome P450s form a large and diverse family of hemecontaining proteins capable of carrying out many different enzymatic reactions. ...
It is possible that dGATAe has a role in the regulation of these P450s in the larval midgut. ...
doi:10.1073/pnas.0812141106
pmid:19289821
pmcid:PMC2667016
fatcat:5tmsolsyjba27p2aw2q2d6qapa
Chemosensation and Evolution of Drosophila Host Plant Selection
2019
iScience
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Although some species of the genus Drosophila are generalists for host plant selection, rapid evolution of olfactory receptors, gustatory receptors, odorant-binding proteins, and cytochrome P450s has enabled ...
Among insects, Drosophila melanogaster has the best characterized olfactory system, and the availability of genome sequences of 30 Drosophila species provides an ideal scenario for studies on evolution ...
The number of functional cytochrome P450 genes in each species is indicated in the boxes along with the number of inferred ancestral cytochrome P450 genes. ...
doi:10.1016/j.isci.2019.100799
pmid:31923648
pmcid:PMC6951304
fatcat:txudrmr6xvg5njxk2pofgwmlx4
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