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Regression mutation testing
2012
Proceedings of the 2012 International Symposium on Software Testing and Analysis - ISSTA 2012
This paper presents Regression Mutation Testing (ReMT), a new technique to speed up mutation testing for evolving systems. ...
Mutation testing is one of the most powerful approaches for evaluating quality of test suites. However, mutation testing is also one of the most expensive testing approaches. ...
ACKNOWLEDGEMENTS The authors would like to thank Milos Gligoric and Vilas Jagannath for the initial discussions on regression mutation testing, David Schuler for providing information about Javalanche, ...
doi:10.1145/2338965.2336793
dblp:conf/issta/ZhangMZK12
fatcat:nzqwplexebhm7pvympngjyqovi
Applying Interface-Contract Mutation in Regression Testing of Component-Based Software
2007
Conference on Software Maintenance, Proceedings of the
Regression testing, which plays an important role in software maintenance, usually relies on test adequacy criteria to select and prioritize test cases. ...
The mutation adequacy score for killing the mutants of interface contracts can serve as a test adequacy criterion. ...
Introduction In software maintenance, regression testing is frequently applied to ensure software quality. ...
doi:10.1109/icsm.2007.4362630
dblp:conf/icsm/HouZXMS07
fatcat:3ngamozpi5cwdljj6cl7hye3bq
Longevity Is Linked to Mitochondrial Mutation Rates in Rockfish: A Test Using Poisson Regression
2015
Molecular biology and evolution
We address these challenges using a novel Poisson regression method to examine the link between mutation rate and lifespan in rockfish (Sebastes). ...
Numerous studies have applied comparative approaches to test one of the predictions of the theory: That the rate of mitochondrial mutations is negatively correlated with longevity. ...
FIG. 3 . 3 The statistical power of our Poisson regression method and least-squares regression after Welch and Waxman (2008) test. ...
doi:10.1093/molbev/msv137
pmid:26048547
fatcat:bkp5sfgp5vbyzeavsusexyu6mi
Evaluation of Complete Pathological Regression after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients with BRCA1 Founder Mutation Aided Bayesian A/B Testing Approach
2021
Diagnostics
The aim of this study was to evaluate the probability of pathologic complete regression (pCR) by the BRCA1 gene mutation status in patients with triple-negative breast cancer (TNBC) treated with neoadjuvant ...
Odds ratios and 95% confidence intervals for pCR vs. non-pCR were calculated using logistic regression. ...
Statistical differences, depending on the mutation status of the BRCA1 gene, were estimated using a t-test (equal variance), Welch test (unequal variance), or the chi-square test (categorical variables ...
doi:10.3390/diagnostics11071144
fatcat:r6fctjnjwferzoxiqvtelwmvrq
THE IMPACT OF MUTATION AND PROMOTION ON THE PERFORMANCE OF SOUTH KALIMANTAN GOVERNMENT'S EMPLOYEES
2017
International Journal of Advanced Research
According to t test for mutation (variable X1), it is discovered that this variable has significancy value less than t table value (2,0195), which is (-0,328< t table) and can be concluded that mutation ...
Variables which related to the study were mutation (X1), promotion (X2), and the employees' performance (Y). ...
Regression model used to test the hypothesis is as follow: Y = α + β 1 X 1 + β 2 X 2 + e ………………...………..… (1) Y
= Performance
α
= constanta
1871
β 1 & β 2 = regression coefisient
X1
= mutation ...
doi:10.21474/ijar01/6157
fatcat:tedz2agd3nfb3fnw6rs5elefw4
HIV-1 Protease Mutations and Protease Inhibitor Cross-Resistance
2010
Antimicrobial Agents and Chemotherapy
We then used least-squares regression to ascertain the relative contribution of each of these 46 mutations. ...
We applied least-angle regression (LARS) to the 200 most common mutations in the data set and identified a set of 46 mutations associated with decreased PI susceptibility of which 40 were not polymorphic ...
For each 5-fold cross-validation, 80% of data were used for learning regression coefficients and 20% were used for testing. ...
doi:10.1128/aac.00574-10
pmid:20660676
pmcid:PMC2944562
fatcat:6pqjvnh3vzhxrkhgkf7nlm73ru
BRCA germline mutation test for all woman with ovarian cancer?
2019
BMC Cancer
Conclusions: Our regression tree-analysis can represent an innovative approach taking into consideration all main clinical pathological information to select OC patients to be candidated for BRCA test. ...
Regression tree analysis permitted to individualize a subset of 66% OC patients with particularly low risk (3.5%) to carry a BRCA mutation vs a subgroup (24% of the series), with a probability higher than ...
of 46% of patients, included in Nodes 3 and 5 of the Regression- (Fig. 1) showed a < 3.8% probability only to carry a BRCA mutation. ...
doi:10.1186/s12885-019-5829-4
fatcat:fcroxhyorbhjzmfg7lg4uiwhte
Structure Based Thermostability Prediction Models for Protein Single Point Mutations with Machine Learning Tools
2015
PLoS ONE
Binary and ternary classifications as well as regression models were built and evaluated. ...
Thermostability issue of protein point mutations is a common occurrence in protein engineering. ...
In this case, the test AUC values of most models in the reverse mutations test were lower than those in the forward mutations test. ...
doi:10.1371/journal.pone.0138022
pmid:26361227
pmcid:PMC4567301
fatcat:kzxx2ofluff7hppnutw3b422ay
Genotypic predictors of human immunodeficiency virus type 1 drug resistance
2006
Proceedings of the National Academy of Sciences of the United States of America
, or highly resistant to the drugs used for testing. ...
Least angle regression predicted susceptibility significantly better than other methods when using the complete set of mutations. ...
, nonnucleoside RT inhibitor; SVR, support vector regression; TDF, tenofovir; TSM, treatment-selected mutation. ...
doi:10.1073/pnas.0607274103
pmid:17065321
pmcid:PMC1622926
fatcat:qcqnkuqtvfbdrmjvpjrq3pegxy
Utility of ctDNA in predicting response to neoadjuvant chemoradiotherapy and prognosis assessment in locally advanced rectal cancer: A prospective cohort study
2021
PLoS Medicine
., features of baseline ctDNA, ctDNA clearance, and acquired mutation status) and MRI tumor regression grade (mrTRG), was developed and demonstrated improved performance in predicting pCR/non-pCR (area ...
Ranging from complete tumor regression (pathological tumor regression grade 0; pTRG0) to poor regression (pTRG3), the ctDNA clearance rate during nCRT showed a significant decreasing trend (95.7%, 77.8% ...
Fisher exact test was used for significance test. ...
doi:10.1371/journal.pmed.1003741
pmid:34464382
pmcid:PMC8407540
fatcat:q4hmmgxezvhpvljas7daa6m7uy
Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing
2013
Journal of Antimicrobial Chemotherapy
NNRTI-resistance mutations and for testing older NNRTIs against virus isolates with mutations identified during the evaluation of a novel NNRTI. ...
We used linear regression to estimate the effects of RTmutations on susceptibility to each of these NNRTIs. ...
Our analysis also underscores the need for systematically testing new NNRTIs against clinical virus isolates containing a broad spectrum of major non-polymorphic NNRTIresistance mutations and of testing ...
doi:10.1093/jac/dkt316
pmid:23934770
pmcid:PMC3861329
fatcat:nm5knwzcgfgwllbal3r5njdm3a
Investigation of the epidermal growth factor receptor mutation rate in non-small cell lung cancer patients and the analysis of associated risk factors using logistic regression
2014
Oncology Letters
The logistic regression analysis revealed that the female gender, adenocarcinoma, distant metastasis and chemotherapy are factors associated with EGFR gene mutation (P<0.05). ...
Investigation of the epidermal growth factor receptor mutation rate in non-small cell lung cancer patients and the analysis of associated risk factors using logistic regression ...
T-test/Mann-Whitney U test results for EGFR mutation and EGFR non-mutation in NSCLC patients. (Tables IV and V) . ...
doi:10.3892/ol.2014.2160
pmid:25013503
pmcid:PMC4081401
fatcat:fk7agz6l4rc7hja2weoynhlauu
Correlation of IDH1 Mutation with Clinicopathologic Factors and Prognosis in Primary Glioblastoma: A Report of 118 Patients from China
2012
PLoS ONE
However, in our further multivariable regression analysis, the independent prognostic effect of IDH1 mutation is limited when considering age, preoperative KPS score, extent of resection, TMZ chemotherapy ...
IDH1 mutations were detected in 19/ 118 pGBM cases (16.1%). ...
Correlation of IDH1 mutation with clinicopathologic characteristics were evaluated by two-sided x2 test or Student's t-test between the patient subgroups. ...
doi:10.1371/journal.pone.0030339
pmid:22291938
pmcid:PMC3264567
fatcat:wz5lufvlkverjanepftawntfga
Prediction of PIK3CA mutations from cancer gene expression data
2020
PLoS ONE
We applied a supervised elastic net penalized logistic regression model to predict PIK3CA mutations from gene expression data. ...
This regression approach was applied to predict modeling using the TCGA pan-cancer dataset. Approximately 10,000 cases were available for PIK3CA mutation and mRNA expression data. ...
We applied a supervised elastic net penalized logistic regression model to predict PIK3CA mutations. ...
doi:10.1371/journal.pone.0241514
pmid:33166334
fatcat:col5v266h5gvbiyygfvvhvquiq
Faster mutation testing inspired by test prioritization and reduction
2013
Proceedings of the 2013 International Symposium on Software Testing and Analysis - ISSTA 2013
Mutation testing is a well-known but costly approach for determining test adequacy. ...
The effectiveness of mutation testing in determining the quality of a test suite relies on the ability to apply it using a large number of mutants. ...
The basic intuitions for regression prioritization and FaMT prioritization are similar: to reorder the tests to make regression/mutation testing faster. ...
doi:10.1145/2483760.2483782
dblp:conf/issta/ZhangMK13
fatcat:hla4whbcqjh6ljd2lrark4x45u
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