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Regions of interest analysis in pharmacological fMRI: How do the definition criteria influence the inferred result?

Georgios D. Mitsis, Gian Domenico Iannetti, Trevor S. Smart, Irene Tracey, Richard G. Wise
2008 NeuroImage  
Here we systematically examine the effects of different ROI definition criteria on the results inferred from a hypothesis-driven pharmacological fMRI experiment, with the aim of maximising sensitivity  ...  Prior hypotheses in functional brain imaging are often formulated by constraining the data analysis to regions of interest (ROIs).  ...  GDI is a University Research Fellow of The Royal Society, UK.  ... 
doi:10.1016/j.neuroimage.2007.11.026 pmid:18226552 fatcat:z27qwdaxcnhvfnizudhtor3sce

Null results of oxytocin and vasopressin administration on mentalizing in a large fMRI sample: evidence from a randomized controlled trial

Mark A. Straccia, Adam R. Teed, Perri L. Katzman, Kevin M. Tan, Michael H. Parrish, Michael R. Irwin, Naomi I. Eisenberger, Matthew D. Lieberman, Benjamin A. Tabak
2021 Psychological Medicine  
To understand the potential of either neuropeptide as a pharmacological treatment for individuals with impairments in social cognition, it is important to demonstrate the beneficial effects of OT and AVP  ...  Methods In the present randomized, double-blind, placebo-controlled study (n = 186) of healthy individuals, we examined the effects of OT and AVP administration on behavioral responses and neural activity  ...  The authors thank Saskia Giebl, Shosuke Suzuki, Elizabeth Castle, and Natalie Saragosa-Harris for their assistant in data collection, and Eunji Kim, Zhixing Luo, and Maira Karan for their assistance in  ... 
doi:10.1017/s0033291721004104 fatcat:prl5u7xkwjdszhtwzlc345n2tu

A short history of causal modeling of fMRI data

Klaas Enno Stephan, Alard Roebroeck
2012 NeuroImage  
in the public portal.  ...  Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of  ...  Acknowledgments We would like to thank our friends and colleagues from Zurich, London, Maastricht and from the wider BCW community for many inspiring discussions and exchanges on models of effective connectivity  ... 
doi:10.1016/j.neuroimage.2012.01.034 pmid:22248576 fatcat:nntnrnsz65gsdmrijattswbjja

Monkey Cortex through fMRI Glasses

Wim Vanduffel, Qi Zhu, Guy A. Orban
2014 Neuron  
In 1998 several groups reported the feasibility of fMRI experiments in monkeys, with the goal to bridge the gap between invasive nonhuman primate studies and human functional imaging.  ...  These studies yielded critical insights in the neuronal underpinnings of the BOLD signal.  ...  Q.Z. is post-doctoral fellow of FWO-Vlaanderen. The Martinos Center for Biomedical Imaging is supported by National Center for Research Resources grant P41RR14075.  ... 
doi:10.1016/j.neuron.2014.07.015 pmid:25102559 pmcid:PMC4698430 fatcat:xoqydg27ozgjfe5myvmvriiw2y

Clinical Concepts Emerging from fMRI Functional Connectomics

Paul M. Matthews, Adam Hampshire
2016 Neuron  
Although fMRI has not become a routine clinical tool, research already has had important influences on clinical concepts guiding diagnosis and patient management.  ...  Studies demonstrating the network plasticity possible in adults and the global consequences of even focal brain injuries or disease have had substantial impact on modern concepts of disease evolution and  ...  PMM is in receipt of generous personal and research support from the Edmond J Safra Foundation and Lily Safra, the Medical Research Council and the Engineering and Physics Science Research Council for  ... 
doi:10.1016/j.neuron.2016.07.031 pmid:27497220 fatcat:plsrga55wfeh5jr6a7htpbqtw4

Functional Magnetic Resonance Imaging (fMRI) [chapter]

Robert L. Savoy
2002 Encyclopedia of the Human Brain  
IV Data Analysis A typical fMRI scanning session lasts 1-2 hours and results in the collection of hundreds of megabytes of data.  ...  visualize and report the results of data analysis).  ... 
doi:10.1016/b0-12-227210-2/00146-1 fatcat:2rdtt3plm5guzgqs6a3mlycehe

Simultaneous brain, brainstem and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia

Valeria Oliva, Ron Hartley-Davies, Rosalyn Moran, Anthony E Pickering, Jonathan CW Brooks
2022 eLife  
To determine which pathway modulates nociceptive activity in humans we used simultaneous whole brain-spinal cord pharmacological-fMRI (N=39) across three sessions.  ...  Activity in an adjacent cluster reported the interaction between task and noxious stimulus.  ...  of good pharmacological tools to resolve the influence of this challenging target.  ... 
doi:10.7554/elife.71877 pmid:35080494 pmcid:PMC8843089 fatcat:erzh3gygyza4rdtmcwlh65qkju

The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram

D. Arnone, T. Wise, C. Walker, P.J. Cowen, O. Howes, S. Selvaraj
2018 Progress in Neuro-psychopharmacology and Biological Psychiatry  
Acknowledgements This study was supported by Academy of Medical Sciences UK grant to Dr Selvaraj (no. AMS-SGCL6) and by  ...  Seed region of interest definition Default mode network regions were identified using group Canonical ICA (Varoquaux et al., 2010) with 20 clusters.  ...  To minimise the influence of head motion on our results, we performed motion scrubbing.  ... 
doi:10.1016/j.pnpbp.2018.01.021 pmid:29409920 pmcid:PMC5886357 fatcat:hghze2u3dzfc7nbttx7l243cnm

Some Points to Consider in a Task-Based fMRI Study: A Guideline for Beginners

Seyed Amir Hossein Batouli, Minoo Sisakhti
2020 Frontiers in biomedical technologies  
The influences of the demographics of the participants, stimuli design, image acquisition, and data analysis methods on the fMRI results are illustrated previously.  ...  In this manuscript, by reviewing the methodology of over one hundred task-based fMRI studies, around 300 substantial tips regarding the different stages of an fMRI experiment are gathered.  ...  However, a few points should be in mind when making inferences of the fMRI results.  ... 
doi:10.18502/fbt.v7i1.2725 fatcat:qqffjtxjb5eopezbrlaz3p3fua

Group-constrained sparse fMRI connectivity modeling for mild cognitive impairment identification

Chong-Yaw Wee, Pew-Thian Yap, Daoqiang Zhang, Lihong Wang, Dinggang Shen
2013 Brain Structure and Function  
To this end, we formulate the R-fMRI time series of each region of interest (ROI) as a linear representation of time series of other ROIs to infer sparse connectivity networks that are topologically identical  ...  We validated the proposed modeling in mild cognitive impairment identification and promising results achieved demonstrate its superiority in disease characterization, particularly greater sensitivity to  ...  ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Abbott; Alzheimer's Association  ... 
doi:10.1007/s00429-013-0524-8 pmid:23468090 pmcid:PMC3710527 fatcat:5mkoejwwvvfc5p7o3iowww6i7m

Evidence for a hijacked brain reward system but no desensitized threat system in quitting motivated smokers: An fMRI study

Stefanie L. Kunas, Heiner Stuke, Andreas Heinz, Andreas Ströhle, Felix Bermpohl
2021 Addiction  
Adult participants (n = 38 TUD subjects and n = 42 never-smokers) were recruited in Berlin, Germany. As contrasts of primary interest, the interactions of group × stimulus-type were assessed.  ...  Several aspects of how quitting-motivated tobacco use disorder (TUD) subjects and never-smokers differ in terms of reward and threat processing remain unresolved.  ...  The study is funded by the German Research Foundation (DFG, Project-ID 402170461, TRR265). DECLARATION OF INTERESTS None.  ... 
doi:10.1111/add.15651 pmid:34312937 fatcat:fpb7pwn73fdnrj2kzv7cj3phwq

Questions and controversies in the study of time-varying functional connectivity in resting fMRI

Daniel J. Lurie, Daniel Kessler, Danielle S. Bassett, Richard F. Betzel, Michael Breakspear, Shella Keilholz, Aaron Kucyi, Raphaël Liégeois, Martin A. Lindquist, Anthony Randal McIntosh, Russell A. Poldrack, James M. Shine (+11 others)
2019 Network Neuroscience  
The possibility of studying these dynamics through careful analysis of neuroimaging data has catalyzed substantial interest in methods which estimate time-resolved fluctuations in functional connectivity  ...  The brain is a complex, multiscale dynamical system composed of many interacting regions.  ...  We also thank Abraham Snyder, Jean-Baptiste Poline, Ted Satterthwaite, Caterina Gratton, and Nico Dosenbach for their participation in the discussion that inspired us to write this review.  ... 
doi:10.1162/netn_a_00116 pmid:32043043 pmcid:PMC7006871 fatcat:ot3p632kojfd5cxe4ud44fmbla

Model-free group analysis shows altered BOLD FMRI networks in dementia

Serge A.R.B. Rombouts, Jessica S. Damoiseaux, Rutger Goekoop, Frederik Barkhof, Philip Scheltens, Stephen M. Smith, Christian F. Beckmann
2009 Human Brain Mapping  
FMRI research in Alzheimer's disease (AD) and mild cognitive impairment (MCI) typically is aimed at determining regional changes in brain function, most commonly by creating a model of the expected BOLD-response  ...  Exploratory data analysis techniques such as independent component analysis (ICA) do not depend on these assumptions and are able to detect unknown, yet structured spatiotemporal processes in neuroimaging  ...  In general, the definition of such selection criteria may not be as straightforward as in this study.  ... 
doi:10.1002/hbm.20505 pmid:18041738 fatcat:szxx4qxotjhzjc2xvgbvi2kine

Comparing dynamic causal models of neurovascular coupling with fMRI and EEG/MEG

Amirhossein Jafarian, Vladimir Litvak, Hayriye Cagnan, Karl J. Friston, Peter Zeidman
2020 NeuroImage  
First, fMRI data are used to localise regionally specific neuronal responses.  ...  The coordinates of these responses are then used as the location priors in a DCM of electrophysiological responses elicited by the same paradigm.  ...  We are grateful to Marta Garrido for helpful conversations about the design of the oddball task, to Martin Havlí cek for helpful advice about haemodynamics, and to Alphonso Reid and Clive Negus for their  ... 
doi:10.1016/j.neuroimage.2020.116734 pmid:32179105 pmcid:PMC7322559 fatcat:gqooqkjq2bhffmf37papps67ry

A systematic review of fMRI neurofeedback reporting and effects in clinical populations

Anita Tursic, Judith Eck, Michael Lührs, David E. J. Linden, Rainer Goebel
2020 NeuroImage: Clinical  
In order to evaluate the evidence of clinical benefits and investigate how consistently studies report their methods and results, an exhaustive search of fMRI neurofeedback studies in clinical populations  ...  To establish fMRI neurofeedback as a clinical tool, more emphasis should be placed in the future on using larger sample sizes determined through a priori power calculations and standardization of procedures  ...  The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Anita Tursic, Judith Eck, Michael Lührs and Rainer Goebel are employed  ... 
doi:10.1016/j.nicl.2020.102496 pmid:33395987 pmcid:PMC7724376 fatcat:ljkkatoykva7nddyrsnt7a37ky
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