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Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer's disease

Milap A. Nowrangi, Constantine G. Lyketsos, Jeannie-Marie S. Leoutsakos, Kenichi Oishi, Marilyn Albert, Susumu Mori, Michelle M. Mielke
2013 Alzheimer's & Dementia  
Background-Diffusion tensor imaging (DTI) is a promising method for identifying significant cross-sectional differences of white-matter tracts in normal controls (NC) and those with mild cognitive impairment  ...  (MCI) or Alzheimer's disease (AD).  ...  This research was funded in part by grants from GlaxoSmithKline and the National Institute on Aging (P50-AG005146, P50-AG021334, and R21 AG033774) and by grants from the National Institutes of Health (  ... 
doi:10.1016/j.jalz.2012.05.2186 pmid:23245561 pmcid:PMC3639296 fatcat:ndhtkr5kpndlnafwfdy4tlmio4

Fibre-specific white matter reductions in Alzheimer's disease and mild cognitive impairment

Remika Mito, David Raffelt, Thijs Dhollander, David N Vaughan, J-Donald Tournier, Olivier Salvado, Amy Brodtmann, Christopher C Rowe, Victor L Villemagne, Alan Connelly
2018 Brain  
loss in people with Alzheimer's disease and mild cognitive impairment.  ...  Diffusion MRI data from Alzheimer's disease (n=49), mild cognitive impairment (n=33), and healthy elderly control subjects (n=95) were obtained from the Australian Imaging, Biomarkers and Lifestyle study  ...  Acknowledgements We thank the patients, researchers and clinicians involved in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, and Dr Vincent Doré for his assistance in coordinating  ... 
doi:10.1093/brain/awx355 pmid:29309541 fatcat:fixbsmcxqbanxb3xprfe44ceea

Diffusion Tensor Metrics as Biomarkers in Alzheimer's Disease

Julio Acosta-Cabronero, Stephanie Alley, Guy B. Williams, George Pengas, Peter J. Nestor, Wang Zhan
2012 PLoS ONE  
There is also, at present, little knowledge of how the biometric properties of diffusion tensor imaging might evolve in the course of Alzheimer's disease.  ...  Although diffusion tensor imaging has been a major research focus for Alzheimer's disease in recent years, it remains unclear whether it has sufficient stability to have biomarker potential.  ...  Acknowledgments We are grateful for the support from our patients and healthy volunteers. Author Contributions  ... 
doi:10.1371/journal.pone.0049072 pmid:23145075 pmcid:PMC3492261 fatcat:fg7guos3cnhjjgbfodbuqsd6l4

Gray and White Matter Changes in Subjective Cognitive Impairment, Amnestic Mild Cognitive Impairment and Alzheimer's Disease: A Voxel-Based Analysis Study

Kuniaki Kiuchi, Soichiro Kitamura, Toshiaki Taoka, Fumihiko Yasuno, Masami Tanimura, Kiwamu Matsuoka, Daisuke Ikawa, Michihiro Toritsuka, Kazumichi Hashimoto, Manabu Makinodan, Jun Kosaka, Masayuki Morikawa (+3 others)
2014 PLoS ONE  
To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease.  ...  Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes.  ...  NC indicates normal control; SCI, subjective cognitive impairment; MCI, mild cognitive impairment; AD, Alzheimer's disease.  ... 
doi:10.1371/journal.pone.0104007 pmid:25093415 pmcid:PMC4122459 fatcat:w67b57cnqneozm3jo33enlzdse

Multilevel diffusion tensor imaging classification technique for characterizing neurobehavioral disorders

Josué Luiz Dalboni da Rocha, Gabriel Coutinho, Ivanei Bramati, Fernanda Tovar Moll, Ranganatha Sitaram
2018 Brain Imaging and Behavior  
impairment, and 83% between mild cognitive impairment and healthy controls.  ...  For validation proposes, this multilevel approach achieved an average classification accuracy of 90% between Alzheimer's disease and healthy controls, 83% between Alzheimer's disease and mild cognitive  ...  Acknowledgements The senior author of this study was supported by the Indigo Project FKZ 01DQ13004, and Fondecyt Regular projects number 1171313 and number 1171320.  ... 
doi:10.1007/s11682-018-0002-2 pmid:30519999 fatcat:3wf3prw4ejfb5cxudcn3v4epv4

Morphological and Microstructural Changes of the Hippocampus in Early MCI: A Study Utilizing the Alzheimer's Disease Neuroimaging Initiative Database

Peter Lee, Hojin Ryoo, Jinah Park, Yong Jeong
2017 Journal of Clinical Neurology  
impairment (EMCI) and late mild cognitive impairment (LMCI).  ...  and Purpose With the aim of facilitating the early detection of Alzheimer's disease, the Alzheimer's Disease Neuroimaging Initiative proposed two stages based on the memory performance: early mild cognitive  ...  Acknowledgements This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and  ... 
doi:10.3988/jcn.2017.13.2.144 pmid:28176504 pmcid:PMC5392456 fatcat:rosyqmdjyratfkbfqg7ci4fedi

White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study

David Medina, Leyla deToledo-Morrell, Fabio Urresta, John D.E. Gabrieli, Michael Moseley, Debra Fleischman, David A. Bennett, Sue Leurgans, David A. Turner, Glenn T. Stebbins
2006 Neurobiology of Aging  
In this study, we examined WM changes in patients with Alzheimer's disease (AD) and in subjects with amnestic mild cognitive impairment (MCI) who are at greater risk for developing AD.  ...  Diffusion tensor imaging (DTI) can detect, in vivo, the directionality of molecular diffusion and estimate the microstructural integrity of white matter (WM) tracts.  ...  We also thank the staff of the RADC clinic, especially Barbara Eubler, for an outstanding job in recruiting participants in the study, and the reviewers for their insightful comments on an earlier draft  ... 
doi:10.1016/j.neurobiolaging.2005.03.026 pmid:16005548 fatcat:6hxz44hgwfgkreheq3fsl72vva

Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity

Joana B Pereira, Rik Ossenkoppele, Sebastian Palmqvist, Tor Olof Strandberg, Ruben Smith, Eric Westman, Oskar Hansson
2019 eLife  
The abnormal accumulation of amyloid-β and tau targets specific spatial networks in Alzheimer's disease.  ...  Alzheimer's disease.  ...  Marianne and Marcus Wallenberg foundation (OH), the Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson's disease) at Lund University (OH, SP), the Swedish Alzheimer Foundation  ... 
doi:10.7554/elife.50830 pmid:31815669 pmcid:PMC6938400 fatcat:vlfhvk6rljh4hoqiriookz4mga

Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment

S E Rose
2006 Journal of Neurology, Neurosurgery and Psychiatry  
Magnetic resonance diffusion tensor imaging (DTI) shows promise in the early detection of microstructural pathophysiological changes in the brain.  ...  Objectives: To measure microstructural differences in the brains of participants with amnestic mild cognitive impairment (MCI) compared with an age-matched control group using an optimised DTI technique  ...  tangle formation or some other neuropathological Abbreviations: ARWMC, age-related white matter change; DTI, diffusion tensor imaging; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination  ... 
doi:10.1136/jnnp.2005.074336 pmid:16754694 pmcid:PMC2077533 fatcat:b6h62nalc5hwta7y6i6fgkmqoa

Group-Level Progressive Alterations in Brain Connectivity Patterns Revealed by Diffusion-Tensor Brain Networks across Severity Stages in Alzheimer's Disease

Javier Rasero, Carmen Alonso-Montes, Ibai Diez, Laiene Olabarrieta-Landa, Lakhdar Remaki, Iñaki Escudero, Beatriz Mateos, Paolo Bonifazi, Manuel Fernandez, Juan Carlos Arango-Lasprilla, Sebastiano Stramaglia, Jesus M. Cortes
2017 Frontiers in Aging Neuroscience  
control subjects, Control), G 2 ( N 2 =36 , early mild cognitive impairment, EMCI), G 3 ( N 3 =36 , late mild cognitive impairment, LMCI) and G 4 ( N 4 =36 , AD).  ...  applied to diffusion-tensor data.  ...  stage and in mild cognitive impairment.  ... 
doi:10.3389/fnagi.2017.00215 pmid:28736521 pmcid:PMC5500648 fatcat:irtihmusujazddscclnabx5ali

Assessment of the quality of brain regions and neuroimaging metrics as biomarkers of Alzheimer's Disease

Tânia Vaz, Filipa Lucena, Joana Pé-Leve, André Ribeiro, Luís Lacerda, Nuno da Silva, David Nutt, John McGonigle, Hugo Ferreira
2015 EJNMMI Physics  
Initiative database, specifically 12healthy controls (CTRL) and 33 patients with early mild cognitive impairment (EMCI), late MCI (LMCI) and AD (11 patients/group).  ...  Multimodal Imaging Brain Connectivity Analysis (MIBCA) toolbox functionalities were used to study AD by T1weighted, Diffusion Tensor Imaging and 18FAV45 PET, with data obtained from the AD Neuroimaging  ...  Initiative database, specifically 12healthy controls (CTRL) and 33 patients with early mild cognitive impairment (EMCI), late MCI (LMCI) and AD (11 patients/group).  ... 
doi:10.1186/2197-7364-2-s1-a46 pmid:26956304 pmcid:PMC4798696 fatcat:6arer22tlbd3xjks2xt5d7picm

Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer's disease with and without cerebrovascular disease

Fang Ji, Ofer Pasternak, Siwei Liu, Yng Miin Loke, Boon Linn Choo, Saima Hilal, Xin Xu, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Juan Zhou
2017 Alzheimer's Research & Therapy  
Mixed vascular and neurodegenerative dementia, such as Alzheimer's disease (AD) with concomitant cerebrovascular disease, has emerged as the leading cause of age-related cognitive impairment.  ...  The brain white matter (WM) microstructural changes in neurodegeneration well-documented by diffusion tensor imaging (DTI) can originate from brain tissue or extracellular free water changes.  ...  Keywords: Alzheimer's disease, Cerebrovascular disease, Diffusion tensor imaging, Free water imaging, Extracellular water, Vascular damage, Cognitive impairment Background Mixed vascular and neurodegenerative  ... 
doi:10.1186/s13195-017-0292-4 pmid:28818116 pmcid:PMC5561637 fatcat:tryva6n5jzawjc36yvxuutrs7u

The Fornix in Mild Cognitive Impairment and Alzheimer's Disease

Milap A. Nowrangi, Paul B. Rosenberg
2015 Frontiers in Aging Neuroscience  
It serves a vital role in memory functions and as such has 28 become the subject of recent research emphasis in Alzheimer's disease (AD) and Mild 29 Cognitive Impairment (MCI).  ...  Though gray matter atrophy has been the 32 most studied, degradation of white matter structures especially the fornix may precede these 33 and has become detectable with use of diffusion tensor imaging  ...  Copenhaver BR, Rabin LA, Saykin AJ, Roth RM, Wishart HA, Flashman LA, Santulli RB, McHugh TL, Mamourian AC: The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment  ... 
doi:10.3389/fnagi.2015.00001 pmid:25653617 pmcid:PMC4301006 fatcat:ib7kh55obvc5jnbnclmm7czvku

Group-level progressive alterations in brain connectivity patterns revealed by diffusion-tensor brain networks across severity stages in Alzheimer's disease [article]

Javier Rasero, Carmen Alonso-Montes, Ibai Diez, Laiene Olabarrieta-Landa, Lakhdar Remaki, Iñaki Escudero, Beatriz Mateos Goñi, Paolo Bonifazi, Manuel Fernandez Martinez, Juan Carlos Arango-Lasprilla, Sebastiano Stramaglia, Jesus M Cortes
2017 bioRxiv   pre-print
participants, HC), G2 (N2=36, early mild cognitive impairment, EMCI), G3 (N3=36, late mild cognitive impairment, LMCI) and G4 (N4=36, AD).  ...  applied to diffusion-tensor data.  ...  stage and in mild cognitive impairment.  ... 
doi:10.1101/105270 fatcat:hul2tk5nzng5fead7k4zkqblty

Detection of gray matter microstructural changes in Alzheimer's disease continuum using fiber orientation

Peter Lee, for the Alzheimer's Disease Neuroimaging Initiative, Hang-Rai Kim, Yong Jeong
2020 BMC Neurology  
Methods We analyzed neuroimages from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including images from 78 cognitively normal (CN), 50 early mild cognitive impairment (EMCI), 34 late  ...  mild cognitive impairment (LMCI), and 39 AD patients.  ...  Acknowledgements Data collection and designing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department  ... 
doi:10.1186/s12883-020-01939-2 pmid:33008321 fatcat:4kwomqyinvc5jod5i6jgw6o4pq
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