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Regional white matter volume differences in nondemented aging and Alzheimer's disease

D SALAT, D GREVE, J PACHECO, B QUINN, K HELMER, R BUCKNER, B FISCHL
2009 NeuroImage  
Accumulating evidence suggests that altered cerebral white matter (WM) influences normal aging, and further that WM degeneration may modulate the clinical expression of Alzheimer's disease (AD).  ...  Here we conducted a study of differences in WM volume across the adult age span and in AD employing a newly developed, automated method for regional parcellation of the subcortical WM that uses curvature  ...  Martinos Center for Biomedical Imaging, NINR NR010827, NIA AG024898, AG05886, AG05681, HHMI, HBP NS39581 and RR14075. We thank the Washington University ADRC for making MRI data available.  ... 
doi:10.1016/j.neuroimage.2008.10.030 pmid:19027860 pmcid:PMC2810540 fatcat:kn7y35752vdpfpuer2hfinoj5i

Frontal-Hippocampal Double Dissociation Between Normal Aging and Alzheimer's Disease

Denise Head, Abraham Z. Snyder, Laura E. Girton, John C. Morris, Randy L. Buckner
2004 Cerebral Cortex  
A separate process, ubiquitous in aging, affects brain white matter with an anteriorto-posterior gradient and may underlie the executive difficulties common in aging.  ...  Controversy persists regarding whether Alzheimer's disease (AD) is a distinct entity or instead exists on a continuum with nondemented aging.  ...  aging may be relatively greater in anterior regions (gray and white matter) and striatal structures.  ... 
doi:10.1093/cercor/bhh174 pmid:15371293 fatcat:6unl4fmhcrcghcx34qqlwnso74

Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease

D.H. Salat, J.J. Chen, A.J. van der Kouwe, D.N. Greve, B. Fischl, H.D. Rosas
2011 NeuroImage  
Recent studies have demonstrated alterations in cortical gray to white matter tissue contrast with nondemented aging and in individuals with Alzheimer's disease (AD).  ...  Decreases in tissue contrast were associated with hippocampal volume, however, the regional patterns of these associations differed for demented and nondemented individuals.  ...  Randy Buckner for his comments on this work, and for his support in the use of the OASIS dataset: Grants P50 AG05681, P01 AG03991, R01 AG021910, P50 MH071616, U24 RR021382, R01 MH56584.  ... 
doi:10.1016/j.neuroimage.2010.10.034 pmid:20965261 pmcid:PMC3021138 fatcat:mgnt7js35ndedavirbctmcymba

Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging

Jeffrey M. Burns, Robyn A. Honea, Eric D. Vidoni, Lewis J. Hutfles, William M. Brooks, Russell H. Swerdlow
2012 Biochimica et Biophysica Acta - Molecular Basis of Disease  
We assessed the relationship of insulin resistance with cognitive decline and brain atrophy over two years in early Alzheimer's disease (AD, n = 48) and nondemented controls (n = 61).  ...  This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.  ...  Acknowledgements This study was supported by grants R03 AG026374 and R21 AG029615 from the National Institutes of Aging, K23NS058252 from the National Institute on Neurological Disorders and Stroke, and  ... 
doi:10.1016/j.bbadis.2011.06.011 pmid:21745566 pmcid:PMC3264795 fatcat:jfhqn6ihujabfc6bhnuhzhbhju

Memory and Executive Function in Aging and AD

Randy L. Buckner
2004 Neuron  
Aging 17, 85-100. orders in aging and age-related diseases. . Double disrelated differences in neural activity during memory encoding and sociation between item and source memory.  ...  Severe memory impairment, such as experi-to white matter change, atrophy, and certain forms of neurotransmitter depletion.  ...  Several DTI studies note age-associated differences in Remembering source information and temporal details white matter that are present in nondemented aging and of past episodes appears to be particularly  ... 
doi:10.1016/j.neuron.2004.09.006 pmid:15450170 fatcat:btrivvso3je5harievyvnkeuru

Impact of APOE on the Healthy Aging Brain: A Voxel-Based MRI and DTI Study

Robyn A. Honea, Eric Vidoni, Amith Harsha, Jeffrey M. Burns
2009 Journal of Alzheimer's Disease  
In conclusion, the presence of an APOEε4 allele in nondemented older adults is associated with decreases in cognition and gray and white matter changes in the medial temporal cortex.  ...  To date, few studies have used automated morphological analysis techniques to assess APOEε4-related brain structure change in both gray and white matter in nondemented older adults.  ...  Acknowledgments This study was supported by grants R03 AG026374 and R21 AG029615 from the National Institutes of Aging and K23NS058252 from the National Institute on Neurological Disorders and Stroke.  ... 
doi:10.3233/jad-2009-1163 pmid:19584447 pmcid:PMC2892293 fatcat:jmllx46xajb6bpumkn6b4vlzn4

Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer Disease

Robyn A. Honea, George P. Thomas, Amith Harsha, Heather S. Anderson, Joseph E. Donnelly, William M. Brooks, Jeffrey M. Burns
2009 Alzheimer Disease and Associated Disorders  
Exercise and cardiorespiratory (CR) fitness may moderate age-related regional brain changes in nondemented (ND) older adults.  ...  We analyzed the relationship of CR fitness with white and gray matter within groups, assessed fitness-related brain volume change in areas most affected by AD-related atrophy, and then analyzed differential  ...  Acknowledgments This study was supported by grants R03AG026374 and R21 AG029615 from the National Institutes of Aging and K23NS058252 from the National Institute on Neurological Disorders and Stroke.  ... 
doi:10.1097/wad.0b013e31819cb8a2 pmid:19812458 pmcid:PMC2760037 fatcat:ixn42aaxezdm7hwknykcgdludu

Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults

Ming Fan, Bing Liu, Yuan Zhou, Xiantong Zhen, Cunlu Xu, Tianzi Jiang
2010 Neuroscience Letters  
Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904).  ...  The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San  ...  To ensure the accuracy of the segmentation, we manually checked the interface between the grey matter and white matter as well as the one between the white matter and the cerebrospinal fluid (CSF), and  ... 
doi:10.1016/j.neulet.2010.05.092 pmid:20573574 pmcid:PMC2954463 fatcat:gy6gwl3k7rdlbc4zypyntonuw4

Neural Correlates of Impaired Functional Independence in Early Alzheimer's Disease

Eric D. Vidoni, Robyn A. Honea, Jeffrey M. Burns
2010 Journal of Alzheimer's Disease  
Cognitive and physical decline are important predictors of functional independence in Alzheimer's disease (AD).  ...  Imaging evidence revealed that in AD, regional gray matter atrophy measures in medial frontal and temporo-parietal areas were related to decreased cognition, physical function, and independence.  ...  Acknowledgments This study was supported by grants R03 AG026374 and R21 AG029615 from the National Institutes of Aging and K23 NS058252 from the National Institute on Neurological Disorders and Stroke.  ... 
doi:10.3233/jad-2010-1245 pmid:20110598 pmcid:PMC2891926 fatcat:i7zno5t6wzgyzptppfhcqdgkte

Cortical and Hippocampal Atrophy in Patients with Autosomal Dominant Familial Alzheimer's Disease

Liana G. Apostolova, Kristy S. Hwang, Luis D. Medina, Amity E. Green, Meredith N. Braskie, Rebecca A. Dutton, Jeffrey Lai, Daniel H. Geschwind, Jeffrey L. Cummings, Paul M. Thompson, John M. Ringman
2011 Dementia and Geriatric Cognitive Disorders  
All analyses were corrected for age and relative age (years to median age of disease onset in the family).  ...  Abstract Background: Both familial and sporadic Alzheimer's disease (AD) result in progressive cortical and subcortical atrophy.  ...  , NCRR RR019771; NIH RR021813, PHS K08 AG-22228, M01-RR00865, California DHS No. 04-35522, the Goldberg Trust, and the Sidell-Kagan Foundation.  ... 
doi:10.1159/000330471 pmid:21952501 pmcid:PMC3222115 fatcat:fx32wpfaxfd4lfu2p7dxy6qjvy

Differential Vulnerability of Anterior White Matter in Nondemented Aging with Minimal Acceleration in Dementia of the Alzheimer Type: Evidence from Diffusion Tensor Imaging

D. Head
2004 Cerebral Cortex  
These data revealed age differences in anisotropy and diffusivity in all assessed regions.  ...  Taken collectively, these results indicate that nondemented aging is characterized by significant changes in white matter most prominently in anterior brain regions.  ...  McDonnell Foundation program in cognitive neuroscience, and the Howard Hughes Medical Institute.  ... 
doi:10.1093/cercor/bhh003 pmid:15028645 fatcat:3rifa6wyrbcw5mqeq46qqv6bju

White matter hypointensities and hyperintensities have equivalent correlations with age and CSF β‐amyloid in the nondemented elderly

Ke Wei, Thao Tran, Karen Chu, Matthew T. Borzage, Meredith N. Braskie, Michael G. Harrington, Kevin S. King
2019 Brain and Behavior  
We evaluated associations between white matter hyperintensity (WM-hyper) volume from FLAIR and white matter hypointensity (WM-hypo) volume from T1-weighted images and compared their associations with age  ...  Leukoaraiosis results in signal abnormalities on T1-weighted images, which are automatically quantified by FreeSurfer, but this marker is poorly characterized and is rarely used.  ...  However, we observed some differences in spatial distribution: WM-hypo distribution is predominantly in the periventricular region, whereas WM-hyper extended more into the deep white matter(Figure 2).  ... 
doi:10.1002/brb3.1457 pmid:31692294 pmcid:PMC6908861 fatcat:ebtr7hcgqzabxey3rroq6dhbdu

Cardiorespiratory fitness and brain atrophy in early Alzheimer disease

J. M. Burns, B. B. Cronk, H. S. Anderson, J. E. Donnelly, G. P. Thomas, A. Harsha, W. M. Brooks, R. H. Swerdlow
2008 Neurology  
In early AD, VO 2 peak was associated with whole brain volume (beta=0.35, p=0.02) and white matter volume (beta=0.35, p=0.04) after controlling for age.  ...  Objective-Examine the correlation of cardiorespiratory fitness with brain atrophy and cognition in early-stage Alzheimer's disease (AD).  ...  Acknowledgments This study was supported by grants R03AG026374 and R21 AG029615 from the National Institutes of Aging and K23NS058252 from the National Institute on Neurological Disorders and Stroke and  ... 
doi:10.1212/01.wnl.0000317094.86209.cb pmid:18625967 pmcid:PMC2657657 fatcat:ryor5wekazdx3l2iy65bqsnfpu

Structural Imaging Measures of Brain Aging

Samuel N. Lockhart, Charles DeCarli
2014 Neuropsychology Review  
The findings reveal highly consistent age-related differences in brain structure, particularly frontal lobe and medial temporal regions that are also accompanied by age-related differences in frontal and  ...  Newer findings also suggest that degeneration of specific white matter tracts such as those passing through the genu and splenium of the corpus callosum may also be related to age-related differences in  ...  to posterior white matter decline, and poorer episodic memory was associated with age-related differences in central white matter regions.  ... 
doi:10.1007/s11065-014-9268-3 pmid:25146995 pmcid:PMC4163469 fatcat:ue4tgbj3ife6hmpkb5c4lyiaua

A radiologic study of dynamic processes in lacunar dementia

Y Tanaka, O Tanaka, Y Mizuno, M Yoshida
1989 Stroke  
Our findings suggest that in most patients with lacunar stroke, periventricular and subcortical white matter lesions with subsequent white matter atrophy first induce ventricular enlargement, followed  ...  We evaluated the extent of white matter lesions and the degree of atrophy of specific anatomic structures, such as the corpus callosum, using magnetic resonance imaging and quantified the volumes of the  ...  Some investigators 24 -36 - 39 have suggested a close correlation, whereas others 15 -40 have found no difference in the severity of white matter lesions between nondemented and demented patients.  ... 
doi:10.1161/01.str.20.11.1488 pmid:2815183 fatcat:olbewhr53bdytko4u7ld6cf2cq
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