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Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)

B. Draganski, J. Ashburner, C. Hutton, F. Kherif, R.S.J. Frackowiak, G. Helms, N. Weiskopf
2011 NeuroImage  
Using a whole-brain approach in a cohort of 26 adults, aged 18-85 years, we performed voxel-based morphometric (VBM) analysis and voxel-based quantification (VBQ) of diffusion tensor, magnetization transfer  ...  VBQ of white matter revealed distinct anatomical patterns of age-related change in microstructure.  ...  Acknowledgment This study and open access to the publication were supported by the Wellcome Trust.  ... 
doi:10.1016/j.neuroimage.2011.01.052 pmid:21277375 pmcid:PMC3093621 fatcat:ff53tqdqdbhp7a4vuozx77gr3e

Insula and somatosensory cortical myelination and iron markers underlie individual differences in empathy

Micah Allen, Darya Frank, James C. Glen, Francesca Fardo, Martina F. Callaghan, Geraint Rees
2017 Scientific Reports  
Here we use a recently developed quantitative MRI technique to examine the neurobiological factors underlying individual differences in cognitive and affective empathy, as captured by the Interpersonal  ...  In particular, individual differences in cognitive empathy were associated with markers of myeloarchitectural integrity of the insular cortex, while affective empathy was predicted by a marker of iron  ...  Acknowledgements This work was supported by a Wellcome Trust grant 100227 (M.A., G.R.). The Wellcome Trust Centre for Neuroimaging is supported by core funding from the Wellcome Trust 091593/Z/10/Z.  ... 
doi:10.1038/srep43316 pmid:28256532 pmcid:PMC5335674 fatcat:awtmn64pbfhx7biezjbu3t7lqm

Brain tissue properties and morphometry assessment after chronic complete spinal cord injury [article]

Andreas Hug, Adriano Bernini, Haili Wang, Antoine Lutti, Johann Jende, Markus Boettinger, Marc-Andre Weber, Norbert Weidner, Simone Lang
2019 bioRxiv   pre-print
Using the established computational anatomy methods of voxel-based morphometry (VBM) and voxel-based quantification (VBQ) we performed statistical analyses of grey matter volume and parameter maps indicative  ...  Structural changes in the brain representing remote changes in the course of chronic SCI could not be confirmed with conventional VBM or VBQ statistical analysis.  ...  (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.  ... 
doi:10.1101/547620 fatcat:epcslcay2ncvfiaokmlshpurvu

Voxel-Based quantitative MRI reveals spatial patterns of grey matter alteration in multiple sclerosis

Emilie Lommers, Camille Guillemin, Gilles Reuter, Eve Fouarge, Gaël Delrue, Fabienne Collette, Christian Degueldre, Evelyne Balteau, Pierre Maquet, Christophe Phillips
2020 Human Brain Mapping  
Voxel-based quantification (VBQ) and voxel-based morphometry (VBM) statistical analyses were carried out using multiple linear regression models.  ...  In conclusion, this quantitative multiparametric voxel-based approach reveals three different spatially-segregated combinations of GM microstructural/volumetric alterations in MS that might be associated  ...  In this paper, we precisely provide a whole-brain voxel-based quantification (VBQ) of three qMRI parameters-MT saturation, R1 and R2*, derived from data acquired in a single MR session-and assess the spatial  ... 
doi:10.1002/hbm.25274 pmid:33155763 pmcid:PMC7856642 fatcat:eshdgoc7rngrpg6uxyjspzzifq

Specific white matter tissue microstructure changes associated with obesity

Stephanie Kullmann, Martina F. Callaghan, Martin Heni, Nikolaus Weiskopf, Klaus Scheffler, Hans-Ulrich Häring, Andreas Fritsche, Ralf Veit, Hubert Preissl
2016 NeuroImage  
By means of multi-parameter mapping, white matter structures showed differences in MRI parameters consistent with reduced myelin, increased water and altered iron content with increasing BMI in the superior  ...  To increase the specificity of DTI results, we explored specific brain tissue properties by combining DTI with quantitative multiparameter mapping in lean, overweight and obese young adults.  ...  Acknowledgments The study was supported in part by a grant (01GI0925) from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V.) and by the  ... 
doi:10.1016/j.neuroimage.2015.10.006 pmid:26458514 pmcid:PMC4692452 fatcat:paxzcnfpd5bkjegqaxpxaz32eq

Metacognitive ability correlates with hippocampal and prefrontal microstructure

Micah Allen, James C. Glen, Daniel Müllensiefen, Dietrich Samuel Schwarzkopf, Francesca Fardo, Darya Frank, Martina F. Callaghan, Geraint Rees
2017 NeuroImage  
Specifically, we examined how neuroimaging markers of local grey matter myelination and iron content relate to insight as measured by a signal-theoretic model of subjective confidence.  ...  In contrast, decreased myelination in the left hippocampus correlated with better metacognitive insight.  ...  The Wellcome Trust Centre for Neuroimaging is supported by core funding from the Wellcome Trust 091593/Z/10/Z.  ... 
doi:10.1016/j.neuroimage.2017.02.008 pmid:28179164 pmcid:PMC5387158 fatcat:3suxga4knzb7zmuil6qpaht3ba

Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging

Martina F. Callaghan, Patrick Freund, Bogdan Draganski, Elaine Anderson, Marinella Cappelletti, Rumana Chowdhury, Joern Diedrichsen, Thomas H.B. FitzGerald, Peter Smittenaar, Gunther Helms, Antoine Lutti, Nikolaus Weiskopf
2014 Neurobiology of Aging  
Whole-brain voxel-wise analysis revealed a global pattern of age-related degeneration. Significant demyelination occurred principally in the white matter.  ...  This study aims to characterize the spatial pattern and age-related differences of biologically relevant measures in vivo over the course of normal aging.  ...  The Wellcome Trust Centre for Neuroimaging is supported by core funding from the Wellcome Trust 091593/Z/10/Z.  ... 
doi:10.1016/j.neurobiolaging.2014.02.008 pmid:24656835 pmcid:PMC4024196 fatcat:rzbnvfoj5fhwhdgucbsopv3a2m

Iron Level and Myelin Content in the Ventral Striatum Predict Memory Performance in the Aging Brain

T. K. Steiger, N. Weiskopf, N. Bunzeck
2016 Journal of Neuroscience  
Age-related memory impairments have been associated with structural changes in the dopaminergic system, but the underlying mechanisms remain unclear.  ...  Furthermore, higher levels of iron within the ventral striatum were accompanied by a negative correlation between myelin and iron specific for the elderly participants.  ...  To test for differences in R2* and MT parameter, a voxel-based quantification (VBQ) analysis was used Callaghan et al., 2014) , which preserves quantitative parameter values and enhances tissue specificity  ... 
doi:10.1523/jneurosci.3617-15.2016 pmid:27013683 pmcid:PMC4804012 fatcat:qj7p6c3cmfgctj7w7rbtnyqw7a

Early brainstem [18F]THK5351 uptake is linked to cortical hyper-excitability in healthy aging

Maxime Van Egroo, Daphne O. Chylinski, Justinas Narbutas, Gabriel Besson, Vincenzo Muto, Christina Schmidt, Davide Marzoli, Paolo Cardone, Nora Vandeleene, Martin Grignard, André Luxen, Eric Salmon (+8 others)
2020 JCI Insight  
By contrast, [18F]THK5351 PET signal in the hippocampal formation, although strongly correlated with brainstem signal in whole-brain voxel-based quantification analyses (pFWE-corrected < .001), was not  ...  These findings reveal potential brain substrates for increased cortical excitability in preclinical AD and may constitute functional in vivo correlates of early brainstem tau accumulation and neuroinflammation  ...  Villar González for their help in different steps of the study.  ... 
doi:10.1172/jci.insight.142514 pmid:33290274 pmcid:PMC7934880 fatcat:i6wc6kzxrfcfnb2r5huu6eh4wi

Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning

Davina Biel, Tineke K Steiger, Nico Bunzeck
2021 Scientific Reports  
However, the specificity of age-related iron increases with respect to cognitive functions remains unclear.  ...  Within the SN/VTA, age correlated negatively with MT, but there was no clear evidence in favor of a relationship between behavior and R2* or MT.  ...  This work was funded by the University of Lübeck.  ... 
doi:10.1038/s41598-021-88840-1 pmid:33941809 fatcat:beuzifelvrbrnc6lvxu2mnd45q

Metacognitive ability predicts hippocampal and prefrontal microstructure [article]

Micah Allen, James C Glen, Daniel Mullensiefen, D. Sam Schwarzkopf, Martina F. Callaghan, Geraint Rees
2016 bioRxiv   pre-print
Here we used a newly developed, high-resolution multi-parameter mapping technique in 48 healthy individuals to delineate quantitative markers of in vivo histological features underlying metacognitive ability  ...  Specifically, we examined how neuroimaging markers of local grey matter myelination, macromolecular and iron content relate to insight.  ...  Total acquisition time 212 for all MRI scans was less than 30 mins. 213 214 Parameter Map Estimation and Voxel-Based Quantification (VBQ) the quantitative maps, all weighted volumes were co-registered  ... 
doi:10.1101/046359 fatcat:vxmzoh4uorh6bo7pvdnquzasli

Structural integrity of the substantia nigra and subthalamic nucleus predicts flexibility of instrumental learning in older-age individuals

Rumana Chowdhury, Marc Guitart-Masip, Christian Lambert, Raymond J. Dolan, Emrah Düzel
2013 Neurobiology of Aging  
Normal aging is associated with a variable loss of dopamine neurons in the SN/VTA. We therefore tested the relationship between flexible instrumental learning and midbrain structural integrity.  ...  The precise contribution of dopaminergic midbrain regions (substantia nigra/ventral tegmental area [SN/VTA]) to this form of behavioral adaptation remains unclear.  ...  Acknowledgements This work was supported by the Wellcome Trust (grant nos.  ... 
doi:10.1016/j.neurobiolaging.2013.03.030 pmid:23623600 pmcid:PMC3713434 fatcat:mdqg4b2m75ec5nj7e2tanh5kpm

The relationship between hippocampal-dependent task performance and hippocampal grey matter myelination and iron content

Ian A Clark, Martina F Callaghan, Nikolaus Weiskopf, Eleanor A Maguire
2021 Brain and Neuroscience Advances  
This was the case using different analysis methods (voxel-based quantification, partial correlations), when whole brain, hippocampal regions of interest, and posterior:anterior hippocampal ratios were  ...  Magnetic resonance imaging data were collected using a multi-parameter mapping protocol (0.8 mm isotropic voxels) from a large sample of 217 people with widely-varying cognitive task scores.  ...  Author contributions Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.  ... 
doi:10.1177/23982128211011923 pmid:33997294 pmcid:PMC8079931 fatcat:re5yx6z5yfddfb6vaee6loosbi

Tracking sensory system atrophy and outcome prediction in spinal cord injury

Patrick Grabher, Martina F. Callaghan, John Ashburner, Nikolaus Weiskopf, Alan J. Thompson, Armin Curt, Patrick Freund
2015 Annals of Neurology  
METHODS: Changes in the sensory system were prospectively followed by applying a comprehensive magnetic resonance imaging (MRI) protocol to 14 patients with subacute traumatic SCI at baseline, 2 months  ...  Methods: Changes in the sensory system were prospectively followed by applying a comprehensive magnetic resonance imaging (MRI) protocol to 14 patients with subacute traumatic SCI at baseline, 2 months  ...  Acknowledgment We thank all participants who spent their valuable time, all colleagues involved in this study, and the staff of the Department of Radiology at the University Hospital Balgrist.  ... 
doi:10.1002/ana.24508 pmid:26290444 pmcid:PMC4737098 fatcat:bjfithvfsvdd3ch7knari3x7t4

Multi-contrast anatomical subcortical structures parcellation

Pierre-Louis Bazin, Anneke Alkemade, Martijn J Mulder, Amanda G Henry, Birte U Forstmann
2020 eLife  
The human subcortex is comprised of more than 450 individual nuclei which lie deep in the brain.  ...  The new algorithm has been tested on 17 prominent subcortical structures based on a large quantitative MRI dataset at 7 Tesla.  ...  Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ) NeuroImage 55 :1423–1434.  ... 
doi:10.7554/elife.59430 fatcat:64xrswbhyzce5frfmbl4g5t5qu
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