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Serotonin Transporter Binding in the Human Brain After Pharmacological Challenge Measured Using PET and PET/MR

Leo R. Silberbauer, Gregor Gryglewski, Neydher Berroterán-Infante, Lucas Rischka, Thomas Vanicek, Verena Pichler, Marius Hienert, Alexander Kautzky, Cecile Philippe, Godber M. Godbersen, Chrysoula Vraka, Gregory M. James (+6 others)
2019 Frontiers in Molecular Neuroscience  
Highest agreement with established methods for quantification of occupancy and SERT BPND at baseline was observed in subcortical high-binding regions.  ...  PET/MR scans resulted in higher BPND estimates than PET scans in all ROIs. For occupancy, a mean difference of 23.12% (21.91%) was observed across all ROIs.  ...  (Center for Biomarker Research in Medicine, Graz, Austria).  ... 
doi:10.3389/fnmol.2019.00172 pmid:31354428 pmcid:PMC6639732 fatcat:mwbqcypqkff3tmouwjivfxfdge

Pet-1 is required across different stages of life to regulate serotonergic function

Chen Liu, Takashi Maejima, Steven C Wyler, Gemma Casadesus, Stefan Herlitze, Evan S Deneris
2010 Nature Neuroscience  
Aims of thesis. 51 CHAPTER II: Pet-1/Fev-dependent transcription is required across different stages of life to regulate serotonergic function.  ...  Discovery of serotonin and its functions in the periphery. 11 B. Vertebrate central 5-HT system: anatomy and projections. 11 C. 5-HT metabolism in the central nervous system. 1. Synthesis. 13 2.  ...  Two forms of Mao mRNAs (MaoA and MaoB) encoded by different genes have been discovered in the mammalian brain.  ... 
doi:10.1038/nn.2623 pmid:20818386 pmcid:PMC2947586 fatcat:yr7x5axal5aqzeai2bulbkgfby

Abstracts from the XXIII CINP Congress, Montréal, June 23–27, 2002

2002 International Journal of Neuropsychopharmacology  
These receptors are characterized by seven transmembrane domains with an extracellular N-terminus and a cytoplasmic C-terminus.  ...  These two opioid receptor types are also able to heterodimerize with each other and heterodimerization leads to changes in agonist affinity, efficacy and/or potency.  ...  Positron Emission Tomography (PET) using C-McN652, a high-affinity SERT antagonist, was used to quantitate SERT binding in vivo throughout the brain to map SERT binding abnormalities in medication-free  ... 
doi:10.1017/s1461145702003176 fatcat:25u2fa2qmve7zpljmks4tqinge

Cognitive impairment in depression: recent advances and novel treatments

Giulia Perini, Matteo Cotta Ramusino, Elena Sinforiani, Sara Bernini, Roberto Petrachi, Alfredo Costa
2019 Neuropsychiatric Disease and Treatment  
This review considers the different issues, in terms of disease evolution, raised by the presence of cognitive disorders associated with depression and considers, particularly from the neurologist's perspective  ...  Finally, after outlining the pharmacodynamics and pharmacokinetics of the first multimodal antidepressant, vortioxetine, it reports the main results obtained with the drug in depressed patients, also in  ...  Acknowledgment Payments of only open access publication fees for this paper were sustained by Lundbeck, Italy. Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/ndt.s199746 pmid:31190831 pmcid:PMC6520478 fatcat:thwdzevping2nowtiaiac5rkvy

ABSTRACTS SCANDINAVIAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY SCNP 54th Annual Meeting, May 3rd – 4th, 2013 Copenhagen, Denmark

2013 Acta Neuropsychiatrica  
Acute vortioxetine reversed these deficits, whereas escitalopram and duloxetine were inactive at equivalent SERT occupancies.  ...  Conclusions: After 12 days of sugar access, raclopride binding to dopamine D2/3 receptors decreased in striatal and thalamic brain regions in minipig.  ...  Aim/Purpose: The aim of the present work was to study acute effects of 17ß-estradiol on anxiety-like behavior and CCK-like immunoreactivity (LI) in the female rat brain (amygdala, hippocampus, nucleus  ... 
doi:10.1017/neu.2013.10 pmid:26953089 fatcat:qtsjbdq3nrdhje3huncbpdne5m

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Salinas for technical support in radiosynthesis and technical assistance in the PET studies. This study was funded by MINECO SAF2014-54070-JIN.  ...  Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases

Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith F. Tipton, Dorotea Mück-Šeler, Irene Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse J. Smolders, Anna Stasiak (+2 others)
2016 Frontiers in Neuroscience  
The increased knowledge regarding the function and interaction of the monoaminergic systems in the brain resulting from in vivo neurochemical and neurophysiological studies indicated new monoaminergic  ...  More recent developments that have resulted in improved drug specificity and responses will be discussed in this review.  ...  PD acknowledges the "Fondation de France" and the Centre National de la Recherche Scientifique."  ... 
doi:10.3389/fnins.2016.00541 pmid:27932945 pmcid:PMC5121249 fatcat:izzff2lvz5eknhjr4noorbfp6u

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

Daniel J Urban, Hu Zhu, Catherine A Marcinkiewcz, Michael Michaelides, Hidehiro Oshibuchi, Darren Rhea, Dipendra K Aryal, Martilias S Farrell, Emily Lowery-Gionta, Reid H J Olsen, William C Wetsel, Thomas L Kash (+3 others)
2015 Neuropsychopharmacology  
Our findings reveal a previously unappreciated brain network elicited by selective activation of DRN serotonin neurons and illuminate potential therapeutic and adverse effects of drugs targeting DRN neurons  ...  In parallel, these behavioral phenotypes were associated with a metabolic map of whole brain network activity via a recently developed non-invasive imaging technology DREAMM (DREADD Associated Metabolic  ...  Mapping functional brain anatomy associated with acute and chronic hyper-serotonergic states in mice during behavior revealed alterations in regions that are implicated in anxiety and depression.  ... 
doi:10.1038/npp.2015.293 pmid:26383016 pmcid:PMC4793125 fatcat:4fhcrsav5bhovlg7yztqfn5hpi

Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012

2012 International Journal of Neuropsychopharmacology  
We further assessed the contributing effects of HIV and cortisol, known to be elevated in MDD, in primary human neuronal-glial in vitro cultures exposed to 6000 pg/ml HIV (BaL) and/or 500 nM cortisol after  ...  Objective : Altered expression of neurotrophic factors has been implicated in both the pathology of human immunodeficiency virus (HIV) infection and major depressive disorder (MDD) in the brain and may  ...  There are at least 4 different brain regions being targeted by different groups.  ... 
doi:10.1017/s1461145712000508 fatcat:ft6ipgmb45azzjxouthbqdn43i

ABSTRACTS SCANDINAVIAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY SCNP 56th Annual Meeting, April 22th – 24th, 2015 Copenhagen, Denmark

2015 Acta Neuropsychiatrica  
In a sleep EEG study with healthy subjects, VOR at a given SERT occupancy seemed to affect REM sleep less than paroxetine.  ...  Furthermore, LPS caused a region-and cytokine-specific response in the brain, but this was not reversed by exercise.  ...  Objectives: The aim of the present study was to investigate the expression of GABAA α5 and α2 adrenoceptors in limbic brain regions in a DOM rat model of epilepsy using autoradiography.  ... 
doi:10.1017/neu.2015.26 fatcat:c3gzlofqlrblhdugvby6h4tepm

Histamine H3 Receptor Antagonists Go to Clinics

Kerstin Sander, Tim Kottke, Holger Stark
2008 Biological and Pharmaceutical Bulletin  
Due to diversity in potential therapeutic applications and in some cases a controversial debate, different indications will be highlighted with the potential and the problems of the test compounds, e.g  ...  First data published on clinical trials phase II (IIb) are presented showing proof of concept of H 3 receptor antagonists in narcolepsy and photoinduced epilepsy.  ...  in the receptor. 136, 137) As a major drawback this structure hardly dissociates from the target and accumulates in brain showing full receptor occupancy after 24 h.  ... 
doi:10.1248/bpb.31.2163 pmid:19043195 fatcat:fp4beldrrzclbaqnfx6telncw4

Why are Antidepressant Drugs Effective Smoking Cessation Aids?

Mohammed Shoaib, Yazead Buhidma
2018 Current Neuropharmacology  
By targeting the pathways of depression in the brain, antidepressants would also treat the pathways affected by smoking and ease nicotine cravings and withdrawal.  ...  to explain the action of antidepressants in smoking cessation.  ...  These brain regions are therefore under continuous modulation by nicotine.  ... 
doi:10.2174/1570159x15666170915142122 pmid:28925882 pmcid:PMC6018185 fatcat:rnkaszox25cbfnzmmor4jjxjqe

ABSTRACTS SCANDINAVIAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY SCNP 55th Annual Meeting, April 24th – 26th, 2014 Copenhagen, Denmark

2014 Acta Neuropsychiatrica  
acute SSRI treatment but attenuated by serotonin depletion and chronic SSRI treatment Poster 17 Is serotonin a mediator of sex differences in anxiety-like behavior?  ...  Poster 16 Temperament differences in male Wistar rats are accentuated by acute SSRI treatment but attenuated by serotonin depletion and chronic SSRI treatment Näslund, J; Studer, E; Nissbrandt, H; Eriksson  ... 
doi:10.1017/neu.2014.10 fatcat:nzk7o7utx5eengoycgvlwg25fe

Poster Session III

2010 Neuropsychopharmacology  
complex), a key brain region for several cognitive and neuropsychiatric-disorders such as obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and addictive disorders.  ...  model the neuroadaptive processes in humans that lead to abnormal brain function and psychosis.  ...  Cholesterol and flotillin, markers for lipid rafts, peaked in factions 4-5 whereas the transferrin receptor and total protein, markers for non-raft membranes, peaked in fractions 9-11.  ... 
doi:10.1038/npp.2010.218 fatcat:i5knteqsgveybffza7g6b4iqei

Poster Session I

2010 Neuropsychopharmacology  
In a subset of subjects, preliminary investigations show a significant correlation (r ¼ 0.56) between delayed discounting and cocaine place preference.  ...  Discussion: Our results corroborate previous finding in bipolar patients and suggest that improvement of mitochondrial dysfunction, mediated by inositol depletion, might underlie the therapeutic effect  ...  Methods: In the present study, we used adeno-associated viral (AAV) and promoter-driven cre-recombinase expression to selectively excise floxed p38alpha MAPK in specific cell types and brain regions to  ... 
doi:10.1038/npp.2010.216 fatcat:v3q2xjxc45b2hckv33pzz7mtee
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