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Multiple sclerosis in 2018: new therapies and biomarkers

Olga Ciccarelli
2019 Lancet Neurology  
2018 has been a year of substantial progress in multiple sclerosis, with breakthroughs in experimental medicine and translational research.  ...  Multiple sclerosis research in 2018 holds great promise for the treatment of progressive multiple sclerosis and for the availability of new biomarkers to monitor multiple sclerosis in the individuals,  ...  Beside the progress in treatments for people with progressive multiple sclerosis and children with multiple sclerosis, in 2018 a large amount of work focused on developing new biomarkers for neurodegeneration  ... 
doi:10.1016/s1474-4422(18)30455-1 pmid:30563672 fatcat:nv46fmj5hfcupcg3jx6q4xkc74

Magnetic resonance imaging characteristics of children and adults with paediatric-onset multiple sclerosis

E. A. Yeh, B. Weinstock-Guttman, M. Ramanathan, D. P. Ramasamy, L. Willis, J. L. Cox, R. Zivadinov
2009 Brain  
Funding This work was supported in part by grants from the National Multiple Sclerosis Society (RG3743 and a Paediatric Multiple Sclerosis Centre of Excellence Centre Grant) and the Children's Guild Foundation  ...  Supplementary material Supplementary material is available at Brain online.  ...  Further, our clinic is located in a regional children's hospital and it is likely that most children in the region with demyelinating disease are evaluated at the centre.  ... 
doi:10.1093/brain/awp278 pmid:19892770 fatcat:c4mrx2aivndcldnnghu453m7xm

This Month in The Archives of Neurology

2005 Archives of Neurology  
loss to spinal cord atrophy in multiple sclerosis.  ...  on suppressing new brain lesions in multiple sclerosis as judged by magnetic resonance imaging.  ... 
doi:10.1001/archneur.62.12.1803 fatcat:prpcphd2nfezdmb2hukpdm2lxe

Brain MRI findings of complex partial seizure in children

Jong Deok Kim, Dong Woo Park, Tchoong Kie Eun, Duck Hwan Chung, Tae Kyu Hwang
1992 Journal of the Korean Radiological Society  
Eleven patients showed abnormal brain MRI findings ; two had focallesions with corresponding seizure foci on the EEG, one arising from temporal lobe(Hippocampal Formation atrophy) and the other from the  ...  Twenty-two children(4 months to 17 years old) with a clincial diagnosis of complex partial seizure(CPS) were examined with a 0.5T MRI scanner using spin-echo sequences.  ...  atrophy) (1) (e) Communicating hydrocephalus with dif- fuse brain atrophy (1) (1) Localized or diffuse brain atrophy ).  ... 
doi:10.3348/jkrs.1992.28.4.631 fatcat:2rfhkz2rgvgalcaneajxxjuio4


1897 Journal of Nervous and Mental Disease  
Although Marie, Unger, Moncorvo and Nolda have reported cases of multiple sclerosis occurring in children, there has not been as yet a single autopsy confirmative of the opinion of these writers.  ...  One is often struck with the marked nervous affections, particularly in the region of the sympathetic, associated with zoster. Dr.  ... 
doi:10.1097/00005053-189705000-00043 fatcat:ztlwkyeunzbalfdtei7f32b3fa


1897 Journal of Nervous and Mental Disease  
The diagnosis of multiple sclerosis could hardly be accepted, as the symptoms were not sufficiently pronounced. MULTIPLE SCLEROSIS IN CHILDREN, WITH A REPORT OF THREE CASES. Dr. L.  ...  Stieglitz read a paper with this title. He stated that the first reported case of multiple sclerosis in children had been published in 1881, together with the post-mortem findings.  ... 
doi:10.1097/00005053-189703000-00005 fatcat:jdefx3ypn5ewlgkjrf4m27onme

Page 1355 of American Medical Association. A.M.A. Archives of Neurology & Psychiatry Vol. 38, Issue 6 [page]

1937 American Medical Association. A.M.A. Archives of Neurology & Psychiatry  
; bilateral atrophic lobar following thrombosis of superior tudinal sinus, 1078 atrophy of parietal and cerebellar lobes asso- ciated in certain cases with multiple sclerosis, 218 atrophy; psychopathology  ...  without drainage, 635 and endocrine glands in old age, 640 angiomas ; importance of cerebral angiography in their diagnosis, 175 arachnoiditis of base of brain, 1095 atrophy; acquired dementias, 162 atrophy  ... 


J. Ramsay Hunt
1903 American Journal of the Medical Sciences  
and operative technique, and with the limitation of the radical opera¬ tion to cases accurately localized. 4.  ...  , as this symptom is rarely met with in multiple sclerosis.  ...  Thickening of the skull over the frontal region. Atrophy of the convolutions. Disseminated plaques of sclerosis in the brain, stem, and cord. Case VII. (Petroff8).-Without autopsy.  ... 
doi:10.1097/00000441-190312000-00003 fatcat:e7oyvzrpwzfufmusqedoell6oa

Page 1281 of American Medical Association. A.M.A. Archives of Neurology & Psychiatry Vol. 41, Issue 6 [page]

1939 American Medical Association. A.M.A. Archives of Neurology & Psychiatry  
and oxidase content in different regions of brain of cat, *223 Brickner, R.  ...  R.: Remissions in multiple sclerosis, *913 Bucy, P. C.: Tremor, 1061 Tremor: physiologic mechanism and abolition by surgical means, *721 Burman, M.  ... 

This Month in

2005 Archives of Neurology  
Galantamine Therapy: FDG-PET Study in Alzheimer Disease M ega and colleagues (page 721) map brain metabolism associated with the treatment response to galantamine with fludeoxyglucose F 18 positron emission  ...  tomography (FDG-PET) in patients with Alzheimer disease.  ...  atrophy as an in vivo marker of regional neuronal loss in patients with Alzheimer disease.  ... 
doi:10.1001/archneur.62.5.709 fatcat:3fb7rafhizblvbtt36nrknlira

Congenital Porencephaly and Hippocampal Sclerosis

J Gordon Millichap
1997 Pediatric Neurology Briefs  
between 1985 and 1992 to the regional referral neonatal ICU at the Hospital for Sick Children, Toronto, Canada.  ...  Of 165 infants with known outcomes, 88 (53%) had severe adverse outcome, 48 died (42 in the first month), and 40 had severe impairment and microcephaly at 1 year.  ...  Hippocampal formation atrophy in 13 (93%) patients was concordant with CPS and EEG temporal localization in 70% cases. Ten had amygdala atrophy, concurrent with HS in 57%.  ... 
doi:10.15844/pedneurbriefs-11-12-3 fatcat:5pfkgly3ubej5i6lk2jes3xos4

Outcome Measures in Relapsing-Remitting Multiple Sclerosis: Capturing Disability and Disease Progression in Clinical Trials

Amy M. Lavery, Leonard H. Verhey, Amy T. Waldman
2014 Multiple Sclerosis International  
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease that manifests as acute relapses and progressive disability.  ...  This review defines the outcome measures and surrogate endpoints used to date in MS clinical trials and presents challenges in the design of both adult and pediatric trials.  ...  Waldman has received an honorarium in the past from Teva Pharmaceutical Industries for a speaking engagement. Ms. Lavery and Dr.  ... 
doi:10.1155/2014/262350 pmid:24883205 pmcid:PMC4026972 fatcat:n2mogqenlnetrf6w4ox5j6sixa

Late onset Alexander's disease presenting as cerebellar ataxia associated with a novel mutation in the GFAP gene

Stephan Schmidt, Mike P. Wattjes, Wanda M. Gerding, Marjo van der Knaap
2010 Journal of Neurology  
Axial T2-weighted MR images of the infratentorial brain region (a, b, c) demonstrate the severe atrophy of the brain stem, particularly of the medulla oblongata, and upper spinal cord (b, c, open arrows  ...  The family history revealed that the patient's father had a tremor and impaired taste with onset after the age of 70. Both grandmothers allegedly suffered from multiple sclerosis.  ... 
doi:10.1007/s00415-010-5849-0 pmid:21165639 fatcat:5k64nmihgrevbl6vlbegcdtxre


1890 Journal of Nervous and Mental Disease  
evidences of unconscious or semi-con-CORTICAL SCLEROSIS OF THE BRAIN IN CHILDREN.  ...  CORTICAL SCLEROSIS OF THE BRAIN IN CHILDREN. 705 Microscopical examination. Pia showed a slight degree of thickening from growth of fibrous tissue. Brain.  ... 
doi:10.1097/00005053-189011000-00001 fatcat:5g7sxn7xzvb6xmvtbh7u673zmm

Page 1034 of American Medical Association. A.M.A. Archives of Neurology & Psychiatry Vol. 48, Issue 6 [page]

1942 American Medical Association. A.M.A. Archives of Neurology & Psychiatry  
region of foramen magnum; basilar impression, 662 Atrophy: See also under names of organs and regions, as Brain, atrophy; etc.  ...  surgical removal of brain Bacillus typhosus following typhoid interna; its atrophy, 844 disseminated sclerosis of brain stem and cord frontalis  ... 
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