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Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis

Yong Wang, Peng Sun, Qing Wang, Kathryn Trinkaus, Robert E. Schmidt, Robert T. Naismith, Anne H. Cross, Sheng-Kwei Song
2015 Brain  
multiple sclerosis patients.  ...  Axon injury/loss, demyelination and inflammation are the primary pathologies in multiple sclerosis lesions.  ...  John Trotter multiple sclerosis Center Chair in Neuroimmunology of Barnes-Jewish Hospital Foundation.  ... 
doi:10.1093/brain/awv046 pmid:25724201 pmcid:PMC4407189 fatcat:l3vwhwthi5b6piixaqawjdgu2q

Diffusion tensor MR imaging evaluation of the corpus callosum of patients with multiple sclerosis

Fernanda Rueda, Luiz Celso Hygino Jr, Romeu Cortês Domingues, Cláudia C. Vasconcelos, Regina M. Papais-Alvarenga, Emerson L. Gasparetto
2008 Arquivos de Neuro-Psiquiatria  
OBJECTIVE: To evaluate the fractional anisotropy (FA) values of the normal-appearing white matter of the corpus callosum (CC) in patients with relapsing-remitting multiple sclerosis (MS).  ...  One neuroradiologist placed the regions of interest (ROIs) in the FA maps in five different portions of the normal-apearing CC (rostrum, genu, anterior and posterior portion of the body and splenium) in  ...  In conclusion, DTI is a promising MR technique to evaluate the NAWM in patients with multiple sclerosis.  ... 
doi:10.1590/s0004-282x2008000400001 pmid:18813697 fatcat:3fz42snvtnfrfmhpr3qj4nqnqm

Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: A combined optical coherence tomography and diffusion tensor imaging study

Michael Scheel, Carsten Finke, Timm Oberwahrenbrock, Alina Freing, Luisa-Maria Pech, Jeremias Schlichting, Carina Sömmer, Jens Wuerfel, Friedemann Paul, Alexander U Brandt
2014 Multiple Sclerosis  
Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls.  ...  Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography.  ...  Table 1 . 1 Demographics of patient and control group. : multiple sclerosis; F: female; M: male; RRMS: relapsing-remitting multiple sclerosis; SPMS: secondary progressive multiple sclerosis; ON: optic  ... 
doi:10.1177/1352458514535128 pmid:24842962 fatcat:zye7fin4gjhmxigphsi25lf33a

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient's clinical status

Mohamed ElSayed Kamel Abdulaziz ElSayed, Mohamed Mohamed Badawy El-Toukhy, Ramy Edward Asaad, Omar Amin El-Serafy
2019 The Egyptian Journal of Radiology and Nuclear Medicine  
However, it is of almost no value in assessing the normal-appearing white matter which has been proved by multiple pathologic studies to be directly and indirectly involved in the process of multiple sclerosis  ...  The purpose of this study was to evaluate the role of diffusion tensor imaging examination of the normal-appearing white matter of the brain and spinal cord in patients with multiple sclerosis and to determine  ...  All patients included in this study gave written informed consent to participate in this research.  ... 
doi:10.1186/s43055-019-0031-x fatcat:yxzz4hea3zd5xcma7xab6srxk4


Mona Alsherif, Eman Soliman, Remon Elia, Mona Nagi
2022 Ain Shams Medical Journal  
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of brain & spinal cord.  ...  Results: our study showed that DTI provide details about early affection of normal appearing white matter in MS cases when no visible plaques are detected in conventional MRI.  ...  The graph displays the significant differences in ADC measurements control. ADC Apparent diffusion coefficient, NAWM normal appearing white matter, MS multiple sclerosis.  ... 
doi:10.21608/asmj.2022.252402 fatcat:h4iknjieozfwfn74lrvpkkituy

Evaluation of white matter in patients with multiple sclerosis through diffusion tensor magnetic resonance imaging

Rachel E. Maia de Andrade, Emerson L. Gasparetto, Luiz Celso Hygino Cruz Jr., Fabiana Brito Ferreira, Roberto Cortês Domingues, Edson Marchiori, Romeu Cortês Domingues
2007 Arquivos de Neuro-Psiquiatria  
OBJECTIVE: To study the white matter of patients with multiple sclerosis (MS) with diffusion tensor magnetic resonance (MR) imaging (DTI).  ...  Statistical significant differences in FA values were observed in plaques, peri-plaque regions and in NAWM around the plaques when compared to the white matter in the control group.  ...  In conclusion, our study supports previous reports of abnormal FA values in the abnormal and normalappearing white matter of patients with multiple sclerosis.  ... 
doi:10.1590/s0004-282x2007000400002 pmid:17876390 fatcat:qydqkaimcbdvjbqquop6kymp4m

Diffusion tensor imaging in assessment of demyelinating diseases of central nervous system

Arindam Mukherjee, Umesh Chandra Garga
2020 International Journal of Research in Medical Sciences  
DTI Tractography shows white matter tract disruption which may play role in assessing clinical outcome of patients.  ...  DTI is an important tool in assessment of anisotropy in affected and apparently normal region of brain. 3D Tractography maps are useful in showing white matter fibre loss.  ...  Temel at al in their study of DTI in patients of Multiple Sclerosis found mean ADC of core 1.08×10-3mm 2 /sec, perilesional region 0.91×10-3mm 2 /sec and NAWM 0.85×10-3mm 2 /sec.  ... 
doi:10.18203/2320-6012.ijrms20202556 fatcat:4qfcjfyqbzagldzutsldi6nk3q

Diffusion tensor imaging of the cervical spinal cord of patients with relapsing-remising multiple sclerosis: a study of 41 cases

L. Celso Hygino Cruz Jr., Romeu C. Domingues, Emerson L. Gasparetto
2009 Arquivos de Neuro-Psiquiatria  
OBJECTIVE: To evaluate the fractional anisotropy (FA) values of the multiple sclerosis (MS) plaques and normal-appearing cervical spinal cord (NASC) by diffusion tensor MRI imaging (DTI).  ...  Regions of interest were placed within the spinal cord lesions and in the normal appearing spinal cord adjacent to the plaque.  ...  The involvement of the spinal cord is a common finding in patients with multiple sclerosis (MS).  ... 
doi:10.1590/s0004-282x2009000300004 pmid:19623432 fatcat:omn5gi4jtvcctjsybiv5b3hp3u

Correlation between white matter damage and gray matter lesions in multiple sclerosis patients

Xia Cao, Xue-mei Han, Hong-ji Tian, Zheng Han, Ce Zhang, Ying Liu, Jie-bing Gu, Rohit Bakshi
2017 Neural Regeneration Research  
These findings suggest that white matter fiber bundles are extensively injured in multiple sclerosis patients.  ...  Graphical Abstract Gray matter atrophy is strongly associated with white matter injury in multiple sclerosis (MS) patients  ...  The data on the second line are the mean FA values in the white matter association fibers in multiple sclerosis patients.  ... 
doi:10.4103/1673-5374.206650 pmid:28616036 pmcid:PMC5461617 fatcat:ack4ripu4rbidbwsrir2tyf4ry


A. Roceanu, M. Onu, V. Ferastraoaru, E. Tarta, F. Preoteasa, F. Antochi, O. Bajenaru
2011 Romanian Journal of Neurology  
It is largely accepted that the inflammatory induced loss of axons and neurons is the underlying cause of disability in multiple sclerosis patients.  ...  We performed DTI to 12 MS patients in order to assess idiffusion parameters (fractional anisotropy, mean diffusivity, longitudinal diffusivity (F1) and transversal diffusivities (F2, F3).  ...  is the underlying cause of disability in multiple sclerosis patients.  ... 
doi:10.37897/rjn.2011.2.2 doaj:7cd2d209539a49f89ebade721b75c7fd fatcat:cndg3tgeyrafzcytuxhn5gkyiy

Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cord

S M Hesseltine, M Law, J Babb, M Rad, S Lopez, Y Ge, G Johnson, R I Grossman
2006 American Journal of Neuroradiology  
Our purpose was to investigate diffusion tensor imaging (DTI) changes in different regions of normal-appearing spinal cord (NASC) in relapsing-remitting multiple sclerosis (RRMS).  ...  Evaluation of the spinal cord is important in the diagnosis and follow-up of patients with multiple sclerosis.  ...  E valuation of the spinal cord has become increasingly important in both the diagnosis and follow-up of multiple sclerosis (MS), in that changes in the spinal cord function of patients with MS have been  ... 
pmid:16775261 pmcid:PMC8133921 fatcat:i6b7cpmtgvfq7jicqwl33jvy2q

Diffusion tensor imaging for characterizing white matter changes in multiple sclerosis

Rasha Elshafey, Omar Hassanien, Mohamed Khalil
2014 The Egyptian Journal of Radiology and Nuclear Medicine  
Patients and methods: Diffusion tensor imaging (DTI) was performed in 45 consecutive MS patients and 20 age-matched healthy control volunteers from March 2011 to November 2013.  ...  Correlation and significant difference between {(increase in MD) and (decrease in FA and VR)} and lesion load (strongest in parietal lobes) and also Kurtzke expanded disability status scale (EDSS) and  ...  The use of the DTI metric study in patients with multiple sclerosis is of benefit as prognostic values, to identify early pathological changes in the normal-appearing white matter and so predict cognitive  ... 
doi:10.1016/j.ejrnm.2014.04.006 fatcat:d63yqfm4nrbgjkrjp2vve2pxj4

Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis

Cristina Granziera, Jens Wuerfel, Frederik Barkhof, Massimiliano Calabrese, Nicola De Stefano, Christian Enzinger, Nikos Evangelou, Massimo Filippi, Jeroen J G Geurts, Daniel S Reich, Maria A Rocca, Stefan Ropele (+7 others)
2021 Brain  
In patients with multiple sclerosis, quantitative MRI techniques such as relaxometry, myelin imaging, magnetization transfer, diffusion MRI, quantitative susceptibility mapping, and perfusion MRI, complement  ...  sclerosis in both research and clinical settings.  ...  sclerosis or in assessing therapies for patients with multiple sclerosis.  ... 
doi:10.1093/brain/awab029 pmid:33970206 fatcat:ymb5zhdvcfgnxgccytqgg37esy

Characterization of relapsing-remitting multiple sclerosis patients using support vector machine classifications of functional and diffusion MRI data

Mariana Zurita, Cristian Montalba, Tomás Labbé, Juan Pablo Cruz, Josué Dalboni da Rocha, Cristián Tejos, Ethel Ciampi, Claudia Cárcamo, Ranganatha Sitaram, Sergio Uribe
2018 NeuroImage: Clinical  
In this paper, we capitalize on machine learning techniques to classify relapsing-remitting multiple sclerosis patients and healthy volunteers based on machine learning techniques, and to identify relevant  ...  In contrast, the performance was noticeably lower when comparing the two groups of patients with different levels of disability, reaching levels below 63% ± 5%.  ...  Weight values of SVM models Discussion Advances in Radiological Sciences allow an accurate diagnosis of multiple sclerosis.  ... 
doi:10.1016/j.nicl.2018.09.002 pmid:30238916 pmcid:PMC6148733 fatcat:hnvjzqp3fzbcrk2x73lqnsyepy

Evaluation of the Degradation of the Selected Projectile, Commissural and Association White Matter Tracts Within Normal Appearing White Matter in Patients with Multiple Sclerosis Using Diffusion Tensor MR Imaging – a Preliminary Study

Anna Banaszek, Joanna Bladowska, Anna Pokryszko-Dragan, Ryszard Podemski, Marek J. Sąsiadek
2015 Polski przeglad radiologii i medycyny nuklearnej  
Backround: The aim of the study was to assess the impairment of the selected white matter tracts within normal appearing white matter (NAWM) in multiple sclerosis (MS) patients using diffusion tensor imaging  ...  There were no significant differences in FA values in the remaining evaluated ROIs, between MS patients and the control group.  ...  These studies differed in terms of DTI data post-processing and analysis methods as well as in sampling of MS patients' groups.  ... 
doi:10.12659/pjr.894661 pmid:26516389 pmcid:PMC4603607 fatcat:k4qdulzy4ng6zeuh7fp7ow4ify
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