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Early Detection of MCI
2020
International journal of recent technology and engineering
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Toxic changes may start in the brain at the beginning stage of Alzheimer's disease. MRI Images are used to detect disease at the earlies stage. ...
Dementia is the brain disorder, that effects the mental cognitive function. ...
INTRODUCTION Brain disorder is a disease which causes drastic changes in the brain structure. ...
doi:10.35940/ijrte.a2398.059120
fatcat:uzoll3swhzellgfh5lh4brnm7a
A panel of clinical and neuropathological features of cerebrovascular disease through the novel neuroimaging methods
2017
Dementia & Neuropsychologia
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Objective: In this review, the novel imaging methods, both structural and metabolic, were summarized and their impact on the diagnostic workup of age-related CVD was analysed. ...
imaging, MRI at 3.0 T enables higher-resolution scanning with greater imaging matrices, thinner slices and more detail on the anatomical structure of vascular lesions. ...
While on the one hand, neuroimaging has evolved quickly in the development of powerful and sensitive methods for studying in vivo brain architecture in CVD and related cognitive disorders, most structural ...
doi:10.1590/1980-57642016dn11-040003
pmid:29354214
pmcid:PMC5769992
fatcat:wqezepqjnbbvrc5iqmvdequpd4
New MRI Biomarkers Advance the Characterization of Parkinson Disease
2013
European Neurological Review
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We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories ...
A major limitation to studies of disease progression in PD has been that conventional MRI techniques provide relatively poor contrast for the structures that are affected by the disease, and thus are not ...
New multispectral structural MRI sequences allowed us to visualize and measure disease-related changes in both structures in a single sample of PD patients and controls. ...
pmid:24999373
pmcid:PMC4078999
fatcat:t6n5ke2ivfbzfbiktju425uybi
New Magnetic Resonance Imaging Biomarkers Advance the Characterisation of Parkinson's Disease
2013
European Neurological Review
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We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories ...
A major limitation to studies of disease progression in PD has been that conventional magnetic resonance imaging (MRI) techniques provide relatively poor contrast for the structures that are affected by ...
New multispectral structural MRI sequences allowed us to visualise and measure disease-related changes in both structures in a single sample of PD patients and controls. ...
doi:10.17925/enr.2013.08.02.85
fatcat:7qimrltjbrhevjbu3rqily2tg4
New Magnetic Resonance Imaging Biomarkers Advance the Characterization of Parkinson Disease
2013
US Neurology
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We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories ...
A major limitation to studies of disease progression in PD has been that conventional magnetic resonance imaging (MRI) techniques provide relatively poor contrast for the structures that are affected by ...
New multispectral structural MRI sequences allowed us to visualize and measure disease-related changes in both structures in a single sample of PD patients and controls. ...
doi:10.17925/usn.2013.09.01.8
fatcat:rbfvplc4jrdbxia4yhs3mt4dea
Combined magnetic resonance imaging and positron emission tomography brain imaging in behavioural variant frontotemporal degeneration: refining the clinical phenotype
2009
Brain
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In patients with the behavioural variant of frontotemporal dementia, prognosis is often surprisingly good when there is normal structural imaging at presentation. ...
We advise caution in diagnosing the illness in patients without imaging abnormalities, and propose that imaging findings are included in criteria for diagnosis. ...
were divided into two groups based on structural imaging features. ...
doi:10.1093/brain/awp077
pmid:19416953
fatcat:6iw5j5lu5bbrrfrrc7r34thfza
Genetics of Brain and Cognitive Aging: Introduction to the Special Issue of Neuropsychology Review
2015
Neuropsychology Review
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This issue of Neuropsychology Review is a timely sequel to the previous special issues on Aging and Dementia (Volume 24, Issue 3) and on Development of Human Brain Structure and Function (Volume 20, Issue ...
Longitudinal studies are needed to understand better the heritability of changes in measurements of structure or function. ...
Nancy Pedersen received support from NIH grant AG037985, the Swedish Research Council 521-2013-8689, and the Swedish Research Council for Health, Working Life and Welfare 2013-2292. ...
doi:10.1007/s11065-015-9282-0
pmid:25701189
pmcid:PMC4395529
fatcat:j4zpetemjrex5fl5be5bcef7xy
Refining Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17
2008
Archives of Neurology
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In this review, we compare and contrast the demographic, clinical, radiologic, neuropathologic, genetic, and pathophysiologic features in patients with FTDP linked to mutations in MAPT and PGRN, highlighting ...
Our findings describe an intriguing oddity of nature in which 2 genes can cause a similar phenotype through apparently different mechanisms yet reside so near to each other on the same chromosome. ...
The net effect of 2 genes linked not only by proximity but also by most overlapping and expanding features requires refinements in our conceptual framework and nomenclature in FTDP. ...
doi:10.1001/archneur.65.4.460
pmid:18413467
pmcid:PMC2746630
fatcat:f3lxmnq2bnem5iv3feg3cbgvpe
Imaging biomarkers in neurodegeneration: current and future practices
2020
Alzheimer's Research & Therapy
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In this review, we focus on neuroimaging, specifically positron emission tomography (PET) and magnetic resonance imaging (MRI), giving an overview of the current established practices clinically and in ...
The application of imaging biomarkers specifically for the in vivo investigation of neurodegenerative disorders has increased substantially over the past decades and continues to provide further benefits ...
Acknowledgements This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. ...
doi:10.1186/s13195-020-00612-7
pmid:32340618
fatcat:ar2ijzszy5fa5jopytcvau2nva
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
2014
Lancet Neurology
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We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. ...
On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent ...
KB has served on advisory boards for lnnogenetics, Pfizer, and Roche. STDK has worked as a consultant for drug development for Pfizer, Merck, Lilly, Genzyme, AstraZeneca, and Helicon Therapeutics. ...
doi:10.1016/s1474-4422(14)70090-0
pmid:24849862
fatcat:dvxzp4nez5fa3kaz7fwif4n5ce
An Interactive Care System Based on a Depth Image and EEG for Aged Patients with Dementia
2017
Journal of Healthcare Engineering
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The input vector of the DNN includes motion and mental features and was extracted from a depth image and electroencephalogram that were acquired by Kinect and OpenBCI, respectively. ...
Due to the limitations of the body movement and functional decline of the aged with dementia, they can hardly make an efficient communication with nurses by language and gesture language like a normal ...
In the refine stage, the model is trained by the two-modal features and labeled data. The network structure is shown in Figure 9 . ...
doi:10.1155/2017/4128183
pmid:29065599
pmcid:PMC5540472
fatcat:vbms753fxzhkdn2j6evm7lkhse
Advances in neuroimaging to support translational medicine in dementia
2021
Journal of Neurology, Neurosurgery and Psychiatry
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Developments in MRI-based imaging and neurophysiology provide complementary quantitative assays of brain function and connectivity, for the direct testing of hypotheses of human pathophysiology. ...
We look beyond traditional structural imaging used routinely in clinical care, to include ultrahigh field MRI (7T MRI), magnetoencephalography and PET with novel ligands. ...
more closely related to a loss of functional connectivity and information transfer in brain networks than a sudden change in structure. 27 In AD, this is reflected in close associations between tau burden ...
doi:10.1136/jnnp-2019-322402
pmid:33568448
pmcid:PMC8862738
fatcat:kfzojf7vpncq7pgln7xiaue324
Conceptual Evolution in Alzheimer's Disease: Implications for Understanding the Clinical Phenotype of Progressive Neurodegenerative Disease
2010
Journal of Alzheimer's Disease
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, and functional decline in the context of our developing understanding of the biological processes responsible for the pathogenesis of AD described in detail in the accompanying articles. ...
Over the past several decades our understanding of Alzheimer's disease (AD) has seen an evolution from the dichotomous concept of normal versus AD in the dementia state to a more accurate and complete ...
Second we acknowledge the many researchers and clinicians in the field that have not been cited in this manuscript. ...
doi:10.3233/jad-2010-1237
pmid:20061643
pmcid:PMC2881218
fatcat:sxczu4gxhjcznlvpt7ibcyteq4
Preliminary Clinical Diagnostic Criteria for Chronic Traumatic Encephalopathy: A Case Report and Literature Review
2021
Interdisciplinary Neurosurgery
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Identifying disease-specific features and developing in vivo biomarkers are current research priorities. ...
The clinical and imaging findings in this case were consistent with a diagnosis of mixed dementia and probable CTE. ...
Chronic traumatic encephalopathy (CTE) can manifest in YOD and is linked to RHI. In this case, the spectrum of clinical and imaging features was suggestive of mixed dementia and probable CTE. ...
doi:10.1016/j.inat.2021.101290
fatcat:bhhmzqh2z5gv3b6uxevxtmjbpe
Repetitive Head Impacts and Chronic Traumatic Encephalopathy
2016
Neurosurgery clinics of North America
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and cognition, including the development of chronic traumatic encephalopathy (CTE). ...
Clinically CTE is associated with violent behaviors, explosivity, a loss of control, depression, suicide, memory loss and cognitive changes. ...
Advanced structural and functional neuroimaging modalities (e.g., diffusion tensor imaging, magnetic resonance spectroscopy, functional magnetic resonance imaging, susceptibility-weight imaging, positron ...
doi:10.1016/j.nec.2016.05.009
pmid:27637402
pmcid:PMC5028120
fatcat:xqns2j5ebbdcnd44b2gg2jkncu
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