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Early Detection of MCI

2020 International journal of recent technology and engineering  
Toxic changes may start in the brain at the beginning stage of Alzheimer's disease. MRI Images are used to detect disease at the earlies stage.  ...  Dementia is the brain disorder, that effects the mental cognitive function.  ...  INTRODUCTION Brain disorder is a disease which causes drastic changes in the brain structure.  ... 
doi:10.35940/ijrte.a2398.059120 fatcat:uzoll3swhzellgfh5lh4brnm7a

A panel of clinical and neuropathological features of cerebrovascular disease through the novel neuroimaging methods

Gilberto Sousa Alves, Luiza de Amorim de Carvalho, Felipe Kenji Sudo, Lucas Briand, Jerson Laks, Eliasz Engelhardt
2017 Dementia & Neuropsychologia  
Objective: In this review, the novel imaging methods, both structural and metabolic, were summarized and their impact on the diagnostic workup of age-related CVD was analysed.  ...  imaging, MRI at 3.0 T enables higher-resolution scanning with greater imaging matrices, thinner slices and more detail on the anatomical structure of vascular lesions.  ...  While on the one hand, neuroimaging has evolved quickly in the development of powerful and sensitive methods for studying in vivo brain architecture in CVD and related cognitive disorders, most structural  ... 
doi:10.1590/1980-57642016dn11-040003 pmid:29354214 pmcid:PMC5769992 fatcat:wqezepqjnbbvrc5iqmvdequpd4

New MRI Biomarkers Advance the Characterization of Parkinson Disease

David A Ziegler, Suzanne Corkin
2013 European Neurological Review  
We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories  ...  A major limitation to studies of disease progression in PD has been that conventional MRI techniques provide relatively poor contrast for the structures that are affected by the disease, and thus are not  ...  New multispectral structural MRI sequences allowed us to visualize and measure disease-related changes in both structures in a single sample of PD patients and controls.  ... 
pmid:24999373 pmcid:PMC4078999 fatcat:t6n5ke2ivfbzfbiktju425uybi

New Magnetic Resonance Imaging Biomarkers Advance the Characterisation of Parkinson's Disease

David A Ziegler, Suzanne Corkin
2013 European Neurological Review  
We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories  ...  A major limitation to studies of disease progression in PD has been that conventional magnetic resonance imaging (MRI) techniques provide relatively poor contrast for the structures that are affected by  ...  New multispectral structural MRI sequences allowed us to visualise and measure disease-related changes in both structures in a single sample of PD patients and controls.  ... 
doi:10.17925/enr.2013.08.02.85 fatcat:7qimrltjbrhevjbu3rqily2tg4

New Magnetic Resonance Imaging Biomarkers Advance the Characterization of Parkinson Disease

David A Ziegler, Suzanne Corkin
2013 US Neurology  
We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories  ...  A major limitation to studies of disease progression in PD has been that conventional magnetic resonance imaging (MRI) techniques provide relatively poor contrast for the structures that are affected by  ...  New multispectral structural MRI sequences allowed us to visualize and measure disease-related changes in both structures in a single sample of PD patients and controls.  ... 
doi:10.17925/usn.2013.09.01.8 fatcat:rbfvplc4jrdbxia4yhs3mt4dea

Combined magnetic resonance imaging and positron emission tomography brain imaging in behavioural variant frontotemporal degeneration: refining the clinical phenotype

C. M. Kipps, J. R. Hodges, T. D. Fryer, P. J. Nestor
2009 Brain  
In patients with the behavioural variant of frontotemporal dementia, prognosis is often surprisingly good when there is normal structural imaging at presentation.  ...  We advise caution in diagnosing the illness in patients without imaging abnormalities, and propose that imaging findings are included in criteria for diagnosis.  ...  were divided into two groups based on structural imaging features.  ... 
doi:10.1093/brain/awp077 pmid:19416953 fatcat:6iw5j5lu5bbrrfrrc7r34thfza

Genetics of Brain and Cognitive Aging: Introduction to the Special Issue of Neuropsychology Review

Nancy L. Pedersen, Lotte Gerritsen
2015 Neuropsychology Review  
This issue of Neuropsychology Review is a timely sequel to the previous special issues on Aging and Dementia (Volume 24, Issue 3) and on Development of Human Brain Structure and Function (Volume 20, Issue  ...  Longitudinal studies are needed to understand better the heritability of changes in measurements of structure or function.  ...  Nancy Pedersen received support from NIH grant AG037985, the Swedish Research Council 521-2013-8689, and the Swedish Research Council for Health, Working Life and Welfare 2013-2292.  ... 
doi:10.1007/s11065-015-9282-0 pmid:25701189 pmcid:PMC4395529 fatcat:j4zpetemjrex5fl5be5bcef7xy

Refining Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17

Bradley F. Boeve, Mike Hutton
2008 Archives of Neurology  
In this review, we compare and contrast the demographic, clinical, radiologic, neuropathologic, genetic, and pathophysiologic features in patients with FTDP linked to mutations in MAPT and PGRN, highlighting  ...  Our findings describe an intriguing oddity of nature in which 2 genes can cause a similar phenotype through apparently different mechanisms yet reside so near to each other on the same chromosome.  ...  The net effect of 2 genes linked not only by proximity but also by most overlapping and expanding features requires refinements in our conceptual framework and nomenclature in FTDP.  ... 
doi:10.1001/archneur.65.4.460 pmid:18413467 pmcid:PMC2746630 fatcat:f3lxmnq2bnem5iv3feg3cbgvpe

Imaging biomarkers in neurodegeneration: current and future practices

Peter N. E. Young, Mar Estarellas, Emma Coomans, Meera Srikrishna, Helen Beaumont, Anne Maass, Ashwin V. Venkataraman, Rikki Lissaman, Daniel Jiménez, Matthew J. Betts, Eimear McGlinchey, David Berron (+7 others)
2020 Alzheimer's Research & Therapy  
In this review, we focus on neuroimaging, specifically positron emission tomography (PET) and magnetic resonance imaging (MRI), giving an overview of the current established practices clinically and in  ...  The application of imaging biomarkers specifically for the in vivo investigation of neurodegenerative disorders has increased substantially over the past decades and continues to provide further benefits  ...  Acknowledgements This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.  ... 
doi:10.1186/s13195-020-00612-7 pmid:32340618 fatcat:ar2ijzszy5fa5jopytcvau2nva

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

Bruno Dubois, Howard H Feldman, Claudia Jacova, Harald Hampel, José Luis Molinuevo, Kaj Blennow, Steven T DeKosky, Serge Gauthier, Dennis Selkoe, Randall Bateman, Stefano Cappa, Sebastian Crutch (+21 others)
2014 Lancet Neurology  
We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease.  ...  On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent  ...  KB has served on advisory boards for lnnogenetics, Pfizer, and Roche. STDK has worked as a consultant for drug development for Pfizer, Merck, Lilly, Genzyme, AstraZeneca, and Helicon Therapeutics.  ... 
doi:10.1016/s1474-4422(14)70090-0 pmid:24849862 fatcat:dvxzp4nez5fa3kaz7fwif4n5ce

An Interactive Care System Based on a Depth Image and EEG for Aged Patients with Dementia

Xin Dang, Bingbing Kang, Xuyang Liu, Guangyu Cui
2017 Journal of Healthcare Engineering  
The input vector of the DNN includes motion and mental features and was extracted from a depth image and electroencephalogram that were acquired by Kinect and OpenBCI, respectively.  ...  Due to the limitations of the body movement and functional decline of the aged with dementia, they can hardly make an efficient communication with nurses by language and gesture language like a normal  ...  In the refine stage, the model is trained by the two-modal features and labeled data. The network structure is shown in Figure 9 .  ... 
doi:10.1155/2017/4128183 pmid:29065599 pmcid:PMC5540472 fatcat:vbms753fxzhkdn2j6evm7lkhse

Advances in neuroimaging to support translational medicine in dementia

Thomas Edmund Cope, Rimona Sharon Weil, Emrah Düzel, Bradford C Dickerson, James Benedict Rowe
2021 Journal of Neurology, Neurosurgery and Psychiatry  
Developments in MRI-based imaging and neurophysiology provide complementary quantitative assays of brain function and connectivity, for the direct testing of hypotheses of human pathophysiology.  ...  We look beyond traditional structural imaging used routinely in clinical care, to include ultrahigh field MRI (7T MRI), magnetoencephalography and PET with novel ligands.  ...  more closely related to a loss of functional connectivity and information transfer in brain networks than a sudden change in structure. 27 In AD, this is reflected in close associations between tau burden  ... 
doi:10.1136/jnnp-2019-322402 pmid:33568448 pmcid:PMC8862738 fatcat:kfzojf7vpncq7pgln7xiaue324

Conceptual Evolution in Alzheimer's Disease: Implications for Understanding the Clinical Phenotype of Progressive Neurodegenerative Disease

Gregory A. Jicha, Sarah A. Carr, Mark A. Lovell
2010 Journal of Alzheimer's Disease  
, and functional decline in the context of our developing understanding of the biological processes responsible for the pathogenesis of AD described in detail in the accompanying articles.  ...  Over the past several decades our understanding of Alzheimer's disease (AD) has seen an evolution from the dichotomous concept of normal versus AD in the dementia state to a more accurate and complete  ...  Second we acknowledge the many researchers and clinicians in the field that have not been cited in this manuscript.  ... 
doi:10.3233/jad-2010-1237 pmid:20061643 pmcid:PMC2881218 fatcat:sxczu4gxhjcznlvpt7ibcyteq4

Preliminary Clinical Diagnostic Criteria for Chronic Traumatic Encephalopathy: A Case Report and Literature Review

Richard Morgan, Jordon Prosapio, Sam Kara, Sreepadma Sonty, Pamela Youssef, Kester Nedd
2021 Interdisciplinary Neurosurgery  
Identifying disease-specific features and developing in vivo biomarkers are current research priorities.  ...  The clinical and imaging findings in this case were consistent with a diagnosis of mixed dementia and probable CTE.  ...  Chronic traumatic encephalopathy (CTE) can manifest in YOD and is linked to RHI. In this case, the spectrum of clinical and imaging features was suggestive of mixed dementia and probable CTE.  ... 
doi:10.1016/j.inat.2021.101290 fatcat:bhhmzqh2z5gv3b6uxevxtmjbpe

Repetitive Head Impacts and Chronic Traumatic Encephalopathy

Ann C. McKee, Michael L. Alosco, Bertrand R. Huber
2016 Neurosurgery clinics of North America  
and cognition, including the development of chronic traumatic encephalopathy (CTE).  ...  Clinically CTE is associated with violent behaviors, explosivity, a loss of control, depression, suicide, memory loss and cognitive changes.  ...  Advanced structural and functional neuroimaging modalities (e.g., diffusion tensor imaging, magnetic resonance spectroscopy, functional magnetic resonance imaging, susceptibility-weight imaging, positron  ... 
doi:10.1016/j.nec.2016.05.009 pmid:27637402 pmcid:PMC5028120 fatcat:xqns2j5ebbdcnd44b2gg2jkncu
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