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Mammalian Target of Rapamycin Inhibition Halts the Progression of Proteinuria in a Rat Model of Reduced Renal Mass

F. Diekmann, J. Rovira, J. Carreras, E. M. Arellano, E. Banon-Maneus, M. J. Ramirez-Bajo, A. Gutierrez-Dalmau, M. Brunet, J. M. Campistol
2007 Journal of the American Society of Nephrology  
In conclusion, sirolimus halted the progression of proteinuria and structural damage in a rat model of reduced renal mass, possibly through a reduction in renal VEGF activity.  ...  Our aim was to evaluate the effect of sirolimus, an mTOR inhibitor, on renal function and histology in a proteinuric model of reduced renal mass.  ...  Renal Functional Analysis Creatinine clearance was markedly reduced after renal mass reduction compared with sham-operated control rats.  ... 
doi:10.1681/asn.2007010087 pmid:17804674 fatcat:yneijql6ibcdjmtzcp67xiiwli

Breast reduction and subsequent cancer: A prophylactic perspective

Beniamino Palmieri, Giorgia Benuzzi, Alberto Costa, Simone Grappolini
2006 Breast  
The actual risk reduction for patients over 40 years of age is related to the weight of the surgical specimens during the previous operation.  ...  Our analysis of the published data suggested that hypertrophic breast remodelling decreases the risk of breast and other types of cancer in post-operative patients.  ...  Specifically, breast cancer was reduced by roughly 50% (29 observed tumours versus 53.9 expected tumours; RR ¼ 0.54).  ... 
doi:10.1016/j.breast.2005.09.011 pmid:16364646 fatcat:byknbghpfzax3afyspegghxciy

Breast reduction and cancer in the gland remnant: a review

Beniamino Palmieri, Alberto Costa, Giorgia Benuzzi
2005 Breast Cancer Research and Treatment  
The actual risk reduction for patients over 40 years of age is related to the weight of the surgical specimens during the previous operation.  ...  Our analysis of the published data suggested that hypertrophic breast remodelling decreases the risk of breast and other types of cancer in post-operative patients.  ...  Specifically, breast cancer was reduced by roughly 50% (29 observed tumours versus 53.9 expected tumours; RR ¼ 0.54).  ... 
doi:10.1007/s10549-005-0094-4 fatcat:axl73odwynaxxjjw2nuwfn2tom

Effect of a Real-Time Radiation Monitoring Device on Operator Radiation Exposure During Cardiac Catheterization: The Radiation Reduction During Cardiac Catheterization Using Real-Time Monitoring Study

G. Christopoulos, A. C. Papayannis, M. Alomar, A. Kotsia, T. T. Michael, B. V. Rangan, M. Roesle, D. Shorrock, L. Makke, R. Layne, R. Grabarkewitz, D. Haagen (+7 others)
2014 Circulation. Cardiovascular Interventions  
First (9 [4-17] versus 14 [7-25] μSv; P<0.001) and second (5 [2-10] versus 7 [4-14] μSv; P<0.001) operator radiation exposure was significantly lower in the Bleeper Sv group.  ...  R adiation exposure is invisible, 1-3 but may cause injury of both the patient and the operator. 4-11 Advances in imaging equipment 12 along with operator education 13,14 can significantly reduce radiation  ...  Similarly, second operator radiation exposure was significantly lower in the Bleeper Sv group (5 [2-10] versus 7 [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] μSv; P<0.001; 29% relative reduction;  ... 
doi:10.1161/circinterventions.114.001974 pmid:25423958 fatcat:lvyqghtmd5f4lbvv2tx3olvgcy

Systematic Review of Clinical Evidence for Local Anesthetic Wound Infiltration in Reduction of Post-Surgical Pain

Kevin LeBlanc, Sarah M. Sweitzer
2015 Internal Medicine Open Access  
Local anesthetic infiltration prior to surgical incision closure is a frequently used technique in the operating room.  ...  Debate continues, with clinicians, as to the effectiveness of this technique in pain reduction.  ...  period while still reducing post-operative pain.  ... 
doi:10.4172/2165-8048.1000207 fatcat:skdlocz2pbgcdboklubb7joq4m

Prevention of Post-operative Delirium in the Elderly Using Pharmacological Agents

Patrice Tremblay, Susan Gold
2016 Canadian Geriatrics Journal  
Fourteen articles found a reduced incidence of post-operative delirium using pharmacological agents: eight with antipsychotics, two with statins, one with melatonin, one with dexamethasone, one with gabapentin  ...  : delirium, post-operative delirium, post-operative cognitive dysfunction, surgical procedures, post-operative period, post-operative complications, antipsychotics, haloperidol, quetiapine, risperidone  ...  There was a reduction of post-operative delirium in the gabapentin group compared to placebo (0% versus 41.7%, p = .045).  ... 
doi:10.5770/cgj.19.226 pmid:27729950 pmcid:PMC5038927 fatcat:rmn5vahcrvcybcu3potp23vsq4

Radiation Dose Reduction during Radial Cardiac Catheterization: Evaluation of a Dedicated Radial Angiography Absorption Shielding Drape

Andrew Ertel, Jeffrey Nadelson, Adhir R. Shroff, Ranya Sweis, Dean Ferrera, Mladen I. Vidovich
2012 ISRN Cardiology  
All drape designs led to substantial reductions in operator radiation exposure compared to control (P<0.0001). The greatest decrease in radiation exposure (72%) was with the L-shaped design.  ...  There are concerns for increased radiation exposure to patients and operators. Methods.  ...  In this angulated projection, the relative reduction in radiation exposure to the operator achieved by Drape 2 was 86% (1432 ± 54 mGy versus 205 ± 14 mGy, P < 0.0001).  ... 
doi:10.5402/2012/769167 pmid:22988525 pmcid:PMC3439952 fatcat:7e4aiymsobcgxnilznnpyfz6ii

Reduction of Blood Loss During Laparoscopic Myomectomy: Uterine Artery Ligation Versus Intra-Vaginal Misoprostol

Ahmed Nofal
2019 Journal of Gynecology and Womens Health  
Objectives: This study was designed to compare laparoscopic uterine artery ligation and vaginal misoprostol in reducing intra-operative blood loss during laparoscopic myomectomy and verifies the effect  ...  blood loss was 522.5+136.6 versus 193.8+78.7 in misoprostol versus UAL groups and there was a highly significant difference between the two groups as regarding blood loss (less in UAL group), also there  ...  Reduction of Blood Loss During Laparoscopic Myomectomy: Uterine Artery Ligation Versus Intra-Vaginal Misoprostol.  ... 
doi:10.19080/jgwh.2019.16.555938 fatcat:podnkle3yvg5bhtrc4v2ewf5me

Mechanisms by Which Transradial Approach May Reduce Mortality in ST-Segment-Elevation Myocardial Infarction

C. M. Huff, S. Kapadia, S. V. Rao
2014 Circulation. Cardiovascular Interventions  
0.8%; P=0.01), and reduced TIMI major/minor bleeding (13.1% versus 2.3%; P=0.002).  ...  When compared with case-matched patients under- going transfemoral PCI, patients undergoing TRI had reduced access site bleeding (29.2% versus 10.0%; P<0.0001), reduced transfusion rate (7.7% versus  ... 
doi:10.1161/circinterventions.114.001627 pmid:25139088 fatcat:73l54cnjgfaghc6u6pu7pb4oha

PHC5 A COST-EFFECTIVENESS ANALYSIS OF RHBMP-2 IN SPINE FUSION SURGERY IN THE NETHERLANDS

M Van Genugten, A Chhabra, V Alt
2008 Value in Health  
As to resource use, the patch resulted in a incremental reduction in the following resource components: mean operating time in all surgery types: 24 min per patient (liver-36 min, herniotomy-25 min, intestine  ...  CONCLUSIONS: According to assessment by surgical experts, the application of a thrombin and fibrinogen coated collaged patch in abdominal surgery potentially leads to reduction of post-operative complications  ...  In RECORD1, rivaroxaban reduced total VTE (composite: any DVT, non-fatal PE, all-cause mortality) by 70% versus enoxaparin after 35 days prophylaxis, although the reduction in symptomatic VTE was not statistically  ... 
doi:10.1016/s1098-3015(10)66759-9 fatcat:nksgwmu6bzcblaeq3tvqqwokie

The effectiveness of variability reduction in decreasing wafer fabrication cycle time

Israel Tirkel
2013 2013 Winter Simulations Conference (WSC)  
Reducing variability for achieving decreased CT is less costly and more effective than reducing machine utilization or increasing capacity.  ...  It relies on queueing networks, CT and variability approximations, operational curve modeling, and common practice.  ...  The motivation for this work stems from the need to study the impact of variability on CT reduction, and to com-Tirkel pare the impact of variability versus the impact of utilization on CT reduction.  ... 
doi:10.1109/wsc.2013.6721739 dblp:conf/wsc/Tirkel13 fatcat:mzr3qkpfhjc5piiysvnnm73zcq

Operative Time and Other Outcomes of the Electrothermal Bipolar Vessel Sealing System (LigaSure™) Versus Other Methods for Surgical Hemostasis: A Meta-Analysis

Alex Macario, Franklin Dexter, Jennifer Sypal, Ned Cosgriff, B. Todd Heniford
2008 Surgical Innovation  
CRD summary The authors concluded that electrothermal bipolar vessel sealing systems reduced operating time by approximately one quarter compared to conventional methods of haemostasis, without increased  ...  The mean percentage reduction in operating time (normalised mean reduction) was calculated from reported mean or median values, with the 95% CI.  ...  reductions in operating time (normalised mean reduction 28%, 95% CI: 18%, 39%, p<0.0001; 15 RCTs), blood loss (mean reduction 43 mL, 95% CI: 14 mL, 73 mL, p=0.0021; five RCTs) and pain score (WMD 2.8  ... 
doi:10.1177/1553350608324933 pmid:18945705 fatcat:l5p3ez37s5frleskizgnndwgja

Commentary on "Enhanced recovery program for minimally invasive and vaginal urogynecologic surgery"

Marianne Koch
2018 International Urogynecology Journal  
The average amount of intravenous fluid administration during operation was significantly reduced (1,403 ml versus 690 ml; p < 0.0001), as well as the overall fluid administration during hospitalization  ...  The ERPs included individual pre-operative patient education, a pre-operative carbohydrate-loading drink, analgesia with reduced opioid doses, goal-directed fluid resuscitation, immediate postoperative  ...  The average amount of intravenous fluid administration during operation was significantly reduced (1,403 ml versus 690 ml; p < 0.0001), as well as the overall fluid administration during hospitalization  ... 
doi:10.1007/s00192-018-3815-z pmid:30478603 fatcat:6eaghhagijc4rob3ixtygrydoq

Page 48 of Aquatic Conservation : Marine and Freshwater Ecosystems Vol. 5, Issue 1 [page]

1995 Aquatic Conservation : Marine and Freshwater Ecosystems  
; downstream versus upstream dredging; and the improved monitoring of sediment build up and selective dredging to reduce the extent of dredging operations.  ...  Approaches to reducing costs and environmental impacts of operational maintenance practices.  ... 

Osteotomy, compression and other modifications of surgical techniques for internal fixation of extracapsular hip fractures

Martyn J Parker, Helen HG Handoll
2009 The Cochrane library  
Comparison 2 Osteotomy versus anatomical reduction: sliding hip screw, Outcome 1 Operative details: length of surgery and blood loss.  ...  operation time for osteotomy of 103 versus 83 minutes.  ...  Unclear B -Unclear Sernbo 1994 Methods Randomised using sealed envelope opened in the operating theatre N O T E S Previous titles no longer in use: 2.  ... 
doi:10.1002/14651858.cd000522.pub2 pmid:19370559 fatcat:mmrpwmqufzfz3cmjbzxtxpbmiq
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