739 Hits in 7.4 sec

Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials

Yuguo Yu, Adam P. Hill, David A. McCormick, Olaf Sporns
2012 PLoS Computational Biology  
Increases in temperature result in an exponential increase in energy efficiency for single action potentials by increasing the rate of Na + channel inactivation, resulting in a marked reduction in overlap  ...  Here we demonstrate that this increase in energy efficiency is due largely to a warmer body temperature.  ...  Methods for Computational Model of Action Potential Generation in Cortical Neurons 1) Original Hodgkin-Huxley Model.  ... 
doi:10.1371/journal.pcbi.1002456 pmid:22511855 pmcid:PMC3325181 fatcat:ctvx7doizrbyldcb74mcvmjxxi

Voltage-gated potassium channels and the diversity of electrical signalling

Lily Yeh Jan, Yuh Nung Jan
2012 Journal of Physiology  
Since Hodgkin and Huxley discovered the potassium current that underlies the falling phase of action potentials in the squid giant axon, the diversity of voltage-gated potassium (Kv) channels has been  ...  Abstract Since Hodgkin and Huxley discovered the potassium current that underlies the falling phase of action potentials in the squid giant axon, the diversity of voltage-gated potassium (Kv) channels  ...  physiological purposes of distinct neuronal types as well as different subcellular compartments of a neuron.  ... 
doi:10.1113/jphysiol.2011.224212 pmid:22431339 fatcat:ide2josdvzgjzmizyv5x6yy65q

Action Potential Energy Efficiency Varies Among Neuron Types in Vertebrates and Invertebrates

Biswa Sengupta, Martin Stemmler, Simon B. Laughlin, Jeremy E. Niven, Karl J. Friston
2010 PLoS Computational Biology  
In the Hodgkin-Huxley model of the squid axon, optimizing the kinetics or number of Na + and K + channels can whittle down the number of ATP molecules needed for each AP by a factor of four.  ...  In the single compartment models studied here, AP energy consumption varies greatly among vertebrate and invertebrate neurons, with several mammalian neuron models using close to the capacitive minimum  ...  Andreas Herz for hosting him at the Bernstein Centre in Munich during the initial stages of the project. Author Contributions  ... 
doi:10.1371/journal.pcbi.1000840 pmid:20617202 pmcid:PMC2895638 fatcat:uwxtwngb45ep5e7yeexvjgnxxu

Action-potential-encoded second-harmonic generation as an ultrafast local probe for nonintrusive membrane diagnostics

M. N. Shneider, A. A. Voronin, A. M. Zheltikov
2010 Physical Review E  
The Hodgkin-Huxley treatment of the dynamics of a nerve impulse on a cell membrane is combined with a phenomenological description of molecular hyperpolarizabilities to develop a closed-form model of an  ...  This model is employed to understand the key properties of the map between the action potential and modulation of the second harmonic from a cell membrane stained with hyperpolarizable chromophore molecules  ...  This work was supported in part by the Federal Program of the Russian Ministry of Education and Science ͑Contracts No. 1130 and No. 02.740.11.0223͒.  ... 
doi:10.1103/physreve.81.031926 pmid:20365789 fatcat:ned3ad37ufa5xdgbp4hbnlbvbu

Function of K2P channels in the mammalian node of Ranvier

Jürgen R. Schwarz
2021 Journal of Physiology  
First, at body temperature K2P channels have a high open probability, thereby inducing a resting potential of about -85 mV.  ...  The mammalian node contains a high density of Na+ channels and K+ -selective leakage channels. Voltage-dependent Kv1 channels are only present in the juxta-paranode.  ...  Acknowledgements I want to thank Dr Christiane Bauer and Dr Vitya Vardanjan for helpful comments on the manuscript, Dr Matthias Kneussel for his hospitality at the Institute of Neurogenetics, ZMNH, and  ... 
doi:10.1113/jp281723 pmid:34425634 fatcat:5ysifhwg3vbtzeqj7wntfjs6q4

Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity

Martin Wechselberger, Chadwick L. Wright, Georgia A. Bishop, Jack A. Boulant
2006 American Journal of Physiology. Regulatory Integrative and Comparative Physiology  
These models suggest that most PO/AH neurons have the same types of ionic channels, but different levels of channel expression can explain the inherent properties of the various types of temperature-sensitive  ...  Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity.  ...  Jack Enyeart for his helpful advice for this work.  ... 
doi:10.1152/ajpregu.00039.2006 pmid:16690776 fatcat:uqqndyf6i5fv5jhqdzu6ksbhlu

Thermodynamic Analyses Of Information Dissipation Along The Passive Dendritic Trees And Active Action Potential

Bahar Hazal Yalçınkaya, Bayram Yılmaz, Mustafa Özilgen
2017 Zenodo  
Neural work transmits information between the neurons or neurons and target cells by moving charged particles in a voltage field; a fraction of the energy utilized in this process is dissipated via entropy  ...  Concurrently, single action potential Na+ ion load, metabolic energy utilization and its thermodynamic aspect contributed for squid giant axon and mammalian motoneuron model.  ...  At a given pH, biophysical conditions set for mammalian motoneuron model are as pH=7, T=310. 15 III. RESULTS A.  ... 
doi:10.5281/zenodo.1128901 fatcat:xtxtce7gmzh7pdz5iky56sioem

Differential effect of brief electrical stimulation on voltage-gated potassium channels

Morven A. Cameron, Amr Al Abed, Yossi Buskila, Socrates Dokos, Nigel H. Lovell, John W. Morley
2017 Journal of Neurophysiology  
Differential effect of brief electrical stimulation on voltagegated potassium channels. stimulation of neuronal tissue is a promising strategy to treat a variety of neurological disorders.  ...  We show that nonspiking amacrine neurons of the retina exhibit a large variety of responses to stimulation, driven by different K V -channel subtypes.  ...  Channels were mathematically described using Hodgkin-Huxley type kinetics.  ... 
doi:10.1152/jn.00915.2016 pmid:28202576 pmcid:PMC5411463 fatcat:l2dfpyu44vhefj26lmwxevwsau

Temporal Considerations for Stimulating Spiral Ganglion Neurons with Cochlear Implants

Jason Boulet, Mark White, Ian C. Bruce
2015 Journal of the Association for Research in Otolaryngology  
However, the exact forms of neural response properties can vary across different types of neurons.  ...  A wealth of knowledge about different types of neural responses to electrical stimulation has been developed over the past 100 years.  ...  Paul Abbas, Lianne Cartee, and Elisabeth Glowatzki for allowing the use of their figures in this paper.  ... 
doi:10.1007/s10162-015-0545-5 pmid:26501873 pmcid:PMC4722016 fatcat:vzyoh2fwnbeuzfc76vhdmvnige

Noisy Inputs and the Induction of On–Off Switching Behavior in a Neuronal Pacemaker

David Paydarfar, Daniel B. Forger, John R. Clay
2006 Journal of Neurophysiology  
Noisy inputs and the induction of on-off switching behavior in a neuronal pacemaker. .  ...  of normal and pathological neurons.  ...  Robichaud for assistance in data analysis and preparation of the figures.  ... 
doi:10.1152/jn.00486.2006 pmid:16956993 fatcat:esquekmgozd35ifm77h63b42ca

Temperature Affects Voltage-Sensitive Conductances Differentially in Octopus Cells of the Mammalian Cochlear Nucleus

Xiao-Jie Cao, Donata Oertel
2005 Journal of Neurophysiology  
As expected, the kinetics of the currents were faster at higher than at lower temperature.  ...  Temperature affects voltagesensitive conductances differentially in octopus cells of the mammalian cochlear nucleus.  ...  In the outward rectification of rat skeletal muscle, Q 10 values of time constants associated with the n parameter in a Hodgkin-Huxley model for activation varied between ϳ2 over 30 -38°C and 6 over 1-  ... 
doi:10.1152/jn.01049.2004 pmid:15800074 fatcat:n3otbmryfnbyffbday377uvhga

GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons

Shlomo S. Dellal, Ray Luo, Thomas S. Otis
2012 Journal of Neurophysiology  
A Hodgkin-Huxleystyle compartmental model of the PF axon and granule cell body was constructed, and this model recapitulated the GABA-dependent decrease in AP threshold and the increase in conduction velocity  ...  In the adult mammalian brain, GABA A receptors (GABA A Rs) are responsible for the predominant forms of synaptic inhibition, but these receptors can excite neurons when the chloride equilibrium potential  ...  ACKNOWLEDGMENTS We are grateful to Vivy Tran for technical support and Dr. Walther Akemann for initial assistance in construction of the computational model.  ... 
doi:10.1152/jn.01028.2011 pmid:22378171 pmcid:PMC3378368 fatcat:5iwgdwpxqzd2pkc22qiirnhe6e

Mechanisms and Distribution of Ion Channels in Retinal Ganglion Cells: Using Temperature as an Independent Variable

Jürgen F. Fohlmeister, Ethan D. Cohen, Eric A. Newman
2010 Journal of Neurophysiology  
The Q10s systematically increase for T Ͻ23°C (kinetic Q10 ϭ 8 at T ϭ 8°C). The Na channels were consistently "sleepy" (non-Arrhenius) for T Ͻ8°C, with a loss of spiking for T Ͻ7°C.  ...  The distributions are cell-type specific and adequate for soma and dendritic excitation with a safety margin.  ...  A C K N O W L E D G M E N T S We thank the Minnesota Supercomputer Institute for access to computing facilities for this study. We thank Drs.  ... 
doi:10.1152/jn.00123.2009 pmid:20053849 pmcid:PMC2887638 fatcat:jtl6cvxb4fdthfnrtygqwhcwmq

Thermal stress and neural function: adaptive mechanisms in insect model systems

R. Meldrum Robertson
2004 Journal of Thermal Biology  
Prior stress down-regulates neuronal K + currents and this is associated with adaptive increases in the duration of action potentials.  ...  Neural circuit function is vulnerable to hyperthermic failure but can be protected by stress pretreatments, such as exposure to a brief, sub-lethal high temperature (heat shock, HS), by increasing the  ...  There are at least two important consequences of a reduction in neuronal K + conductance: first the increase in action potential duration noted above, and second a reduction in the potential build-up of  ... 
doi:10.1016/j.jtherbio.2004.08.073 fatcat:mnbfgmucbbao3anwq26n7eoxrm

Peptidergic Counter-Regulation of Ca2+- and Na+-Dependent K+ Currents Modulates the Shape of Action Potentials in Neurosecretory Insect Neurons

Dieter Wicher, Jens Berlau, Christian Walther, Alexander Borst
2006 Journal of Neurophysiology  
We quantified the hormone-induced changes in ion currents in terms of Hodgkin-Huxley models and simulated the resulting activity of DUM neurons.  ...  Upregulation of P/Q-type Ca 2ϩ and K Ca current enhanced the hyperpolarization but had a weak effect on spiking.  ...  To simulate spiking of DUM neurons, we developed a one-compartment model that includes a set of 10 ion currents described in terms of the Hodgkin-Huxley formalism.  ... 
doi:10.1152/jn.00904.2005 pmid:16177173 fatcat:svsiw5sey5elji7jixpgzqvskm
« Previous Showing results 1 — 15 out of 739 results