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Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers

A.C. Burggren, M.M. Zeineh, A.D. Ekstrom, M.N. Braskie, P.M. Thompson, G.W. Small, S.Y. Bookheimer
<span title="">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
APOE-4 carriers had reduced cortical thickness compared with non-carriers in entorhinal cortex (ERC) and the subiculum (Sub), but not in the main hippocampal body or perirhinal cortex.  ...  ) using a high-resolution in-plane (.4×.4mm) MRI sequence in 30 cognitively normal volunteers (14 APOE-4 carriers, 16 non-carriers, mean age 57 years).  ...  Debbie Dorsey for help in subject recruitment, data management, and study coordination.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2008.03.039">doi:10.1016/j.neuroimage.2008.03.039</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18486492">pmid:18486492</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2601686/">pmcid:PMC2601686</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/m2rt3rbx2vc4bhwjm3ypdhp674">fatcat:m2rt3rbx2vc4bhwjm3ypdhp674</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211121832/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2601686&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4d/7f/4d7f9646d155891cc1076168e2a61d1d61cef981.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2008.03.039"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601686" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Family History of Alzheimer's Disease and Hippocampal Structure in Healthy People

Markus Donix, Alison C. Burggren, Nanthia A. Suthana, Prabha Siddarth, Arne D. Ekstrom, Allison K. Krupa, Michael Jones, Laurel Martin-Harris, Linda M. Ercoli, Karen J. Miller, Gary W. Small, Susan Y. Bookheimer
<span title="">2010</span> <i title="American Psychiatric Publishing"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dqvsfzghyzfq3bbad65qqfafui" style="color: black;">American Journal of Psychiatry</a> </i> &nbsp;
The authors investigated the influence of APOE-4 genotype and family history risks on cortical thickness in medial temporal lobe subregions among volunteers without cognitive impairment.  ...  In addition to the e4 allele of the apolipoprotein E gene (APOE-4), the major known genetic risk factor, a family history of Alzheimer's disease also increases the risk to develop the disease, reflecting  ...  Debbie Dorsey for assistance in subject recruitment, data management, and study coordination.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1176/appi.ajp.2010.09111575">doi:10.1176/appi.ajp.2010.09111575</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20686185">pmid:20686185</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3086166/">pmcid:PMC3086166</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vlkjsxa4wngolba3y7orhryfuq">fatcat:vlkjsxa4wngolba3y7orhryfuq</a> </span>
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Reduced hippocampal CA2, CA3, and dentate gyrus activity in asymptomatic people at genetic risk for Alzheimer's disease

Nanthia A. Suthana, Allison Krupa, Markus Donix, Alison Burggren, Arne D. Ekstrom, Michael Jones, Linda M. Ercoli, Karen J. Miller, Prabha Siddarth, Gary W. Small, Susan Y. Bookheimer
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
We found reduced left CA2, 3 and dentate gyrus (CA23DG) activity in cognitively intact APOE-4 carriers.  ...  These results suggest that reduced neural activity in hippocampal subregions may underlie the compensatory increase in extra hippocampal activity in people with a genetic risk for Alzheimer's disease prior  ...  Finally, we also wish to thank all of the subjects for their participation in this study.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2009.12.014">doi:10.1016/j.neuroimage.2009.12.014</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20005961">pmid:20005961</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3260048/">pmcid:PMC3260048</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/do2vrvwrhzgxhphva4qju6oyx4">fatcat:do2vrvwrhzgxhphva4qju6oyx4</a> </span>
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Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism

Markus Donix, Alison C. Burggren, Nanthia A. Suthana, Prabha Siddarth, Arne D. Ekstrom, Allison K. Krupa, Michael Jones, Anup Rao, Laurel Martin-Harris, Linda M. Ercoli, Karen J. Miller, Gary W. Small (+1 others)
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
People with the apolipoprotein-Eε4 (APOE-4) genetic risk for Alzheimer's disease show morphologic differences in medial temporal lobe regions when compared to non-carriers of the allele.  ...  Using a high-resolution MRI and cortical unfolding approach, our aim was to determine the rate of cortical thinning among medial temporal lobe subregions over the course of 2 years.  ...  Debbie Dorsey for help in subject recruitment, data management, and study coordination. Supported by NIH grants P01-AG025831, AG13308, P50 AG  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2010.06.009">doi:10.1016/j.neuroimage.2010.06.009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20541611">pmid:20541611</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3118546/">pmcid:PMC3118546</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/omtz535wjfewha7cywquskvow4">fatcat:omtz535wjfewha7cywquskvow4</a> </span>
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APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease

Markus Donix, Alison C. Burggren, Maria Scharf, Kira Marschner, Nanthia A. Suthana, Prabha Siddarth, Allison K. Krupa, Michael Jones, Laurel Martin-Harris, Linda M. Ercoli, Karen J. Miller, Annett Werner (+5 others)
<span title="2013-09-27">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pqgqyradj5fpvb5x22wo3ecaui" style="color: black;">Psychiatry Research : Neuroimaging</a> </i> &nbsp;
Non-carriers of the allele showed this asymmetry only in the patient group. Cortical thickness in the hippocampus did not vary between hemispheres among APOE-4 allele carriers and non-carriers.  ...  The APOE-4 allele modulates hemispheric asymmetry in entorhinal cortical thickness.  ...  Small is among the inventors, has received royalties, and may receive royalties on future sales. Dr.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pscychresns.2013.09.006">doi:10.1016/j.pscychresns.2013.09.006</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24080518">pmid:24080518</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3851589/">pmcid:PMC3851589</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5s4yov7yavcxfaob5ownrt4k4a">fatcat:5s4yov7yavcxfaob5ownrt4k4a</a> </span>
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Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers

Nicholas G. Dowell, Simon L. Evans, Paul S. Tofts, Sarah L. King, Naji Tabet, Jennifer M. Rusted
<span title="2016-02-29">2016</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rr3xugvwirasdcilw2b3upxqpi" style="color: black;">NMR in Biomedicine</a> </i> &nbsp;
2016) Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers. NMR in Biomedicine, 29 (5).  ...  Index Terms-apolipoprotein E e4; cortical thickness; white matter volume; resting-state MRI; regional brain volume; neurogenesis. I.  ...  Measures of cortical thickness in the hippocampal subregions have shown that e4+ aged 45-55 years suffer a thinning of the entorhinal cortex and subiculum: overall volume only differed at the trend level  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/nbm.3502">doi:10.1002/nbm.3502</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26929040">pmid:26929040</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qvkteycmdjfjtfdxcshwhpm6n4">fatcat:qvkteycmdjfjtfdxcshwhpm6n4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170921221051/http://sro.sussex.ac.uk/59840/1/APOE_volume_paper_LYX_template.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/81/e8/81e8e29d4fbc5ad9052c4458b4d74ddf9d1c3106.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/nbm.3502"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a>

APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease

Ivar Reinvang, Thomas Espeseth, Lars Tjelta Westlye
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bphxj3vvszarjlpalo447rq3nm" style="color: black;">Neuroscience and Biobehavioral Reviews</a> </i> &nbsp;
Individuals carrying the *E4 allele of the apolipoprotein E gene (APOE) are at increased risk of developing Alzheimer's disease (AD).  ...  In vivo techniques such as neuroimaging and cognitive testing offer valuable insights into the effects of APOE genotype on brain structure and function in healthy and clinical populations.  ...  Fennema-Notestine et al. (2011) studied a large group of healthy 50-59 year olds and found reduced cortical thickness in frontal but not in temporal regions in *E4 carriers.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neubiorev.2013.05.006">doi:10.1016/j.neubiorev.2013.05.006</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23701948">pmid:23701948</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/js4cp5zvjrfpnf7elnq6g3jcky">fatcat:js4cp5zvjrfpnf7elnq6g3jcky</a> </span>
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APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease

Michela Pievani, Samantha Galluzzi, Paul M. Thompson, Paul E. Rasser, Matteo Bonetti, Giovanni B. Frisoni
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
E4 carriers and non-carriers did not differ in their level of impairment in global cognition (p = 0.91, Mann-Whitney test) or memory (p N 0.29).  ...  Prior studies reported that the hippocampal volume is smaller in Alzheimer's disease patients carrying the Apolipoprotein E ε4 allele (APOE4) versus patients who are non-carriers of this allele.  ...  Several clinical and genetic factors may modulate AD pathology, such as age at onset, gender, the Apolipoprotein E (ApoE) gene, or education (Frisoni et al., 2007; Juottonen et al., 1998; Bennett et al  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2010.12.081">doi:10.1016/j.neuroimage.2010.12.081</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21224004">pmid:21224004</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ohztyc37rnevle5enhqnzmpeie">fatcat:ohztyc37rnevle5enhqnzmpeie</a> </span>
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Five-Year Longitudinal Brain Volume Change in Healthy Elders at Genetic Risk for Alzheimer's Disease

Katherine Reiter, Kristy A. Nielson, Sally Durgerian, John L. Woodard, J. Carson Smith, Michael Seidenberg, Dana A. Kelly, Stephen M. Rao, Mark Bondi
<span title="2016-12-20">2016</span> <i title="IOS Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uux5o5kf5zaednhl4637xcmbte" style="color: black;">Journal of Alzheimer&#39;s Disease</a> </i> &nbsp;
Cross-sectional studies of cognitively intact elders have noted smaller hippocampal/medial temporal volumes in ε4 carriers (ε4+) compared to ε4 non-carriers (ε4-).  ...  Possession of an Apolipoprotein-E (APOE) ε4 allele is the strongest genetic risk factor for late onset AD.  ...  *Corresponding author: Schey Center for Cognitive Neuroimaging, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue/U10, Cleveland,  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/jad-160504">doi:10.3233/jad-160504</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27834774">pmid:27834774</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5924681/">pmcid:PMC5924681</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rnn4fuqxkffinamy37nx7nr5vy">fatcat:rnn4fuqxkffinamy37nx7nr5vy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719071649/https://epublications.marquette.edu/cgi/viewcontent.cgi?article=1261&amp;context=psych_fac" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b1/00/b100255ac96ea2e91edf269fedc59faed2dc97ea.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/jad-160504"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924681" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Applying surface-based hippocampal morphometry to study APOE-E4 allele dose effects in cognitively unimpaired subjects

Qunxi Dong, Wen Zhang, Jianfeng Wu, Bolun Li, Emily H. Schron, Travis McMahon, Jie Shi, Boris A. Gutman, Kewei Chen, Leslie C. Baxter, Paul M. Thompson, Eric M. Reiman (+2 others)
<span title="2019-03-04">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/47gmsc3hojdm5kdlgbg4peyvyi" style="color: black;">NeuroImage: Clinical</a> </i> &nbsp;
Apolipoprotein E (APOE) e4 is the major genetic risk factor for late-onset Alzheimer's disease (AD).  ...  (mean = 57.4, SD = 6.3), including 36 heterozygotes (e3/e4), 37 homozygotes (e4/e4) and 44 non-carriers (e3/e3).  ...  Acknowledgements Algorithm development and image analysis for this study was funded, in part, by the National Institute on Aging (R21AG043760 to TM, JS, LCB, RJC and YW, R21AG049216 to WZ, JS, PMT and  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2019.101744">doi:10.1016/j.nicl.2019.101744</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30852398">pmid:30852398</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6411498/">pmcid:PMC6411498</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j52cs6je5nazxort5nx3pwvyoq">fatcat:j52cs6je5nazxort5nx3pwvyoq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200503084509/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6411498&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/76/83/76835aaff3f250fdcaf69d9baf1d4fb09ab849cb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nicl.2019.101744"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411498" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Characterizing the Preclinical Stages of Alzheimer's Disease and the Prospect of Presymptomatic Intervention

Richard J. Caselli, Eric M. Reiman, George Perry, Xiongwei Zhu, Mark A. Smith, Aaron Sorensen, Jesús Avila
<span title="2012-12-27">2012</span> <i title="IOS Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uux5o5kf5zaednhl4637xcmbte" style="color: black;">Journal of Alzheimer&#39;s Disease</a> </i> &nbsp;
The most prevalent genetic risk factor is the e4 allele of apolipoprotein E (APOE).  ...  MRI studies have shown progressive hippocampal and gray matter atrophy with the advent of mild cognitive impairment (MCI), and fluorodeoxyglucose PET scans show reduced cerebral metabolism in posterior  ...  Acknowledgments This work was supported in part by NIA P30AG19610, R01AG031581, and the Arizona Alzheimer's Research Consortium.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/jad-2012-129026">doi:10.3233/jad-2012-129026</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22695623">pmid:22695623</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3628721/">pmcid:PMC3628721</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/allha3cczffl5fx7ewz6vgd6hy">fatcat:allha3cczffl5fx7ewz6vgd6hy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200502044005/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3628721&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2f/35/2f350d88a61fe82babe08ec221278aad879d97b3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/jad-2012-129026"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628721" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging

Susan Bookheimer, Alison Burggren
<span title="">2009</span> <i title="Annual Reviews"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rpukehwtajcnzphwqlgxiyudsi" style="color: black;">Annual Review of Clinical Psychology</a> </i> &nbsp;
Recent studies using a variety of brain imaging technologies have detected subtle changes in brain structure and function in normal adults with a genetic risk for AD; these brain changes have similar pathological  ...  A few pharmacotherapies may improve cognition for a relatively short duration, and although new treatments are under development, the most promising treatments aim to reduce or halt the rate of decline  ...  Our lab examined the thickness of the cortical ribbon across the many subregions of the hippocampal complex-including the entorhinal cortex, subiculum, and the Ammon's Horn (CA) fields-in older, nondemented  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1146/annurev.clinpsy.032408.153625">doi:10.1146/annurev.clinpsy.032408.153625</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19327032">pmid:19327032</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3118550/">pmcid:PMC3118550</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/y6rar2w4cne45pzhnndx3nl2dy">fatcat:y6rar2w4cne45pzhnndx3nl2dy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200505214508/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3118550&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d5/45/d5456f754e44450d7f6e52a94d107c8621aebb19.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1146/annurev.clinpsy.032408.153625"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118550" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Episodic memory on the path to Alzheimer's disease

Michela Gallagher, Ming Teng Koh
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/k3yjoadbwjdifhgyc2nqlfzg2u" style="color: black;">Current Opinion in Neurobiology</a> </i> &nbsp;
The layer II neurons in the entorhinal cortex and their targets in the dentate gyrus and CA3 region of hippocampus comprise a system that rapidly encodes representations that are distinct from prior memories  ...  This review is focused on specific circuits of the medial temporal lobe that have become better understood in recent years for their computational properties contributing to episodic memory and to memory  ...  In comparison to older heterozygote carriers and non-carriers, e4 homozygote carriers have greater deficits in episodic memory tasks [58] , and e4 carrier status is associated with greater longitudinal  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.conb.2011.10.021">doi:10.1016/j.conb.2011.10.021</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22079495">pmid:22079495</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3254732/">pmcid:PMC3254732</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lkxopcjq45fgxmmd6lna7g3hsu">fatcat:lkxopcjq45fgxmmd6lna7g3hsu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20150630092248/http://neuroscience.jhu.edu/uploads/publications/Gallagher_M/1-s2_0-S0959438811001875-main.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9b/26/9b26447e79c2027a76bd9c9632e9cede9ccac33d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.conb.2011.10.021"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254732" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Family History and APOE-4 Genetic Risk in Alzheimer's Disease

Markus Donix, Gary W. Small, Susan Y. Bookheimer
<span title="2012-02-23">2012</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/op3rjsbjzndt7o3szw2e425u7m" style="color: black;">Neuropsychology Review</a> </i> &nbsp;
There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.  ...  The e4 allele of the apolipoprotein E gene (APOE-4) on Chromosome 19 is a perfect example for this scientific challenge.  ...  risk on hippocampal subfield and entorhinal cortical thickness (Donix et al. 2010a ).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11065-012-9193-2">doi:10.1007/s11065-012-9193-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22359096">pmid:22359096</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3797601/">pmcid:PMC3797601</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/n4qyfoqvlvhs3pyowvsorsxrl4">fatcat:n4qyfoqvlvhs3pyowvsorsxrl4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200206045712/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3797601&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/dc/25/dc259c643215efd3ae02a7b4231c00e0978e9bf8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11065-012-9193-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797601" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Enchi Liu, John C. Morris, Ronald C. Petersen (+7 others)
<span title="">2012</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/skzqffpatvawfgf7uspguqs4yu" style="color: black;">Alzheimer&#39;s &amp; Dementia</a> </i> &nbsp;
When cortical thickness in predefined ROIs was examined in carriers and noncarriers of the APOE ɛ4 allele who had a CSF biomarker profile consistent with AD, carriers were more impaired in measures of  ...  They found that ventricular expansion was associated with reduced CSF Aβ levels in normal elderly carriers of APOE ɛ4, but that in APOE ɛ4-positive AD patients, ventricular expansion was associated with  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2011.09.172">doi:10.1016/j.jalz.2011.09.172</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22047634">pmid:22047634</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3329969/">pmcid:PMC3329969</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kkpjb6lv6zbe3lkv7nllgxdnga">fatcat:kkpjb6lv6zbe3lkv7nllgxdnga</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830020340/http://www.adni-info.org/Scientists/doc/ADNI_review_update2013-manuscript.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ee/67/ee672e84921308979927c8fdb93433efd05e947f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2011.09.172"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329969" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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