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Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder

Zaiyang Long, Carla Medlock, Mario Dzemidzic, Yong-Wook Shin, Andrew W. Goddard, Ulrike Dydak
2013 Progress in Neuro-psychopharmacology and Biological Psychiatry  
A significant decrease in GABA, expressed as the ratio of GABA over total creatine (GABA/tCr), was detected in the anterior cingulate cortex (ACC)/medial prefrontal cortex (mPFC) in PD patients (p<0.05  ...  Changes of various brain metabolites including γ-aminobutyric acid (GABA), measured by 1Hmagnetic resonance spectroscopy (MRS), have been reported in panic disorder (PD).  ...  This work was supported by a Collaborative Research Grant by the Indiana Clinical and Translational Sciences Institute, funded in part by grant # RR 02576 from the National Institutes of Health, National  ... 
doi:10.1016/j.pnpbp.2013.01.020 pmid:23391588 pmcid:PMC3758115 fatcat:dnecdeacabaibhyr4nu4xcv43y

Cortical Gamma-Aminobutyric Acid and Glutamate in Posttraumatic Stress Disorder and Their Relationships to Self-Reported Sleep Quality

Dieter J. Meyerhoff, Anderson Mon, Thomas Metzler, Thomas C. Neylan
2014 Sleep  
Design: Laboratory study using in vivo proton magnetic resonance spectroscopy (1H MRS) and behavioral testing. Setting: VA Medical Center Research Service, Psychiatry and Radiology.  ...  Conclusions: Low brain gamma-Aminobutyric acid (GABA) concentration in posttraumatic stress disorder (PTSD) is consistent with most findings in panic and social anxiety disorders.  ...  ACKNOWLEDGMENTS The authors thank Clare Henn-Haase, Charles Marmar, Maryann Lenoci, and all volunteers for their participation in this research.  ... 
doi:10.5665/sleep.3654 pmid:24790267 pmcid:PMC3985106 fatcat:eqs5susct5cn3dyj5rlca77z44

Reduced Hippocampal Volume and Neurochemical Response to Adult Stress Exposure in a Female Mouse Model of Urogenital Hypersensitivity

Aaron D. Brake, Xiaofang Yang, Chu-Yu Lee, Phil Lee, Paul Keselman, Olivia C. Eller, In-Young Choi, Janna L. Harris, Julie A. Christianson
2022 Frontiers in Pain Research  
Here, we are using magnetic resonance imaging and spectroscopy (MRI and MRS) to further investigate both NMS- and acute stress-induced changes in the hippocampus of female mice.  ...  Together, these data suggest that NMS in mice reduces left hippocampal volume and may result in mitochondrial dysfunction and reduced neuronal integrity of the right hippocampus in adulthood.  ...  Asymmetry of temporal lobe phosphorous metabolism in schizophrenia: a 31phosphorous magnetic resonance spectroscopic imaging study. Biol Psychiatry.  ... 
doi:10.3389/fpain.2022.809944 pmid:35295799 pmcid:PMC8915737 fatcat:nhs5gv7tancznf4mobujskixgy

Society of biological psychiatry 2001 annual meeting

2001 Biological Psychiatry  
At the molecular level, stimulation of dopamine D1 receptors in the striatum promotes activation of the transcription factor CREB.  ...  Addictive drugs promote dopamine release in multiple forebrain regions. In the dorsal and ventral striatum, dopamine can act as a reinforcement signal controlling learning processes.  ...  Methods: Using proton magnetic resonance spectroscopic imaging (1H MRSI) previous findings have shown reduced N-acetylaspartate (NAA: a putative neuronal marker) levels within this region in schizophrenia  ... 
doi:10.1016/s0006-3223(01)01102-7 fatcat:iyjyq4h4qjavffdvbmr3vlfwj4

Poster Session I

2013 Neuropsychopharmacology  
A significant contributor to cognitive impairments seen in SZ may be the elevated levels of kynurenic acid (KYNA), observed in the brains of patients with SZ.  ...  Acute elevation of KYNA in adult rats results in significantly reduced, delay-dependent performance in the DNMTP task.  ...  We focused on the whole medial temporal lobe.  ... 
doi:10.1038/npp.2013.279 fatcat:54ipecxjarcvljrvn5fgtgif5u

Poster Session III

2004 Neuropsychopharmacology  
Immunoblot analysis detected increased levels of GluR1 expression in the VTA of social defeat-sensitized rats.  ...  A diagnosis of ASPD was made by applying the International Personality Disorder Examination and the psychopathic traits were evaluated in the patients by the Hare Psychopathy Checklist revised.  ...  Methods: BOLD-sensitive functional magnetic resonance imaging (fMRI) and single-voxel 1H-proton magnetic resonance spectroscopy (MRS) were performed on ten subjects with DSM-IV generalized SAD and ten  ... 
doi:10.1038/sj.npp.1300648 fatcat:vw22deytbbeyrpwv7zwkwotqgm

Poster Session II

2005 Neuropsychopharmacology  
The corpus callosum was the focus of this analysis, which was divided into 7 segments based on the previous work by Witelson (1989) in order to compare regions of the corpus callosum and thereby examine  ...  Results: Results showed a significant increase in λ2 in the genu of the anterior corpus callosum in cocaine dependent subjects compared to controls.  ...  Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S Kegeles, Gordon W Frankle, Raj Narendran, Roberto Gil,  ... 
doi:10.1038/sj.npp.1300970 fatcat:ikayo4dkwrdrthgopr2hltn2hi

Poster Session III

2006 Neuropsychopharmacology  
in the resting-state using functional magnetic resonance imaging (fMRI).  ...  Magnetic resonance imaging was performed for region definition (including posterior cingulate/precuneus (PRC) and parietal (PAR) cortex) and partial volume correction.  ...  cortical degeneration which starts in the entorhinal regions of the medial temporal lobes.  ... 
doi:10.1038/sj.npp.1301268 fatcat:rl22v3qzwfh4hcr2c4z3b2daoi

Poster Session I

2004 Neuropsychopharmacology  
In cocaine-dependent subjects, the anterior cingulate and right anterior temporal cortex demonstrated increased rCBF following ondansetron relative to saline, whereas there were no regions of interest  ...  Results: In controls, increased rCBF was observed in the right orbitofrontal cortex (OFC) and NAc region following ondansetron in comparison to saline.  ...  Since neurochemical changes have been documented with normal aging and in patients with schizophrenia, this study used proton proton magnetic resonance spectroscopy (1H MRS) to assess white matter abnormalities  ... 
doi:10.1038/sj.npp.1300646 fatcat:ee4zdyczlzc2pgxomn5ucq6cm4

Poster Session II

2012 Neuropsychopharmacology  
Using specialized Magnetic Resonance Spectroscopy (MRS) techniques it is possible to measure in vivo GABA levels in localized regions of the brain.  ...  frontal lobe and right temporal lobe compared to controls.  ...  Moreover, neuroimaging studies have detected abnormalities in schizophrenia patients in the structure and function of brain areas mediating emotional learning, including regions of the medial temporal  ... 
doi:10.1038/npp.2012.220 fatcat:coblfrtlujc6hdycjbnrdwzslm

Poster Session I

2015 Neuropsychopharmacology  
To-date, no studies have explored the effect of yoga on cognition and resting state functional Magnetic Resonance Imaging (rs-fMRI).  ...  Increased DMN connectivity correlated with improved verbal memory in the frontal medial cortex, pregenual anterior cingulate cortex, right middle frontal cortex, posterior cingulate cortex, and left lateral  ...  The goal of our study was to measure TSPO levels with [11C] PBR28 PET imaging in alcohol dependent subjects during acute abstinence and healthy controls, preliminarily assessing neuroimmune function in  ... 
doi:10.1038/npp.2015.325 pmid:26632286 pmcid:PMC4672310 fatcat:cqqyl6zydfeuxltv6zkqhn7qry

Poster Session II

2015 Neuropsychopharmacology  
)-alpha led to increased glutamate (normalized to creatine or Glu/Cr) in the left basal ganglia and dorsal anterior cingulate cortex (dACC) as measured by proton magnetic resonance spectroscopy (MRS).  ...  We used proton magnetic resonance spectroscopy (1HMRS) to investigate possible neurochemical abnormalities in the left and right ventrolateral prefrontal cortices (VLPFC), and the anterior cingulate cortex  ...  Alternatively, results could reflect the motivation of these patients to reduce their food intake and lose weight.  ... 
doi:10.1038/npp.2015.326 pmid:26632287 pmcid:PMC4672311 fatcat:ib64i5qmzngvxcpn5hznkcagie

39th Meeting of the Canadian Congress of Neurological Sciences

2004 Canadian Journal of Neurological Sciences  
Objective: To detect Tau and Glx by proton magnetic resonance spectroscopy (MRS) in neonates with HIE and/or seizures (SZ).  ...  P-028 In vivo detection of abnormal taurine and glutamate by 1H magnetic resonance in neonatal hypoxic-ischaemic encephalopathy and seizures.  ...  Renal Impairment In patients with severe renal impairment, the clearance of almotriptan was decreased.  ... 
doi:10.1017/s0317167100002961 fatcat:3umzmupwt5b6vc2ec5akfgbms4

Poster Session I

2014 Neuropsychopharmacology  
in these regions.  ...  two regions (60% above the values later in the episode).  ...  Using 1H-[13C]-nuclear magnetic resonance spectroscopy, we demonstrate that the antidepressant efficacy of three unique drugs with rapid antidepressant properties (ketamine, Ro-25, 6981, and scopolamine  ... 
doi:10.1038/npp.2014.280 fatcat:xunw4pdn75hlnmhvvksgp2lsse

31st Meeting of the Canadian Congress of Neurological Sciences

1996 Canadian Journal of Neurological Sciences  
dominant side of medial temporal lobe epilepsy (MTLE).  ...  Methods: We describe the results of cortical stimulation, of functional Positron Emission Tomography (f-PET) and of Magnetic Resonance Spectroscopy (MRS) in 3 patients with CD operated on for the treatment  ...  Results: The patient underwent craniotomy for a lesion that on magnetic resonance imaging was suspicious for a left parietal lobe neoplasm. At the time of craniotomy infarcted tissue was encountered.  ... 
doi:10.1017/s0317167100020849 fatcat:rueh6t47qzb55abv7q46jgctl4
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