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Realistic modeling of mesoscopic ephaptic coupling in the human brain

Giulio Ruffini, Ricardo Salvador, Ehsan Tadayon, Roser Sanchez-Todo, Alvaro Pascual-Leone, Emiliano Santarnecchi, Daniele Marinazzo
2020 PLoS Computational Biology  
Here we aim to model mesoscopic ephaptic activity in the human brain and explore its trajectory during aging by characterizing the electric field generated by cortical dipoles using realistic finite element  ...  of 401 realistic human brain models from healthy subjects aged 16-83.  ...  Acknowledgments Giulio Ruffini would like to thank Niels Birbaumer for inspiring discussions on the relation of tES with EEG neurofeedback.  ... 
doi:10.1371/journal.pcbi.1007923 pmid:32479496 fatcat:t3dvtxrxy5e4rj4yw6f4nahtpq

Personalization of hybrid brain models from neuroimaging and electrophysiology data [article]

Roser Sanchez-Todo, Ricardo Salvador, Emiliano Santarnecchi, Fabrice Wendling, Gustavo Deco, Giulio Ruffini
2018 bioRxiv   pre-print
We propose to model the individual human brain as a network of neural masses embedded in a realistic physical matrix capable of representing measurable electrical brain activity.  ...  We show that individual information can be represented in model space through the proper adjustment of two parameters (global coupling strength and conduction velocity), and that the underlying structural  ...  Conflict of interest RS-T and RS work for Neuroelectrics, a company developing medical devices in the space of transcranial current stimulation.  ... 
doi:10.1101/461350 fatcat:7ms3p5vcwvgqnbxtzoqtcrh3li

Revisiting the Quantum Brain Hypothesis: Toward Quantum (Neuro)biology?

Peter Jedlicka
2017 Frontiers in Molecular Neuroscience  
A conventional wisdom is that in the brain the quantum fluctuations are self-averaging and thus functionally negligible.  ...  However, this intuition might be misleading in the case of non-linear complex systems.  ...  A more specific prediction of Al-Khalili and McFadden's theory (see above) would be that successful models will have to include quantum coherence in ion channels as well as ephaptic coupling between endogenous  ... 
doi:10.3389/fnmol.2017.00366 pmid:29163041 pmcid:PMC5681944 fatcat:zzisg2nbsrac7mw4ccipfyyt7a

Computational Algorithms Derived from Multiple Scales of Neocortical Processing

Lester Ingber
2011 Cognitive Computation  
Even within this confined context, a case has been made that it should not be expected that the proposed Holy Grail of neuroscience, i.e., to ultimately explain all brain processing in terms of a nonlinear  ...  science at molecular scales, is at all realistic.  ...  It hank Paul Nunez for several discussions on electrical and magnetic fields in neocortex.  ... 
doi:10.1007/s12559-011-9105-4 fatcat:vct2pchtdvfhbpxj4ywxigyl7q

Spatial Working Memory in Humans Depends on Theta and High Gamma Synchronization in the Prefrontal Cortex

Ivan Alekseichuk, Zsolt Turi, Gabriel Amador de Lara, Andrea Antal, Walter Paulus
2016 Current Biology  
working memory performance in humans.  ...  Here we externally modulated the interaction of theta and gamma rhythms in the prefrontal cortex using novel cross-frequency protocols of transcranial alternating current stimulation to affect spatial  ...  ACKNOWLEDGMENTS The authors wish to thank Christine Crozier for proofreading the manuscript. This research was supported by the Deutsche Forschungsgemeinschaft (Priority Program SPP 1665 to W.P.).  ... 
doi:10.1016/j.cub.2016.04.035 pmid:27238283 fatcat:tl6am2x3jbdf5poyuxpbb5s5qy

Emerging Phenomenological and Biological Principles of Consciousness: Top Insights of Prevailing Models, Concepts, and Observations

Ravinder Jerath, Connor Beveridge
2019 World Journal of Neuroscience  
In this article, we review potential principles of consciousness revealed by prominent consciousness models, theories, and experimental observations such as the Default Space Theory, Operational Architectonics  ...  The concepts we review include the unity of consciousness, bioelectric operations as the substrate of consciousness, the emergence of a virtual 3D matrix, and the top-down dominance of perception.  ...  Conflicts of Interest The authors declare no conflict of interest.  ... 
doi:10.4236/wjns.2019.93011 fatcat:gjk5iqh6l5hevbohhdm3v6wpze

Toward integrative approaches to study the causal role of neural oscillations via transcranial electrical stimulation

Valeriia Beliaeva, Iurii Savvateev, Valerio Zerbi, Rafael Polania
2021 Nature Communications  
Diverse transcranial electrical stimulation (tES) techniques have recently been developed to elucidate the role of neural oscillations, but critically, it remains questionable whether neural entrainment  ...  Here, we provide a perspective on an emerging integrative research program across systems, species, theoretical and experimental frameworks to elucidate the potential of tES to induce neural entrainment  ...  This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 758604).  ... 
doi:10.1038/s41467-021-22468-7 pmid:33854049 fatcat:pcn3ole7kfdunbus7prxwe7euu

Analysis and extension of exact mean-field theory with dynamic synaptic currents [article]

Giulio Ruffini
2021 bioRxiv   pre-print
As an example, we analyze the dynamics of a single population model, and a model of two coupled populations with a simple excitation-inhibition (E-I) architecture, showing it displays rich dynamics with  ...  Neural mass models such as the Jansen-Rit system provide a practical framework for representing and interpreting electrophysiological activity (1-6) in both local and global brain models (7).  ...  This work has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 855109) and from FET under the European  ... 
doi:10.1101/2021.09.01.458563 fatcat:m6pykglplngjjetwjizajtkjuy

Coupled Oscillators Model Of Hyperexcitable Neuroglial Networks

Firas H. Farah, Vasily Grigorovsky, Berj L. Bardakjian
2018 International Journal of Neural Systems  
Furthermore, there was evidence of theta-HFO phase-amplitude cross-frequency coupling (CFC) in the short SEDs, and delta-HFO CFC in the long SEDs, as was previously reported in a mouse model of Seizure-Like  ...  Events (SLEs) and in human patients with epilepsy. iii  ...  Furthermore, the presence of delta-HFO coupling has been identified as a marker for epileptogenesis in humans [33] .  ... 
doi:10.1142/s0129065718500417 pmid:30415633 fatcat:eypxogew55ecvizcncpulpl5qu

27th Annual Computational Neuroscience Meeting (CNS*2018): Part One

2018 BMC Neuroscience  
Alliance through the Initiative and Networking Fund of the Helmholtz Association and the Helmholtz Portfolio theme "Supercomputing and Modeling for the Human Brain" and the European Union Seventh Framework  ...  Acknowledgements We acknowledge the Initiative and Networking Fund of the Helmholtz Association, the Helmholtz Association through the Helmholtz Portfolio Theme"Supercomputing and Modeling for the Human  ...  In order to study these effects in greater detail, we have developed a generalized framework for modeling ephaptic coupling in morphologically more-realistic neurons.  ... 
doi:10.1186/s12868-018-0452-x pmid:30373544 pmcid:PMC6205781 fatcat:xv7pgbp76zbdfksl545xof2vzy

Nonlinear brain dynamics as macroscopic manifestation of underlying many-body field dynamics

W FREEMAN, G VITIELLO
2006 Physics of Life Reviews  
We focus on a mesoscopic level that offers a multi-step pathway between the microscopic functions of neurons and the macroscopic functions of brain systems revealed by hemodynamic imaging.  ...  Neural activity patterns related to behavior occur at many scales in time and space from the atomic and molecular to the whole brain.  ...  Acknowledgements We are grateful to Harald Atmanspacher, Eliano Pessa and Terence Barrett for reading the manuscript and for useful comments.  ... 
doi:10.1016/j.plrev.2006.02.001 fatcat:2lvuuxt6r5aybei5ha45m2maym

Bringing Anatomical Information into Neuronal Network Models [article]

Sacha Jennifer van Albada, Aitor Morales-Gregorio, Timo Dickscheid, Alexandros Goulas, Rembrandt Bakker, Sebastian Bludau, Günther Palm, Claus-Christian Hilgetag, Markus Diesmann
2020 arXiv   pre-print
In addition, we touch upon the most prominent features of brain organization that are likely to influence predicted neuronal network dynamics, with a focus on the mammalian cerebral cortex.  ...  It is instructive, and in certain cases necessary, to use organizational principles that link the plethora of data within a unifying framework where regularities of brain structure can be exploited to  ...  Accurate representations of volume transmission effects such as ephaptic coupling (nonsynaptic communication via electrical fields or ions) [97] , as well as the prediction of meso-and macroscopic signals  ... 
arXiv:2007.00031v2 fatcat:lud5jok65re5rhecxjtsis3x5u

29th Annual Computational Neuroscience Meeting: CNS*2020

2020 BMC Neuroscience  
by visual experience, and (iii) how patterns of neural activity in the zebrafish brain develop to facilitate precisely targeted hunting behaviour.  ...  Deep RL offers a rich framework for studying the interplay among learning, representation and decision-making, offering to the brain sciences a new set of research tools and a wide range of novel hypotheses  ...  Acknowledgments: The research reported here was supported, in part, by NSF grant #1544383 and in part by AFOSR grant #FA9550-16-1-0410.  ... 
doi:10.1186/s12868-020-00593-1 pmid:33342424 fatcat:edosycf35zfifm552a2aogis7a

28th Annual Computational Neuroscience Meeting: CNS*2019

2019 BMC Neuroscience  
We have recently revealed the presence of dynamical invariants in the pyloric CPG in the form of cycle-by-cycle linear relations among specific time intervals and the instantaneous period [4].  ...  supercritical Hopf bifurcation, that in presence of the theta forcing is excited, giving rise to gamma oscillations super imposed on the theta rhythm, somehow similarly to what previously found in [8].  ...  [2] constructed a two-brain model in which Kuramoto oscillators, as brain regions, are connected according to an anatomically realistic human connectome.  ... 
doi:10.1186/s12868-019-0538-0 fatcat:3pt5qvsh45awzbpwhqwbzrg4su

30th Annual Computational Neuroscience Meeting: CNS*2021–Meeting Abstracts

2021 Journal of Computational Neuroscience  
One of the goals of neuroscience is to understand the computational principles that describe the formation of behaviorally relevant signals in the brain, as well as how these computations are realized  ...  Currently, most functional models of neural activity are based on firing rates, while the most relevant signals for inter-neuron communication are spikes.  ...  Programme for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project SGA3) and No. 785907 (Human Brain Project SGA2).  ... 
doi:10.1007/s10827-021-00801-9 pmid:34931275 pmcid:PMC8687879 fatcat:evpmmfpaivgpxdqpive5xdgmwu
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