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StdpC: A modern dynamic clamp
2006
Journal of Neuroscience Methods
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With the advancement of computer technology many novel uses of dynamic clamp have become possible. ...
These examples illustrate that with modern dynamic clamp software like StdpC, the dynamic clamp has developed beyond the mere introduction of artificial synapses or ionic conductances into neurons to a ...
Taking advantage of the versatility of the new dynamic clamp software we can now create a biophysically more realistic neuron model within the dynamic clamp and connect it to biological neurons through ...
doi:10.1016/j.jneumeth.2006.05.034
pmid:16846647
fatcat:gbry5y34s5hq3dbquhm6ewurgm
Real-time closed-loop electrophysiology: towards new frontiers in in vitro investigations in the neurosciences
2007
Archives Italiennes de Biologie
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In this contribution, we review some of the most relevant examples of a new trend in in vitro electrophysiology, ranging from the use of dynamic-clamp to multi-electrode distributed feedback stimulation ...
In contrast, most in vitro preparations and experimental protocols operate autonomously, and do not depend on the output of the studied system. ...
Quantifying the "burstiness" of the cultures during spontaneous activity and during different stimulation protocols, they observed that slow stimulation through individual electrodes increased "burstiness ...
pmid:18075116
fatcat:pgethf2ntzdb5k5jbr5jbbwfvy
Cell-Specific Cardiac Electrophysiology Models
2015
PLoS Computational Biology
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In this study, we develop a new approach in which data are collected via a series of complex electrophysiology protocols from single cardiac myocytes and then used to tune model parameters via a parallel ...
The dynamical complexity of the electrophysiological data, which can only be fit by an automated method such as a GA, leads to more accurately parameterized models that can simulate rich cardiac dynamics ...
The protocol consists of (1) stochastic current-clamp stimulation and (2) multi-step voltage clamping. ...
doi:10.1371/journal.pcbi.1004242
pmid:25928268
pmcid:PMC4415772
fatcat:vsc2r7kulzfdtk62cbk5m2hkxq
A reconfigurable visual-programming library for real-time closed-loop cellular electrophysiology
2015
Frontiers in Neuroinformatics
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Moreover, advanced experimental protocols requiring real-time closed-loop operation to investigate excitability, plasticity, dynamics, are largely inaccessible to users without moderate to substantial ...
We provide and validate several examples, implementing conventional and more sophisticated experimental protocols such as dynamic-clamp or the combined use of intracellular and extracellular methods, involving ...
EPSP SIZE CLAMP Demo of clamping the response size, evoked by extracellular stimulation. ...
doi:10.3389/fninf.2015.00017
pmid:26157385
pmcid:PMC4477165
fatcat:qh2kk7uesnfnxmynzjfsnm6p7e
Synaptic Dynamics Do Not Determine Proper Phase of Activity in a Central Pattern Generator
2005
Journal of Neuroscience
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implemented with the dynamic-clamp technique. ...
The phase differences between rhythmically active neurons in a network are thought to arise from the interplay between their intrinsic properties and the temporal dynamics of synapses among these neurons ...
When the voltage-clamped PD neurons were stimulated with the realistic waveform with duty cycle 17%, we again observed that the dynamics of the IPSPs elicited in the LP and PY neurons were not significantly ...
doi:10.1523/jneurosci.3284-05.2005
pmid:16339022
fatcat:psmr645w4jdlvlug63fuhfihl4
Application of active electrode compensation to perform continuous voltage-clamp recordings with sharp microelectrodes
2014
Journal of Neural Engineering
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The AECVC method provides an entirely digital method to perform continuous recording and smooth switching between voltage-clamp, current clamp or dynamic-clamp configurations without introducing artifacts ...
We compared the performance of the two methods to dSEVC using a dynamic model cell and experiments in brain slices. Significance. ...
In order to perform advanced tests of the AECVC we built a 'dynamic model cell' (DMC) ( figure 3(B) ), which is a passive electronic model cell endowed with realistic membrane properties simulated by ...
doi:10.1088/1741-2560/11/5/056028
pmid:25246226
fatcat:4rp6bwwlhvhknbukvqweudpftu
Dynamic clamp with StdpC software
2011
Nature Protocols
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Here, we present a dynamic clamp protocol using free, fully integrated, open-source software (StdpC, Spike timing dependent plasticity Clamp). ...
Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs. ...
Other researchers have even extended the principles of dynamic clamp to interact with the nervous system through mechanical stimulation 24 or micro-injection of drugs 25 . ...
doi:10.1038/nprot.2010.200
pmid:21372819
pmcid:PMC3188375
fatcat:fzyhq3hpvzbprjxwyhw6qn6llq
Dynamic action potential clamp predicts functional separation in mild familial and severe de novo forms ofSCN2Aepilepsy
2018
Proceedings of the National Academy of Sciences of the United States of America
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Dynamic clamp is well positioned to impact our understanding of pathomechanisms and for development of disease mechanism-targeted therapies in genetic epilepsy. de novo SCN2A mutation | dynamic action ...
potential clamp | epilepsy | voltage clamp | modeling ...
We used two stimulating protocols to elicit action potentials. ...
doi:10.1073/pnas.1800077115
pmid:29844171
fatcat:wnutbiiklvf7zeszhvxmkjbhfa
Nanoscale Nonlinear Dynamic Characterization of the Neuron-Electrode Junction
2008
Journal of Computational and Theoretical Nanoscience
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For the characterization, NG108-15 cells were cultured on microelectrode arrays and stimulated with broadband Gaussian white noise under voltage clamp mode. ...
We present here the results obtained from a 'data-true' nonlinear dynamic characterization of the neuron-electrode junction using Volterra-Wiener modeling. ...
Micrograph of a neuron that is over an extracellular microelectrode while simultaneously being stimulated with bandlimited Gaussian white noise through a glass patch-clamp micropipette. ...
doi:10.1166/jctn.2008.1114
pmid:20204183
pmcid:PMC2831233
fatcat:nkjsrstuljfnzgmbuhzqv3ybyq
Matching storage and recall: hippocampal spike timing–dependent plasticity and phase response curves
2005
Nature Neuroscience
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Here, we develop a normative theory of autoassociative memory encompassing such network dynamics. ...
We show through simulation that such memories are competent analog autoassociators and demonstrate directly that the attributes of phase response curves of CA3 pyramidal cells recorded in vitro qualitatively ...
Sinusoidal inhibitory conductance mimicking hippocampal theta oscillation (5 Hz) was injected through the patch pipette using dynamic clamp. An EPSP was evoked using extracellular stimulation. ...
doi:10.1038/nn1561
pmid:16261136
fatcat:uqnsdqceo5asfc2uf2oxmxzwr4
Dynamic Control of Presynaptic Ca2+ Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons
2000
Neuron
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., 1997) but also show dynamic resolution (see Experimental Procedures), we obtained patch-clamp recordings from spherical structures of 3-5 m diameter in stratum lucidum of acute hippocampal ...
to 3-fold during high-frequency stimulation. ...
Voltage protocol: mock action potentials in (A) (holding potential Ϫ80 mV, 75 s ramp to ϩ40 mV, 125 s at ϩ40 mV, and ramp of variable duration back to Ϫ80 mV) and realistic action potentials in (B) (action ...
doi:10.1016/s0896-6273(00)00164-1
pmid:11163277
fatcat:q3hv5van6zer3cffelw3v6p3he
Dynamic clamp constructed phase diagram for the Hodgkin and Huxley model of excitability
2020
Proceedings of the National Academy of Sciences of the United States of America
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Here we experimentally assembled excitable membranes using the dynamic clamp and voltage-gated potassium ionic channels (Kv1.3) expressed in Xenopus oocytes. ...
Moreover, we demonstrate activity dependence and hysteretic dynamics over the phase diagram due to the impacts of complex slow inactivation kinetics. ...
Following the voltage clamp protocol, the system configuration was switched to dynamic clamp mode to screen the S-K plane. ...
doi:10.1073/pnas.1916514117
pmid:32024761
fatcat:nvciwkmjtzfmlaol7zywn3fkoi
Complex Dynamics in Simplified Neuronal Models: Reproducing Golgi Cell Electroresponsiveness
2018
Frontiers in Neuroinformatics
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Although these properties emerge from detailed representations of molecular-level mechanisms in "realistic" models, they cannot usually be generated by simplified neuronal models (although these may show ...
Importantly, E-GLIF is designed to maintain a correspondence between model parameters and neuronal membrane mechanisms through a minimum set of equations. ...
(C) The short continuous stimulation protocol is represented. ...
doi:10.3389/fninf.2018.00088
pmid:30559658
pmcid:PMC6287018
fatcat:nizmdoom6vab7hxdc4r3y7cks4
Integrated Mechanisms of Anticipation and Rate-of-Change Computations in Cortical Circuits
2007
PLoS Computational Biology
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Through biophysically realistic computer simulations and neuronal recordings, we show that the rateof-change computation is operated robustly in cortical networks through the combination of two ubiquitous ...
These basic computations of the cortical microcircuit emerge through the interplay of neuronal connectivity, cellular intrinsic properties, and synaptic plasticity dynamics. ...
By doing this, we reconstructed a smoother voltage time series that only incorporated events associated with our stimulation protocol. ...
doi:10.1371/journal.pcbi.0030082
pmid:17500584
pmcid:PMC1866356
fatcat:srl2bv6hhneq7oginvqzwzv5wu
Integrated Mechanisms of Anticipation and Rate-of-Change Computations in Cortical Circuits
2005
PLoS Computational Biology
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Through biophysically realistic computer simulations and neuronal recordings, we show that the rateof-change computation is operated robustly in cortical networks through the combination of two ubiquitous ...
These basic computations of the cortical microcircuit emerge through the interplay of neuronal connectivity, cellular intrinsic properties, and synaptic plasticity dynamics. ...
By doing this, we reconstructed a smoother voltage time series that only incorporated events associated with our stimulation protocol. ...
doi:10.1371/journal.pcbi.0030082.eor
fatcat:zqwca35bcrhdzjgbatillbvo5i
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