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A Mixed Filtering Approach for Real-Time Seizure State Tracking Using Multi-Channel Electroencephalography Data

Alexander G. Steele, Sankalp Parekh, Hamid Fekri Azgomi, Mohammad Badri Ahmadi, Alexander Craik, Sandipan Pati, Joseph T. Francis, Jose L. Contreras-Vidal, Rose T. Faghih
2021 IEEE transactions on neural systems and rehabilitation engineering  
In this research, we make multiple seizure state estimations using a mixed-filter and multiple channels found over the entire sensor space; then by applying a Kalman filter, we produce a single seizure  ...  Real-time continuous tracking of seizure state is necessary to develop feedback neuromodulation therapy that can prevent or terminate a seizure early.  ...  Expanding on previous work [1] , where the authors employed a mixed-filter approach to perform seizure state estimation using two EEG channels, we propose that the removal of the self-imposed channel  ... 
doi:10.1109/tnsre.2021.3113888 pmid:34543199 pmcid:PMC8626138 fatcat:ecqxtdtx7bchbe3kcomvvvxb7m

64-Channel UWB Wireless Neural Vector Analyzer SOC With a Closed-Loop Phase Synchrony-Triggered Neurostimulator

Karim Abdelhalim, Hamed Mazhab Jafari, Larysa Kokarovtseva, Jose Luis Perez Velazquez, Roman Genov
2013 IEEE Journal of Solid-State Circuits  
To minimize both the area and power dissipation of the SoC, the SAR ADC is re-used as a multiplier for FIR filtering and as a DAC and duty cycle controller for the biphasic neural stimulator.  ...  , a tri-core CORDIC processor, 64 biphasic current stimulation channels, and a 3.1-10.6 GHz UWB wireless transmitter onto a 4 mm × 3 mm 0.13 µm CMOS die.  ...  In a future study, we plan to trigger the neurostimulator before the In early seizure detection in rodents, the real-time processing of phase synchrony between two inputs in the 4 Hz and 8 Hz bands was  ... 
doi:10.1109/jssc.2013.2272952 fatcat:gel33rmobvgx3kewgqs3fhyvoq

Neuromorphic Architecture Accelerated Automated Seizure Detection in Multi-Channel Scalp EEG

Ravi Ambati, Shanker Raja, Majed Al-Hameed, Titus John, Youness Arjoune, Raj Shekhar
2022 Sensors  
A real-time automated seizure detection system with minimal latency can help time the injection properly to find the seizure origin accurately.  ...  Reliable real-time seizure detection systems have not been clinically reported yet.  ...  A real-time automated seizure detection system with minimal latency can help time the injection properly to find the seizure origin accurately.  ... 
doi:10.3390/s22051852 pmid:35271005 pmcid:PMC8914704 fatcat:wnhhg477qnbjtcesauhzufttny

Ping-pong beam training for reciprocal channels with delay spread

Elisabeth de Carvalho, Jorgen Bach Andersen
2015 2015 49th Asilomar Conference on Signals, Systems and Computers  
For a network where nodes must empty a queue in minimum time the use of CoF can outperform a traditional TDMA approach.  ...  Kalman filters can be used to track these drifts to maintain synchronization. A major challenge lies in the lack of precise knowledge of the process noise parameters.  ...  It is evaluated using simulations in a two-dimensional target tracking scenario. WA6a-3 9:05 AM Period Estimation and Tracking: Filter Bank Design using Truth Tables of Logic Srikanth V. Tenneti, P.  ... 
doi:10.1109/acssc.2015.7421451 dblp:conf/acssc/CarvalhoA15 fatcat:mqokuvnh3zg45licnfbgxyvxfu

Ion channels in EEG: isolating channel dysfunction in NMDA receptor antibody encephalitis

Mkael Symmonds, Catherine H Moran, M Isabel Leite, Camilla Buckley, Sarosh R Irani, Klaas Enno Stephan, Karl J Friston, Rosalyn J Moran
2018 Brain  
We show that the autoimmune patients exhibit distinct fronto-parietal network changes from which ion channel estimates can be obtained using a microcircuit model.  ...  Given that EEG is a ubiquitously available clinical method, our findings suggest a unique re-purposing of EEG data as an assay of brain network dysfunction at the molecular level.  ...  Using these time series we then applied an autoregressive method developed to calculate the complex cross spectral energy across these eight spatial modes, including the real auto-spectral energies and  ... 
doi:10.1093/brain/awy107 pmid:29718139 pmcid:PMC6207885 fatcat:ig6kcn4aanh3llbtjvpiuq7ley

Phase lag index: Assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources

Cornelis J. Stam, Guido Nolte, Andreas Daffertshofer
2007 Human Brain Mapping  
Methods: The PLI is a measure of the asymmetry of the distribution of phase differences between two signals.  ...  , and (iv) two MEG data sets.  ...  The state of oscillator i at time t was given by A sin u i -note that we used a constant amplitude A that was equal across oscillators.  ... 
doi:10.1002/hbm.20346 pmid:17266107 fatcat:ic5lfupaejg6hjegtdf2y4klvu

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

R. C. Wykes, J. H. Heeroma, L. Mantoan, K. Zheng, D. C. MacDonald, K. Deisseroth, K. S. Hashemi, M. C. Walker, S. Schorge, D. M. Kullmann
2012 Science Translational Medicine  
Thus, gene therapy in a rodent model can be used to suppress seizures acutely, prevent their occurrence after an epileptogenic stimulus, and successfully treat established focal epilepsy.  ...  We report the potential efficacy of gene therapy in focal neocortical epilepsy using a rodent model in which epilepsy is induced by tetanus toxin injection in the motor cortex.  ...  They took two approaches to reduce brain circuit excitability and hence epileptic seizures in the rat model.  ... 
doi:10.1126/scitranslmed.3004190 pmid:23147003 pmcid:PMC3605784 fatcat:egv56wrxqbdijamsskqwd2ixbe

A Minimally Invasive 64-Channel Wireless μECoG Implant

Rikky Muller, Hanh-Phuc Le, Wen Li, Peter Ledochowitsch, Simone Gambini, Toni Bjorninen, Aaron Koralek, Jose M. Carmena, Michel M. Maharbiz, Elad Alon, Jan M. Rabaey
2015 IEEE Journal of Solid-State Circuits  
The device is comprised of a highly flexible, high-density, polymer-based 64-channel electrode array and a flexible antenna, bonded to 2.4 mm × 2.4 mm CMOS integrated circuit (IC) that performs 64-channel  ...  The IC digitizes the signal from each electrode at 1 kS/s with 1.2 μV input referred noise, and transmits the serialized data using a 1 Mb/s backscattering modulator.  ...  As shown in Fig. 12 , the active rectifier utilizes two mixed-signal feed back loops to control the timing of the synchronous switches and prevent reverse conduction.  ... 
doi:10.1109/jssc.2014.2364824 fatcat:5y2uo3sdw5ahzjfqgzscb4yacy

System-Level Design of a 64-Channel Low Power Neural Spike Recording Sensor

Manuel Delgado-Restituto, Alberto Rodriguez-Perez, Angela Darie, Cristina Soto-Sanchez, Eduardo Fernandez-Jover, Angel Rodriguez-Vazquez
2017 IEEE Transactions on Biomedical Circuits and Systems  
Neural signals are acquired, filtered, digitized and compressed in the channels.  ...  This paper reports an integrated 64-channel neural spike recording sensor, together with all the circuitry to process and configure the channels, process the neural data, transmit via a wireless link the  ...  The tuning approach for the adjustment of the HP and LP channel corners is based on a mixed-signal control loop which uses, as feedback signal, the output of the ADC (see Fig. 5 ) and, as controlled signals  ... 
doi:10.1109/tbcas.2016.2618319 pmid:28212096 fatcat:kk2hkiahu5f7xkrx4kswvnqzja

Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury

Chase M. Carver, Haley R. DeWitt, Aiola P. Stoja, Mark S. Shapiro
2021 Frontiers in Neuroscience  
We observed that the time-dependent upregulation of TRPC4/TRPC5-containing channels alters cholinergic responses and activity of principal neurons acting to increase proexcitatory sensitivity.  ...  Overall, our evidence suggests that TBI-induced plasticity of TRPC channels strongly contributes to overt hyperexcitability and primes the hippocampus and cortex for seizures.  ...  Quantitative real-time PCR reactions were performed in a 7900 HT Fast Real-Time PCR system (Life Technologies) using SYBR Green PCR master mix (Thermo Fisher Scientific, Waltham, MA, United States).  ... 
doi:10.3389/fnins.2021.681144 pmid:34489621 pmcid:PMC8416999 fatcat:lfhqu25bpfbkjkcpakxjgw33te

Back-Channel Negotiation: International Bargaining in the Shadows

Anthony Wanis-St. John
2006 Negotiation journal  
The author concludes that while BCN can facilitate breakthrough agreements, it can also damage a peace process by helping to reinforce some of the uncertainties that gave rise to the use of back channels  ...  Back-channel negotiations (BCNs) are officially sanctioned negotiations conducted in secret between the parties to a dispute.  ...  By using two channels, a leader can float different proposals in each channel and see how it is received.  ... 
doi:10.1111/j.1571-9979.2006.00091.x fatcat:olmj5evv2rbfrjqpvz3urmy7ey


Edwin W. McCleskey, Michael S. Gold
1999 Annual Review of Physiology  
We thank Rachel James, from Edanz Group ( for editing a draft of this manuscript. Conflicts of Interest: The authors declare no conflict of interest.  ...  PCR was performed using a standard approach and PCR green master mix (Promega Corporation, Madison, WI, USA).  ...  different structural states of the selectivity filter.  ... 
doi:10.1146/annurev.physiol.61.1.835 pmid:10099712 fatcat:6cukvjnt3verlc26x7gm7bxooy

Detection of Schizophrenia Using Machine Learning on the Five Most Predictive EEG-Channels

Hermann Baumgartl, Stefanie Scholtz, Daniel Sauter, Ricardo Buettner
2021 Pacific Asia Conference on Information Systems  
For this, we only use one-minute recording time and a fine granular division of resting-state EEG spectra.  ...  Using Random Forest and majority voting, we detect schizophrenia based on those five channels.  ...  Acknowledgment We would like to thank the reviewers and mini-track chairs, who provided very helpful comments on the refinement of this paper.  ... 
dblp:conf/pacis/BaumgartlSSB21 fatcat:ip2qgq5mkbeedjbkhp7ic77xta

Collaborative Adaptive Filters for Online Knowledge Extraction and Information Fusion [chapter]

Beth Jelfs, Phebe Vayanos, Soroush Javidi, Vanessa Su Lee Goh, Danilo Mandic
2008 Signal Processing Techniques for Knowledge Extraction and Information Fusion  
We show that it is possible to use the fusion of the outputs of adaptive filters to produce a single collaborative hybrid filter and that by tracking the dynamics of the mixing parameter of this filter  ...  Implementations of the proposed hybrid filter in both the real R and complex C domains are analysed and the potential of such a scheme for tracking signal nonlinearity in both domains is highlighted.  ...  A simple form of mixing algorithm for two adaptive filters is a convex combination.  ... 
doi:10.1007/978-0-387-74367-7_1 fatcat:pyhbwt2pmvawhgmwn47nihyt4a

A Low Power System with EEG Data Reduction for Long-term Epileptic Seizures Monitoring

Syed Anas Imtiaz, Saam Iranmanesh, Esther Rodriguez-Villegas
2019 IEEE Access  
The results in this paper demonstrate the feasibility of a long-term seizure monitoring system capable of running autonomously for over two weeks.  ...  All the modules of the algorithm have been implemented on chip to use a small number of clock cycles and remain mostly in an idle mode.  ...  on a mobile phone in real-time.  ... 
doi:10.1109/access.2019.2920006 fatcat:rul5znk2g5f3tijp7brfh24jbm
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