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Analytical Study Of Hargouri Ras: An Ayurvedic Formulation

Dr Rashmi Saini, Dr Sharad Porte, Dr. Dipak Saini
2021 International Research Journal of Ayurveda & Yoga  
doi:10.47223/irjay.2021.4514 fatcat:odxzmrocmvfgnmnlavjlzlloya

DIAGNOSTIC METHOD OF CHRONIC MERCURY TOXICITY AND ITS AYURVEDIC MANAGEMENT

Rashmi Saini
2017 World Journal of Pharmaceutical Research  
net Vol 6, Issue 10, 2017. 236 Rashmi et al.  ...  [10] w.wjpr.net Vol 6, Issue 10, 2017. 231 Rashmi et al.  ... 
doi:10.20959/wjpr201710-9289 fatcat:cw62mlhzcbco3j4i5qufgl7jxy

Document Image Binarization Techniques, Developments and Related Issues: A Review

Rashmi Saini
2015 International Journal of Computer Applications  
Image binarization is still a relevant research area due to its wide range of applications in the field of document analysis and recognition. Accuracy of binarization methods affected by many factors such as shadows non-uniform illumination, low contrast, large signal-dependent noise etc. This paper provides a comprehensive survey of major binarization techniques. We also emphasis on the problems being encountered and the related issues in the research area of document image binarization. In
more » ... ition, some important issues affecting the performance of image binarization methods are also discussed. This literature review suggests that designing a suitable document image binarization method is a prerequisite for a successful document image analysis and recognition. General Terms Image Processing, Document image analysis.
doi:10.5120/20352-2541 fatcat:55tttebdkze4dfefcltbkemck4

Carbon dioxide (CO2) utilizing strain database
English

Saini Rashmi, C Majhi Manash, Kapoor Rupam, Kumar Rita, Kumar Anil
2011 African Journal of Biotechnology  
Culling of excess carbon dioxide from our environment is one of the major challenges to scientific communities. Many physical, chemical and biological methods have been practiced to overcome this problem. The biological means of CO 2 fixation using various microorganisms is gaining importance because database of their substantial role in reversing global warming. Carbon dioxide utilizing strain database (CSD) presents a comprehensive overview of microorganisms involved in biological fixation of
more » ... carbon dioxide. As a part of this work, the wealth of information on CO 2 utilizing strains was first collected and was then managed within four classes, that is, microorganisms, genus listing, mechanisms and literature. The first two classes consolidate information regarding the microbial genus and species, while the later two provide information regarding the CO 2 fixing pathways and the taxonomic details of these organisms. The database also holds the current information about the issue. CSD can be used to gain information related to CO 2 fixing microbes. It can also contribute to devising biological strategies for reducing carbon dioxide from the environment. It introduces an innovative idea of exploring the potential of these bacterial strains for reversing global warming. The CSD can be accessed at http://csd.igib.res.in.
doi:10.5897/ajb10.2643 fatcat:xyh7cl2zazbo5mg3zygcm7k42a

A study of the association of leukopenia with disease severity and mortality in patients diagnosed with COVID-19

Anant Parasher, Vishakha Saini, Ajay Saini, Rashmi Ranjan Barik, Abhinav Aggarwal, Javed Khan
2020 International Journal of Advances in Medicine  
It has been observed in patients suspected with COVID-19 or presenting as confirmed cases of COVID-19 that a decreased total white blood cell count (leukopenia) is quite a common haematological presentation. In this study we aimed to determine the effect of leukopenia on the progress and severity of COVID-19, as well as to establish the association of leukopenia with disease severity and overall mortality.Methods: This was a longitudinal study conducted at Guru Teg Bahadur hospital, New Delhi
more » ... om 1st July 2020 to 3rd August 2020. A sample size of 34 cases each in two groups (group A and B) was taken as one random case each day for the duration of the study; group A consisting of the patients presenting with leukopenia, while group B comprising of the patients with a normal leukocyte count.Results: The mean duration of hospital stay in group A was found to be 5.5±2.23 days, while the mean duration of stay in group B was found to be 2.9±1.17 days, showing a significant difference in the two groups with a p<0.001. It was also seen that a total of 8 out of 34 cases in group A and 2 out of the 34 cases in group B had expired during their hospital stay; a significant difference seen among the two groups with a p=0.04.Conclusions: Thus, in conclusion, this study demonstrates a definite and significant association between a decreased leukocyte count (leukopenia) and disease severity and mortality in patients with COVID-19.
doi:10.18203/2349-3933.ijam20204526 fatcat:y2tlrmkzh5frbpbzr2whsuzzba

Image Segmentation for Uneven Lighting Images based on Initial Window Size Selection

Rashmi Saini
2016 International Journal of Computer Applications  
Thresholding is a simple but effective technique for image segmentation. In this paper, a novel method is presented to address the problem of image segmentation for uneven lighting images that is based on dynamic size of window. In pyramid approach (window merging), segmentation accuracy depends on the initial size selection. The proposed method is based on the concept of window growing approach, in which after selecting the initial window, selection criterion is tested. If a sub-image or
more » ... does not satisfies the selection criterion, instead of merging with neighboring window (pyramid approach), window is incremented by small value. This process is repeated until it satisfies the given selection criterion. Thereafter segment the window by thresholding method. In the proposed method, initial size of window is computed at run time, which is based on image statistics. This method provides superior image segmentation over existing thresholding methods for images that are degraded, uneven illumination and suffer from the problem like shadow.
doi:10.5120/ijca2016912354 fatcat:xumzs7pa7jaydgh7drdcxqkpae

Characterization of Mce4A protein of Mycobacterium tuberculosis: role in invasion and survival

Neeraj Saini, Monika Sharma, Amita Chandolia, Rashmi Pasricha, Vani Brahmachari, Mridula Bose
2008 BMC Microbiology  
The mce4 operon is one of the four homologues of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. The mce4A (Rv3499c) gene within this operon is homologous to mce1A (Rv0169), that has a role in host cell invasion by M. tuberculosis. Our earlier reports show that mce4 operon is expressed during the stationary phase of growth of the bacillus in culture and during the course of infection in mammalian hosts. M. tuberculosis carrying mutation in mce4 operon shows growth defect and
more » ... duced survival in infected mice. However, the intracellular localization of Mce4A protein and its direct role in cell entry or survival of the bacillus has not been demonstrated so far. By transmission electron microscopy we have demonstrated that recombinant Mce4A protein facilitates the invasion of non-pathogenic strain of E. coli into non-phagocytic HeLa cells. We observe that mce4A gene has a role comparable to mce1A in the survival of recombinant E. coli in human macrophages. Using antibodies raised against Mce4A protein, we show that the protein is localized in the cell wall fraction of M. tuberculosis H37Rv stationary phase culture only. Mce4A protein is expressed during the stationary phase of broth culture and localizes in the cell wall fraction of M. tuberculosis. Mce4A protein expressed in non-pathogenic E. coli enables it to enter and survive within HeLa cells and the macrophages. As Mce4A protein is expressed during later phase of mycobacterial growth, our results raise the possibility of it playing a role in maintenance of persistent tubercular infection.
doi:10.1186/1471-2180-8-200 pmid:19019220 pmcid:PMC2596156 fatcat:sezfflabgbc2lbni6cp74z5qni

AN EXPERIMENTAL INVESTIGATION ON THE MECHANICAL PROPERTIES OF CONCRETE WITH GRADE M55 AND M60 BY PARTIAL REPLACEMENT WITH SILICA FUME

Laxmi Kant Saini, Laxmi Kant Saini, Jyoti Rashmi Nayak
2019 International Journal of Recent Trends in Engineering and Research  
Green Concrete is homogenous an artificial mixture of cement, natural sand, coarse aggregate and water. Its achievement lies in its versatility as can be designed to withstand harvest environment while taking on the most inspiring forms. This study investigates the performance of concrete under influence of silica fume in terms of slump, compressive strength at 7days and 28 days, flexural strength of beam at 28 days and splitting tensile strength of Cylinder at 28 days respectively. Total
more » ... of specimens of cubes, cylinders and beams were 50, 30 and 30 respectively, which were casted for testing to study influence of Silica fume on concrete. These Concrete specimens were deep cured in water under normal atmospheric temperature. On the basis of result that Silica fume mix concrete was found to increase in all strength (Compressive, Flexural & Splitting Tensile strength) of various mix of concrete at all age when compared to normal concrete. Its use should be promoted for better performance as well as for environmental sustainability. A total ten mix (trial mix, control mix and variation mix) were prepared for M55 & M60 grade of concrete.
doi:10.23883/ijrter.2019.5080.roqjv fatcat:j3w5usay5ve5nhcwhvhj3wdn7q

Role of Proton Beam Therapy in Current Day Radiation Oncology Practice

Gagan Saini, Rashmi Shukla, Kanika S. Sood, Sujit K. Shukla, Ritu Chandra
2020 Asian Journal of Oncology  
For example, an early-stage tumor on left side Role of Proton Beam Therapy in Current Day Radiation Oncology Saini et al. especially in the inner/central quadrant 44 or a locally advanced breast cancer  ...  currently being conducted to compare the biological effectiveness and safety of carbon-ion therapy with PT for skull base chordomas. 74 Role of Proton Beam Therapy in Current Day Radiation Oncology Saini  ... 
doi:10.1055/s-0040-1713703 fatcat:keeya2ywm5grnnnjfgt2hsgxha

AYURVEDIC ASPECT OF ENDOMETRIAL CARCINOMA AND ITS AYURVEDIC MANAGEMENT

Rashmi Saini, Sharad Maroti Porte, Vinod Kumar Gothecha, Anita Sharma
2016 International Journal of Research in Ayurveda and Pharmacy  
Cancer is the abnormal growth of cells or tissues and endometrial cancer. It is special abnormal uncontrolled growth of endometrial tissue. It is the 6 th most common cancer in women worldwide and 2 nd most cancer in the Indian women. Cancer is not new for Ayurveda which is described under the heading of the arbud (tumour). Though the endometrial cancer is not directly described in any textbook of Ayurveda but it is one part of asargdar having uterine bleeding other than menstrual bleeding
more » ... other causes. The main clinical feature of both endometrial cancer and asargdar is uterine bleeding along with its other complications. Uterine bleeding other than menstrual bleeding may be non-washable stain on clothes which may be help to differentiate normal menstrual and other than menstrual bleeding. Trividh pariksha also helps to diagnose the disease including endometrial cancer by means of darshan (Inspection), sparshan (palpitation) and prashan (Questioning). Chedan karma is recommended for the excision of arbud (tumour) which applicable in the solid tumour of endometrial carcinoma after excision polyherbal or herbal minerals Ayurvedic yogas Rodra ras, Vradhdaru churn, Vradhdaru yoga, Nityanand ras, Kachnar gugulu, Hargori ras will play major role in inhibiting the growth of cancer. Rakta praderhar yog, Ashokaristha, Pradarantak ras, Pradrari ras may helpful to stop the bleeding and will helpful to cure pandu with bleeding. Ratnaprabha vatika is a balya, vrishya, rasayan in nature along with anticancer property due to hirak bhasam. Thus Ayurveda may play a major role to cure endometrial cancer in future. Symptomatic Ayurvedic management of endometrium cancer (For Bleeding) Rkata Pradehar Yog -Having kashthodember (Ficus hispida) 25ml, mixed with 10grm honey then this is given in qvath form 29 .
doi:10.7897/2277-4343.0714 fatcat:3bx3ibdopfhgnjj4al5s37opaq

Effect of pioglitazone treatment in a patient with secondary multiple sclerosis

Harrihar A Pershadsingh, Michael T Heneka, Rashmi Saini, Navin M Amin, Daniel J Broeske, Douglas L Feinstein
2004 Journal of Neuroinflammation  
BACKGROUND: Ligands of the peroxisome proliferator-activated receptor-gamma (PPARgamma) induce apoptosis in activated T-lymphocytes and exert anti-inflammatory effects in glial cells. Preclinical studies have shown that the thiazolidinedione pioglitazone, an FDA-approved PPARgamma agonist used to treat type 2 diabetes, delays the onset and reduces the severity of clinical symptoms in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS). We therefore tested the
more » ... fety and therapeutic potential of oral pioglitazone in a patient with secondary MS. CASE PRESENTATION: The rationale and risks of taking pioglitazone were carefully explained to the patient, consent was obtained, and treatment was initiated at 15 mg per day p.o. and then increased by 15 mg biweekly to 45 mg per day p.o. for the duration of the treatment. Safety was assessed by measurements of metabolic profiles, blood pressure, and edema; effects on clinical symptoms were assessed by measurement of cognition, motor function and strength, and MRI. Within 4 weeks the patient exhibited increased appetite, cognition and attention span. After 12 months treatment, body weight increased from 27.3 to 35.9 kg (32%) and maintained throughout the duration of the study. Upper extremity strength and coordination improved, and increased fine coordination was noted unilaterally after 8 months and bilaterally after 15 months. After 8 months therapy, the patient demonstrated improvement in orientation, short-term memory, and attention span. MRIs carried out after 10 and 18 months of treatment showed no perceptible change in overall brain atrophy, extent of demyelination, or in Gd-enhancement. After 3.0 years on pioglitazone, the patient continues to be clinically stable, with no adverse events. CONCLUSIONS: In a patient with secondary progressive MS, daily treatment with 45 mg p.o. pioglitazone for 3 years induced apparent clinical improvement without adverse events. Pioglitazone should therefore be considered for further testing of therapeutic potential in MS patients.
doi:10.1186/1742-2094-1-3 pmid:15285799 pmcid:PMC483056 fatcat:ryulq3is3fba5hobt7ibapqllq

The protective effect of Podophyllum hexandrum on hepato-pulmonary toxicity in irradiated mice

Savita Verma, Bhargab Kalita, Rashmi Saini, Manju Gupta
2014 Oxidants and Antioxidants in Medical Science  
Objective: Present study reports the modulatory effect of a novel formulation (G-002M), prepared from three isolated molecules of Podophyllum hexandrum rhizomes on radiation induced oxidative stress in lung and liver tissues of strain A mice. Methods: Mice, administered with G-002M formulation 1 h prior to lethal (9Gy) radiation exposure dose, were sacrificed at different time intervals. Lung and liver tissues were processed to assess the expression of extracellular superoxide dismutase
more » ... by immunohistochemistry and Western blotting techniques. Histological alterations along with the biochemical determinations, using as reported markers of hepatic and lung oxidative stress were recorded. Preadministration of G-002M resulted in significant restoration of radiation induced decline in the expression of EC-SOD in both lung and liver tissues. Results: In lungs, radiation mediated histological alterations like alveolar edema, interalveolar septa thickening, inflammation and infiltration of inflammatory cells into alveolar spaces were significantly prevented by G-002M pre-treatment. Histopathological features of liver in response to radiation such as steatosis, deformed cell structure, vacuolization of the cytoplasm and injury of hepatocyte membranes were also minimized by formulation pre-treatment. The formulation could successfully inhibit radiation induced malondialdehyde (MDA) content and counter the radiation induced depletion in SOD, catalase, glutathione reductase, glutathione S-transferase and glutathione, in serum, lung and liver tissues. Radiation induced alterations in serum aspartate aminotransferase, alanine tranaminase, cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, alkaline phosphatase, total protein, albumin and lactate dehydrogenase were maintained by G-002M pre-treatment. Conclusion: These results demonstrated that the bioactive phyto-constituents of Podophyllum hexandrum could significantly protect lung and liver against radiation, predominantly by reduction in lipid peroxidation and elevation of EC-SOD along with a set of endogenous defense enzymes.
doi:10.5455/oams.261213.or.057 fatcat:3pl2f3ygibagrkiqi45sr6bvkq

Pseudomonas: A Major Bacteria in Heavy Metal Contaminated Soil of South-West Punjab, India

Arindam Adhikary, Rashmi Saini, Sanjeev Kumar, Sanjeev Kumar, Pankaj Bhardwaj
2019 International Journal of Plant and Environment  
Soil microflora is continuously changing with altered soil conditions. These soil alterations are a consequence of heavy metals entering and affecting every sphere of life. Heavy metals are not only hazardous for crops but also affect the soil microbial community. Soil bacteria with the potential of plant growth promotion and multiple metal resistances can be an instrument for crop improvement and heavy metal detoxification. In this study, predominant bacterial community associated with the
more » ... y metal contaminated soil was studied using 16S rRNA gene sequencing in association with culture-based techniques. Elemental metal analysis of collected soil samples showed an elevated level of metal content in the soil. 16S rRNA gene analysis and phylogenetic analysis of 126 bacterial clones revealed the probable predominance of Pseudomonas (40.48%) followed by Flavisolibacter (13.49%). Based on morphological and biochemical characterization, nine Pseudomonas strains were selected from the soil and were further confirmed by 16S rRNA gene sequencing with 92%-100% similarity with Pseudomonas species. The minimum inhibitory concentration (MIC) and maximum tolerance capacity (MTC) of three essential metals Cu, Zn, and Fe were determined individually and in combinations. It was found that Zn is the most toxic metal among the three metals and the metal showed a synergistic effect in inhibiting microbial growth when used in combinations. Presence of three metal resistant/tolerant genes czcA, pcoA and copB were also determined in the isolated Pseudomonas sp. by PCR. The soil in this region has high concentrations of heavy metals. The indigenous Pseudomonas sp. has multiple metal resistances and can be used for bioremediation of heavy metals and microbe assisted phytoremediation.
doi:10.18811/ijpen.v5i01.5 fatcat:lsrj4gv2dvgtzjcj5nqqe7d7pq

CORRELATION BETWEEN TOXIC STRESS BY HEAVY METAL TOXICANTS AND PERIPHYTIC PROTOZOAN COLONIZATION RATES

Neena Kumar, Rashmi Saini, Khushboo Chaudhary, Muskaan Bansal, Kanika A, Namrata Pandey
2017 International Journal of Advanced Research  
Metal pollution is considered hazardous to biological systems because of their toxic and carcinogenic potential. The behavioral, morphological and physiological changes have been prominently used in toxicity assessment studies in unicellular organisms. Recent studies have demonstrated that ciliates and flagellates play an important trophic role in periphytic communities and as bioindicator organisms for pollution degree in aquatic ecosystems. The present research was carried out to assess the
more » ... rrelation of toxic stress and deleterious impact of heavy metals (Copper, Cadmium, Zinc and Lead) on population densities of fresh water protozoans. Toxicity of four metals Cu 2+ (CuSO 4 . 5H 2 O), Cd 2+ (CdCl 2 ), Zn 2+ (ZnSO 4 ) and Pb 2+ (Pb(NO 3 ) 2 ) were studied at three different concentrations 50μg/ L, 100 μg/ L and 150 μg/ L each. Direct count method was employed for enumerating the population densities and toxic stress responses were seen quantitatively as well as qualitatively. Colonization rates expressed by the species number over time obtained depicted a geometric regression of the average number of protozoans with increasing concentration of metals as compared with controls. Irregular beating of flagella and cilia and erratic and spinning movements of ciliates along with blebbing, stress egestions were observed in presence of these toxic metals. Copper was found to be least toxic followed by Cadmium, Zinc and Lead in terms of increasing toxicity.Pb and Cd form organometallic complexes, the toxicological properties of which can be more toxic than individual ions due to their high bioaccumulation tendencies. With significant metal uptake tendencies, protozoans can have a potential use in bioremediation of polluted waters.
doi:10.21474/ijar01/4140 fatcat:3gygkwxgpjbpfnrknwku4yfmnu

Predictive Value of Platelet Indices in Development of Preeclampsia

Shaifali Dadhich, Sudesh Agrawal, Monica Soni, Rekha Choudhary, Rashmi Jain, Saroj Sharma, Sharad Lata Saini, Narendra Malhotra, Randhir Puri
2012 Journal of SAFOG with DVD  
Aim: To evaluate the association between changes in platelet indices (platelet count, mean platelet volume, platelet distribution width) and development of preeclampsia. Materials and methods: Two hundred pregnant women at 20 to 24 weeks of gestation with singleton pregnancy and normal blood pressure were enrolled after taking well-informed consent. At monthly intervals CBC (complete blood count) was done from 20 to 24 weeks till 40 weeks and 7 days after delivery. Data regarding changes in
more » ... elet indices with increasing gestation was collected and analyzed. Results: Platelet count decreased significantly in patients with preeclampsia compared to normal pregnant patients (19.4% vs 7.4%). Mean platelet volume increased significantly in preeclampsia patients (44.5% vs 9.22%). Increase in PDW was observed significantly in patients with preeclampsia (47.19% vs 29.4%). Conclusion: Patients with preeclampsia are more likely to have significant decrease in platelet count, increase in PDW and MPV. These changes can be observed at an earlier gestational age than significant rise in BP can be observed and are directly proportional to progressive rise in hypertension. Thus, estimation of platelet indices can be considered as an early, simple and cost-effective procedure in the assessment of severity of preeclampsia.
doi:10.5005/jp-journals-10006-1164 fatcat:bgc5vsd6rvacno4wt2phrlmvn4
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