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Anticancer activities of adenine nucleotides in tumor bearing hosts

Eliezer Rapaport
1993 Drug development research (Print)  
[Rapaport, 1990 ]?  ...  , 1983; Rapaport et al., 19831 .  ... 
doi:10.1002/ddr.430280344 fatcat:fc4wv3zkive4zptjmhpyn42hxa

Stress- and Growth Phase-Associated Proteins of Clostridium acetobutylicum

Joseph S. Terracciano, Eliezer Rapaport, Eva R. Kashket
1988 Applied and Environmental Microbiology  
The response of Clostridium acetobutylicum ATCC 4259 to the stresses produced by a temperature upshift from 28°C to 45°C and by exposure of the organisms to 0.1 % n-butanol or to air was examined by analysis of pulse-labeled proteins. The stress response was the induction of the synthesis of a number of proteins, some of which were elicited by the three forms of stress. Eleven heat shock proteins were identified by two-dimensional electrophoresis, as were two proteins whose synthesis was heat
more » ... nsitive. In the absence of applied stress, the synthesis of four proteins was found to be associated with the growth phase in batch culture; three of these proteins had a higher rate of de novo synthesis when the cells entered the solvent production phase. One of the stress-induced proteins, hsp74, was partially purified an found to be immunologically related to Escherichia coli heat shock protein DnaK. The similarities of the proteins induced at the onset of solventogenesis and by stress suggest a relationship between the two processes. Clostridiijumn acetohittvlicum cells growing in batch culture ferment sugars to butyric and acetic acids, which decrease the external pH to below 5 at the end of exponential phase (for reviews, see references 17 and 37). During stationary phase, the sugar and the preformed acids are converted to solvents (butanol, acetone, and ethanol) and traces of acetoin; H2 and CO, are also produced. The switch of catabolism to solventogenesis has the effect of raising the medium pH. As stationary phase progresses, the cells undergo a series of morphological and physiological changes in motility, shape, and granulose content, culminating in the formation of endospores (16). The ability to produce solvents is associated with an early step in sporulation (17, 37). The accumulation of solvents causes the cell membranes to become progressively more permeable to small molecules, as shown by decreased rates of glucose uptake and glycolysis, dissipation of the H+ gradient across the cell membrane (42), loss of internal glycolytic intermediates (15). and decrease in the viability of the vegetative cells (24). Thus, it is likely that solvents, endogenously produced membranechaotropic agents, are stressful to the cells.
doi:10.1128/aem.54.8.1989-1995.1988 fatcat:kqh6hsgnkreujovtqgk5xg35iy

Acidic peptide hydrogel scaffolds enhance calcium phosphate mineral turnover into bone tissue

Nadav Amosi, Shlomo Zarzhitsky, Eliezer Gilsohn, Olga Salnikov, Efrat Monsonego-Ornan, Ron Shahar, Hanna Rapaport
2012 Acta Biomaterialia  
Designed peptides may generate molecular scaffolds in the form of hydrogels to support tissue regeneration. We studied the effect of hydrogels comprising b-sheet-forming peptides rich in aspartic amino acids and of tricalcium phosphate (b-TCP)-loaded hydrogels on calcium adsorption and cell culture in vitro, and on bone regeneration in vivo. The hydrogels were found to act as efficient depots for calcium ions, and to induce osteoblast differentiation in vitro. In vivo studies on bone defect
more » ... ing in rat distal femurs analyzed by microcomputerized tomography showed that the peptide hydrogel itself induced better bone regeneration in comparison to non-treated defects. A stronger regeneration capacity was obtained in bone defects treated with b-TCP-loaded hydrogels, indicating that the peptide hydrogels and the mineral act synergistically to enhance bone regeneration. In vivo regeneration was found to be better with hydrogels loaded with porous b-TCP than with hydrogels loaded with non-porous mineral. It is concluded that biocompatible and biodegradable matrices, rich in anionic moieties that efficiently adsorb calcium ions while supporting cellular osteogenic activity, may efficiently promote b-TCP turnover into bone mineral.
doi:10.1016/j.actbio.2012.04.003 pmid:22503952 fatcat:cfbzhavogbg4lbjgz6r3d4mjyi

Ap4A and Ap5A prefer folded unstacked conformations at ph 4-5, in sharp contrast with Ap2A and Ap3A

Nancy H. Kolondy, Elvira Kisteneff, Christina Redfield, Eliezer Rapaport
1979 FEBS Letters  
doi:10.1016/0014-5793(79)80477-9 pmid:40826 fatcat:zoqbg5fli5g45lhfp4ewnw2lsy

2,4-Dinitrophenol does not reduce ATP levels in starving hamster fibroblasts although hexose transport regulation is markedly affected

Eliezer Rapaport, Paul Plesner, Donna B. Ullrey, Herman M. Kalckar
1983 Carlsberg Research Communications  
doi:10.1007/bf02911914 fatcat:w2nf62j2mrcujj5kipq2fhh3ri

Cystic fibrosis improves COVID-19 survival and provides clues for treatment of SARS-CoV-2

Edward H. Abraham, Guido Guidotti, Eliezer Rapaport, David Bower, Jack Brown, Robert J. Griffin, Andrew Donnelly, Ellen D. Waitzkin, Kenon Qamar, Mark A. Thompson, Sukumar Ethirajan, Kent Robinson
2021 Purinergic Signalling Purinergic Signalling  
paper showing that IV ATP can elevate the depleted ATP pools of advanced cancer patients up to levels found in CF patients with subsequent clinical, biochemical, and quality of life (QOL) improvements (Rapaport  ...  In retrospect, this finding should not be surprising in view of the work of Rapaport who demonstrated that intraperitoneal (IP) administration of ATP inhibited the growth of tumors implanted into mice  ...  while simultaneously letting these patients experience the Fig. 2 Total blood ATP pool measurements following IV ATP administration to elderly cancer patients as discussed in detail in the paper by Rapaport  ... 
doi:10.1007/s11302-021-09771-0 pmid:33970408 fatcat:r2v4avrvuvbthkaz7vktt43r5q

The origins of David Rapaport's 'Portrait of Moses' story

Richard Raskin
2021 Scandinavian Jewish Studies  
David Rapaport, one of the founders of psychoanalytic ego psychology, used a story about a portrait of Moses in three of his papers in the 1950s in order to illustrate his view that the self has the power  ...  the portrait of Moses legend, where already in the late eighteenth century, Rabbi Moses Hayyim Ephrayim of Sudlykow had attributed this statement to his grandfather, the Baal Shem Tov, Rabbi Israel ben Eliezer  ...  (Rapaport 1951: 113) Explicitly citing Rapaport's use of the story, Alan Dershowitz tells it once again in 2000, but entirely changing the focus that meant so much to Rapaport.  ... 
doi:10.30752/nj.110168 fatcat:kumjvu66lbbj7kcviffdb3oqai

Page 9528 of Mathematical Reviews Vol. , Issue 2004k [page]

2004 Mathematical Reviews  
Raoult, Annie Rapaport, A. Rapaport, Ivan 05077 Rapoport, Diego L. ......... See Rapoport Campodonico, Diego Lucio Rapoport Campodonico, Diego Lucio 37164 35170 See Sree Hari Rao, V.  ...  GNOZ; PAOUOS, i.e de cic cs etinwscs 62019 R RBG VE Is oo imate vavaes ce ecomege 62255 Rabinovici, Eliezer 83059,83087 Rabinowitz, Paul EH... .........65s60-0e0% 35129, See also * 00019 74038,76117 See  ... 

Page 3536 of Mathematical Reviews Vol. , Issue 2004d [page]

2004 Mathematical Reviews  
Rabinovich, Vladimir S. ............. 35058 Rabinovici, Eliezer Rabinowicz, Wlodek Rabinowitz, Paul H. ...........  ...  B. 70026 11031 62052 90140 Re See Rao, Seela Veerabhadreswara Rao, Seela Veerabhadreswara 68167 Rao Jammalamadaka, S. ............ 62202 jc TTS, Pa Sere ee See * 74001 Rapallo, Fabio Rapaport, A.  ... 

Page 3994 of Psychological Abstracts Vol. 85, Issue 9 [page]

1998 Psychological Abstracts  
Rapaport, Mark Hyman; Wolkow, Robert M. & Clary, Cathryn M.  ...  Rosler, Ariel & Witztum, Eliezer. (Hadassah U, Medi- cal Ctr, Jerusalem, Israel) “Treatment of men with paraphilia with a _ long-acting analogue of gonadotropin-releasing horomone”: Reply.  ... 

Page 528 of National Union Catalog Vol. 30, Issue SUPPLEMENT [page]

National Union Catalog  
X 46-12793 Rapaport, Meir Fliezer see Rapaport-Hartstein, Meir Eliezer.  ...  Dohm, Christian Wilhelm von, 1751-1820. 9-20700 Revised HB107.D7K3 Library of Congress Rapaport-Hartstein, Meir Eliezer. ND ... [ID .np2 ‘9 PMT NM NP ant n2wIw .  ... 

Tevrat'ın Lut Kıssası Üzerine Bir Araştırma

KATAR Mehmet
2007 Ankara Üniversitesi İlahiyat Fakültesi Dergisi  
Samuel Rapaport, London-New York 1907, 225 tmm20.htm; Ginzberg, I/253; Alexander, 290; ayrýca bkz. Pirke De Rabbi Eliezer, 184).  ...  Pirke De Rabbi Eliezer, 185). Tonson, 99; ayrýca bkz. Pirke De Rabbi Eliezer, 185. 36 Tekvin, 19/4-5. 37 Bkz. Greenberg, 63, 67, 72; Ide, 67. 38 Bkz.  ... 
doi:10.1501/ilhfak_0000000929 fatcat:knfxas6wrvet7hsawc5euazxja

Page 6 of Health Rights News Vol. 1, Issue 4 [page]

1968 Health Rights News  
Jack Eliezer Nanuet, NY MCHR ad stimulates nationwide response We have recently launched a new concept in the insurance industry which we call a disease specific pro- gram for diabetics.  ...  This group has produced such con- tributors to the profession as Anna Freud, Kris, Melanie Klein, David Rapaport, Waelder, Theodore Reik, Erik Erikson and numerous others; while analytically untrained  ... 

Page 84 of New York Academy of Sciences. Transactions of the New York Academy of Sciences Vol. 41, Issue Annual [page]

New York Academy of Sciences. Transactions of the New York Academy of Sciences  
At the Huntington Laboratory at MGH, Paul Zamecnik had just acquired a Waters HPLC setup, which he and his associate Eliezer Rapaport used for determina¬ tions of nucleoside triphosphates in cell cultures  ...  Rapaport was able to join our project as well and in this way we soon obtained a number of intriguing data, especially on the ATP-GTP pools in our fibroblast cultures under a variety of culture conditions  ... 

Page 253 of National Union Catalog Vol. 16, Issue SUPPLEMENT [page]

National Union Catalog  
Enoch Pratt free library for Library of Congress ot Hartstein, Meir Eliezer Rapaport- see Rapaport-Hartstein, Meir Eliezer.  ... 
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