Filters








32,123 Hits in 3.6 sec

Quantitative imaging of mixing dynamics in microfluidic droplets using two-photon fluorescence lifetime imaging

Yan Zeng, Liguo Jiang, Wei Zheng, Dong Li, Shuhuai Yao, Jianan Y. Qu
2011 Optics Letters  
In this Letter, we developed a two-photon excitation fluorescence lifetime imaging technique to quantitatively image the mixing dynamics in microfluidic droplets.  ...  Droplet-based microfluidic systems enable miniaturization of chemical reactions in femtoliter to picoliter volume compartments.  ...  Recently, confocal FLIM based on the maximum likelihood estimator (MLE) method was used to analyze the fluorescence lifetime images of microfluidic droplets [6, 7] .  ... 
doi:10.1364/ol.36.002236 pmid:21685978 fatcat:igt4xaeghfe2zmncut34bevzny

An instrument for time resolved monitoring of fast chemical transitions: Application to the kinetics of refolding of a globular protein

Vladimir Ratner, Elisha Haas
1998 Review of Scientific Instruments  
A new device based on the single pulse approach was developed.  ...  The chemical process was synchronized by means of a fast mixing stopped flow device. The low cost laser used here is suitable for use with dyes with excitation wavelengths of 337 nm and higher.  ...  Alex Goldin ͑Haifa, Israel͒ for development of the improved software package for data analysis.  ... 
doi:10.1063/1.1148914 fatcat:m7tvph3mqjgsbgzw6iyikrvkmm

High-throughput, non-equilibrium studies of single biomolecules using glass-made nanofluidic devices

Mattia Fontana, Carel Fijen, Serge G Lemay, Klaus Mathwig, Johannes Hohlbein
2018 Lab on a Chip  
Here, we introduce glass-made nanofluidic devices for the high-throughput detection of freely-diffusing single biomolecules by camera-based fluorescence microscopy.  ...  In a device geometry featuring a T-shaped junction of nanochannels, we drive steady-state non-equilibrium conditions by continuously mixing reactants and triggering chemical reactions.  ...  Acknowledgements We thank Timo Wenzel and Ebru Acun for initial characterizations of the fluidic devices. We thank Adrie  ... 
doi:10.1039/c8lc01175c pmid:30468446 fatcat:dx36p54765bkdnj6oqlljocrm4

A fast and precise chemiluminescence ozone detector for eddy flux and airborne application

A. Zahn, J. Weppner, H. Widmann, K. Schlote-Holubek, B. Burger, T. Kühner, H. Franke
2011 Atmospheric Measurement Techniques Discussions  
Recommendations on the adequate inlet tube configuration (inlet tube length, sampling flow) and on the way of calibration at stationary ground-based platforms and onboard aircraft are given. www.atmos-meas-tech.net  ...  Its precision is entirely determined by the number of photons reaching the detector (being a photomultiplier), i.e. is quantum-noise limited.  ...  On request, the instrument is delivered within a splash guard cabinet. uses eosin-Y as dye (Ray et al., 1986) . (2) A device manufactured by the company GFAS is based on the instrument described by Schurath  ... 
doi:10.5194/amtd-4-6539-2011 fatcat:wnzx37pfrvhoxjiktjzhyvw6py

A fast and precise chemiluminescence ozone detector for eddy flux and airborne application

A. Zahn, J. Weppner, H. Widmann, K. Schlote-Holubek, B. Burger, T. Kühner, H. Franke
2012 Atmospheric Measurement Techniques  
Recommendations on the adequate inlet tube configuration (inlet tube length, sampling flow) and on the way of calibration at stationary ground-based platforms and onboard aircraft are given.</p>  ...  Its precision is entirely determined by the number of photons reaching the detector (being a photomultiplier), i.e. is quantum-noise limited.  ...  On request, the instrument is delivered within a splash guard cabinet. uses eosin-Y as dye (Ray et al., 1986) . (2) A device manufactured by the company GFAS is based on the instrument described by Schurath  ... 
doi:10.5194/amt-5-363-2012 fatcat:2cbj4rvxorgzvgh67f4wve3efm

Passive micromixer for luminol-peroxide chemiluminescence detection

Khoi Seng Lok, Yien Chian Kwok, Nam-Trung Nguyen
2011 The Analyst  
Abstracts This paper reports a microchip with an integrated passive micromixer based on chaotic advection.  ...  The light intensity was detected using an optical fiber attached along the mixing channel and a photon detector.  ...  Effect of mixing channel length on CL intensity Next, the effect of mixing length on CL intensity emitted from the reactions was explored for flow rates ranging from 1.67 to 16.7 µl min -1 .  ... 
doi:10.1039/c1an15280g pmid:21552614 fatcat:ip6xfoketnbk3g2y6hplkshkie

Tantala Kerr-nonlinear integrated photonics [article]

Hojoong Jung, Su-Peng Yu, David R. Carlson, Tara E. Drake, Travis C. Briles, Scott B. Papp
2020 arXiv   pre-print
Optical materials with favorable properties are essential for nanofabrication of integrated-photonics devices.  ...  like data communication and signal processing.  ...  Based on the threshold power for optical parametric oscillation, we obtain an estimate of * .  ... 
arXiv:2007.12958v1 fatcat:ljuedjkg7zactikjm4ohfihk2m

A portable microfluidic fluorescence spectrometer device for γ-H2AX-based biological dosimetry

I.A. Pope, P.R. Barber, S. Horn, E. Ainsbury, K. Rothkamm, B. Vojnovic
2011 Radiation Measurements  
Further effort is required to fully develop this approach into a portable triage tool that could be used to help classify people into appropriate treatment categories based on radiation exposure levels  ...  chamber and records emission spectra over the range 495e725 nm.  ...  The sponsors had no involvement in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.  ... 
doi:10.1016/j.radmeas.2011.02.004 fatcat:eal5sqxlmvejrgijpvtlasx6li

Recent Advances and Future Perspectives on Microfluidic Mix-and-Jet Sample Delivery Devices

Majid Hejazian, Eugeniu Balaur, Brian Abbey
2021 Micromachines  
Finally, we discuss future perspectives on the emerging field of microfluidic mix-and-jet sample delivery devices.  ...  Here, we review the recent advances in the emerging field of microfluidic mix-and-jet sample delivery devices for the study of biomolecular reaction dynamics.  ...  microfluidic mix-and-jet devices under gas flow rates ranging from 162 to 234 mg/min and liquid flow rates of 80 to 100 μL/min, (c) mixing of water and a diluted fluoresceine salt solution in the serpentine  ... 
doi:10.3390/mi12050531 pmid:34067131 pmcid:PMC8151207 fatcat:7akbb7ksnncgfllcvukck35h3m

Generalized unmixing model for multispectral flow cytometry utilizing nonsquare compensation matrices

David Novo, Gérald Grégori, Bartek Rajwa
2013 Cytometry Part A  
of appropriate noise models is the key to accurately estimating the true label abundance on the cells.  ...  These results are applicable to any flow-based system with more detectors than labels where Poisson noise is the dominant contributor to the overall system noise and highlight the fact that explicit incorporation  ...  Paul Robinson (Purdue University) for allowing us to access the prototype of the multispectral flow cytometry system and to Dr.  ... 
doi:10.1002/cyto.a.22272 pmid:23526804 pmcid:PMC4177998 fatcat:pyhgjlxbyncu3c2wmampvqdsyi

Fluorescence Lifetime Imaging, a New Tool in Confocal Microscopy [chapter]

A. Draaijer, R. Sanders, H. C. Gerritsen
1995 Handbook of Biological Confocal Microscopy  
Here, IEM is modified for a wider resolvability range and implemented on the FPGA of the new SPAD array imager.  ...  A compact real-time fluorescence lifetime imaging microscopy (FLIM) system based on an array of low dark count 0.13µm CMOS singlephoton avalanche diodes (SPADs) is demonstrated.  ...  The low photon detection efficiency of the current SPAD device led to a rather low photon count rate in fluorescence mode, but nevertheless lifetime estimates are available after about 9s.  ... 
doi:10.1007/978-1-4757-5348-6_31 fatcat:vtjiqjlwrnettavwqbgcugfvei

Doppler-Based Flow Rate Sensing in Microfluidic Channels

Liron Stern, Avraham Bakal, Mor Tzur, Maya Veinguer, Noa Mazurski, Nadav Cohen, Uriel Levy
2014 Sensors  
As such, the device is appealing for variety of "lab on chip" bio-applications where a simple and accurate speed measurement is needed, e.g., for flow-cytometry and cell sorting.  ...  We design, fabricate and experimentally demonstrate a novel generic method to detect flow rates and precise changes of flow velocity in microfluidic devices.  ...  fluid based photonic devices and systems.  ... 
doi:10.3390/s140916799 pmid:25211195 pmcid:PMC4208200 fatcat:cbnsphrh55fkjfdhrib3ool3uy

A Vision for Thermally Integrated Photonics Systems

Ryan Enright, Shenghui Lei, Kevin Nolan, Ian Mathews, Alexandre Shen, Guillaume Levaufre, Ronan Frizzell, Guang-Hua Duan, Domhnaill Hernon
2014 Bell Labs technical journal  
Within the III-V Lab and CEA LETI he is now working on Si-based hybrid lasers, other Si-based devices, and photonic integrated circuits.  ...  Our initial step to explore the integration of AlN into InP-based photonic devices has been to investigate how AlN deposits on single crystal InP.  ... 
doi:10.15325/bltj.2014.2364431 fatcat:jxv4ovsrwzbtrosf37ffq6ycsm

Scalable and massively parallel Monte Carlo photon transport simulations for heterogeneous computing platforms

Leiming Yu, Fanny Nina-Paravecino, David Kaeli, Qianqian Fang
2018 Journal of Biomedical Optics  
A number of parallel computing techniques are investigated to achieve portable performance over a wide range of computing hardware.  ...  We present a highly scalable Monte Carlo (MC) three-dimensional photon transport simulation platform designed for heterogeneous computing systems.  ...  Enqiang Sun for his help on utilizing multiple NVIDIA GPUs.  ... 
doi:10.1117/1.jbo.23.1.010504 pmid:29374404 fatcat:rw5kihpu6vhuvhjd2kzyqgv6py

On the advancements of digital signal processing hardware and algorithms enabling the Origins Space Telescope

Damon C. Bradley, Tracee L. Jamison-Hooks, Johannes Staguhn, Edward Amatucci, Tyler Browning, Michael Dipirro, David Leisawitz, Ruth Carter
2021 Journal of Astronomical Telescopes Instruments and Systems  
We also present a small case study, comparing a more conventional readout system with one based on the RFSoC and show a trade of system complexity versus technology readiness level.  ...  A key component of this study report includes the technology roadmap for detector readout and how new radio frequency-system-on-chip (RFSoC)-based technology would be used to advance the far-infrared polarimeter  ...  FIP Readout Electronics Hardware The current design for the FIP readout is based on the Xilinx RFSoC device.  ... 
doi:10.1117/1.jatis.7.1.011018 fatcat:k7uyxloyizasnbvidppbipasym
« Previous Showing results 1 — 15 out of 32,123 results