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A systematic review of comparisons of effect sizes derived from randomised and non-randomised studies

MacLehose, Reeves, Harvey, Sheldon, Russell, Black
2000 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  are more precise (i.e. for larger sample sizes).  ...  were considered for strategy1 * TABLE 8 8 Summary of sample sizes, outcome frequencies and effect sizes for RCT and QEO study elements of studies that were considered for strategy 1 Pooled estimates  ... 
doi:10.3310/hta4340 fatcat:exqhxhm4wfhhjj2jld6lqi57du

Systematic review of treatments for atopic eczema

Hoare, Li Wan Po, Williams
2000 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  This needs to be taken into account when conducting sample size estimates for RCTs.  ...  Both studies used an intrasubject design with randomised applications to comparable lesions. Neither provided any justification for sample size chosen.  ... 
doi:10.3310/hta4370 fatcat:2apnwvzzqnei5ghtkuaneptwoq

Randomised controlled trials for policy interventions: a review of reviews and meta-regression

S Oliver, AM Bagnall, J Thomas, J Shepherd, A Sowden, I White, J Dinnes, R Rees, J Colquitt, K Oliver, Z Garrett
2010 Health Technology Assessment  
of the review by others. iii Objectives: To determine whether randomised controlled trials (RCTs) lead to the same effect size and variance as non-randomised studies (NRSs) of similar policy interventions  ...  Review methods: Analyses of previous resampling studies, replication studies, comparable field studies and meta-epidemiology investigated the relationship between randomisation and effect size of policy  ...  No obvious differences in sample size or length of followup No rationale stated for not pooling study designs.  ... 
doi:10.3310/hta14160 pmid:20338119 fatcat:dkh4x4fhora7hkb6cxotl5q7je

Implantable cardioverter defibrillators: arrhythmias. A rapid and systematic review

Parkes, Bryant, Milne
2000 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  Future research Future research should include the use of British Pacing and Electrophysiological Group registries to assess the use of different types of ICD and current service provision.  ...  Chapter 5 Conclusions Factors relevant to NHS policy The policy implications of ICDs are considerable.  ... 
doi:10.3310/hta4260 fatcat:prtqrv365fbebov4vyau7avf5y

Assessing the costs of healthcare technologies in clinical trials

Johnston, Buxton, Jones, Fitzpatrick
1999 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (http://www.hta.ac.uk).  ...  Acknowledgements Health Technology Assessment 1999; Vol. 3: No. 6  ... 
doi:10.3310/hta3060 fatcat:dgs3fi6alrefhc65j6mntcreby

Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review

Jonathan Cook, Jennifer Hislop, Temitope Adewuyi, Kirsten Harrild, Douglas Altman, Craig Ramsay, Cynthia Fraser, Brian Buckley, Peter Fayers, Ian Harvey, Andrew Briggs, John Norrie (+3 others)
2014 Health Technology Assessment  
In total, 1434 were selected for full-text assessment and 777 were included in the review.  ...  Methods for specifying the target difference for a RCT were considered. The search identified 11,485 potentially relevant studies.  ...  Such papers will only be included if it is the primary reference for a relevant method. z Studies reporting only on the statistical considerations for sample size (e.g. a new formula for the sample size  ... 
doi:10.3310/hta18280 pmid:24806703 pmcid:PMC4781097 fatcat:4injmk3yljgmbn44py4vkf2rwu

The clinical effectiveness, cost-effectiveness and acceptability of community-based interventions aimed at improving or maintaining quality of life in children of parents with serious mental illness: a systematic review

Penny Bee, Peter Bower, Sarah Byford, Rachel Churchill, Rachel Calam, Paul Stallard, Steven Pryjmachuk, Kathryn Berzins, Maria Cary, Ming Wan, Kathryn Abel
2014 Health Technology Assessment  
Separate syntheses were conducted for SMI and severe depression. Standardised effect size (ES) trials were pooled using random-effects modelling for which sufficient data were available.  ...  Data were extracted independently by two reviewers and the study quality was assessed via Cochrane criteria for randomised/non-randomised designs, Critical Appraisal Skills Programme (CASP) qualitative  ...  We would also like to thank Professor Karina Lovell for her involvement in reviewing the draft report. This report was commissioned by the NHS R&D Health Technology Assessment programme.  ... 
doi:10.3310/hta18080 pmid:24502767 pmcid:PMC4780907 fatcat:phpf465ozncwtcc7nqo6e546ya

Home parenteral nutrition: a systematic review

Richards, Deeks, Sheldon, Shaffer
1997 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  The sample sizes were similar to those for Section 1. Retrospective case series predominated, the only other study design being a quality-of-life assessment.  ...  The sample sizes ranged from nine to more than 9000.  ... 
doi:10.3310/hta1010 fatcat:fueilzz27fcr5ca5n5cbauvoca

Review of guidelines for good practice in decision-analytic modelling in health technology assessment

Z Philips, L Ginnelly, M Sculpher, K Claxton, S Golder, R Riemsma, N Woolacoot, J Glanville
2004 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  G There is a need for research into how to prioritise searching for parameter estimates. The use of value of information methods, in particular, is worthy of consideration.  ...  RCTs may miss clinically important benefits because of inadequate attention to sample size.  ... 
doi:10.3310/hta8360 pmid:15361314 fatcat:6zppvcklzvghphfyzkac2zzt74

Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds

Bradley, Cullum, Nelson, Petticrew, Sheldon, Torgerson
1999 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  Randomisation Appropriate Blinded Withdrawals ITT exclusion sample sample procedure baseline outcome stated † analysis citeria size size stated characteristics assessment stated [arms]  ...  reported Study Inclusion and Overall A priori Randomisation Appropriate Blinded Withdrawals ITT exclusion sample sample procedure baseline outcome stated † analysis citeria size size  ... 
doi:10.3310/hta3172 fatcat:se7skt344ffyvhbatf5oepojhe

Advanced therapy medicinal products and health technology assessment principles and practices for value-based and sustainable healthcare

Bengt Jönsson, Grace Hampson, Jonathan Michaels, Adrian Towse, J.-Matthias Graf von der Schulenburg, Olivier Wong
2018 European Journal of Health Economics  
Finally, consideration of the feasibility of assessing the value of ATMPs beyond health gain may also be key for decision-making.  ...  Results Three key topics were identified and prioritised for discussion-uncertainty, discounting, and health outcomes and value.  ...  For example, in England, the National Institute for Health and Care Excellence (NICE) framework allows for the consideration of non-randomised evidence where it is difficult to conduct randomised controlled  ... 
doi:10.1007/s10198-018-1007-x pmid:30229376 fatcat:lwxytzw4avhmhompdo3ufdsv7a

Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds

M Bradley, N Cullum, E A Nelson, M Petticrew, T Sheldon, D Torgerson
1999 Health Technology Assessment  
The Standing Group on Health Technology advises on national priorities for health technology assessment. Six advisory panels assist the Standing Group in identifying and prioritising projects.  ...  produced in the most efficient way for those who use, manage and work in the NHS.  ...  Randomisation Appropriate Blinded Withdrawals ITT exclusion sample sample procedure baseline outcome stated † analysis citeria size size stated characteristics assessment stated [arms]  ... 
pmid:10683589 fatcat:vcsm7fsl4nb3jbdxcjs3rohtey

Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation

J Wilby, A Kainth, N Hawkins, D Epstein, H McIntosh, C McDaid, A Mason, S Golder, S O'Meara, M Sculpher, M Drummond, C Forbes
2005 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  The study was based on a small sample size and patients were not randomised to treatment.  ...  Was an a priori power calculation for adequate sample population size performed?  ... 
doi:10.3310/hta9150 pmid:15842952 fatcat:hc4xmntidbbd7eqidwii6w7o4a

Systematic reviews of wound care management: (5) beds; (6) compression; (7) laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy

N. Cullum, E. A. Nelson, K. Flemming, T. Sheldon
2001 Health Technology Assessment  
Contents Further high-quality trials are required in order to assess the impact of both new and established wound care interventions.  ...  Small sample size was a major limitation of many of the studies; the median sample size was 80 (range 25-505) and only 14/45 studies described an a priori sample size.  ...  A priori True Baseline Blinded Grade 1 Main inclusion and total number sample-size randomisation comparability outcome sores interventions exclusion (arms) calculation with allocation of treatment assessment  ... 
doi:10.3310/hta5090 fatcat:sls24hn3pfhcjfguugspdd3bgi

Sugammadex for the reversal of muscle relaxation in general anaesthesia: a systematic review and economic assessment

D Chambers, M Paulden, F Paton, M Heirs, S Duffy, D Craig, J Hunter, J Wilson, M Sculpher, N Woolacott
2010 Health Technology Assessment  
Limitations: The evidence base was not large and many of the published trials were dose-finding and safety studies with very small sample sizes.  ...  Considerable uncertainties remain about whether the full benefits of sugammadex can be realised in clinical practice.  ...  Total sample sizes for relevant treatment arms (i.e. sugammadex 2 mg/kg or placebo or comparator) ranged from 9 to 189 patients, with sample sizes per treatment group ranging from 1 to 48 patients.  ... 
doi:10.3310/hta14390 pmid:20688009 fatcat:watuenn7svfb5lqracgglvgh44
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