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A systematic review of comparisons of effect sizes derived from randomised and non-randomised studies
2000
Health Technology Assessment
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are more precise (i.e. for larger sample sizes). ...
were considered for strategy1 *
TABLE 8 8 Summary of sample sizes, outcome frequencies and effect sizes for RCT and QEO study elements of studies that were considered for strategy 1 Pooled estimates ...
doi:10.3310/hta4340
fatcat:exqhxhm4wfhhjj2jld6lqi57du
Systematic review of treatments for atopic eczema
2000
Health Technology Assessment
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This needs to be taken into account when conducting sample size estimates for RCTs. ...
Both studies used an intrasubject design with randomised applications to comparable lesions. Neither provided any justification for sample size chosen. ...
doi:10.3310/hta4370
fatcat:2apnwvzzqnei5ghtkuaneptwoq
Randomised controlled trials for policy interventions: a review of reviews and meta-regression
2010
Health Technology Assessment
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of the review by others. iii Objectives: To determine whether randomised controlled trials (RCTs) lead to the same effect size and variance as non-randomised studies (NRSs) of similar policy interventions ...
Review methods: Analyses of previous resampling studies, replication studies, comparable field studies and meta-epidemiology investigated the relationship between randomisation and effect size of policy ...
No obvious differences in sample size or length of followup No rationale stated for not pooling study designs. ...
doi:10.3310/hta14160
pmid:20338119
fatcat:dkh4x4fhora7hkb6cxotl5q7je
Implantable cardioverter defibrillators: arrhythmias. A rapid and systematic review
2000
Health Technology Assessment
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Future research Future research should include the use of British Pacing and Electrophysiological Group registries to assess the use of different types of ICD and current service provision. ...
Chapter 5
Conclusions
Factors relevant to NHS policy The policy implications of ICDs are considerable. ...
doi:10.3310/hta4260
fatcat:prtqrv365fbebov4vyau7avf5y
Assessing the costs of healthcare technologies in clinical trials
1999
Health Technology Assessment
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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph. ...
An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (http://www.hta.ac.uk). ...
Acknowledgements Health Technology Assessment 1999; Vol. 3: No. 6 ...
doi:10.3310/hta3060
fatcat:dgs3fi6alrefhc65j6mntcreby
Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review
2014
Health Technology Assessment
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In total, 1434 were selected for full-text assessment and 777 were included in the review. ...
Methods for specifying the target difference for a RCT were considered. The search identified 11,485 potentially relevant studies. ...
Such papers will only be included if it is the primary reference for a relevant method. z Studies reporting only on the statistical considerations for sample size (e.g. a new formula for the sample size ...
doi:10.3310/hta18280
pmid:24806703
pmcid:PMC4781097
fatcat:4injmk3yljgmbn44py4vkf2rwu
The clinical effectiveness, cost-effectiveness and acceptability of community-based interventions aimed at improving or maintaining quality of life in children of parents with serious mental illness: a systematic review
2014
Health Technology Assessment
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Separate syntheses were conducted for SMI and severe depression. Standardised effect size (ES) trials were pooled using random-effects modelling for which sufficient data were available. ...
Data were extracted independently by two reviewers and the study quality was assessed via Cochrane criteria for randomised/non-randomised designs, Critical Appraisal Skills Programme (CASP) qualitative ...
We would also like to thank Professor Karina Lovell for her involvement in reviewing the draft report. This report was commissioned by the NHS R&D Health Technology Assessment programme. ...
doi:10.3310/hta18080
pmid:24502767
pmcid:PMC4780907
fatcat:phpf465ozncwtcc7nqo6e546ya
Home parenteral nutrition: a systematic review
1997
Health Technology Assessment
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The sample sizes were similar to those for Section 1. Retrospective case series predominated, the only other study design being a quality-of-life assessment. ...
The sample sizes ranged from nine to more than 9000. ...
doi:10.3310/hta1010
fatcat:fueilzz27fcr5ca5n5cbauvoca
Review of guidelines for good practice in decision-analytic modelling in health technology assessment
2004
Health Technology Assessment
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G There is a need for research into how to prioritise searching for parameter estimates. The use of value of information methods, in particular, is worthy of consideration. ...
RCTs may miss clinically important benefits because of inadequate attention to sample size. ...
doi:10.3310/hta8360
pmid:15361314
fatcat:6zppvcklzvghphfyzkac2zzt74
Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds
1999
Health Technology Assessment
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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph. ...
Randomisation Appropriate
Blinded
Withdrawals ITT
exclusion
sample
sample
procedure
baseline
outcome stated †
analysis
citeria
size
size
stated
characteristics assessment
stated
[arms] ...
reported Study
Inclusion and Overall
A priori
Randomisation Appropriate
Blinded
Withdrawals ITT
exclusion
sample
sample
procedure
baseline
outcome stated †
analysis
citeria
size
size ...
doi:10.3310/hta3172
fatcat:se7skt344ffyvhbatf5oepojhe
Advanced therapy medicinal products and health technology assessment principles and practices for value-based and sustainable healthcare
2018
European Journal of Health Economics
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Finally, consideration of the feasibility of assessing the value of ATMPs beyond health gain may also be key for decision-making. ...
Results Three key topics were identified and prioritised for discussion-uncertainty, discounting, and health outcomes and value. ...
For example, in England, the National Institute for Health and Care Excellence (NICE) framework allows for the consideration of non-randomised evidence where it is difficult to conduct randomised controlled ...
doi:10.1007/s10198-018-1007-x
pmid:30229376
fatcat:lwxytzw4avhmhompdo3ufdsv7a
Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds
1999
Health Technology Assessment
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The Standing Group on Health Technology advises on national priorities for health technology assessment. Six advisory panels assist the Standing Group in identifying and prioritising projects. ...
produced in the most efficient way for those who use, manage and work in the NHS. ...
Randomisation Appropriate
Blinded
Withdrawals ITT
exclusion
sample
sample
procedure
baseline
outcome stated †
analysis
citeria
size
size
stated
characteristics assessment
stated
[arms] ...
pmid:10683589
fatcat:vcsm7fsl4nb3jbdxcjs3rohtey
Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation
2005
Health Technology Assessment
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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph. ...
The study was based on a small sample size and patients were not randomised to treatment. ...
Was an a priori power calculation for adequate sample population size performed? ...
doi:10.3310/hta9150
pmid:15842952
fatcat:hc4xmntidbbd7eqidwii6w7o4a
Systematic reviews of wound care management: (5) beds; (6) compression; (7) laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy
2001
Health Technology Assessment
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Contents Further high-quality trials are required in order to assess the impact of both new and established wound care interventions. ...
Small sample size was a major limitation of many of the studies; the median sample size was 80 (range 25-505) and only 14/45 studies described an a priori sample size. ...
A priori True Baseline Blinded Grade 1 Main inclusion and total number sample-size randomisation comparability outcome sores interventions exclusion (arms) calculation with allocation of treatment assessment ...
doi:10.3310/hta5090
fatcat:sls24hn3pfhcjfguugspdd3bgi
Sugammadex for the reversal of muscle relaxation in general anaesthesia: a systematic review and economic assessment
2010
Health Technology Assessment
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Limitations: The evidence base was not large and many of the published trials were dose-finding and safety studies with very small sample sizes. ...
Considerable uncertainties remain about whether the full benefits of sugammadex can be realised in clinical practice. ...
Total sample sizes for relevant treatment arms (i.e. sugammadex 2 mg/kg or placebo or comparator) ranged from 9 to 189 patients, with sample sizes per treatment group ranging from 1 to 48 patients. ...
doi:10.3310/hta14390
pmid:20688009
fatcat:watuenn7svfb5lqracgglvgh44
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