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Random Pooling Designs Under Various Structures

F.K. Hwang, Y.C. Liu
2003 Journal of combinatorial optimization  
showed that randomizing over the k-set space yields much better pooling designs than the random pooling design without the k-restriction.  ...  ., a space with more structure, will yield even better results.  ...  They showed that the random k-set design improves over the random design significantly.  ... 
doi:10.1023/b:joco.0000017382.83399.0b fatcat:ew62h67npfdqpnvbfkwpbuykwe

Pooling Designs for Outcomes under a Gaussian Random Effects Model

Yaakov Malinovsky, Paul S. Albert, Enrique F. Schisterman
2011 Biometrics  
In this article, we consider the problem of estimating the parameters of a Gaussian random effects model when the repeated outcome is subject to pooling.  ...  We evaluate the efficiencies of different pooling design strategies using analytic and simulation study results.  ...  In this article, we investigate various pooling strategies for estimating the variance components under a Gaussian random effects model.  ... 
doi:10.1111/j.1541-0420.2011.01673.x pmid:21981372 pmcid:PMC4159259 fatcat:pz2spd3sbjbdhcogsfd5g4fh7m

A Recovery Algorithm and Pooling Designs for One-Stage Noisy Group Testing under the Probabilistic Framework [article]

Yining Liu, Sachin Kadyan, Itsik Pe'er
2021 medRxiv   pre-print
Our findings highlight the implications of introducing randomness to the infection vectors -- we find that the combinatorial structure of the pooling designs plays a less important role than the parameters  ...  Yet, the practical challenge of adjusting pooling designs based on infection rate has not been systematically addressed.  ...  Pooling Matrices Optimal Pool Size In order to test the theoretically optimal pool size given in Equation 1, we simulated 1000 infection vectors under various infection rates and evaluated the performance  ... 
doi:10.1101/2021.03.09.21253193 fatcat:vampzcco45gt7ojlarcmiflsr4

Liquid Sloshing in Fuel Storage Bays of Advanced Reactor Subjected to Earthquake Loading

M. Eswaran, G.R. Reddy
2016 Procedia Engineering  
It is found through Computational Fluid Dynamics (CFD) approach that the maximum slosh height is 0.35 m under design seismic load computed.  ...  The two-way mechanical interaction between the fluid and the pool wall is simulated using a partitioned strong fluid-structure coupling.  ...  However, in the CFD simulation under design random load gives the value around 0.35 m.  ... 
doi:10.1016/j.proeng.2016.05.118 fatcat:l77b3zujojbhpgbc4tcawb74ii

NGCE – Network Graphs for Computer Epidemiologists [chapter]

Vasileios Vlachos, Vassiliki Vouzi, Damianos Chatziantoniou, Diomidis Spinellis
2005 Lecture Notes in Computer Science  
Graphs are useful data structures capable of efficiently representing a variety of technological and social networks.  ...  Inspired by the popular tgff (Task Graphs For Free) toolkit, which creates task graphs for embedded systems, we present the ngce, an easy to use graph generator that produces structures for the study of  ...  The algorithm has the following structure. 1. Create a pool K and add to it m o initial nodes. 2. Create a pool L of all the other nodes. 3.  ... 
doi:10.1007/11573036_64 fatcat:fzftrz6tjjgexaujtxwj6h2ez4

Challenges to Design and Develop of DNA Aptamers for Protein Targets. II. Development of the Aptameric Affinity Ligands Specific to Human Plasma Coagulation Factor VIII Using SEC-SELEX

Hossein Vahidi, Nastaran Nafissi-Varcheh, Bahram Kazemi, Reza Aboofazeli, Soraya Shahhosseini, Maryam Tabarzad
2017 Iranian journal of pharmaceutical research  
They have been developed against various targets, in particular, bio-macromolecules such as proteins.  ...  Binding affinity constant of selected aptamer and aptameric enriched pool were in nanomolar range that was comparable to monoclonal antibodies.  ...  Results and Discussion Preparation and amplification of Random DNA library A random ssDNA pool was designed by 30nts central random region which provide efficient diversity of 10 13 -10 15 various  ... 
pmid:28979328 pmcid:PMC5603883 fatcat:indhsk5ksbb2pht73dwg6qxexe

Family-Based Association Tests for Different Family Structures Using Pooled DNA

Guohua Zou, Hongyu Zhao
2005 Annals of Human Genetics  
DNA pooling is a cost-effective strategy for genomewise association studies to identify disease genes.  ...  In the following, we derive the mean and variance of p̂( r, s, a) A − p̂( r, s, a) U under the alternative hypothesis.  ...  Equations (A.27) and (A.28) give unified formulae for various family structures.  ... 
doi:10.1046/j.1529-8817.2005.00164.x pmid:15996171 pmcid:PMC4664084 fatcat:44o3fqeifrhy5kf2w4vzo56y5q

Computational generation and screening of RNA motifs in large nucleotide sequence pools

Namhee Kim, Joseph A. Izzo, Shereef Elmetwaly, Hin Hark Gan, Tamar Schlick
2010 Nucleic Acids Research  
We also show that designed pools using our nucleotide transition probability matrices can produce higher yields for RNA ligase motifs than random pools.  ...  of active motifs in random pools.  ...  Our approach is applicable to tree and pseudoknot structures in large random and designed pools.  ... 
doi:10.1093/nar/gkq282 pmid:20448026 pmcid:PMC2910066 fatcat:k43b3ht2rrboxooh77prekklfa

metaSEM: an R package for meta-analysis using structural equation modeling

Mike W.-L. Cheung
2015 Frontiers in Psychology  
It also implements the two-stage SEM approach to conducting fixed-and random-effects meta-analytic SEM on correlation or covariance matrices.  ...  The metaSEM package provides functions to conduct univariate, multivariate, and three-level meta-analyses using a structural equation modeling (SEM) approach via the OpenMx package in the R statistical  ...  correlation (or covariance matrices) under the random-effects model.  ... 
doi:10.3389/fpsyg.2014.01521 pmid:25601849 pmcid:PMC4283449 fatcat:nir4ls5j4jg5dbhag4wau5jh3q

Statistical methodologies to pool across multiple intervention studies

Shrikant I. Bangdiwala, Alok Bhargava, Daniel P. O'Connor, Thomas N. Robinson, Susan Michie, David M. Murray, June Stevens, Steven H. Belle, Thomas N. Templin, Charlotte A. Pratt
2016 Translational Behavioral Medicine  
Keywords Statistical pooling of studies, Random-effects metaanalysis, Study-level meta-regression, Multilevel meta-regression, Multilevel structural models  ...  Pooling, when supported by statistical tests, can allow exploratory investigation of potential hypotheses and for the design of future interventions.  ...  Practice: Pooling the data from similarly designed randomized controlled trials may be useful for identifying intervention components that may be more effective for diverse participants.  ... 
doi:10.1007/s13142-016-0386-8 pmid:27356993 pmcid:PMC4927450 fatcat:7b3k6unu75elhpunf7dvdvzwka

Real and quasi-experiments in capture-recapture studies

Carl James Schwarz
2002 Journal of Applied Statistics  
By casting capture-recapture studies in an experimental design framework, the various roles of these sources of variation become clear and the sources that are pooled when these experiments are analyzed  ...  The three key elements of experimental design are randomization, replication, and variance identification and control.  ...  units; treatment structure; and randomization structure.  ... 
doi:10.1080/02664760120108511 fatcat:m2roybk5zrfg7nq5efilege64q

A computational proposal for designing structured RNA pools for in vitro selection of RNAs

N. Kim, H. H. Gan, T. Schlick
2007 RNA: A publication of the RNA Society  
We show that, in contrast to random sequences, which are associated only with a local region of sequence space, our designed pools, including a structured pool for GTP aptamers, can target specific motifs  ...  Thus, enriching in vitro selection pools with complex structures could increase the probability of discovering novel RNAs.  ...  Automation of our pool design method is presently under way. FIGURE 1. Modeling the RNA pool generation process using mixing matrices and analysis of pool structural distributions using tree graphs.  ... 
doi:10.1261/rna.374907 pmid:17322501 pmcid:PMC1831855 fatcat:kssc3dftv5hyzilva7lxzjkrgm

In vitro RNA random pools are not structurally diverse: A computational analysis

J. GEVERTZ
2005 RNA: A publication of the RNA Society  
These analyses show not only that random pools do not lead to a uniform distribution of possible RNA secondary topologies; they point to avenues for designing pools with specific simple and complex structures  ...  However, the structural diversity in random pools is not well understood.  ...  Our analyses have implications for designing sequence pools possessing greater structural diversity than those found in random pools.  ... 
doi:10.1261/rna.7271405 pmid:15923372 pmcid:PMC1370770 fatcat:ovbdpt2e3vbvbksjdt6pbn3tt4

Research and Development of Gearbox Load Spectrum Database under Variable Working Conditions

Changlun Gao, Collage of Engineering, South China Agricultural University Guangzhou 510642, China., Junliang Huo, Zhantong Li, Beihuo Yao, Zhaokai He, Fangren Zhang, Shunli Sun, Weibin Wu
2021 International Journal of Emerging Technology and Advanced Engineering  
Moreover, the current status of load spectrum database and the design steps of load spectrum database are summarized.  ...  The design of load spectrum database can be roughly divided into six stages: demand analysis, conceptual structure design, logical structure design, physical structure design, database implementation and  ...  Database design Database design refers to the process of designing the database structure and establishing the database on a specific database management system according to the needs of users.  ... 
doi:10.46338/ijetae1021_04 fatcat:u4ql7em2pndh7hus4gnido7hmi

Structural bias in T4 RNA ligase-mediated 3′-adapter ligation

Fanglei Zhuang, Ryan T. Fuchs, Zhiyi Sun, Yu Zheng, G. Brett Robb
2012 Nucleic Acids Research  
The effect of RNA-adapter cofold structures on ligation is supported by experiments where the ligation efficiency of specific miRNAs was changed by designing adapters to alter cofold structure.  ...  In addition, we show that using adapters with randomized regions results in higher ligation efficiency and reduced ligation bias.  ...  Ligation and HTS of oligonucleotide pools to study ligation bias To study the bias of T4 RNA ligases, we designed an in vitro ligation selection assay that uses a pool of random RNA oligos to which a 3  ... 
doi:10.1093/nar/gkr1263 pmid:22241775 pmcid:PMC3326334 fatcat:q5h3xh7vwzgzfeoxficybvyqga
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