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BBMRI catalogue

Klaus Kuhn, Raffael Bild, Helmut Spengler
2015 Journal of Clinical Bioinformatics  
doi:10.1186/2043-9113-5-s1-s19 pmcid:PMC4460659 fatcat:3dxsj43drjfjxgqt4u7peh2yku

A scalable software solution for anonymizing high-dimensional biomedical data

Thierry Meurers, Raffael Bild, Kieu-Mi Do, Fabian Prasser
2021 GigaScience  
Background Data anonymization is an important building block for ensuring privacy and fosters the reuse of data. However, transforming the data in a way that preserves the privacy of subjects while maintaining a high degree of data quality is challenging and particularly difficult when processing complex datasets that contain a high number of attributes. In this article we present how we extended the open source software ARX to improve its support for high-dimensional, biomedical datasets.
more » ... ngs For improving ARX's capability to find optimal transformations when processing high-dimensional data, we implement 2 novel search algorithms. The first is a greedy top-down approach and is oriented on a formally implemented bottom-up search. The second is based on a genetic algorithm. We evaluated the algorithms with different datasets, transformation methods, and privacy models. The novel algorithms mostly outperformed the previously implemented bottom-up search. In addition, we extended the GUI to provide a high degree of usability and performance when working with high-dimensional datasets. Conclusion With our additions we have significantly enhanced ARX's ability to handle high-dimensional data in terms of processing performance as well as usability and thus can further facilitate data sharing.
doi:10.1093/gigascience/giab068 pmid:34605868 pmcid:PMC8489190 fatcat:rtiyyriharen3etiqb6pfjkfwe

Privacy-enhancing ETL-processes for biomedical data

Fabian Prasser, Helmut Spengler, Raffael Bild, Johanna Eicher, Klaus A. Kuhn
2019 International Journal of Medical Informatics  
Modern data-driven approaches to medical research require patient-level information at comprehensive depth and breadth. To create the required big datasets, information from disparate sources can be integrated into clinical and translational warehouses. This is typically implemented with Extract, Transform, Load (ETL) processes, which access, harmonize and upload data into the analytics platform. Objective: Privacy-protection needs careful consideration when data is pooled or re-used for
more » ... ry purposes, and data anonymization is an important protection mechanism. However, common ETL environments do not support anonymization, and common anonymization tools cannot easily be integrated into ETL workflows. The objective of the work described in this article was to bridge this gap. Methods: Our main design goals were (1) to base the anonymization process on expert-level risk assessment methodologies, (2) to use transformation methods which preserve both the truthfulness of data and its schematic properties (e.g. data types), (3) to implement a method which is easy to understand and intuitive to configure, and (4) to provide high scalability. Results: We designed a novel and efficient anonymization process and implemented a plugin for the Pentaho Data Integration (PDI) platform, which enables integrating data anonymization and re-identification risk analyses directly into ETL workflows. By combining different instances into a single ETL process, data can be protected from multiple threats. The plugin supports very large datasets by leveraging the streaming-based processing model of the underlying platform. We present results of an extensive experimental evaluation and discuss successful applications. Conclusions: Our work shows that expert-level anonymization methodologies can be integrated into ETL workflows. Our implementation is available under a non-restrictive open source license and it overcomes several limitations of other data anonymization tools.
doi:10.1016/j.ijmedinf.2019.03.006 fatcat:yhwxovtsp5b4tjmir56qsc3go4

Efficient Protection of Health Data from Sensitive Attribute Disclosure

Raffael Bild, Johanna Eicher, Fabian Prasser
2020 Studies in Health Technology and Informatics  
Bild et al. / Efficient Protection of Health Data from Sensitive Attribute Disclosure  ... 
doi:10.3233/shti200149 pmid:32570373 fatcat:klkfghh5fbhs7pyoexfizhxu5y

SafePub: A Truthful Data Anonymization Algorithm With Strong Privacy Guarantees

Raffael Bild, Klaus A. Kuhn, Fabian Prasser
2018 Proceedings on Privacy Enhancing Technologies  
Methods for privacy-preserving data publishing and analysis trade off privacy risks for individuals against the quality of output data. In this article, we present a data publishing algorithm that satisfies the differential privacy model. The transformations performed are truthful, which means that the algorithm does not perturb input data or generate synthetic output data. Instead, records are randomly drawn from the input dataset and the uniqueness of their features is reduced. This also
more » ... s an intuitive notion of privacy protection. Moreover, the approach is generic, as it can be parameterized with different objective functions to optimize its output towards different applications. We show this by integrating six well-known data quality models. We present an extensive analytical and experimental evaluation and a comparison with prior work. The results show that our algorithm is the first practical implementation of the described approach and that it can be used with reasonable privacy parameters resulting in high degrees of protection. Moreover, when parameterizing the generic method with an objective function quantifying the suitability of data for building statistical classifiers, we measured prediction accuracies that compare very well with results obtained using state-of-the-art differentially private classification algorithms.
doi:10.1515/popets-2018-0004 dblp:journals/popets/BildKP18 fatcat:ahsldstdind6flgx6lum7cvt7q

Better Safe than Sorry - Implementing Reliable Health Data Anonymization

Raffael Bild, Klaus A Kuhn, Fabian Prasser
2020 Studies in Health Technology and Informatics  
Bild et al. / Better Safe than Sorry -Implementing Reliable Health Data Anonymization  ... 
doi:10.3233/shti200124 pmid:32570348 fatcat:fgplw4mq25ej7jnby7q5z43syi

Flexible data anonymization using ARX-Current status and challenges ahead

Fabian Prasser, Johanna Eicher, Helmut Spengler, Raffael Bild, Klaus A. Kuhn
2020 Software, Practice & Experience  
How to cite this article: Prasser F, Eicher J, Spengler H, Bild R, Kuhn KA. Flexible data anonymization using ARX-Current status and challenges ahead.  ... 
doi:10.1002/spe.2812 fatcat:5mzoacmnjjdwrn2xsoincydjyy

Orchestrating differential data access for translational research: a pilot implementation

Marco Brandizi, Olga Melnichuk, Raffael Bild, Florian Kohlmayer, Benedicto Rodriguez-Castro, Helmut Spengler, Klaus A. Kuhn, Wolfgang Kuchinke, Christian Ohmann, Timo Mustonen, Mikael Linden, Tommi Nyrönen (+3 others)
2017 BMC Medical Informatics and Decision Making  
Translational researchers need robust IT solutions to access a range of data types, varying from public data sets to pseudonymised patient information with restricted access, provided on a case by case basis. The reason for this complication is that managing access policies to sensitive human data must consider issues of data confidentiality, identifiability, extent of consent, and data usage agreements. All these ethical, social and legal aspects must be incorporated into a differential
more » ... ent of restricted access to sensitive data. Methods: In this paper we present a pilot system that uses several common open source software components in a novel combination to coordinate access to heterogeneous biomedical data repositories containing open data (open access) as well as sensitive data (restricted access) in the domain of biobanking and biosample research. Our approach is based on a digital identity federation and software to manage resource access entitlements. Results: Open source software components were assembled and configured in such a way that they allow for different ways of restricted access according to the protection needs of the data. We have tested the resulting pilot infrastructure and assessed its performance, feasibility and reproducibility. Conclusions: Common open source software components are sufficient to allow for the creation of a secure system for differential access to sensitive data. The implementation of this system is exemplary for researchers facing similar requirements for restricted access data. Here we report experience and lessons learnt of our pilot implementation, which may be useful for similar use cases. Furthermore, we discuss possible extensions for more complex scenarios.
doi:10.1186/s12911-017-0424-6 pmid:28330491 pmcid:PMC5363029 fatcat:aigfcw4jjzdipnhtkwwatpik4u

Towards a comprehensive and interoperable representation of consent-based data usage permissions in the German medical informatics initiative

Raffael Bild, Martin Bialke, Karoline Buckow, Thomas Ganslandt, Kristina Ihrig, Roland Jahns, Angela Merzweiler, Sybille Roschka, Björn Schreiweis, Sebastian Stäubert, Sven Zenker, Fabian Prasser
2020 BMC Medical Informatics and Decision Making  
The aim of the German Medical Informatics Initiative is to establish a national infrastructure for integrating and sharing health data. To this, Data Integration Centers are set up at university medical centers, which address data harmonization, information security and data protection. To capture patient consent, a common informed consent template has been developed. It consists of different modules addressing permissions for using data and biosamples. On the technical level, a common digital
more » ... epresentation of information from signed consent templates is needed. As the partners in the initiative are free to adopt different solutions for managing consent information (e.g. IHE BPPC or HL7 FHIR Consent Resources), we had to develop an interoperability layer. First, we compiled an overview of data items required to reflect the information from the MII consent template as well as patient preferences and derived permissions. Next, we created entity-relationship diagrams to formally describe the conceptual data model underlying relevant items. We then compared this data model to conceptual models describing representations of consent information using different interoperability standards. We used the result of this comparison to derive an interoperable representation that can be mapped to common standards. The digital representation needs to capture the following information: (1) version of the consent, (2) consent status for each module, and (3) period of validity of the status. We found that there is no generally accepted solution to represent status information in a manner interoperable with all relevant standards. Hence, we developed a pragmatic solution, comprising codes which describe combinations of modules with a basic set of status labels. We propose to maintain these codes in a public registry called ART-DECOR. We present concrete technical implementations of our approach using HL7 FHIR and IHE BPPC which are also compatible with the open-source consent management software gICS. The proposed digital representation is (1) generic enough to capture relevant information from a wide range of consent documents and data use regulations and (2) interoperable with common technical standards. We plan to extend our model to include more fine-grained status codes and rules for automated access control.
doi:10.1186/s12911-020-01138-6 pmid:32503529 fatcat:2m4v36zejbcr7c4wny4oohbnme

Raffael und Lievens

Hans Schneider
1917 Oud-Holland  
Am keiner Linie des grossen Urbinaten lasst sich eben ungestraft rtitteln. 1) Wir haben es bei diesem Bild des LIEVENS mit einem ganz analogen Fall zu tun, wie es die Benutzung von RAFFAELS Castiglione  ...  oder teilweisen Wiedergaben unseres Bildes.  ... 
doi:10.1163/187501717x00030 fatcat:et5rhsgs7zhlzogrxnmqtfrbmq

Page 42 of Monatshefte Vol. 3, Issue 2 [page]

1901 Monatshefte  
Piadagogische Monatshefte. als Puppen, aber kein Bild.  ...  Anders bei Raffael. Bei ihm sind die Gestaiten voll ausgebildet, aber nicht wie bei Werner, sondern sie sind zu einander in Beziehung gebracht durch die Einheit der Farbe.  ... 

Page 42 of Monatshefte Vol. 3, Issue 2 [page]

1902 Monatshefte  
Padagogische Monatshefte. als Puppen, aber kein Bild.  ...  Anders bei Raffael. Bei ihm sind die Gestaiten voll ausgebildet, aber nicht wie bei Werner, sondern sie sind zu einander in Beziehung gebracht durch die Einheit der Farbe.  ... 

"Mona Lisa" – Das Porträt der Lisa del Giocondo [chapter]

Frank Zöllner, Pim den Boer, Heinz Duchhardt, Georg Kreis, Wolfgang Schmale
2012 Europäische Erinnerungsorte 2  
Während der Kubakrise im Herbst 1962 beschloss die französische Regierung, das Bild für zwei Ausstellungen in die Vereinigten Staaten zu schicken.  ...  UmständeninFlorenzwiederentdeckt und dann in einem wahren Triumphzug nach Paris zurückgeführt worden war, gilt "Mona Lisa" als berühmtestes Bild der Welt.  ...  Inzwischen wissen wir deutlich mehr über die frühe Geschichte des Bildes als noch zu Beginn des 20.  ... 
doi:10.1524/9783486704211-013 fatcat:3nzo6co26fc3hhh5zw3uaeiwfy

Tempel des Ernstes und des fake. Der Raffael-Saal in der Orangerie zu Potsdam, ein Kopienmuseum im Zeitalter der technischen Reproduzierbarkeit [chapter]

Bénédicte Savoy, Gilbert Heß, Elena Agazzi, Elisabeth Décultot
2011 Raffael als Paradigma  
Viele wussten gar nicht, was sie aus einem Bilde machen sollten, das so auffallend von OVÖS OMNF.S.QUI TR AJfSITIS PKR VIAM Abb. 5: Jakob Schlesinger: Kopte nach Raffael, Lo Spasimo (um 1516. Madrid.  ...  Ihr ganzer Wuchs sagte diesem Bilde zu, ihre Haltung war der Idee des Künstlers entsprechend, und eine Ruhe herrschte in dieser schwierigen Stellung, als wenn das Bild lebendig auf der Leinwand da stände  ... 
doi:10.1515/9783110255638.201 fatcat:2ksyclrvtbeqlcoialuqllf4hq

Vorwort [chapter]

1979 Komposition und Rhythmus  
Denen aber, die es aufnahmen, ging bald Bild für Bild ein Licht auf: die Bilder lebten als Sinn-gebilde, als Darstellungen in neuer Weise.  ...  Disputa und Raffaels Schule von Athen, sogar fundamental umgebrochen, ereignishaft, wie aus dem Nichts heraus, gewendet wird.  ... 
doi:10.1515/9783112418161-001 fatcat:w5scnwcgsrhc5mzxvonko65r2y
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