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Afternoon Nap and Bright Light Exposure Improve Cognitive Flexibility Post Lunch

Hichem Slama, Gaétane Deliens, Rémy Schmitz, Philippe Peigneux, Rachel Leproult, Vladyslav Vyazovskiy
2015 PLoS ONE  
Beneficial effects of napping or bright light exposure on cognitive performance have been reported in participants exposed to sleep loss. Nonetheless, few studies investigated the effect of these potential countermeasures against the temporary drop in performance observed in mid-afternoon, and even less so on cognitive flexibility, a crucial component of executive functions. This study investigated the impact of either an afternoon nap or bright light exposure on post-prandial alterations in
more » ... k switching performance in well-rested participants. Twenty-five healthy adults participated in two randomized experimental conditions, either wake versus nap (n=15), or bright light versus placebo (n=10). Participants were tested on a switching task three times (morning, post-lunch and late afternoon sessions). The interventions occurred prior to the post-lunch session. In the nap/wake condition, participants either stayed awake watching a 30-minute documentary or had the opportunity to take a nap for 30 minutes. In the bright light/placebo condition, participants watched a documentary under either bright blue light or dim orange light (placebo) for 30 minutes. The switch cost estimates cognitive flexibility and measures task-switching efficiency. Increased switch cost scores indicate higher difficulties to switch between tasks. In both control conditions (wake or placebo), accuracy switch-cost score increased post lunch. Both interventions (nap or bright light) elicited a decrease in accuracy switch-cost score post lunch, which was associated with diminished fatigue and decreased variability in vigilance. Additionally, there was a trend for a post-lunch benefit of bright light with a decreased latency switch-cost score. In the nap group, improvements in accuracy switch-cost score were associated with more NREM sleep stage N1. Thus, exposure to bright light during the post-lunch dip, a countermeasure easily applicable in daily life, results in similar beneficial effects as a short nap on performance in the cognitive flexibility domain with possible additional benefits on latency switch-cost scores.
doi:10.1371/journal.pone.0125359 pmid:26016658 pmcid:PMC4446306 fatcat:pb5pjef7nbgqpaoavk56fxen4m

Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices

Arja Ray, Zachary M. Slama, Rachel K. Morford, Samantha A. Madden, Paolo P. Provenzano
2017 Biophysical Journal  
Directed cell migration by contact guidance in aligned collagenous extracellular matrix (ECM) is a critical enabler of breast cancer dissemination. The mechanisms of this process are poorly understood, particularly in 3D, in part because of the lack of efficient methods to generate aligned collagen matrices. To address this technological gap, we propose a simple method to align collagen gels using guided cellular compaction. Our method yields highly aligned, acellular collagen constructs with
more » ... edictable microstructural features, thus providing a controlled microenvironment for in vitro experiments. Quantifying cell behavior in these anisotropic constructs, we find that breast carcinoma cells are acutely sensitive to the direction and extent of collagen alignment. Further, live cell imaging and analysis of 3D cell migration reveals that alignment of collagen does not alter the total motility of breast cancer cells, but simply redirects their migration to produce largely one-dimensional movement. However, a profoundly enhanced motility in aligned collagen matrices is observed for the subpopulation of carcinoma cells with high tumor initiating and metastatic capacity, termed cancer stem cells (CSCs). Analysis of the biophysical determinants of cell migration show that nuclear deformation is not a critical factor associated with the observed increases in motility for CSCs. Rather, smaller cell size, a high degree of phenotypic plasticity, and increased protrusive activity emerge as vital facilitators of rapid, contactguided migration of CSCs in aligned 3D collagen matrices.
doi:10.1016/j.bpj.2017.01.007 pmid:28297639 pmcid:PMC5355487 fatcat:z3eogwo7sjczhg3qasypxlta4y

Large-Scale Learning for Local Change: The Challenge of Massive Open Online Courses as Educator Professional Learning

Joshua Littenberg-Tobias, Rachel Slama
2022 Frontiers in Education  
How can large-scale open online learning serve the professional learning needs of educators which are often highly localized? In this mixed-methods study, we examine this question through studying the learning experiences of participants in four massive open online courses (MOOCs) that we developed on educational change leadership (N = 1,712). We observed that educators were able to integrate their learning from the online courses across a variety of educational settings. We argue that a key
more » ... tor in this process was that the design of online courses was attentive to various levels in which participants processed and applied their learning. We therefore propose the "Content-Collaboration-Context Model" (C-C-C) as a design model for designing and researching open online learning experiences for professional learning settings where participants' work is highly localized. In analyzing learner experiences in our MOOCs, we apply this model to illustrate how individuals integrated the de-contextualized content of the online courses into their context-specific practices. We conclude with implications for the design and research on open online professional learning experiences.
doi:10.3389/feduc.2022.899535 fatcat:yyjxskfxczahhkdatf4elbakai

Smoking and asthma: Disentangling their mutual influences using a longitudinal approach

Lucile Vignoud, Isabelle Pin, Anne Boudier, Christophe Pison, Rachel Nadif, Nicole Le Moual, Remy Slama, Molière Nguile Makao, Francine Kauffmann, Valérie Siroux
2011 Respiratory Medicine  
The association between smoking and asthma remains unclear and has mostly been assessed in cross-sectional studies, with potential selection bias ("healthy smoker effect"). Aims: Using a longitudinal approach, the aims were to assess whether 1) childhood asthma modifies smoking initiation, 2) active smoking influences asthma incidence in adults and 3) active smoking among subjects with asthma influences the persistence of the disease or the 12-year evolution in lung function in children and
more » ... ts. Methods: Subjects (513 children and 1190 adults) were recruited and followed-up for 12 years in the context of the EGEA study (Epidemiological study on the Genetics and Environment of Asthma). Results: Childhood asthma was not associated with a decreased probability of starting active smoking (Hazard Ratio, HR Z 0.96; 95% confidence interval (CI): 0.72, 1.27). Smoking at baseline was associated with a higher risk for asthma incidence in adulthood (HR Z 1.95, 95% CI: 1.00, 3.77). Among subjects with asthma, smoking was unrelated to lung function evolution; however, among children with moderate to severe asthma at inclusion, smoking tended to slow down the lung function growth (P Z 0.04). (L. Vignoud). a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / r m e d Respiratory Medicine (2011) 105, 1805e1814 0954-6111/$ -see front matter ª
doi:10.1016/j.rmed.2011.07.005 pmid:21873041 fatcat:yhiejz4kq5d6zdixrnzjitdx6e

Eliciting Learner Knowledge: Enabling Focused Practice through an Open-Source Online Tool

Meredith Thompson, Griffin Leonard, Jamie N. Mikeska, Pamela S. Lottero-Perdue, Adam V. Maltese, Giancarlo Pereira, Garron Hillaire, Rick Waldron, Rachel Slama, Justin Reich
2022 Behavioral Sciences  
Eliciting and interpreting students' ideas are essential skills in teaching, yet pre-service teachers (PSTs) rarely have adequate opportunities to develop these skills. In this study, we examine PSTs' patterns of discourse and perceived learning through engaging in an interactive digital simulation called Eliciting Learner Knowledge (ELK). ELK is a seven-minute, chat-based virtual role play between a PST playing a "teacher" and a PST playing a "student" where the goal is for the teacher to find
more » ... out what the student knows about a topic. ELK is designed to be a practice space where pre-service and in-service teachers can learn strategies for effectively eliciting their students' knowledge. We review the implementation of ELK in eight teacher education courses in math or science methods at six different universities and assess (a) patterns of interaction during ELK and (b) PSTs' perceptions of ELK and their learning from the simulation. Our findings suggest that PSTs engage in effective practices such as eliciting and probing more often than less effective practices such as evaluating and telling. Results suggest that PSTs gain experience in practicing talk moves and having empathy for students' perspectives through using ELK.
doi:10.3390/bs12090324 pmid:36135128 fatcat:hdl3ckrr2zfttlvdgc537o3jcm

Focusing on the Whole Student: An Evaluation of Massachusetts's Wraparound Zone Initiative

Allison Gruner Gandhi, Rachel Slama, So Jung Park, Patrick Russo, Kendra Winner, Robin Bzura, Wehmah Jones, Sandra Williamson
2018 Journal of Research on Educational Effectiveness  
doi:10.1080/19345747.2017.1413691 fatcat:dn5ycjzmujf2nogcrj2fryxhlu


Katharine E. Vieira, Paola Gilsanz, Maria M. Corrada, Claudia H. Kawas, Charles Decarli, Dan M. Mungas, Maria Glymour, Charles P. Quesenberry, Elizabeth Rose Mayeda, Natalie Slama, Sharan Johal, Rachel A. Whitmer
2019 Alzheimer's & Dementia  
enrollment data, such as: type of recruitment event (print media, word of mouth, community talks, etc.), return on participant contact, and participant follow-through. Data was split by ethnicity and recruitment approach. Results: The total number of new potential participants reached was 2,235. Of that, 1058 (47.3%) were scheduled for a study visit; of those scheduled, 867 (81.9%) completed the study. When broken down by ethnicity, most Non-Hispanic Whites were recruited through: word of mouth
more » ... (30.3%), print media (26.5%) and our referral program (17.0%). On the other hand, most Mexican Americans were recruited through: word of mouth (37.3%), community events/talks (25.6%) and non-paid local TV and newspaper (7.7%). Less fruitful efforts include: social media, health fairs and physician referrals. Conclusions: Recruiting elders into aging research involves varying types of recruitment techniques depending on the target population. Word of mouth was the most important overall recruitment strategy. Our data shows that recruiting elderly Mexican Americans requires a direct approach; community events/ talks in which our staff was present and interacting with attendees were highly effective. Non-Hispanic Whites responded mostly to an indirect approach: print media (brochures, postcards or paid newspaper advertisements). Overall our successful enrollment strategies and our acquired understanding of the ethnic differences in recruitment techniques can be used in the future to recruit more elderly minorities into research.
doi:10.1016/j.jalz.2019.06.1150 fatcat:p5ehdboetfhu7msel3pewikn6m

The International Collaboration on Air Pollution and Pregnancy Outcomes: Initial Results

Jennifer D. Parker, David Q. Rich, Svetlana V. Glinianaia, Jong Han Leem, Daniel Wartenberg, Michelle L. Bell, Matteo Bonzini, Michael Brauer, Lyndsey Darrow, Ulrike Gehring, Nelson Gouveia, Paolo Grillo (+15 others)
2011 Environmental Health Perspectives  
., 2004; Slama et al. 2008; Woodruff et al. 2009 ). Comparisons of findings across different geographic locations are hindered, in part, by differences in research designs.  ...  While in some places, mothers with higher SES live in less polluted areas (Woodruff et al. 2003) , in others, the opposite relationship holds (Slama et al. 2007) .  ... 
doi:10.1289/ehp.1002725 pmid:21306972 pmcid:PMC3222970 fatcat:qfldexf6pra2xcgqycpvzagc6y

Maternal Exposure to Particulate Air Pollution and Term Birth Weight: A Multi-Country Evaluation of Effect and Heterogeneity

Payam Dadvand, Jennifer Parker, Michelle L. Bell, Matteo Bonzini, Michael Brauer, Lyndsey A. Darrow, Ulrike Gehring, Svetlana V. Glinianaia, Nelson Gouveia, Eun-hee Ha, Jong Han Leem, Edith H. van den Hooven (+17 others)
2013 Environmental Health Perspectives  
2011; Glinianaia et al. 2008; Gouveia et al. 2004; Ha et al. 2004; Jalaludin et al. 2007; Lepeule et al. 2010; Mannes et al. 2005; Morello-Frosch et al. 2010; Pesatori et al. 2008; Rich et al. 2009; Slama  ... 
doi:10.1289/ehp.1205575 pmid:23384584 pmcid:PMC3621183 fatcat:4x3q5dybjjbgllqqxy3gmiuwqm


2017 Journal of Pediatric Endocrinology & Metabolism (JPEM)  
Tajima A newborn with combined pituitary hormone deficiency developing shock and sludge 1333 Imen Boussaid, Asma Boumiza, Ramzi Zemni, Elyes Chabchoub, Latifa Gueddah, Ines Slim and Foued Ben Hadj Slama  ...  Marzouki Serum progranulin levels in relation to insulin resistance in childhood obesity 1251 Valeria Calcaterra, Rachele De Giuseppe, Ginevra Biino, Melissa Mantelli, Sonia Marchini, Giulia Bendotti  ... 
doi:10.1515/jpem-2017-frontmatter12 fatcat:btwqy6g2xrh4lenpqx5lrosao4

Page 756 of Journal of Pharmaceutical Sciences Vol. 28, Issue 11 [page]

1939 Journal of Pharmaceutical Sciences  
Kelly Laboratory 100.00 17, No 4164 Rachel D. Shelton Laboratory 75.00 17, No. 4165 W. May Sisney Laboratory 40.00 17. No. 416¢ 4. G. DuMez Salaries 500.00 JOURNAL & ABSTRACTS 19 37 17, No. 4167 Wm.  ...  Slama | R u & As RAC 88.57 17, No. 4189 Edgar B. Starkey louURNAL & ABSTRA 11.80 7,N 4190 Marvin R. Thompson JOURNAL & Ap aC $+. 58 17, N 4191 E.G. Vanden Bosche JOUR u & ABSTRAC 74.30 l No. 4192 G.  ... 

Page 485 of Florida Bar Journal Vol. 78, Issue 8 [page]

2004 Florida Bar Journal  
3RD Ave Ste 100 Fort Lauderdale 33316-1154 jslama 9 SLAMA, Robed John . 904/3464390 Robert J Slama Pa 3821 Hendricks Ave Jacksonville 32207-5303 Fax: 904/346-4225 SLANDA  ...  3944)400 3352 Water Oak Or Hollywood 33021-8430 Fax: 954/986-0469 SKUTHAN, James Thomas . 407/6484338 80 N Hughey Ave Ste 417 Orlando 32801-2226 jim SKV»SKY,Caren Rachel  ... 

Page 685 of The Journal of the Royal Anthropological Institute Vol. 19, Issue 3 [page]

2013 The Journal of the Royal Anthropological Institute  
MARTIN SLAMA Austrian Academy of Sciences SPRONK, RACHEL. Ambiguous pleasures: sexuality and middle class self-perceptions in Nairobi. xi, 310 pp., bibliogr.  ... 

Rutherford, Danilyn. Laughing at Leviathan: sovereignty and audience in West Papua. xvi, 301 pp., illus., bibliogr. London, Chicago: Univ. Chicago Press, 2012. £18.00 (paper)

Martin Slama
2013 Journal of the Royal Anthropological Institute  
MARTIN SLAMA Austrian Academy of Sciences SPRONK, RACHEL. Ambiguous pleasures: sexuality and middle class self-perceptions in Nairobi. xi, 310 pp., bibliogr.  ... 
doi:10.1111/1467-9655.12058_25 fatcat:idpzyn5ilrfbvct7p77eja7mf4

Spronk, Rachel. Ambiguous pleasures: sexuality and middle class self-perceptions in Nairobi. xi, 310 pp., bibliogr. Oxford, New York: Berghahn, 2012. £60.00 (cloth)

Hannah Brown
2013 Journal of the Royal Anthropological Institute  
MARTIN SLAMA Austrian Academy of Sciences SPRONK, RACHEL. Ambiguous pleasures: sexuality and middle class self-perceptions in Nairobi. xi, 310 pp., bibliogr.  ... 
doi:10.1111/1467-9655.12058_26 fatcat:r3qwnyl25jasjegpizjx4xzle4
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