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The ADEPT Concept-Based Digital Learning Environment
[chapter]
2003
Lecture Notes in Computer Science
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We describe the design and application of a Digital Learning Environment (DLE) that is integrated with the collections and services of the Alexandria Digital Library (ADL). This DLE is in operational use in undergraduate teaching environments. Its design and development incorporate the assumption that deep understanding of both scientific phenomena and scientific methods is facilitated when learning materials are explicitly organized, accessed and presented at the level of granularity of
doi:10.1007/978-3-540-45175-4_28
fatcat:mxx4fbdlafabfplmqtejulamre
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... iate sets of scientific concepts and their interrelationships. The DLE supports services for the creating, searching, and displaying: (1) knowledge bases (KBs) of strongly structured models of scientific concepts; (2) DL collections of information objects organized and accessible by the concepts of the KBs; and (3) collections of presentation materials, such as lectures and laboratory materials, that are organized as trajectories through the KB of concepts.
Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells
2008
Journal of Medical Microbiology
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The intestinal epithelial cell line HT-29 was used to study the apoptotic effect of Clostridium difficile toxin A (TcdA). TcdA is a 300 kDa single-chain protein, which glucosylates and thereby inactivates small GTPases of the Rho family (Rho, Rac and Cdc42). The effect of TcdA-catalysed glucosylation of the Rho GTPases is well known: reorganization of the actin cytoskeleton with accompanying morphological changes in cells, leading to complete rounding of cells and destruction of the intestinal
doi:10.1099/jmm.0.47769-0
pmid:18480335
fatcat:4gfes2pu3zbdpjcvnna34dhlqy
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... arrier function. Less is known about the mechanism by which apoptosis is induced in TcdA-treated cells. In this study, TcdA induced the activation of caspase-3, -8 and -9. Apoptosis, as estimated by the DNA content of cells, started as early as 24 h after the addition of TcdA. The impact of Rho glucosylation was obvious when mutant TcdA with reduced or deficient glucosyltransferase activity was applied. TcdA mutant W101A, with 50-fold reduced glucosyltransferase activity, induced apoptosis only at an equipotent concentration compared with wild-type TcdA at a 50 % effective concentration of 0.2 nM. The enzyme-deficient mutant TcdA D285/287N was not able to induce apoptosis. Apoptosis induced by TcdA strictly depended on the activation of caspases, and was completely blocked by the pan-caspase inhibitor z-VAD-fmk. Destruction of the actin cytoskeleton by latrunculin B was not sufficient to induce apoptosis, indicating that apoptosis induced by TcdA must be due to another mechanism. In summary, TcdA-induced apoptosis (cytotoxic effect) depends on the glucosylation of Rho GTPases, but is not triggered by destruction of the actin cytoskeleton (cytopathic effect). Abbreviation: FACS, fluorescence-activated cell sorting.
Binding of the Human Prp31 Nop Domain to a Composite RNA-Protein Platform in U4 snRNP
2007
Science
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Kim for analytical assistance, and R. Pelker for assistance with blood serum assays of IGF1. ...
N indicates any nucleotide; R, purine. Binding of 15.5K and the secondary binding proteins is indicated. ...
doi:10.1126/science.1137924
pmid:17412961
fatcat:ecpk6ylusvfl5opscrnjuyz35e
Protein-Protein and Protein-RNA Contacts both Contribute to the 15.5K-Mediated Assembly of the U4/U6 snRNP and the Box C/D snoRNPs
2006
Molecular and Cellular Biology
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The binding of hPRP31 to the U4 snRNA was assayed by the method of Nottrott et al. ...
CYPH/hPRP4/hPRP3 binding to U4/U6 snRNA was performed by the method of Nottrott et al. ...
doi:10.1128/mcb.02374-05
pmid:16782898
pmcid:PMC1489164
fatcat:r4tpt3u3srfcte2no5d7kw2xce
Page 96 of National Union Catalog Vol. 110, Issue
[page]
1942
National Union Catalog
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Berlin, R. Giirgens, 1925.
216 p. 22"
Literaturverzeichnis” : p. (17)-18
1 Banking law— Germany. 2. Finance omen Money— Germany Law 1. ...
(Pell name: Carl Gustav Rudolph Edward Alfred Nottrott, 12-19104 Revised Library of Congress PLAGAO.NOT —-——— Copy 2 (Thab2,
Nottrott, Carl Gustav Rudolsh Eduard \ifred
Nottrott, ilfred, 1837-1924. ...
A notation for describing multiple views of VLSI circuits
25th ACM/IEEE, Design Automation Conference.Proceedings 1988.
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,l, i n r c i d , route-r, evalCc1ockJ. pnCsolect, clockl, one. zoro; x b ] , clock; yC2**d ; ixrow I (I (dec~rowCrow1) (roo = 2 * * r i . .O)); route-1 --(--(hT[X[COl]]> (col = n-i..O)) -route-r; eral ...
The second element of the environment is a database or "model" which uides the generation p r e cess. ...
doi:10.1109/dac.1988.14743
fatcat:6frhvl2hzrbk3kim2nu46zriri
A Common Core RNP Structure Shared between the Small Nucleoar Box C/D RNPs and the Spliceosomal U4 snRNP
2000
Cell
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The nucleolus contains a The human ortholog of Snu13p, 15.5kD, directly binds multitude of small nucleolar RNAs (snoRNAs), several the 5Ј stem-loop of the U4 snRNA (Nottrott et al., 1999). of which are ...
The box loop-stem structure (Nottrott et al., 1999) . ...
into pRS316 to create pRS316SNU13. and grants from the Deutsche Forschungsgemeinschaft (SFB397) Three copies of the HA epitope tag were added to the C terminus and the Fonds der Chemischen Industrie (to R. ...
doi:10.1016/s0092-8674(00)00137-9
pmid:11081632
fatcat:67wvis6nqjdjragxtf7p7tikry
Crystal Structure of the Spliceosomal 15.5kD Protein Bound to a U4 snRNA Fragment
2000
Molecular Cell
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Bringmann, P., Appel, B., Rinke, J., Reuter, R., Theissen, H., and Lü hrmann, R. (1984). ...
It additionally This protein was shown to play an important part in the late stage of spliceosome assembly before splicing suggests a general recognition principle in a novel catalysis (Nottrott et al. ...
R-factor ϭ ...
doi:10.1016/s1097-2765(00)00131-3
pmid:11163207
fatcat:24sumbexsff55nhkfidbk7yd3e
Long-term mechanical properties of a novel low-modulus bone cement for the treatment of osteoporotic vertebral compression fractures
2021
Journal of The Mechanical Behavior of Biomedical Materials
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Nottrott et al. (2007) reported an increase in CS and E after 1 week followed by a decrease of both properties onwards over a period of 1 year, for Palacos® R cement, which contains 67% less ZrO 2 radio-opacifier ...
(Nottrott et al., 2007 (Nottrott et al., , 2008 Baleani et al., 2001 ) and were expected. ...
doi:10.1016/j.jmbbm.2021.104437
pmid:33706086
fatcat:krvtzgwjoffr3cw4ye436f4tw4
VI. Additions to the Library
1895
Journal of the Royal Asiatic Society of Great Britain & Ireland
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Gundry (R. S.). China, Present and Past.
8vo. London, 1895.
By the Kgl. Museum fur Volkerkunde, Berlin.
Pander (Eugen). ...
Nottrott (A.). Grammatik der Kolhsprache.
8vo. Gutersloh, 1882.
Skrefsrud (Presented by Mrs. Beveridge.
Beveridge (H.). Trial of Nanda Kumar.
8vo. Calcutta, 1886. ...
doi:10.1017/s0035869x00145320
fatcat:6czyoxnxtnf5fh6563pdhxkifu
Biochemical defects in minor spliceosome function in the developmental disorder MOPD I
2014
RNA: A publication of the RNA Society
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In other work, we show that this mutation causes a splicing defect due to the lengthening or hyperstabilization of stem I (R Dietrich, G Shukla, and R Padgett, in prep.) . ...
The 15.5K protein belongs to a family of RNA-binding proteins that bind to K-turn motifs through an induced fit interaction (Nottrott et al. 1999 (Nottrott et al. , 2002 Turner et al. 2005; Woźniak et ...
doi:10.1261/rna.045187.114
pmid:24865609
pmcid:PMC4114687
fatcat:r5r6eluiyrdibntwtume3ikka4
Page 185 of The American Antiquarian and Oriental Journal Vol. 8, Issue 3
[page]
1886
The American Antiquarian and Oriental Journal
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Nottrott Grammatik der, Kolh-Sprache, pp. 104, Guetersloh, 1882; The Four Gospels in Mundari-Kolh; Rev. L...O. ...
Clark, Jour R. A. 8. Vol. XI. Part II., and the Gos- pels of Matthew and John and the Life of Joseph in, Ao Naga, by. the same; : The Nagas and Neighboring Tribes, by 8. i. Peele, Jour. ...
Page 250 of Christian Literature Vol. 12, Issue 4
[page]
1895
Christian Literature
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NOTTROTT, L. Die Gossnersche Mission un- ter den Kolhs. 2. Jubiliiums-[Titel-]Ausg. Halle (1874. 88), Miihlmann, 1894. x+455, vii+235 p. 8°. 6M.
SCHIMMELMANN, A. ...
R. Oowikapun; or, how the gos- pel reached the Nelson River Indians. N. Y., Hunt & Baton, 1894. 240 p. 12°. $1.
b. Other.
FUEGUNGEN, unverkennbare, Gottes. Auf-_
zeichnungen e. bekehrten Israeliten. ...
Differential association of microRNAs with polysomes reflects distinct strengths of interactions with their mRNA targets
2012
RNA: A publication of the RNA Society
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Results in B, C, E, and F are displayed as mean +/À standard error (SE). 0.91 compared, respectively, with R 2 = 0.91 and correlation = 0.95) (Supplemental Fig. S1A,B) . ...
D, P-value = 0.009 based on Fisher's r-to-z transformation). inverse correlation between abundance and occupancy of microRNAs was much weaker (correlation = À0.23 in hFFs vs. ...
doi:10.1261/rna.033142.112
pmid:22836355
pmcid:PMC3425777
fatcat:fjt6xiiacje4heeackrsnbddyu
Page 558 of Cellular and Molecular Life Sciences Vol. 65, Issue 4
[page]
2008
Cellular and Molecular Life Sciences
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Thermann, R. and Hentze, M. W. (2007) Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Nature 447, 875-878
Nottrott, S., Simard, M. J. and Richter, J. ...
Pillai, R. S., Bhattacharyya, S. N., Artus, C. ...
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