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Quick fixing ATL model transformations

Jesus Sanchez Cuadrado, Esther Guerra, Juan de Lara
2015 2015 ACM/IEEE 18th International Conference on Model Driven Engineering Languages and Systems (MODELS)  
Based on a static analyser for ATL model transformations which we have previously built, we present a method and a system to propose quick fixes for transformation errors.  ...  Our approach integrates seamlessly with the ATL editor.  ...  As future work, we plan to use speculative analysis [14] to improve the accuracy of the quick fixes.  ... 
doi:10.1109/models.2015.7338245 dblp:conf/models/CuadradoGL15 fatcat:gkij3wbkfrhxvbbpjhw4n2u7gm

Introduction to the special issue on the 18th international conference on model driven engineering languages and systems (MODELS'15)

Jordi Cabot, Alexander Egyed
2017 Journal of Software and Systems Modeling  
The approach relates syntactic change operations and semantic difference witnesses. • "Quick fixing ATL transformations with speculative analysis" by Jesús Sánchez-Cuadrado, Esther Guerra and Juan de Lara  ...  a combines program analysis and constraint solving to identify errors in ATL model transformations and to propose suitable quick fixes for ATL transformation errors.  ... 
doi:10.1007/s10270-017-0577-x fatcat:ejdbenbxnbet5ec4ubqjyp3tru

CADM1 Interacts with Tiam1 and Promotes Invasive Phenotype of Human T-cell Leukemia Virus Type I-transformed Cells and Adult T-cell Leukemia Cells

Mari Masuda, Tomoko Maruyama, Tsutomu Ohta, Akihiko Ito, Tomayoshi Hayashi, Kunihiko Tsukasaki, Shimeru Kamihira, Shoji Yamaoka, Hiroo Hoshino, Teruhiko Yoshida, Toshiki Watanabe, Eric J. Stanbridge (+1 others)
2010 Journal of Biological Chemistry  
Despite being a tumor suppressor in various carcinomas, recent DNA microarray analysis of primary adult T-cell leukemia/lymphoma (ATL) 3 cells from acute type ATL patients revealed that CADM1 was up-regulated  ...  In this study, we demonstrated that the cytoplasmic domain of CADM1 directly interacted with the PDZ domain of Tiam1 and induced formation of lamellipodia through Rac activation in HTLV-I-transformed cell  ...  Tesshi Yamada, Yoshinori Ino, and Kazufumi Honda for generous help with the Bio-Rad Radiance 2000 confocal system. We are also grateful to Dr.  ... 
doi:10.1074/jbc.m109.076653 pmid:20215110 pmcid:PMC2865322 fatcat:wgt56b3sdndnnjaznrk24nprp4

Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia

K. Tada, M. Kobayashi, Y. Takiuchi, F. Iwai, T. Sakamoto, K. Nagata, M. Shinohara, K. Io, K. Shirakawa, M. Hishizawa, K. Shindo, N. Kadowaki (+6 others)
2015 Science Advances  
Because IFN-a is combined with AZT to treat ATL patients (7-9), we also tested  ...  These results suggest a model in which ATL cells with reduced TDP1 expression are unable to excise abacavir incorporated into genomic DNA, leading to irreparable DSBs.  ...  Chromosomal analysis The cells were cultured with colcemid (50 ng/ml) for 2 hours at 37°C, fixed with Carnoy's solution, and placed on a glass slide.  ... 
doi:10.1126/sciadv.1400203 pmid:26601161 pmcid:PMC4640626 fatcat:763kchisrvcujo6i2wi7lhzvji

Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model

Wakako Kuribayashi, Kazuya Takizawa, Kenji Sugata, Madoka Kuramitsu, Haruka Momose, Eita Sasaki, Yuki Hiradate, Keiko Furuhata, Yoshihisa Asada, Atsushi Iwama, Masao Matsuoka, Takuo Mizukami (+1 others)
2016 OncoTarget  
Here, with a new ATL mouse model using HBZ-transgenic mice, we further discovered that the functional ATLSC candidate, which commonly expresses c-kit, is drug-resistant and has the ability to initiate  ...  Inhibition of c-kit-SCF signaling with the neutralizing antibody ACK2 affected ATLSC self-renewal and proliferation.  ...  Histological analysis Tissues were fixed with Bouin's solution (Sigma-Aldrich) and then dehydrated using graded series of ethanol and cleared with xylen.  ... 
doi:10.18632/oncotarget.10210 pmid:27340921 pmcid:PMC5239456 fatcat:ba6defj62zcpbpol7gttakqqni

Umbelliferone Impedes Biofilm Formation and Virulence of Methicillin-Resistant Staphylococcus epidermidis via Impairment of Initial Attachment and Intercellular Adhesion

Thirukannamangai Krishnan Swetha, Murugesan Pooranachithra, Ganapathy Ashwinkumar Subramenium, Velayutham Divya, Krishnaswamy Balamurugan, Shunmugiah Karutha Pandian
2019 Frontiers in Cellular and Infection Microbiology  
Furthermore, real time PCR analysis revealed the reduced expression of adhesion encoding genes (icaD, atlE, aap, bhp, ebh, sdrG, and sdrF).  ...  Down regulation of agrA and reduced production of secreted hydrolases upon UMB treatment were speculated to hinder invasive lifestyle of MRSE.  ...  With these observations, 500 µg/ml of UMB was fixed as MBIC and used for subsequent bioassays.  ... 
doi:10.3389/fcimb.2019.00357 pmid:31681633 pmcid:PMC6813203 fatcat:qds2zru47va6zpkl6kexgd6nn4

A Decomposition of the Atlantic Meridional Overturning Circulation into Physical Components Using Its Sensitivity to Vertical Diffusivity

Juliette Mignot, Anders Levermann, Alexa Griesel
2006 Journal of Physical Oceanography  
The export of water at 30°S varies only weakly with , but is strongly correlated with the strength of the overflow over the Greenland-Scotland ridge.  ...  It increases linearly with . This is consistent with the classic 2/3 scaling law only when taking the linear variation of the density difference to into account.  ...  These two effects can be illustrated through the analysis of additional simulations where high values of mixing are imposed equatorward of 40°latitude only, with fixed to a low value of ϭ 0.1 cm 2 s Ϫ1  ... 
doi:10.1175/jpo2891.1 fatcat:l6xfg4syqfax7duck3fmshc4sa

Methods in search of methodology---combining HCI and object orientation

Susan E. McDaniel, Gary M. Olson, Judith S. Olson
1994 Proceedings of the SIGCHI conference on Human factors in computing systems celebrating interdependence - CHI '94  
We describe the use of these methods in a project case study and conclude with a synopsis of how the methods worked and lessons we learned.  ...  We propose a combination of object-oriented analysis and design, human computer interaction, and process redesign forged into one methodology.  ...  In the quick analysis we did, we looked for obvious problems, ones which could be quickly fixed, and would not require any major reworking of the software.  ... 
doi:10.1145/191666.191728 dblp:conf/chi/McDanielOO94a fatcat:lcadqzeb3jhkbl4hfhjjv7dlq4

HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein

Jun Matsumoto, Takayuki Ohshima, Osamu Isono, Kunitada Shimotohno
2004 Oncogene  
of ATL.  ...  Among these, Tax is postulated to play a pivotal role in the development of ATL, since it has the capacity to immortalize human T cells (Grassmann et al., 1992; Akagi and Shimotohno, 1993) , transform  ...  For in vitro translation, [ 35 S]methionine (Amersham)-labeled proteins were produced with TNT quick-coupled translation system (Promega).  ... 
doi:10.1038/sj.onc.1208297 pmid:15592508 fatcat:uu2wmf5gvbdsndakmokcj67vcy

Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2

M. Gullberg
1986 Journal of Experimental Medicine  
HTLV-I, the etiologic agent of adult T cell leukemia (ATL) (38, 39) , transforms T4 + cells preferentially.  ...  The percentage of cells in the G0/G] phase of the cell cycle was estimated using the quick-estimate method of cell cycle analysis provided with the 2150 Data Handler software. [SH]TdR Incorporation.  ... 
doi:10.1084/jem.163.2.270 pmid:2935591 pmcid:PMC2188024 fatcat:s6fzvcscwbayxok7bcu624mop4

Estimation of Default Probabilities: Application of the Discriminant Analysis and the Structural Approach for Companies Listed on the BVC

Lahsen Oubdi, Abdessamad Touimer
2017 Journal of Financial Risk Management  
This article aims to compare the calculated results of the structural approach (Internal Ratings-Based IRB) and the discriminant analysis (Z-score of Altman, 1968), based on data from companies listed  ...  On the contrary, for the speculative category, the probability of default is often a decreasing function of the horizon.  ...  The popularity of this model allowed the dissemination of Merton's ideas and transformed into a few decades the vision of credit risk.  ... 
doi:10.4236/jfrm.2017.63021 fatcat:pjq4iloobbfjtbuiifxpxhzaku

A novel nucleolar G-protein conserved in eukaryotes

J H Park, B C Jensen, C T Kifer, M Parsons
2001 Journal of Cell Science  
TbNOG1 localized to the trypanosome nucleolus and interacted with domains of NOPP44/46 that are found in several other nucleolar proteins.  ...  The founding member of this family, TbNOG1, was identified in a two-hybrid screen as a protein that interacts with NOPP44/46, a nucleolar phosphoprotein of Trypanosoma brucei.  ...  We speculate that proteins with U-or J-like domains may interact with their corresponding NOG1 homologues.  ... 
pmid:11112701 fatcat:q47e5xojg5aqlmynstvpu2xdxy

Estimating the Competitive Storage Model: A Simulated Likelihood Approach [article]

Tore Selland Kleppe, Atle Oglend
2017 arXiv   pre-print
Simulation experiments also show that the precision of the particle filter estimator improves faster than for composite quasi-maximum likelihood with more price data.  ...  It is shown that the storage model estimated with the particle filter estimator beats, in terms of log-likelihood, commonly used reduced form time-series models such as the linear AR(1), AR(1)-GARCH(1,1  ...  The price is considered fixed when making storage decisions and speculators are assumed to hold rational expectations.  ... 
arXiv:1701.02156v1 fatcat:kedyem25xvc7rfchtxmjq7w4fa

Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice

Georg D. Duerr, Daniela Dewald, Eva J. Schmitz, Luise Verfuerth, Katharina Keppel, Christine Peigney, Alexander Ghanem, Armin Welz, Oliver Dewald
2016 Mediators of Inflammation  
Molecular analysis revealed maladaptation of myosin heavy chain isoforms and antioxidative enzymes in MT1/2-/--hearts.  ...  Hearts were examined with M-mode echocardiography and processed for histological and mRNA studies.Results.  ...  The fluorescence signal was converted and then stained with diaminobenzidine (AXXORA) and slides were counterstained with Quick hemalaun kit (Vector) [19] . Gene Expression.  ... 
doi:10.1155/2016/7174127 pmid:27403038 pmcid:PMC4923606 fatcat:3wfeytpqdjcfzaidwabql73fze

Correct Public Prediction and the Stability of Equilibrium

Evangelos A. Devletoglou
1961 Journal of Political Economy  
vergent cobwebs converg¢ more quick- yy.  ...  .* My analysis deals exclusively with the second prob- lem, assuming throughout perfect public forecasting.  ... 
doi:10.1086/258450 fatcat:u5jp2qles5aw7dudkkmurodfhy
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