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The related life/death decision strictly depends on cell-to-cell variability in the formation of the death-inducing complex (DISC) on one side (extrinsic noise) vs. stochastic gene expression of the NF-κB ... Moreover, our analysis has uncovered that the stochasticity in apoptosis and NF-kB pathways leads not only to survival or death of a cell, but also causes a third type of response to CD95 stimulation that ... The crosstalk between apoptotic and anti-apoptotic pathways plays a key role in shaping life/death decisions in the cell. ...doi:10.1371/journal.pcbi.1006368 fatcat:wlguet3q2veovcb4vqruellcvq
Death receptor activation leads to the formation of death receptor signaling platforms, resulting in the demolition of the cell. ... Creation of mathematical models of death receptor signaling led to an enormous progress in the quantitative understanding of the network regulation and provided fascinating insights into the mechanisms ... the Helmholtz-Russia Joint Research Groups-2008-2 and RFFI 14-04-00699 for supporting our work. ...doi:10.1038/cddis.2014.160 pmid:24874731 pmcid:PMC4047881 fatcat:sf52jpvhvfbn5d6ejh2ife2joq
Here we review progress made over the last decade in using mathematical models and quantitative, often single-cell, data to study apoptosis. ... Cell death plays an essential role in the development of tissues and organisms, the etiology of disease, and the responses of cells to therapeutic drugs. ... ACKNOWLEDGMENTS The authors thank J. Albeck, J. Bachman, D. Flusberg, S. Gaudet, T. Letai, and C. Lopez for their help and acknowledge NIH grants GM68762 and CA139980 for support. ...doi:10.1016/j.cell.2011.03.002 pmid:21414484 pmcid:PMC3087303 fatcat:qxxsrccfizej3eiu4dmgoawjqe
To explain cell decision making downstream of death receptor activation, we developed a semi-stochastic model of DISC/RIPoptosome formation. ... The model highlights how kinetic proofreading leads to heterogeneous cell responses and results in fractional cell killing at low levels of receptor stimulation. ... Buchbinder JH, Pischel D, Sundmacher K, Flassig RJ, Lavrik IN. Quantitative single cell analysis uncovers the life/death decision in CD95 network. ...doi:10.1371/journal.pcbi.1007374 pmid:31553717 pmcid:PMC6779275 fatcat:3ow5sf3cmzdqvarmtjrov6vajq
We argue that a comparative analysis of different types of p53 responses, elicited by different triggers in a time-resolved manner in well-defined model systems, is critical to understand the cell-type-specific ... Here, we discuss how mitotic errors alert the p53 network and give an overview of multiple ways that p53 can trigger cell death. ... Life-Death Decisions by p53-Flicking the Switch What ultimately defines cell fate after p53 activation in diverse cell types? ...doi:10.3390/ijms221910883 pmid:34639222 fatcat:ehfobn6tgraqzdowydperlbpea