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Quantitative estimation of pesticide-likeness for agrochemical discovery

Sorin Avram, Simona Funar-Timofei, Ana Borota, Sridhar Rao Chennamaneni, Anil Kumar Manchala, Sorel Muresan
2014 Journal of Cheminformatics  
These findings are valuable for the efficient estimation of pesticide-likeness of vast chemical libraries in the field of agrochemical discovery.  ...  The aim of this study is to develop quantitative estimates of herbicide-(QEH), insecticide-(QEI), fungicide-(QEF), and, finally, pesticide-likeness (QEP).  ...  In the panels: QEH, Quantitative estimate of herbicide-likeness; QEI, Quantitative estimate of insecticide-likeness; QEF, Quantitative estimate of fungicide-likeness; QEP, Quantitative estimate of pesticide-likeness  ... 
doi:10.1186/s13321-014-0042-6 pmid:25264458 pmcid:PMC4173135 fatcat:kvmsp3f4dnbnpbwjs3pbse536q

Predicting mammalian metabolism and toxicity of pesticides in silico

Robert D Clark
2018 Pest Management Science  
Animal testing is key to ensuring safety, but it comes late in the agrochemical development process, is expensive, and requires relatively large amounts of material.  ...  Their broader use could substantially reduce the amount of time and effort wasted in pesticide development.  ...  ACKNOWLEDGEMENTS SUPPORTING INFORMATION Supporting information may be found in the online version of this article.  ... 
doi:10.1002/ps.4935 pmid:29762898 pmcid:PMC6099302 fatcat:j5jek4moevfxhppm62cl7aubza

Pesticide Persistence in Agriculture and its hazardous effects on Environmental Components

Ronika Thapa, Anjal Nainabasti, Ashish Lamsal, Santoshi Malla, Bronika Thapa, Yushika Subedi, Shirish Ghimire
2022 International Journal of Applied Sciences and Biotechnology  
Concerns have also been raised about pesticide currently uses and its impact on the environment with the possibility for hazardous or carcinogenic residues.  ...  There would be a 78 percent loss of fruit output, a 54 percent loss of vegetable production, and a 32 percent loss of cereal production if pesticides were not used.  ...  They did not receive any funding for the completion of this paper writing.  ... 
doi:10.3126/ijasbt.v10i2.45095 fatcat:aodop5phxvh6fpox4kgghdm7pi

Molecular pharmacology on insect biogenic amines

Hiroto Ohta
2009 Journal of pesticide science  
E-mail: hiohta@gpo.kumamoto-u.ac.jp © Pesticide Science Society of Japan * Society Awards 2009 (for high prospectiveness)  ...  For example, demethylchlordimeform (the in vivo metabolite of the formamidine insecticide chlordimeform) acts as an OA receptor agonist, exerting pesticidal and pestistatic effects.  ... 
doi:10.1584/jpestics.j09-05 fatcat:jcofbl4zxnemledi23cofdwmky

Computer-Aided Drug Discovery in Plant Pathology

Gnanendra Shanmugam, Junhyun Jeon
2017 The Plant Pathology Journal  
up exciting possibilities for application of CADD in discovery and development of agrochemicals.  ...  Control of plant diseases is largely dependent on use of agrochemicals.  ...  Syed Mohammed, Department of Chemistry, Sadakathullah Appa College, Tirunelveli, India for supporting the pharmacophore modelling and 3D database screening with their software facilities (Discovery studio  ... 
doi:10.5423/ppj.rw.04.2017.0084 pmid:29238276 pmcid:PMC5720600 fatcat:bc7uoqjwnzdrbhnfngi7pkz4nq

Environmental, Health and Economic Implications of Emerging Contaminants in Nigeria Environment

S. A. Adesokan, A. A. Giwa, I. A. Bello
2022 Journal of the Nigerian Society of Physical Sciences  
From 1983 to 1990, an estimated 15,000 metric tons of pesticides were reported to have been imported annually.  ...  In 2016, a yearly application of about 130,000 metric tons of pesticides was reported for Nigeria. Nigeria's pesticides imports were worth USD128.671 in that year.  ...  Acknowledgments We thank the referees for the positive enlightening comments and suggestions, which have greatly helped us in making improvements to this paper.  ... 
doi:10.46481/jnsps.2022.842 fatcat:gxnyk4k7tfddfaprseujlzxbme

Pesticide productivity and food security. A review

József Popp, Károly Pető, János Nagy
2012 Agronomy for Sustainable Development  
This review presents (1) worldwide crop losses due to pests, (2) estimates of pesticide-related productivity, and costs and benefits of pesticide use, (3) approaches to reduce yield losses by chemical,  ...  of meat and milk products and to the increasing use of grains for livestock feed.  ...  Acknowledgements This paper was made with the support of the Hungarian Development Agency for the research project TECH_09-A3-2009-0227. We gratefully acknowledge Dr.  ... 
doi:10.1007/s13593-012-0105-x fatcat:kwka7rgvybflbkrejqkyuxo4fm

Impact of agriculture on the selection of insecticide resistance in the malaria vector Anopheles gambiae: a multigenerational study in controlled conditions

Theresia Estomih Nkya, Rodolphe Poupardin, Frederic Laporte, Idir Akhouayri, Franklin Mosha, Stephen Magesa, William Kisinza, Jean-Philippe David
2014 Parasites & Vectors  
A microarray approach was used for pinpointing transcription level variations selected by the agricultural pesticide mixture at the adult stage.  ...  Conclusions This study confirms the potency of agriculture in selecting for insecticide resistance in malaria vectors.  ...  We also acknowledge additional funding from the federative structure Environmental and Systems Biology (BEeSy) of Grenoble -Alpes University. We thank Prof. H.  ... 
doi:10.1186/s13071-014-0480-z pmid:25318645 pmcid:PMC4201709 fatcat:xdplodljfzgmblafvopfl4g4gq

Impact of agriculture on the selection of insecticide resistance in the malaria vector Anopheles gambiae : a multigenerational study in controlled conditions

Theresia Nkya, Rodolphe Poupardin, Frederic Laporte, Idir Akhouayri, Franklin Mosha, Stephen Magesa, William Kisinza, Jean-Philippe David
2014 Parasites & Vectors  
A microarray approach was used for pinpointing transcription level variations selected by the agricultural pesticide mixture at the adult stage.  ...  This study confirms the potency of agriculture in selecting for insecticide resistance in malaria vectors.  ...  We also acknowledge additional funding from the federative structure Environmental and Systems Biology (BEeSy) of Grenoble -Alpes University. We thank Prof. H.  ... 
doi:10.1186/preaccept-1961934091135119 pmid:25318645 pmcid:PMC4201709 fatcat:bte2l3runncydajiwu7qqnjyz4

Be(e)coming experts: The controversy over insecticides in the honey bee colony collapse disorder

Sainath Suryanarayanan, Daniel Lee Kleinman
2013 Social Studies of Science  
Numerous long-time commercial beekeepers contend that newer systemic agricultural insecticides are a crucial part of the cocktail of factors responsible for colony collapse disorder.  ...  came to dominate the investigation of the links between pesticides and honey bee health, and how the epistemological dominance of these norms and practices served to marginalize the knowledge claims and  ...  Hess, Michael Lynch, Sergio Sismondo, and anonymous reviewers for suggesting ways to improve the manuscript. The views represented in this article are those of the authors. Notes  ... 
doi:10.1177/0306312712466186 fatcat:567l4nupzjcipp2mrmrmv3uify

Impacts of agrochemical intensification on the assembly and reassembly of a mainland-island model metacommunity [article]

Rodolfo Mei Pelinson, Bianca Rodrigues Strecht, Erika Mayumi Shimabukuro, Luis C Schiesari
2021 bioRxiv   pre-print
Therefore, spatial isolation did not change the effects of agrochemicals on community structure.  ...  These habitats are vulnerable to contamination by agrochemicals, which can differentially affect local communities depending on the intensity and variability of species dispersal rates.  ...  that was analyzed for pesticide concentrations.  ... 
doi:10.1101/2021.02.23.432475 fatcat:pykq76lqtvedjocg5izbzrpxki

Accountability in the Pesticide Industry

Peter Rriggs, Megan Waples
2003 International journal of occupational and environmental health  
Our task, therefore, is to better document and communicate these risks and liabilities to investors, analysts, and consumers so that they will able to better assess the market value of agrochemical firms  ...  PARTICIPANTS We believe this disconnect is due to a misunderstanding and underestimation of the risks, liabilities, and long-term viability of this industry.  ...  An accelerated move away from pesticide dependency is likely to dramatically decrease the attractiveness of the agrochemical sector for investors.  ... 
doi:10.1179/107735203800328902 pmid:12749634 fatcat:4n6whwd6f5ajjhhtczukddhcoa

Abiotic and biotic factors affecting the replication and pathogenicity of bee viruses

Alexander J McMenamin, Laura M Brutscher, William Glenny, Michelle L Flenniken
2016 Current Opinion in Insect Science  
The evidence to date suggests that bee colony losses are not solely dependent upon agrochemicals, but are likely a result of a combination of factors.  ...  For many agrochemical formulations a lethal dose 50 (LD 50 ) and/or exposure threshold for bees at various stages of development is not known and even less information is available regarding synergistic  ... 
doi:10.1016/j.cois.2016.04.009 pmid:27720045 pmcid:PMC5113721 fatcat:vxb5ponkoja6hdwln22zct7w7i

Relaxation of putative plant defenses in a tropical agroecosystem

Lauren N. Carley, Susan G. Letcher
2021 Ecology and Evolution  
To explore whether exposure to agrochemicals may influence selective pressures and phenotypic expression in nonagricultural plant populations, we characterized the expression of putative antiherbivore  ...  In one species with multiple modes of putative defenses, we observed parallel reductions of three metrics of putative biotic and physical defenses.  ...  for information on pesticide use in the Tempisque basin.  ... 
doi:10.1002/ece3.7497 pmid:34141186 pmcid:PMC8207448 fatcat:3zmsgzevtvga3c4764ucnwzjo4

Study to Evaluate the Physicochemical Properties and Phytochemical Constituents of Five Aromatic Plants

B Srivastava, P Singh, A Sagar, NK Dubey
2011 Journal of Phytomedicine and Therapeutics  
Keywords: Aromatic plants are a tremendous source for the discovery of new products of medicinal value for drug development.  ...  Of late, several distinct chemicals derived from plants are important drugs.  ...  Acknowledgments The authors are thankful to University Grants Commission, New Delhi for providing financial assistance in the form of Dr. D. S. Kothari postdoctoral fellowship.  ... 
doi:10.4314/jopat.v14i1.69403 fatcat:zmzv2wxl5bbljil24ebhg3n4se
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