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Physics of pure and non-pure positron emitters for PET: a review and a discussion
2016
EJNMMI Physics
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(prompt gamma), gamma-gamma cascades, intense Bremsstrahlung radiation, high-energy positrons that may escape out of the patient skin, and high-energy gamma rays that result in some e + /e − pair production ...
Some of the most interesting radioisotopes with prospective use in the new fields are not pure short-range β + emitters but can be associated with gamma emissions in coincidence with the annihilation radiation ...
emitters (>1 mm). 3) Prompt gamma contamination: gammas emitted in decay cascades with the positron emission produce spurious coincidences, which blur the PET image and produce quantification errors, ...
doi:10.1186/s40658-016-0144-5
pmid:27271304
pmcid:PMC4894854
fatcat:wxwo5drogva37mhzshjhdn6q7i
Positron range-free and multi-isotope tomography of positron emitters
2021
Physics in Medicine and Biology
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Additionally, prompt gamma imaging was tested for 89Zr that emits very high-energy prompts (909keV). ...
Here we realize multi-isotope and sub-mm resolution PET of isotopes with several mm positron range by utilizing prompt gamma photons that are commonly neglected. ...
Acknowledgments This work financed by the research grant QUARAT: Quantitative Universal Radiotracer Tomography (TTW16885) which is financed in part by the Dutch Research Council (NWO). ...
doi:10.1088/1361-6560/abe5fc
pmid:33578400
fatcat:ix7cfccgyjgqxj34myuoyaukay
Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review
2017
Theranostics
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However, I-124 and Y-86 are not pure positron emitters and they are associated with spurious coincidences such as prompt gamma coincidences (PGC), gamma-gamma cascades, intense bremsstrahlung radiation ...
For example, about 50% of the positrons are emitted with a 603-keV gamma photon simultaneously for I-124. ...
Competing Interests The authors have declared that no competing interest exists. ...
doi:10.7150/thno.19782
pmid:29158844
pmcid:PMC5695148
fatcat:uulyhakfazdsbejnoydkawus6y
Precision imaging of 4.4 MeV gamma rays using a 3-D position sensitive Compton camera
2018
Scientific Reports
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In proton therapy, 4.4 MeV gamma rays are emitted from the excited nucleus of either 12 C* or 11 B* and are considered good indicators of dose delivery and/or range verification. ...
Thus, by setting an energy window of 3D-PSCC from 3 to 5 MeV, we show that a gamma ray image sharply concentrates near the Bragg peak, as expected from the minimum energy threshold and sharp peak profile ...
Positron emission tomography (PET) allows visualization of FDG (fluoro-deoxy-glucose) tagged with positron emitters, most often 18 F 3 . ...
doi:10.1038/s41598-018-26591-2
pmid:29802312
pmcid:PMC5970135
fatcat:zvpmdrfs6fh4zleeb6m2qr6ex4
NON-CONVENTIONAL PET NUCLIDES: PRODUCTION AND IMAGING
2015
Momento
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Los ciclotrones médicos son usados actualmente para la producción de Nucleidos de PET. ...
Los nucleidos no convencionales de PET han surgido recientemente y ofrecen nuevas oportunidades para diagnóstico y farmacoterapia. ...
Since the cascade gamma rays are emitted by the daughter nucleus with a very short half-live and the annihilation photons by the emitted positrons, the emission time difference will typically be shorter ...
doi:10.15446/mo.n51.56186
fatcat:cc62yfbrrra7dpqe7xfq5hvusi
Precision imaging of 4.4 MeV gamma rays using a 3-D position sensitive Compton camera
[article]
2018
arXiv
pre-print
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In proton therapy, 4.4 MeV gamma rays are emitted from the excited nucleus of either 12^C^* or 11^B^* and are considered good indicators of dose delivery and/or range verification. ...
Thus, by setting an energy window of 3D-PSCC from 3 to 5 MeV, we show that a gamma ray image sharply concentrates near the Bragg peak, as expected from the minimum energy threshold and sharp peak profile ...
Positron emission tomography (PET) allows visualization of FDG (fluoro-deoxy-glucose) tagged with positron emitters, most often 18 F 3 . ...
arXiv:1805.06132v1
fatcat:dnqfzhupwndlzb7atcfnqsmvle
Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators
2020
PET Clinics
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Total-body PET opens a new diagnostic paradigm with prospects for personalized disease treatment, yet the high cost of the current crystal-based PET technology limits dissemination of total-body PET in ...
High sensitivity of total-body J-PET and triggerless data acquisition enable multiphoton imaging, opening possibilities for multitracer and positronium imaging, thus promising quantitative enhancement ...
gamma rays (blue dashed arrows) emitted by the b 1 g radionuclide such as for example, 44 Sc or 82 Rb. ...
doi:10.1016/j.cpet.2020.06.009
pmid:32739047
fatcat:3jkwmzuy35dybct4itdxm4ztgy
Improved Quantification of 18F-FDG PET during 131I-Rituximab Therapy on Mouse Lymphoma Models after 131I Prompt Emission Correction
2019
Diagnostics
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18F-FDG Positron Emission Tomography (PET) is used to monitor tumor response to 131I-therapy, but is confounded by prompt emissions (284, 364, 637, and 723 keV) from 131I, particularly in animal PET imaging ...
We applied a single gamma correction method to a phantom and in vivo mouse model. ...
Figure 1B shows the prompt emissions due to 131 I. 131 I emitted 284, 364, 637, and 723 keV gamma rays. ...
doi:10.3390/diagnostics9040144
pmid:31597334
pmcid:PMC6963650
fatcat:tkxhy43q5jddzggms4friqax5u
Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides
2006
Nuclear Medicine and Biology
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One of the limiting factors in achieving the best spatial resolution in positron emission tomography (PET), especially in smallanimal PET, is the positron range associated with the decay of nuclides, and ...
Methods: Phantoms were imaged with three positron emitting isotopes of Cu ( 60 Cu, 61 Cu and 64 Cu), and mice and rats were imaged with two radiopharmaceuticals labeled with these isotopes in a microPET-R4 ...
Small-animal PET imaging was partially supported by an NIH/NCI SAIRP grant (R24 CA 083060), with additional support from the Small-Animal Imaging Core of the Alvin J. ...
doi:10.1016/j.nucmedbio.2005.11.001
pmid:16546676
fatcat:5u4hpfkosvbmpds7co54nhgqwm
Quantitative small animal PET imaging with nonconventional nuclides
2009
Nuclear Medicine and Biology
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We show that, with the knowledge of the measured point spread functions, the accurate activity concentration in small lesions can be recovered when imaging with long-range positron emitters. ...
Positron Emission Tomography (PET) has gained a tremendous momentum recently for clinical applications notably with the availability of 18 F-fluorodeoxyglucose for staging and evaluation of therapy efficacy ...
Spatial resolutions [full-width at half- Only the most abundant prompt gamma rays are listed. ...
doi:10.1016/j.nucmedbio.2009.01.019
pmid:19520296
fatcat:zbr2lh6k2bczfpzf6h3jmdzf3m
Introduction to PET instrumentation
2001
Journal of Nuclear Medicine Technology
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The purpose of this paper is to introduce technologists to the basic principles of PET imaging and to the instrumentation used to acquire PET data. ...
PET imaging is currently being done on a variety of imaging system types, and the technologist will be introduced to these systems and learn about the basic physical image-degrading factors in PET. ...
The terminology associated with PET imaging on rotating gamma cameras has become very confusing. All tomographic imaging of positron emitters is fairly termed "PET". ...
pmid:11283211
fatcat:ic2ytqvr3zgztoxyz5pzjie2ga
In vivo functional imaging with SPECT and PET
2001
Radiochimica Acta
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Dependent on the radionuclide involved, two different tomographic procedures are available: single photon emission computed tomography (SPECT) and positron emission tomography (PET). ...
Although planar scintigraphy has been found useful for many questions, detailed spatial information about the diseased organ can only be obtained with tomographic methods. ...
The scintillation crystal is sensitive to the energy of γ -radiation that is emitted by radionuclides used in nuclear medicine, no matter whether they are single photon or positron emitters. ...
doi:10.1524/ract.2001.89.4-5.203
fatcat:ollzzd4rbzdujfeihhvzl5fv2i
The Beginning and Development of the Theranostic Approach in Nuclear Medicine, as Exemplified by the Radionuclide Pair 86Y and 90Y
2017
Pharmaceuticals
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In 1992, a few researchers at the Research Center Jülich, Germany, came to the idea of combining PET and endoradiotherapy by using a pair of radionuclides of the same element, one emitting positrons and ...
1 /2 = 3.06 d), etc., and positron emitters, like 11 C (t 1 /2 = 20.4 min), 18 F (t 1 /2 = 110 min), 68 Ga (t 1 /2 = 67.6 min), etc., are commonly used. ...
emitters. ...
doi:10.3390/ph10020056
pmid:28632200
pmcid:PMC5490413
fatcat:jf4rjis7enb5blg3wlud7p4gwa
Investigation of optimized prompt gamma detection strategy for real-time Bragg Peak tracking in proton radiation therapy
2015
2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
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Prompt gamma (PG) ray signal from proton radiation has been proposed for in vivo beam range verification to provide unique real-time tracking of the Bragg Peak (BP) during proton therapy (PT) delivery. ...
Abstract-Prompt gamma (PG) ray signal from proton radiation has been proposed for in vivo beam range verification to provide unique real-time tracking of the Bragg Peak (BP) during proton therapy (PT) ...
These include that it cannot offer real-time monitoring because of the delayed decay of the positron emitters and a relatively low rate of positron emissions, which limit the conventional PET for in-beam ...
doi:10.1109/nssmic.2015.7582237
fatcat:si3usngrlzfj7b3nvns2j2tra4
124Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging
2014
BioMed Research International
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The physical characteristics of124I permit taking advantages of the higher PET image quality. ...
The availability of new molecules that may be targeted with124I represents one of the more interesting reasons for the attention in nuclear medicine. ...
studies. 124 I, a positron-emitting nuclide with a halflife of 4.2 days, could permit PET quantitative imaging over several days. ...
doi:10.1155/2014/672094
pmid:24895600
pmcid:PMC4034399
fatcat:lw3tv6a2yvacxpn525y6qu7td4
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